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Search Results: 1 - 10 of 208563 matches for " L. Saidu "
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Experimental infection of domesticated pigeons with newcastle disease virus (kudu 113 strain)
M Bisalla, L Saidu, EO Ariyo
Nigerian Veterinary Journal , 2005,
Abstract:
ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF ETHANOL AND N-HEXANE EXTRACTS OF WALTHERIA INDICA AND MUCUNA PRURIENS
Saidu Garba,L Salihu,M. U. Ahmed
Journal of Pharmaceutical and Scientific Innovation , 2012,
Abstract: The antioxidant and antimicrobial activities of many Nigerian Medicinal plants used in folk medicine have been reported. In the present study extracts of shoots of Waltheria indica and Mucuna pruriens were evaluated for their antioxidant and antimicrobial activities using 2,2 diphenyl-1-picrylhydrazyl free radical scavenging activity and paper disc diffusion method respectively. The results showed that the n-hexane extracts of Mucuna pruriens and Waltheria indica showed the best 2,2 diphenyl-1-picrlylhydroxyl free radical scavenging activities whereas ethanol extracts of Mucuna pruriens and Waltheria indica gave the best antimicrobial activities, against Salmonella typhi, Bacillus subtillis, Streptococci, Escherichia coli, Aspergillus niger, Aspergillus flavus and Candida albicans indicating that the plants could be potential sources for antioxidant and antimicrobial compounds needed for the treatment of pathological conditions and various microbial diseases caused by the test organisms.
Effect of Vitamins A, C, and E Supplementation in the Treatment of Metabolic Syndrome in Albino Rats
L. S. Bilbis,S. A. Muhammad,Y. Saidu,Y. Adamu
Biochemistry Research International , 2012, DOI: 10.1155/2012/678582
Abstract: Obesity and metabolic syndrome increase the risk of cardiovascular morbidity and mortality. Oxidative stress seems to be involved in the path physiology of cardiovascular complications of metabolic syndrome. In this study we investigated the effects of vitamins A, C, and E in the management of metabolic syndrome traits condition in albino rats fed with high salt diet. The rats were placed on 8% NaCl diet for 5 weeks and then supplemented with these vitamins for additional 4 weeks in the presence of salt diet. Supplementation with vitamins significantly (<0.01 ) decreased blood pressure of the rats as compared with the control. Supplementation also significantly (<0.05) reduced serum total cholesterol, triglyceride, low-density lipoprotein cholesterol, and very-low-density lipoprotein cholesterol and increased high-density lipoprotein cholesterol, and total antioxidant status as compared with untreated group. The percentage protection of the supplemented groups against atherogenesis indicated 55.50±3.75%. Percentage weight gain indicated significant positive correlation with triglyceride, insulin resistance, and malondialdehyde while total antioxidant status and nitric oxide showed significant negative correlation. Salt diet significantly (<0.05) induced features of metabolic syndrome. The result, therefore, indicated strong relationship between obesity and metabolic syndrome and underscores the role of these vitamins in the management of metabolic syndrome.
Effect of Antioxidant Mineral Elements Supplementation in the Treatment of Hypertension in Albino Rats
S. A. Muhammad,L. S. Bilbis,Y. Saidu,Y. Adamu
Oxidative Medicine and Cellular Longevity , 2012, DOI: 10.1155/2012/134723
Abstract: Oxidative stress has been implicated in various pathologies, including hypertension, atherosclerosis, diabetes, and chronic renal disease. The current work was designed with the aim of investigating the potentials of antioxidants copper, manganese, and zinc in the treatment of hypertension in Wistar rats. The rats were fed 8% NaCl diet for 5 weeks and treatment with supplements in the presence of the challenging agent for additional 4 weeks. The supplementation significantly decreased the blood pressure as compared with hypertensive control. The result also indicated significant decreased in the levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol, malondialdehyde, insulin and increase in the high-density lipoprotein cholesterol, total antioxidant activities, and nitric oxide of the supplemented groups relative to the hypertensive control. The average percentage protection against atherogenesis indicated 47.13 ± 9.60% for all the supplemented groups. The mean arterial blood pressure showed significant positive correlation with glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, atherogenic index, insulin resistance and malondialdehyde while high density lipoprotein-cholesterol and total antioxidant activities showed negative correlation. The result therefore indicated strong relationship between oxidative stress and hypertension and underscores the role of antioxidant minerals in reducing oxidative stress, dyslipidemia, and insulin resistance associated with hypertension.
Case Report: Atresia of the Left Oviduct and Anormaly of the Caecum of a 12 Month Old Layer
M.H. Sulaiman,L. Saidu,P.A. Abdu
Research Journal of Poultry Sciences , 2012, DOI: 10.3923/rjpscience.2010.39.42
Abstract: This study describe a rare case of congenital defects involving the atresia of the left oviduct with the accompanying abnormalities of ovaries and caecum observed in a 12 month old layer presented to the Avian Ambulatory Clinic of the Veterinary Teaching Hospital, Ahmadu Bello University, Zaria. At post mortem, a thin wall oviduct measuring 18 cm long which opens into the cloaca was noticed while the left oviduct was completely absent. In addition the right hypolastic oviduct had a large cyst with a morphometric measurement of 18 cm by 14 cm by 7 cm and containing 1.25 L of clear non proteinous fluid, weighing 1.01 kg. When the cystic fluid was cultured in blood agar at 37°C for 72 h, no bacteria colony growth was observed. However, biochemical analysis revealed a composition of electrolytes. The bird also had undeveloped ovaries, malformed illeocaecal junction cranially measuring 6.5 cm.
Retrospect studies on the prevalence of fowl cholera in Zaria-Kaduda state Nigeria
MA Raji, JS Ahmed, L Saidu, JA Ameh
Sokoto Journal of Veterinary Sciences , 2010,
Abstract:
Atresia of the Left Oviduct and Abnormality of the Caecum of a 12-month-old Layer:A Case Report
M.H. Sulaiman,L. Saidu,P.A. Abdu
International Journal of Poultry Science , 2010,
Abstract: This report describe a rare case of congenital defects involving the atresia of the left oviduct with the accompanying abnormalities of ovaries and caecum observed in a 12-month-old layer presented to the Avian Ambulatory Clinic of the Veterinary Teaching Hospital, Ahmadu Bello University, Zaria. At post mortem, a thin wall oviduct measuring 18 cm long, which opens into the cloaca, was noticed, while the left oviduct was completely absent. In addition the right hypolastic oviduct had a large cyst, with a morphometric measurement of 18 cm by 14 cm by 7 cm and containing 1.25 litres of clear non proteinous fluid, weighing 1.01 kg. When the cystic fluid was cultured in blood agar, at 37oC for 72 h, no bacteria colony growth was observed. However biochemical analysis revealed a composition of electrolytes. The bird also had undeveloped ovaries, malformed illeocaecal junction cranially measuring 6.5 cm. To our knowledge, this is the first case report of congenital abnormalities of the atresia of the left oviduct, malformed caecum and hypoplastic right oviduct in ISA-Brown layer bird in Nigeria.
Effect of Vitamins A, C, and E Supplementation in the Treatment of Metabolic Syndrome in Albino Rats
L. S. Bilbis,S. A. Muhammad,Y. Saidu,Y. Adamu
Biochemistry Research International , 2012, DOI: 10.1155/2012/678582
Abstract: Obesity and metabolic syndrome increase the risk of cardiovascular morbidity and mortality. Oxidative stress seems to be involved in the path physiology of cardiovascular complications of metabolic syndrome. In this study we investigated the effects of vitamins A, C, and E in the management of metabolic syndrome traits condition in albino rats fed with high salt diet. The rats were placed on 8% NaCl diet for 5 weeks and then supplemented with these vitamins for additional 4 weeks in the presence of salt diet. Supplementation with vitamins significantly ( ) decreased blood pressure of the rats as compared with the control. Supplementation also significantly ( ) reduced serum total cholesterol, triglyceride, low-density lipoprotein cholesterol, and very-low-density lipoprotein cholesterol and increased high-density lipoprotein cholesterol, and total antioxidant status as compared with untreated group. The percentage protection of the supplemented groups against atherogenesis indicated %. Percentage weight gain indicated significant positive correlation with triglyceride, insulin resistance, and malondialdehyde while total antioxidant status and nitric oxide showed significant negative correlation. Salt diet significantly ( ) induced features of metabolic syndrome. The result, therefore, indicated strong relationship between obesity and metabolic syndrome and underscores the role of these vitamins in the management of metabolic syndrome. 1. Introduction Metabolic syndrome, a constellation of cardiovascular risk factors that is characterized by hypertension, hyperglycemia, insulin resistance, dyslipidaemia, and abdominal obesity, is associated with increased risk of developing cardiovascular diseases [1–4]. High blood pressure is considered one of the key features of metabolic syndrome [5]. The increasing prevalence of metabolic syndrome is due to rising number of people who are obese and inactive [6, 7]. It is important to emphasize that obesity increases the likelihood of an individual to develop insulin resistance [8]. The cluster of risk factors of metabolic syndrome is responsible for cardiovascular morbidity among overweight, obese, and type 2 diabetic subjects [9]. Approximately 1 adult in 4 or 5, depending on the country, shows features of the syndrome. In the category over 50 years of age, it affects more than 40% of the population in the United States and nearly 30% in Europe [10]. There is evidence of increasing incidence and prevalent of the metabolic syndrome in sub-Saharan Africans [11, 12]. However, the establishment of hypertension as a
Effect of Antioxidant Mineral Elements Supplementation in the Treatment of Hypertension in Albino Rats
S. A. Muhammad,L. S. Bilbis,Y. Saidu,Y. Adamu
Oxidative Medicine and Cellular Longevity , 2012, DOI: 10.1155/2012/134723
Abstract: Oxidative stress has been implicated in various pathologies, including hypertension, atherosclerosis, diabetes, and chronic renal disease. The current work was designed with the aim of investigating the potentials of antioxidants copper, manganese, and zinc in the treatment of hypertension in Wistar rats. The rats were fed 8% NaCl diet for 5 weeks and treatment with supplements in the presence of the challenging agent for additional 4 weeks. The supplementation significantly decreased the blood pressure as compared with hypertensive control. The result also indicated significant decreased in the levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol, malondialdehyde, insulin and increase in the high-density lipoprotein cholesterol, total antioxidant activities, and nitric oxide of the supplemented groups relative to the hypertensive control. The average percentage protection against atherogenesis indicated 47.13 ± 9.60% for all the supplemented groups. The mean arterial blood pressure showed significant positive correlation with glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, atherogenic index, insulin resistance and malondialdehyde while high density lipoprotein-cholesterol and total antioxidant activities showed negative correlation. The result therefore indicated strong relationship between oxidative stress and hypertension and underscores the role of antioxidant minerals in reducing oxidative stress, dyslipidemia, and insulin resistance associated with hypertension. 1. Introduction Hypertension is one of the most common diseases worlds over and a major cause of death from cardiovascular failure. Due to associated morbidity and mortality, hypertension is a public health problem [1], and thus the need to search for proper preventive and management strategies should be the concern of health care providers. Increased vascular oxidative stress could be involved in the pathogenesis of hypertension [2, 3] a major risk factor for cardiovascular disease and mortality in the developed and developing countries. The onset of hypertension is caused by complex interactions between genetic predisposition and environmental factors [4]. Increased salt intake may aggravate the rise in blood pressure and the development of consequential end-organ damage [5]. The novel concept that structural and functional abnormalities in the vasculature, including endothelial dysfunction, increased oxidative stress, and decreased antioxidant
Physicochemical features of rhodanese: A review
Y Saidu
African Journal of Biotechnology , 2004,
Abstract: Rhodanese is a multifunctional, mitochondrial, sulphur transferase that catalyses the detoxification of cyanide by sulphuration in a double displacement (ping pong) mechanistic reaction. It is widely distributed occurring in varieties of plants and animals, where it activity is modulated by a number of factors including differences in species, organs, sex, age and diet. The enzyme is a single polypeptide chain of 289 amino acids with molecular weight of up to 37,000. The active site of rhodanese contains a tryptophanyl residue in close proximity with an essential sulphahydryl group. Many methods for assaying rhodanese have been reported, the most prominent being the one based on the colorimetric estimation of thiocyanate formed from the reaction of cyanide and thiosulphate, catalysed by rhodanese.
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