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Search Results: 1 - 10 of 2503 matches for " LIEN ALINA SUTASURYA "
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Methoxyacetic Acid Induced Apoptosis on the Forelimb Bud of Swiss Webster Mice
AGUS HARYONO,TIEN WIATI SURJONO,LIEN ALINA SUTASURYA,SRI SUDARWATI
HAYATI Journal of Biosciences , 2011,
Abstract: Methoxyacetic acid (MAA) causes digit malformations of mice when it was given orally on gestation day 11. Previous observation showed that malformation was caused by cell death. The aims of the research were to determine the types of cell death, first time of cell death and their distribution pattern on forelimb bud of Swiss Webster (SW) mice. Ten mM/kg of body weight (bw) of MAA were administered by gavage to SW mice on gestation day 11. Forelimb bud of mouse embryos of gestation day 11 + 0, 1, 2, 3, 4, 5 hours were processed with paraffin method and were made plantar section. Cell death at plantar section were colored with 4,6-diamino-2-phenylindole hydrochloride (DAPI) and hematoxylin. The result showed, that digit malformations initially by apoptosis mesenchymal cell at proximal of axial mesoderm in around of primary axial artery has done one hour after treatment. Apoptosis at the axial area, the site formation of digital ray III distributed to preaxial area where digits I and II are formed, and to the site formation of digits IV and V. The number of mesenchyme cell of digital rays II, III, and V was decrease by the increasing of gestation day, while digital ray was not formed and finally digits I, II, III, and V were missing. The reduction number of cell of digital ray IV were delayed time to be formed and its small size. Thereby it can be concluded, that MAA induced digit malformations of SW mice started by apoptosis which is occurrence has been increase in area of digital ray formation, so that digital ray can not be formed, but when formed it will not developed.
THE EFFECTS OF a-CHLOROHYDRIN ON THE GESTATION OF THE WISTAR RAT (Rattus norvegicus)
RAHMANIAH,LIEN A. SUTASURYA
BIOTROPIA : the Southeast Asian Journal of Tropical Biology , 1999,
Abstract: The investigation of the effects of a-chlorohydrin on the gestation of the wistar rat has been carried out to determine whether a-chlorohydrin could interfere with the gestation of the rat and gestation period for optimal sensitivity. Alpha-chlorohydrin was administered by gavage to three different groups of pregnant rats, namely on the first (pre-implantation period), sixth (early post-implantation period) or fourteenth (late post-implantation period) gestation day, at a single dose of 62.5; 75 and 90 mg/kg body weight. Rats were sacrificed on the IS* gestation day. Number of implantations, gestation loss and post-implantation mortality were recorded. The results revealed that 75 and 90 mg/kg body weight of a-chlorohydrin significantly interfered with all the gestation periods used. For the pre-implantation group, a-chlorohydrin decreased significantly the implantation number, but increased the gestation loss as well as the post-implantation mortality compared to the control groups. For the early post-implantation and late post-im plantation groups, a-chlorohydrin caused a significant increase in post-implantation mortality compared to the control groups. From these results it is concluded that a-chlorohydrin at 75 and 90 mg/kg body weight influences the gestation of the wistar rat administered during the pre-implantation period as the most sensitive gestation period.
Redise?o y estandarización de un método inmunoenzimático para detectar anticuerpos anti-estreptoquinasa en muestras de suero humano
López Matilla,Lien; González Griego,Antonio; Santiesteban Torres,Jorge Arturo; Alerm González,Alina;
Revista Cubana de Investigaciones Biom??dicas , 2002,
Abstract: a sandwich, heterogenous, qualitative, doble antigen immunoenzimatic method was standardized to detect anti-streptokinase antibodies in pure samples of human serum. different concentrations of the recovering antigen and conjugate dilutions, as well as various times and temperatures of incubation of the samples were assayed. the cut-off value of the assay and its detection limit were established and it was proved if there were some unspecificities. 0.1 mg/ml was determined as an optimal recovering concentration for a conjugate dilution of 1:100 000. the optimum conditions of incubation of the samples were 30 min at lab temperature and there were no interferences of other analytes with the technique.the optical densities between 0.282 and 0.654 were established as normal values of the technique.
Estudio del transporte madre-hijo de anticuerpos antiestreptoquinasa
Lien López Matilla,Antonio González Griego,Alina Alerm González,Arturo Santiesteban Torres
Revista Cubana de Investigaciones Biom??dicas , 2002,
Abstract: Se estudió cómo se comporta el transporte de anticuerpos anti-estreptoquinasa entre la madre y el recién nacido y cuáles son los factores que influyen en este. Se colectaron 125 muestras sanguíneas de puérperas, por la vena antecubital y de sus respectivos hijos a partir del cordón umbilical. Se confeccionaron encuestas para la recolección de datos a partir de las historias clínicas de las madres y los recién nacidos. Se empleó un método inmunoenzimático, heterogéneo, cualitativo, tipo sandwich de doble antígeno para la detección de anticuerpos anti-estreptoquinasa. A partir de los resultados obtenidos se concluyó que existe un transporte activo de los anticuerpos anti-estreptoquinasa de la madre al feto y que este transporte se ve influenciado por la edad cronológica de la madre, la edad gestacional, el estado nutricional de la madre y el peso del recién nacido. The behavior of the transport of streptokinase antibodies from the mother to the newborn infant, as well as the factors influencing on it, were studied here. 125 blood samples were obtained from the antecubital vein of the puerperas and from the umbilical cord of their children. Surveys were done to collect data from the medical histories of the mothers and the newborn infants. An immunoenzimatic, heterogenous and qualitatitve sandwich doble antigen method was used to detect anti-streptokinase antibodies. According to the results, it was concluded that there is an active transport of anti-streptokinase antibodies from the mother to the fetus and that this transport is influenced by the chronological age of the mother, the gestational age, the mother’s nutritional status and the birth weight.
Redise o y estandarización de un método inmunoenzimático para detectar anticuerpos anti-estreptoquinasa en muestras de suero humano
Lien López Matilla,Antonio González Griego,Jorge Arturo Santiesteban Torres,Alina Alerm González
Revista Cubana de Investigaciones Biom??dicas , 2002,
Abstract: Se procedió a estandarizar un método inmunoenzimático, heterogéneo, cualitativo, tipo sandwich de doble antígeno para la detección de anticuerpos contra la estreptoquinasa en muestras puras de suero humano. Se ensayaron diferentes concentraciones del antígeno de recubrimiento y diluciones del conjugado, así como diferentes tiempos y temperaturas de incubación de las muestras. Se estableció el valor de corte del ensayo y su límite de detección y se comprobó si existían inespecificidades. Se determinó como concentración óptima de recubrimiento 0,1 μg/mL para una dilución del conjugado de 1:100 000. Las condiciones óptimas de incubación de las muestras fueron 30 min a temperatura de laboratorio y no se comprobaron interferencias de otros analitos con la técnica. Se establecieron como valores normales de la técnica las densidades ópticas que se encuentran entre 0,282 y 0,654. A sandwich, heterogenous, qualitative, doble antigen immunoenzimatic method was standardized to detect anti-streptokinase antibodies in pure samples of human serum. Different concentrations of the recovering antigen and conjugate dilutions, as well as various times and temperatures of incubation of the samples were assayed. The cut-off value of the assay and its detection limit were established and it was proved if there were some unspecificities. 0.1 mg/mL was determined as an optimal recovering concentration for a conjugate dilution of 1:100 000. The optimum conditions of incubation of the samples were 30 min at lab temperature and there were no interferences of other analytes with the technique.The optical densities between 0.282 and 0.654 were established as normal values of the technique.
Northern Labyrinth—A Key to Time, Space, Information  [PDF]
Alina Paranina
Natural Resources (NR) , 2013, DOI: 10.4236/nr.2013.44042
Abstract:

Northern labyrinths are stone constructions of different shapes, dating back to III-I century BC. They mainly appear on capes on peninsulas and islands up to 13-25 metresabove the sea level. Their area begins from Scilly Isles (England) and in the White Sea (Russia). Opinions of scientists concerning their designation are controversial. Assumptions about their practical meaning haven’t been proved: no burials have been found underneath; fishing equipment cannot be located so far from the area of tides. Most of the scientists link labyrinths with the sphere of spiritual culture: sanctuaries, altars, sacred places, schemes of rituals and magical centers. Assumptions about calendar designation link the picture of labyrinth with schemes of orbits of the Sun, the Moon, planets and stars. However they do not explain the application of this technology. The author’s concept is based on the opposite astronomical alignment by the shade of gnomon and considers peculiarities of the geographical space of Northern regions (polar days and white nights). The aim of the research is to prove that the key to decoding the picture of a classic Northern labyrinth is a gnomon located in the centre of the construction. Field research has been conducted on Zayztskiy Island in Solovetskiy Archipelago. Experiments of imitation modeling have been done, analysis of linguistic and toponymic materials, archeological, astronomical, ethnographical and mythological and other sources has been implemented. The research has proved that observations of the shade can help to create a calendar in a shape of a bispiral labyrinth. The structure of labyrinth is convenient for defining the North, dividing daytime and defining geographical altitude of the observation point. Orientation in space and time has become the basis for navigation frame of the territory. A set of stone instruments is the key of a navigation frame of the territory. Life-essential stages of the yearly lighting are reflected in specific geometry shapes of shades. They have been preserved in mythological images of the Sun, solar symbols and modern sign systems. Languages, alphabets, numeric systems can be considered as models of geographical space and have evolved thanks to observations of the light movement. Key results of the

Navigation in Space-Time as the Basis for Information Modeling  [PDF]
Alina Paranina
Archaeological Discovery (AD) , 2014, DOI: 10.4236/ad.2014.23010
Abstract: The article presents the author’s concept of information modeling of the world, based on the leading role of solar navigation (orientation in space-time by the sun). The concept was developed in the course of comprehensive research on the main patterns of use of information resources (semiotics) during the exploration of nature of geographical space by humans. The objects of the study were the monuments of ancient material culture of European Russia and Southern Siberia. The applied field research methods include survey, description, observation, work with maps and Earth remote sensing, as well as methods of mathematical, conceptual modeling and mapping. Theoretical analysis is based on the theory of reflection and systemic and chorological approach, methodological statements of historical geography by V.I. Paranin.
Indoor Air Quality Measurement with the Installation of a Rooftop Turbine Ventilator  [PDF]
Jason Lien, Noor Ahmed
Journal of Environmental Protection (JEP) , 2012, DOI: 10.4236/jep.2012.311166
Abstract: The present paper presents a numerical analysis of the difference in comfort level inside a room of a residential building when roof top turbine ventilator is installed. This analysis simulates various comfort factors which includes the indoor air movement, room temperature, Predicted Mean Vote (PMV) and Predicted Percentage of Dissatisfied (PPD). Various test cases of ventilator exhaust rate were examined. The results showed that general comfort satisfying international standards in building can be achieved. This study also presents a qualitative and quantitative study of indoor air temperature and overall indoor air flow pattern. A promising conclusion that can be drawn from this study is that wind driven ventilators can play an important role in the design of a cost effective and energy efficient ventilation system inside a building.
Microstructure of Plasma Sprayed Al2O3-3wt%TiO2 Coating Using Freeze Granulated Powder  [PDF]
Yiming Yao, Ola Lyckfeldt, Aurélien Tricoire, Aurélien Tricoire
Journal of Materials Science and Chemical Engineering (MSCE) , 2016, DOI: 10.4236/msce.2016.47002
Abstract:

This study is aiming at controlling the microstructure of plasma sprayed Al2O3-TiO2 composite coatings using freeze granulated powders. As sprayed and sintered Al2O3 + 3wt%TiO2 powders were air plasma sprayed with industry process parameters and compared with a commercial powder. The resulting coatings were investigated with respect to powder flowability, porosity and microstructure of the granules. The results showed that microstructure and melting fraction in the coatings could be tailored with the freeze granulation process and heat treatment conditions.

Biomarkers and atrial fibrillation: A new paradigm for assessing the progression of left atrial endocardial remodelling  [PDF]
Philippe Chevalier, Alina Scridon
Open Journal of Clinical Diagnostics (OJCD) , 2012, DOI: 10.4236/ojcd.2012.22004
Abstract: Atrial fibrillation is a heterogeneous disorder that is usually characterized by paroxysmal onset, particularly in patients without structural heart disease. Defining biological markers of atrial remodelling would help identify patients at high risk who would benefit most from prophylactic treatment and careful monitoring. Biomarkers of atrial fibrillation progression would be helpful for following patients that present with asymptomatic atrial fibrillation. Notably, the roles of such markers in the pathophysiology of atrial fibrillation must be determined. Some markers may indicate the presence, complications or progression of the disease, while others may be involved in key pathological processes and thus represent novel therapeutic targets. Although a number of markers have been reported as potential predictors of paroxysmal atrial fibrillation progression towards persistent arrhythmia, their usefulness and clinical value need further validation. This report reviews several newly identified markers of atrial fibrillation progression.
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