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Search Results: 1 - 10 of 71391 matches for " LIN Yan "
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A Study on Anchoring Ability of Three-Leg Micro Intestinal Robot  [PDF]
Wei Lin, Guozheng Yan
Engineering (ENG) , 2012, DOI: 10.4236/eng.2012.48062
Abstract: This paper proposes an anchoring and extending micro intestinal robot for medical inspection and surgery propose. The three-leg anchoring method is discussed in detail, and micro robot phantom model is used to test anchoring related parameters for mechanical design. A prototype is designed and fabricated base on the experiment results and is tested in in-vitro experiment. The prototype is locomotive in a pig small intestine under a diameter limitation.
Timing and Spouting Height of Sand Boils Caused by Liquefaction during the 2010 Mw 6.9 Yushu Earthquake, Tibetan Plateau, China  [PDF]
Bing Yan, Aiming Lin
Open Journal of Earthquake Research (OJER) , 2015, DOI: 10.4236/ojer.2015.41002
Abstract: The 2010 Mw 6.9 Yushu earthquake produced a ~33-km-long co-seismic surface rupture zone along the pre-existing active Yushu Fault on China’s central Tibetan Plateau. Sand boils occurred along the tension cracks of the co-seismic surface rupture zone, and locally spouted up above the ground to coat the top of limestone blocks that had slid down from an adjacent ~300-m-high mountain slope. Based on our observations, the relations between the arrival times of P- and S-waves at the sand-boil location and the seismic rupture velocity, we conclude that 1) the sand boils occurred at least 18.24 s after the main shock; 2) it took at least 4.09 - 9.79 s after the formation of co-seismic surface rupture to generate liquefaction at the sand-boil location; 3) the spouting height of sand boils was at least 65 cm. Our findings help to clarify the relationships between the timing of lique-faction and the spouting height of sand boils during a large-magnitude earthquake.
The Results From The NICMOS Parallel Imaging and Grism Survey
Lin Yan
Physics , 1999,
Abstract: We present the results of a survey which utilizes the NICMOS Camera 3 Parallel grism and imaging observations of random fields. We have identified 33 H$\alpha$ emission-line galaxies at 0.75 5$ and $H$ brighter than 20.6. The surface density of these objects is around 0.6 per square arcminutes.
A Model of Carbon Price Interactions with International Embodied Carbon  [PDF]
Yan Lin
Open Journal of Social Sciences (JSS) , 2017, DOI: 10.4236/jss.2017.53004
Abstract: This paper takes the EU as an example to discuss the relationship between international embodied carbon and carbon price through VAR model. The result shows that there is a long-term interaction but an asymmetric relationship between them: The impact of the scale of international embodied carbon on carbon futures price is significantly negative, while the impact of carbon futures price on the scale of international embodied carbon is negligible. Then this paper tries to come up with corresponding policy suggestion in the end based on empirical findings.
Granular Reasoning and Decision System’s Decomposition
Yan Lin,Yan Shuo
Journal of Software , 2012, DOI: 10.4304/jsw.7.3.683-690
Abstract: In order to make further researches on decision logic, a generalized form of decision reasoning called granular reasoning is introduced, which is induced by the inclusion relation over granules, and is connected with granule’s operations. The investigations on it shows that granular reasoning not only covers a wider range including decision reasoning, but also satisfies the rules of deduction in classical logic. Thus, granular reasoning can be taken as a foundation to support decision reasoning. On the other hand, granular reasoning has close links with a decision system. Based on granular reasoning, a decision system can be divided into sub-decision systems. Consequently, as a special form of granular reasoning, decision reasoning defined in a decision system becomes to rely on sub-decision systems. This makes decision reasoning easier.
Extraction of the Main Ingredients from Chuanxiong by CO2 Supercritical Fluid Extraction  [PDF]
Ru Yan, Song-Lin Li, Ge Lin
American Journal of Analytical Chemistry (AJAC) , 2012, DOI: 10.4236/ajac.2012.312A120

As one of the most frequently used medicinal herbs in China, Chuanxiong Rhizoma (Chuanxiong) is notable for its beneficial effects in alleviation of cardio- and cerebro- vascular disorders. Results from previous phytochemical, pharmacological and pharmacokinetic studies supported the contributions of 10 main components, namely ferulic acid (3), senkyunolide I (4), senkyunolide H (5), senkyunolide A (6), coniferylferulate (7), Z-ligustilide (8), sedanolide (9), 3-butylidenephthalide (10), riligustilide (11) and levistolide A (12), for therapeutic outcomes of the herb. To prepare a Chuanxiong extract, which is selectively enriched with these main components, the supercritical fluid extraction (SCFE) technique using CO2 was chosen in the present study due to its superiority in extraction of lipophilic components, especially thermo-labile components from natural products. Eight Chuanxiong samples were extracted under different SCFE conditions. Contents of 3 - 12 in SCFE extracts and remained in herbal residues were determined using HPLC-UV and compared with those in 95% ethanol extracts of the respective herbal samples. The results showed that contents of 3 - 12 were generally enriched by SCFE with higher recoveries achieved for lipophilic constituents, including the three most abundant constituents 6, 7 and 8. Moreover, extraction yield of the less lipophilic 3, 4 and 5 was improved by adding ethanol as entrainer. Higher flow rate of CO2 (10 - 13 L/h vs 9 -

Notch 1 and NF-κB Expression and Clinical Correlation in Chinese Patients with Lymphoblastic Lymphoma  [PDF]
Lin Lin, Xiaofei Sun, Juan Wang, Zijun Zhen, Suxia Lin, Gangling Tong, Yan Chen
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.43A053

T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/T-LBL) is commonly associated with Notch 1 mutations. There is limited data on the relationship between Notch l and NF-κB expression and clinical features in LBL. We evaluated the expression of Notch l and NF-κB in LBL using immunohistochemistry and analyzed their relationship with clinical characteristics, treatment results, and survival. From October 2000 to August 2008, 34 untreated patients with LBL were enrolled in the study. Median age was 11.8 years (range, 1 - 25 years). Twenty-five patients were diagnosed with T-LBL and 9 patients with B-LBL. Most patients received chemotherapy consisting of modified ALL-BFM- 90. Notch l showed high expression in 68% of T-LBL and low expression in 100% of B-LBL (p = 0.015). High expression of Notch l positively correlated with presence of a mediastinal mass but not with 5-year event free survival (EFS) in T-LBL. NF-κB showed high expression in 65% of all patients with LBL, with no difference between T- and B-LBL. NF-κB expression was higher in T-LBL patients with bulky disease and B symptom; it did not correlate with 5-year EFS in T-LBL. Expression of Notch 1 and NF-κB strongly correlated (p = 0.014) in T-LBL. Notch 1 is highly ex- pressed in T-LBL. NF-κB is highly expressed in all patients with LBL with no difference between T-LBL and B-LBL. Notch 1 expression was significantly associated with NF-κB expression in T-LBL. Notch l and NF-κB may play an important role in the development of T-LBL; further investigation is warranted.

In Silico Investigations of the Anti-Catabolic Effects of Pamidronate and Denosumab on Multiple Myeloma-Induced Bone Disease
Yan Wang, Bo Lin
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044868
Abstract: It is unclear whether the new anti-catabolic agent denosumab represents a viable alternative to the widely used anti-catabolic agent pamidronate in the treatment of Multiple Myeloma (MM)-induced bone disease. This lack of clarity primarily stems from the lack of sufficient clinical investigations, which are costly and time consuming. However, in silico investigations require less time and expense, suggesting that they may be a useful complement to traditional clinical investigations. In this paper, we aim to (i) develop integrated computational models that are suitable for investigating the effects of pamidronate and denosumab on MM-induced bone disease and (ii) evaluate the responses to pamidronate and denosumab treatments using these integrated models. To achieve these goals, pharmacokinetic models of pamidronate and denosumab are first developed and then calibrated and validated using different clinical datasets. Next, the integrated computational models are developed by incorporating the simulated transient concentrations of pamidronate and denosumab and simulations of their actions on the MM-bone compartment into the previously proposed MM-bone model. These integrated models are further calibrated and validated by different clinical datasets so that they are suitable to be applied to investigate the responses to the pamidronate and denosumab treatments. Finally, these responses are evaluated by quantifying the bone volume, bone turnover, and MM-cell density. This evaluation identifies four denosumab regimes that potentially produce an overall improved bone-related response compared with the recommended pamidronate regime. This in silico investigation supports the idea that denosumab represents an appropriate alternative to pamidronate in the treatment of MM-induced bone disease.
Oxidative Decarboxylation of Levulinic Acid by Silver(I)/Persulfate
Yan Gong,Lu Lin
Molecules , 2011, DOI: 10.3390/molecules16032714
Abstract: The oxidative decarboxylation of levulinic acid (LA) by silver(I)/persulfate [Ag(I)/S2O82?] has been investigated in this paper. The effects of buffer solution, initial pH value, time and temperature and dosages of Ag(I)/S2O82? on the decarboxylation of LA were examined in batch experiments and a reaction scheme was proposed on basis of the reaction process. The experimental results showed that a solution of NaOH-KH2PO4 was comparatively suitable for the LA decarboxylation reaction by silver(I)/persulfate. Under optimum conditions (temperature 160 °C, pH 5.0, and time 0.5 h), the rate of LA conversion in NaOH-KH2PO4 solutions with an initial concentration of 0.01 mol LA reached 70.2%, 2-butanone (methyl ethyl ketone) was the single product in the gas phase and the resulted molar yield reached 44.2%.
Biosynthesis of caffeic acid in Escherichia coli using its endogenous hydroxylase complex
Yuheng Lin, Yajun Yan
Microbial Cell Factories , 2012, DOI: 10.1186/1475-2859-11-42
Abstract: We first identified that an Escherichia coli native hydroxylase complex previously characterized as the 4-hydroxyphenylacetate 3-hydroxylase (4HPA3H) was able to convert p-coumaric acid to caffeic acid efficiently. This critical enzymatic step catalyzed in plants by a membrane-associated cytochrome P450 enzyme, p-coumarate 3-hydroxylase (C3H), is difficult to be functionally expressed in prokaryotic systems. Moreover, the performances of two tyrosine ammonia lyases (TALs) from Rhodobacter species were compared after overexpression in E. coli. The results indicated that the TAL from R. capsulatus (Rc) possesses higher activity towards both tyrosine and L-dopa. Based on these findings, we further designed a dual pathway leading from tyrosine to caffeic acid consisting of the enzymes 4HPA3H and RcTAL. This heterologous pathway extended E. coli native tyrosine biosynthesis machinery and was able to produce caffeic acid (12.1 mg/L) in minimal salt medium. Further improvement in production was accomplished by boosting tyrosine biosynthesis in E. coli, which involved the alleviation of tyrosine-induced feedback inhibition and carbon flux redirection. Finally, the titer of caffeic acid reached 50.2 mg/L in shake flasks after 48-hour cultivation.We have successfully established a novel pathway and constructed an E. coli strain for the production of caffeic acid. This work forms a basis for further improvement in production, as well as opens the possibility of microbial synthesis of more complex plant secondary metabolites derived from caffeic acid. In addition, we have identified that TAL is the rate-limiting enzyme in this pathway. Thus, exploration for more active TALs via bio-prospecting and protein engineering approaches is necessary for further improvement of caffeic acid production.Caffeic acid (3,4-dihydroxycinnamic acid) is a natural phenolic compound initially found in plants. Previous studies on its biological activities suggested that caffeic acid possesses anti-o
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