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Search Results: 1 - 10 of 140627 matches for " LI Ke-Qin "
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Independent Expansion of Zincin Metalloproteinases in Onygenales Fungi May Be Associated with Their Pathogenicity
Juan Li, Ke-Qin Zhang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0090225
Abstract: To get a comprehensive view of fungal M35 family (deuterolysin) and M36 family (fungalysin) genes, we conducted genome-wide investigations and phylogenetic analyses of genes in these two families from 50 sequenced Ascomycota fungi with different life styles. Large variations in the number of M35 family and M36 family genes were found among different fungal genomes, indicating that these two gene families have been highly dynamic through fungal evolution. Moreover, we found obvious expansions of Meps in two families of Onygenales: Onygenaceae and Arthodermataceae, whereas species in family Ajellomycetace did not show expansion of these genes. The strikingly different gene duplication and loss patterns in Onygenales may be associated with the different pathogenicity of these species. Interestingly, likelihood ratio tests (LRT) of both M35 family and M36 family genes suggested that several branches leading to the duplicated genes in dermatophytic and Coccidioides fungi had signatures of positive selection, indicating that the duplicated Mep genes have likely diverged functionally to play important roles during the evolution of pathogenicity of dermatophytic and Coccidioides fungi. The potentially positively selected residues discovered by our analysis may have contributed to the development of new physiological functions of the duplicated Mep genes in dermatophytic fungi and Coccidioides species. Our study adds to the current knowledge of the evolution of Meps in fungi and also establishes a theoretical foundation for future experimental investigations.
Molecular Evolution of the Deuterolysin (M35) Family Genes in Coccidioides
Juan Li, Li Yu, Yanmei Tian, Ke-Qin Zhang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0031536
Abstract: Coccidioides is a primary fungal pathogen of humans, causing life-threatening respiratory disease known as coccidioidomycosis (Valley fever) in immunocompromised individuals. Recently, Sharpton et al (2009) found that the deuterolysin (M35) family genes were significantly expanded in both the Coccidioides genus and in U. reesii, and that Coccidioides has acquired three more M35 family genes than U. reesii. In the present work, phylogenetic analyses based on a total of 28 M35 family genes using different alignments and tree-building methods consistently revealed five clades with high nodal supports. Interestingly, likelihood ratio tests suggested significant differences in selective pressure on the ancestral lineage of three additional duplicated M35 family genes from Coccidioides species compared to the other lineages in the phylogeny, which may be associated with novel functional adaptations of M35 family genes in the Coccidioides species, e.g., recent pathogenesis acquisition. Our study adds to the expanding view of M35 family gene evolution and functions as well as establishes a theoretical foundation for future experimental investigations.
Research on Tasks Scheduling Algorithms for Dynamic and Uncertain Computing Grid Based on a+bi Connection Number of SPA
Decai Huang,Yuan Yuan,Li-jun Zhang,Ke-qin Zhao
Journal of Software , 2009, DOI: 10.4304/jsw.4.10.1102-1109
Abstract: Task scheduling algorithms are key techniques in task management system of computing grid. Because of the uncertainty nature of a grid, traditional task scheduling algorithms do not work well in an open, heterogeneous and dynamic grid environment of real world. In this paper, Set Pair Analysis (SPA), a new soft computation method is used to process the synthetic uncertainty in the task scheduling of a computing grid. After introducing SPA and its application, the paper goes on to introduce the definition of connection number to express the uncertain Expected Time to Compute of tasks, analysis operation properties and linear order relation suitable for computing grid scheduling. Three online uncertain dynamic scheduling algorithms, OUD_OLB, OUD_MET, OUD_MCT, and three batch uncertain dynamic scheduling algorithms BUD_Min-min, BUD_Min-max, BUD_Surferage, are presented for the uncertain dynamic computing grid. Theoretical analysis and experimental results illustrate that these algorithms are capable of representing the dynamics and uncertainty in a computing grid environment. These algorithms are the generalization of traditional grid scheduling algorithms, and they possess high value in theory and application in a grid environment. Certainly it will be a new method to design tasks scheduling algorithm in uncertain computing grid environment.
董克勤 Dong Ke-qin,李曾中 Li Zeng-zhong
大气科学 , 1980, DOI: 10.3878/j.issn.1006-9895.1980.03.12
Abstract: 本文对1949—1976年40次经过海南岛台风的强度、移速和移向等特性进行了统计分析。结果得出:强台风受地形影响过岛前后衰减较大,弱台风则受影响较小;当台风路径比较平直时,其移速在登陆后有所减小,但在登陆前弱台风的移速反而有所增大;移向的偏转与台风路径有关,但除在登陆前后转向的台风外,都在登陆后有向左偏的现象。上述结果与过去有关岛屿地形对台风影响的研究进行了比较。
A Practical Approach to Management of Chronic Hepatitis B
Hu Ke-Qin
International Journal of Medical Sciences , 2005,
Abstract: Chronic hepatitis B (CHB) is one of the important public health problems worldwide. Major advances have been made in the treatment of CHB during the past several years. This article systemically reviews advances in the application of HBV DNA quantitation and three approved drugs for HBV treatment, and presents an updated and practical clinical approach to managing CHB. Highly sensitive PCR-based quantitation of HBV DNA makes it possible to precisely determine pre-treatment HBV load and monitor HBV DNA response during treatment. HBV DNA level, HBeAg status, degree of hepatic histological activity and fibrosis, and serum transaminases are the most important parameters in determining indication, regimen, and duration of HBV treatment. Although interferon alfa-2b, lamivudine, and adefovir are all approved as initial HBV treatment, understanding the advantages and advantages of each agent is important in choosing the best treatment for each individual patient with CHB.
Guest Editor's Editorial: Advances in Managing Hepatitis C Virus (HCV) Infection (A Special Issue)
Hu Ke-Qin
International Journal of Medical Sciences , 2006,
Peroxisome and pathogenicity of pathogenic fungi

LI Li,ZHANG Ke-Qin,YANG Jin-Kui,

微生物学通报 , 2011,
Abstract: 过氧化物酶体(Peroxisome)是一类单层膜的细胞器, 普遍存在于各种真核细胞中。过氧化物酶体是丰富的酶库, 含有至少50种酶类, 参与生物体的多种生理代谢过程, 如乙醛酸循环、脂肪酸的β-氧化及活性氧的调节等。近年来, 日益增多的研究表明过氧化物酶体和病原真菌的乙醛酸循环及脂肪酸的β-氧化功能的发挥密切相关, 并影响病原真菌的致病性。总结过氧化物酶体中酶的种类和功能, 评述过氧化物酶体与乙醛酸循环、脂肪酸β-氧化和病原真菌致病性的关系。
Research on Freeform Feature and Constraint Solving Feature-based Modeling

WANG Yuan-zhi,SUN Li-quan,JIANG Ke-qin,

中国图象图形学报 , 2006,
Abstract: The freeform feature modeling was introduced in HUST-CAID.Classification and parameters were defined combining with the HUST-CAID system(computer aided industry design system developed by Harbin university of science and technology);users could intuitively design any curved surface using a set of suitable parameters provided by the system without concerning the lower layer design.If users want to modify the parameters,the system will correspondingly provide feedback automatically.In order to obtain the right graphics agree with the constraint,it is provided a new novel prototype-driven constraint solving algorithm.The simulation result in HUST-CAID shows that this novel algorithm simplified constraint solving and feature modeling greatly.
A review on the research of nematophagous fungal species

ZHANG Ying,LI Guo-Hong,ZHANG Ke-Qin,

菌物学报 , 2011,
Abstract: Nematophagous fungi are those fungi with the capacity to capture, parasitise or paralyse nematodes at all stages of their life cycles. They play an important role as antagonists of plant-parasitic and animal-parasitic nematodes, therefore, there is a great interest in using these fungi as model samples in adaptative evolution researches and as biological control agents against parasitic nematodes. This review presents progress made in the field of fungal antagonists of parasitic nematodes, including trapping fungi, endoparasitic fungi, toxin-producing fungi and opportunistic fungi.
Static Scheduling Algorithms Based on Connective-number of Type a+bi for Uncertain Computing Grid


计算机科学 , 2007,
Abstract: Job scheduling algorithms are kernel technique in task management system of computing grid. Because the dynamic and uncertainty exist in grid environment, the traditional job scheduling algorithms cannot be applied effectively in the real open, heterogene
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