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Search Results: 1 - 10 of 39062 matches for " LING Chang-Quan "
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Study of a qualitative diagnostic criterion for basic syndromes of traditional Chinese medicine in patients with primary liver cancer
LING Chang-Quan
Zhong Xi Yi Jie He Xue Bao , 2005,
Abstract: Objective: To work out a qualitative diagnostic criterion for basic syndromes of traditional Chinese medicine in patients with primary liver cancer. Methods: Based on the collection and analysis of related medical literature, clinical investigation, and experts’ discussion, a preliminary qualitative diagnostic criterion for basic syndromes of traditional Chinese medicine in patients with primary liver cancer was formulated. Then it was used in clinic to be verified and revised repeatedly till it was improved to be a satisfied formal criterion. Results: The basic syndromes listed in the qualitative diagnostic criterion for basic syndromes in patients with primary liver cancer consisted of two parts: excessive syndromes, including the syndromes of stagnation of qi, blood stasis, excess-heat and dampness, and deficient syndromes, including the syndromes of deficiency of qi, deficiency of blood, deficiency of yin and deficiency of yang. Each of the above syndromes could be diagnosed according to specific combination of its corresponding symptoms or signs. The clinical verification results showed that the total matching ratio was 73.92% between the diagnoses made according to the criterion and the diagnoses acquired from the experts’ experience. Conclusions: The qualitative diagnostic criterion for basic syndromes of traditional Chinese medicine in patients with primary liver cancer is coincident with the experts’ clinical practice. However, it needs to be further studied.
Cancerous toxin is the key pathogenic factor of malignant tumor
Chang-quan LING
Zhong Xi Yi Jie He Xue Bao , 2008,
Abstract: ABSTRACT: The definition of cancerous toxin and the relationships between cancerous toxin and other factors including the etiopathogenesis, pathogenesis and treatment of malignant tumor were discussed in this paper. The author suggests that the cancerous toxin is engendered by the disequilibrium of human body, which is the foundation of tumorigenesis. Cancerous toxin is the main pathogenic factor or one of the main pathogenic factors during the development of malignant tumor, hence it is also the key point for understanding and treating malignant tumor.
Problems in cancer treatment and major research of integrative medicine
LING Chang-Quan
Zhong Xi Yi Jie He Xue Bao , 2003,
Abstract: ABSTRACT: There exist some problems in the present cancer treatment, such as: (1) prevalence of excessive treatment; (2) lack of long-term research plan; (3) lack of reasonable comprehensive treatment; (4) lack of operative individualized treatment; (5) the superiority of traditional Chinese medicine (TCM) was undervalued and underused. Integrative medicine should play an important role in the prevention and treatment of cancer. Further research should be carried out in the following aspects: (1) enrich and improve the theoretical knowledge of TCM on cancer; (2) enhance the research on rationalization and standardization of cancer treatment program of integrative medicine; (3) enhance the research on criterion of therapeutical effect of integrative medicine in treating cancer; (4) enhance the research on prevention and treatment of postoperative recurrence and metastasis of cancer by integrative medicine.
Pondering the research on syndrome of traditional Chinese medicine
LING Chang-Quan
Zhong Xi Yi Jie He Xue Bao , 2004,
Abstract: Syndrome research is a challenging field in the research on traditional Chinese medicine and there is no breakthrough at all in this field as yet, although some progresses from various aspects have been achieved in recent years. The definition of syndrome based on the conceptions of traditional Chinese medicine is basically clear, but the qualitative macro-criteria for syndrome are not standardized and the research methods for quantification of such criteria are not unified. These hindered the processing of the modernization of traditional Chinese medicine to a great extent; therefore new research methods for syndrome using techniques of modern sciences should be further investigated. During the research of syndrome, it is suggested that: (1) the research should be turned to complex syndrome from the fundamental simple syndrome gradually, on the basis of certain diseases in western medicine; (2) animal experiment would be of no significance before quite a successful research performed in human body; (3) the results of the research of syndrome should be in agreement with the life science as well as the entire natural science.
Analysis of literature on therapeutic methods and medicines of traditional Chinese medicine for primary liver cancer
LIU Qing,LING Chang-Quan
Zhong Xi Yi Jie He Xue Bao , 2005,
Abstract: Objective: To find out the rules of therapeutic methods, formulas and medicines of traditional Chinese medicine (TCM) for primary liver cancer (PLC). Methods: The frequencies of treatments and medicines of TCM in 978 pieces of documents concerning PLC were analyzed. Results: Among the 165 therapeutic methods, 277 formulas and 459 kinds of herbs, the methods for activating blood circulation, the formulas for regulating qi-flowing and the herbs for invigorating qi are the most commonly used. Conclusion: Therapeutic methods such as invigorating qi, regulating qi-flowing and activating blood circulation are the main choices for PLC, and the methods such as clearing heat, removing dampness and nourishing yin are used as supplements.
Quantitative study on tongue color in primary liver cancer patients by analysis system for comprehensive information of tongue diagnosis
LIU Qing,Ling Chang-Quan
Zhong Xi Yi Jie He Xue Bao , 2003,
Abstract: Objective: To explore the characteristics of tongue color in patients with primary liver cancer (PLC). Methods: Tongue color and its RGB value were analyzed quantitatively for PLC patients in different clinical periods and other cancer patients by analysis system for comprehensive information of tongue diagnosis. Results: The rate of blue and purple tongue was higher (P <0.05) and all the values of RGB were lower (P <0.01) in PLC patients compared with other cancer patients. In different clinical periods, the rate of blue and purple tongue in stage Ⅲ was the highest (P <0.05). Conclusion: The blue and purple tongue is one of the most important tongue characteristics of PLC patients.
Inhibition action of bufalin on human transplanted hepatocellular tumor and its effects on expressions of Bcl-2 and Bax proteins in nude mice
Wei GU,Chang-quan LING
Zhong Xi Yi Jie He Xue Bao , 2007,
Abstract: Objective: To investigate the anti-tumor effect of bufalin and its regulation on Bcl-2 and Bax proteins in orthotopically transplanted tumor of human hepatocellular carcinoma in nude mice. Methods: Orthotopically transplanted tumor of human hepatocellular carcinoma was established in nude mice. The mice were randomly divided into five groups: high-dose bufalin-treated group (1.5 mg/kg), medium-dose bufalin-treated group (1 mg/kg), low-dose bufalin-treated group (0.5 mg/kg), adriamycin-treated group (8.0 mg/kg), and normal saline-treated group. After 25 days, mice were sacrificed. The tumor volume was measured, and the pathological changes of tumor tissues were detected by HE staining to observe the tumor necrosis degree. Cell morphological changes were also observed by an electron microscopy. Label index of tumor cell apoptosis was assessed by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL), and the expressions of Bcl-2 and Bax proteins were determined by immunohistochemical method. Results: The tumor volume in the bufalin-treated groups was shrunk significantly compared with that in the normal saline-treated group (P<0.01). The survival time of the bufalin-treated groups was prolonged compared with that of the adriamycin-treated group and the normal saline-treated group (P<0.05). Apoptotic characteristics could be seen in tumor tissues of the bufalin-treated groups. The label index of tumor cell apoptosis in the bufalin-treated groups (5.87±2.13, 8.86±2.96 and 10.60±3.42 in low-, medium- and high-dose groups respectively) was higher than that in the adriamycin-treated group (3.28 ±0.98) (P<0.05, P<0.01). The expression of Bax was up-regulated, while no changes were detected as to Bcl-2 protein in tumors of the bufalin-treated groups. Conclusion: Bufalin has significant anti-tumor effect on the orthotopically transplanted tumor of human hepatocellular carcinoma in nude mice. Its effect might be related to up-regulation of Bax protein and inducement of the tumor cell apoptosis.
Establishment of a multidrug-resistant cell line BEL-7402/5-FU of human hepatocellular carcinoma and its biological characteristics
Wei GU,Chang-Quan LING
Zhong Xi Yi Jie He Xue Bao , 2006,
Abstract: Objective: To establish a multidrug-resistant cell line BEL-7402/5-FU of hepatocellular carcinoma (HCC). Methods: BEL-7402/5-FU was induced by pulse therapy combined with continuous stepwise exposure to 5-fluorouracil in vitro. MTT assay was used to determine its multidrug resistance (MDR). Biological characteristics of the BEL-7402/5-FU cell line were observed including morphological changes, cell growth curve, population doubling time, plate cloning efficiency, adherence rate, cell cycle distribution, chromosome and tumorigenicity. Accumulation amount of adriamycin (ADM) in cytoplasm was measured by flow cytometry. The protein expression of thymidylate synthase (TS) was evaluated by immuno-cytochemical method. Results: The acquired MDR cell line of BEL-7402/5-FU was established successfully. The BEL-7402/5-FU cells showed cross-resistance to ADM, vincristine (VCR), methotrexate (MTX) and oxaliplatin (OHP), whereas still sensitive to hydroxycamptothecin (HCPT). The BEL-7402/5-FU cells tended to grow in clusters in vitro. It was found that the population doubling time of BEL-7402/5-FU cells was longer than that of its parental cells. The plate cloning efficiency and the adherence rate of BEL-7402/5-FU cells at the 2nd and 3rd hour were both lower than those of the parental cells. The distributing proportion of BEL-7402/5-FU cells in G0/G1 phase was less than that of the parental cells, whereas the distributing proportion of BEL-7402/5-FU cells in S phase was higher than that of the parental cells. The accumulation amount of ADM in cytoplasm of BEL-7402/5-FU cells was significantly lower while the expression level of TS protein of which was highly up-regulated as compared with those of the parental cells. Conclusion: Establishment of the human HCC cell line BEL-7402/5-FU might be beneficial to the studies of 5-Fluorouracil acquired MDR mechanisms and the selection of reversal modifiers.
Ginsenosides combined with dexamethasone in preventing and treating postembolization syndrome following transcatheter arterial chemoembolization: A randomized, controlled and double-blinded prospective trial
FENG Ying-Lu,LING Chang-Quan
Zhong Xi Yi Jie He Xue Bao , 2005,
Abstract: Objective: To observe the effect of ginsenosides (GS) and low dose glucocorticoid in preventing and treating the postembolization syndrome following transcatheter arterial chemoembolization (TACE). Methods: Eighty patients with primary liver carcinoma were randomly divided into 4 double-blinded groups, with 20 patients in each group. Patients in groups A, B, C, D were treated with placebo, dexamethasone (Dex), GS, Dex and GS, respectively. The changes of clinical symptoms and laboratory tests after TACE were observed. Results: Dex combined with GS markedly decreased the occurrence ratio and lasting time of the symptoms such as nausea, vomiting, fever and pain, and protected the function of liver as compared with the placebo (P<0.05). Single use of Dex or GS improved some symptoms as compared with the placebo, but it was not as good as the combination of Dex and GS. Conclusion: Dex combined with GS can effectively prevent and treat the postembolization syndrome following TACE.
α-linolenic acid and linoleic acid in extract of Portulaca oleracea L. determined by high-performance liquid chromatography
Hai-liang XIN,Chang-quan LING
Zhong Xi Yi Jie He Xue Bao , 2008,
Abstract: Objective: To determine α-linolenic acid and linoleic acid in extract of Portulaca oleracea L. by high performance liquid chromatography (HPLC).Methods: The determination was done with a Shim-pack CLC-ODS (250 mm×4.6 mm, 5 μm) and a DIKMA Easyguard C18 (10 mm×4.6 mm). Elution was employed with the mobile phase of methanol-acetonitrile-0.5% phosphonic acid (60︰22︰18) at flow rate of 1.1 ml/min. Column temperature was 26 ℃. Detection wavelength was 210 nm. Injection volume was 25 μl.Results: The standard curves of α-linolenic acid and linoleic acid were linear in the range 0.016 2 to 0.194 4 mg/ml and 0.016 9 to 0.203 0 mg/ml, respectively. The regression equations were A=2.915 8×107 C+12 250.9, r=0.999 9 and A=1.366 4×107 C-9 759.39, r=0.999 9, respectively. The average recovery rates were 100.5 % and 100.8 %, respectively.Conclusion: The present method (HPLC) may be considered to be reliable and simple for the determination of α-linolenic acid and linoleic acid in extract of Portulaca oleracea L.
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