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Search Results: 1 - 10 of 660940 matches for " L.M. Li "
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The importance of accurate anatomic assessment for the volumetric analysis of the amygdala
Bonilha, L.;Kobayashi, E.;Cendes, F.;Li, L.M.;
Brazilian Journal of Medical and Biological Research , 2005, DOI: 10.1590/S0100-879X2005000300012
Abstract: there is a wide range of values reported in volumetric studies of the amygdala. the use of single plane thick magnetic resonance imaging (mri) may prevent the correct visualization of anatomic landmarks and yield imprecise results. to assess whether there is a difference between volumetric analysis of the amygdala performed with single plane mri 3-mm slices and with multiplanar analysis of mri 1-mm slices, we studied healthy subjects and patients with temporal lobe epilepsy. we performed manual delineation of the amygdala on t1-weighted inversion recovery, 3-mm coronal slices and manual delineation of the amygdala on three-dimensional volumetric t1-weighted images with 1-mm slice thickness. the data were compared using a dependent t-test. there was a significant difference between the volumes obtained by the coronal plane-based measurements and the volumes obtained by three-dimensional analysis (p < 0.001). an incorrect estimate of the amygdala volume may preclude a correct analysis of the biological effects of alterations in amygdala volume. three-dimensional analysis is preferred because it is based on more extensive anatomical assessment and the results are similar to those obtained in post-mortem studies.
Laterization of epileptiform discharges in patients with epilepsy and precocious destructive brain insults
Teixeira Ricardo A.,Li Li M.,Santos Sergio L.M.,Amorim Bárbara J.
Arquivos de Neuro-Psiquiatria , 2004,
Abstract: Unilateral destructive brain lesions of early development can result in compensatory thickening of the ipsilateral cranial vault. The aim of this study was to determine the frequency of these bone changes among patients with epilepsy and precocious destructive lesions, and whether a relationship exists between these changes and epileptiform discharges lateralization. Fifty-one patients had their ictal / interictal scalp EEG and skull thickness symmetry on MRI analyzed. Patients were divided into three main groups according to the topographic distribution of the lesion on the MRI: hemispheric (H) (n=9); main arterial territory (AT) (n=25); arterial borderzone (Bdz) (n=17). The EEG background activity was abnormal in 26 patients and were more frequent among patients of group H (p= 0.044). Thickening of the skull was more frequent among patients of group H (p= 0.004). Five patients (9.8%) showed discordant lateralization between epileptiform discharges and structural lesion (four of them with an abnormal background, and only two of them with skull changes). In one of these patients, ictal SPECT provided strong evidence for scalp EEG false lateralization. The findings suggest that compensatory skull thickening in patients with precocious destructive brain insults are more frequent among patients with unilateral and large lesions. However, EEG lateralization discordance among these patients seems to be more related to EEG background abnormalities and extent of cerebral damage than to skull changes.
Effects of Methionine or Lysine Served as Sole Nitrogen and Carbon Sources on Level of Free Amino Acids and Activity of Transaminases at in vitro Incubation of Rumen Microorganisms
L.M. Li,H. Diao,X.L. Ding,K. Qian,Z.J. Yin
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2011.1588.1591
Abstract: This study aimed at investigating the effect of Met or Lys as sole Nitrogen (N) and Carbon (C) sources on Glutamic Oxaloacetic Transaminase (GOT), Glutamic Pyruvic Transaminase (GPT) and Amino Acid (AA) metabolism of rumen microorganisms in vitro. Three fistulated goats were used as a source of ruminal microorganisms. Microbial suspensions with or without Met or Lys as substrate were anaerobically incubated at 39°C for 16 h. Free AA and transaminases in the supernatants of the incubation were analyzed by HPLC and an automatic biochemistry analyzer, respectively. When Met was used as a unique source of N and C, the content of free Val and His were significantly (p<0.01 and p<0.05) reduced but Gly was increased (p<0.01). No significant differences in the other free AA were found as well as for GOT and GPT activities. When Lys was used as a sole source of N and C, the content of free His and activities of GOT and GPT were significantly lower (p<0.01) than that of controls however Tyr was significantly increased (p<0.05). The results indicated that Val and Cys are probably the most important AA of rumen microorganisms when Met serves as the only source of N and C. But when Lys serves as a sole source of N and C, His becomes the most important AA. At the same time, GPT plays a weaker role when Met serves as a sole source of N and C.
Ictal ECG changes in temporal lobe epilepsy
Li, L.M.;Roche, J.;Sander, J.W.A.S.;
Arquivos de Neuro-Psiquiatria , 1995, DOI: 10.1590/S0004-282X1995000400012
Abstract: changes in cardiac rhythm may occur during epileptic seizures and this has been suggested as a possible mechanism for sudden unexpected death amongst patients with chronic epilepsy (sudep). we have studied ecg changes during 61 complex partial seizures of temporal lobe origin in 20 patients. tachycardia was observed in 24/61 (39%) and bradycardia in 3/61 (5%). the mean and median tachycardia rate was 139 and 140 beats/min (range 120-180). the longest r-r interval observed was 9 seconds. no difference was found in regard to the lateralisation of seizures and cardiac arrhytmia. one of the patients with bradycardia was fitted with a demand cardiac pacemaker, which appeared to decrease the number of his falls. in conclusion, ictal cardiac changes which may be seen in temporal lobe epilepsy (tle) are sinus tachycardia and occasionally sinus bradycardia. patients presenting vague complains suggestive of either tle or cardiac dysrhythmia, simultaneous monitoring with eeg/ecg is required, and if the episodes are frequent, video-eeg should be considered. further studies on this subject are warranted as this may shed some light on possible mechanisms for sudep.
Abnormalities of hippocampal signal intensity in patients with familial mesial temporal lobe epilepsy
Coan, A.C.;Kobayashi, E.;Lopes-Cendes, I.;Li, L.M.;Cendes, F.;
Brazilian Journal of Medical and Biological Research , 2004, DOI: 10.1590/S0100-879X2004000600007
Abstract: mesial temporal lobe epilepsy (mtle) is associated with hippocampal atrophy and hippocampal signal abnormalities. in our series of familial mtle (fmtle), we found a high proportion of hippocampal abnormalities. to quantify signal abnormalities in patients with fmtle we studied 152 individuals (46 of them asymptomatic) with fmtle. we used nih-image? for volumetry and signal quantification in coronal t1 inversion recovery and t2 for all cross-sections of the hippocampus. values diverging by 2 or more sd from the control mean were considered abnormal. t2 hippocampal signal abnormalities were found in 52% of all individuals: 54% of affected subjects and 48% of asymptomatic subjects. t1 hippocampal signal changes were found in 34% of all individuals: 42.5% of affected subjects and 15% of asymptomatic subjects. analysis of the hippocampal head (first three slices) revealed t2 abnormalities in 73% of all individuals (74% of affected subjects and 72% of asymptomatic subjects) and t1 abnormalities in 59% (67% of affected subjects and 41% of asymptomatic subjects). affected individuals had smaller volumes than controls (p < 0.0001). there was no difference in hippocampal volumes between asymptomatic subjects and controls, although 39% of asymptomatic patients had hippocampal atrophy. patients with an abnormal hippocampal signal (133 individuals) had smaller ipsilateral volume, but no linear correlation could be determined. hippocampal signal abnormalities in fmtle were more frequently found in the hippocampal head in both affected and asymptomatic family members, including those with normal volumes. these results indicate that subtle abnormalities leading to an abnormal hippocampal signal in fmtle are not necessarily related to seizures and may be determined by genetic factors.
Abnormalities of hippocampal signal intensity in patients with familial mesial temporal lobe epilepsy
Coan A.C.,Kobayashi E.,Lopes-Cendes I.,Li L.M.
Brazilian Journal of Medical and Biological Research , 2004,
Abstract: Mesial temporal lobe epilepsy (MTLE) is associated with hippocampal atrophy and hippocampal signal abnormalities. In our series of familial MTLE (FMTLE), we found a high proportion of hippocampal abnormalities. To quantify signal abnormalities in patients with FMTLE we studied 152 individuals (46 of them asymptomatic) with FMTLE. We used NIH-Image for volumetry and signal quantification in coronal T1 inversion recovery and T2 for all cross-sections of the hippocampus. Values diverging by 2 or more SD from the control mean were considered abnormal. T2 hippocampal signal abnormalities were found in 52% of all individuals: 54% of affected subjects and 48% of asymptomatic subjects. T1 hippocampal signal changes were found in 34% of all individuals: 42.5% of affected subjects and 15% of asymptomatic subjects. Analysis of the hippocampal head (first three slices) revealed T2 abnormalities in 73% of all individuals (74% of affected subjects and 72% of asymptomatic subjects) and T1 abnormalities in 59% (67% of affected subjects and 41% of asymptomatic subjects). Affected individuals had smaller volumes than controls (P < 0.0001). There was no difference in hippocampal volumes between asymptomatic subjects and controls, although 39% of asymptomatic patients had hippocampal atrophy. Patients with an abnormal hippocampal signal (133 individuals) had smaller ipsilateral volume, but no linear correlation could be determined. Hippocampal signal abnormalities in FMTLE were more frequently found in the hippocampal head in both affected and asymptomatic family members, including those with normal volumes. These results indicate that subtle abnormalities leading to an abnormal hippocampal signal in FMTLE are not necessarily related to seizures and may be determined by genetic factors.
The influence of fasting/refeeding on the lipoprotein lipase activity of adipose tissue and muscle
Botion, L.M.;
Brazilian Journal of Medical and Biological Research , 2001, DOI: 10.1590/S0100-879X2001001100006
Abstract: lipoprotein lipase activity in adipose tissue and muscle is modulated by changes in the pattern of food intake. we have measured total lipoprotein lipase activity in adipose tissue and muscle of male wistar rats (n = 6-10), weighing 200-250 g (~12 weeks), during the refeeding/fasting state following 24 h of fasting. lipoprotein lipase activity in tissue homogenates was evaluated using a [3h]-triolein-containing substrate, and released [3h]-free fatty acids were extracted and quantified by liquid scintillation. adipose tissue lipoprotein lipase activity did not completely recover within 2 h of refeeding (60% of refed ad libitum values). cardiac lipoprotein lipase activity remained increased even 2 h after refeeding (100% of refed ad libitum values), whereas no significant changes were observed in the soleus and diaphragm muscles. adipose tissue lipoprotein lipase activities were consistently higher than the highest skeletal muscle or heart values. it is therefore likely that adipose tissue, rather than muscle makes the major contribution to triacylglycerol clearance. there was concomitant relatively high lipoprotein lipase activity in both adipose tissue and cardiac muscle during the first few hours of refeeding, therefore cardiac muscle may contribute significantly to triacylglycerol clearance during this period. the results suggest that during fasting, increased lipoprotein lipase activity provides a complementary source of free fatty acids from circulating triacylglycerol, allowing the heart to maintain its continuous, high-energy expenditure.
Mathematical Analysis of the Correction Factor for Analysing Space Frame under the Action of Horizontal Crane Load
L.M. Olanitori
Journal of Engineering and Applied Sciences , 2012,
Abstract: This research attempts to analytically investigate, the effect of the space nature of an industrial frame building on its strength. The above subject matter is divided into two parts; the mathematical analysis of the correction factor and design procedures of an industrial frame building considering its space nature. This study examines only the first part of the above subject matter that is the analytical investigation of the effect the space nature of an industrial frame building on its strength in the form of a correction factor. The result obtained shows that frame structures are being over loaded if their space nature is not considered, hence, leading to uneconomic design.
Hilos de agua, lazos de sangre: enfrentando la escasez en el desierto de Lavalle (Mendoza, Argentina)
L.M. Torres
Ecosistemas , 2008,
Abstract: En el trabajo se analizan las posibles relaciones existentes entre las dinámicas de uso de los recursos naturales y las estrategias de localización de las unidades domésticas en el territorio, dentro de espacios rurales de desierto que poseen una oferta ambiental limitada. Cómo, en el marco de qué estrategias, los grupos humanos convierten distintas porciones de la naturaleza en recurso natural? y cómo usan y administran esos recursos en procura de asegurar su propia reproducción social? Para avanzar en esta dirección se analiza un estudio de caso (el desierto de Lavalle, provincia de Mendoza, Argentina) y, dentro de él, se procede con las técnicas cualitativas de entrevista en profundidad y observación participante. Los datos que se presentan sugieren que en los territorios analizados rurales, emplazados en tierras secas, afectados por desertificación y con elevados índices de pobreza- las limitaciones que impone el medio ambiente son sobrellevadas en alguna medida- mediante una estrategia de localización íntimamente relacionada con el proceso de producción, que maximiza el acceso de determinados recursos naturales y que "ordena" la competencia por ellos con los vecinos y parientes.
Preface
L.M. Fourie
Koers : Bulletin for Christian Scholarship , 2009, DOI: 10.4102/koers.v74i1&2.121
Abstract:
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