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Search Results: 1 - 10 of 208457 matches for " L. Pase "
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Hydrogen Peroxide in Inflammation: Messenger, Guide, and Assassin
C. Wittmann,P. Chockley,S. K. Singh,L. Pase,G. J. Lieschke,C. Grabher
Advances in Hematology , 2012, DOI: 10.1155/2012/541471
Abstract: Starting as a model for developmental genetics, embryology, and organogenesis, the zebrafish has become increasingly popular as a model organism for numerous areas of biology and biomedicine over the last decades. Within haematology, this includes studies on blood cell development and function and the intricate regulatory mechanisms within vertebrate immunity. Here, we review recent studies on the immediate mechanisms mounting an inflammatory response by in vivo analyses using the zebrafish. These recently revealed novel roles of the reactive oxygen species hydrogen peroxide that have changed our view on the initiation of a granulocytic inflammatory response. 1. Introduction The innate immune system comprises the cells and mechanisms that defend the host from infection by other organisms or damage to tissue integrity, in a nonspecific manner. This means that the cells of the innate system recognise and respond to pathogens and trauma in a generic way, but unlike the adaptive immune system, it does not confer long-lasting or protective immunity to the host. The innate immune system provides an immediate defence. A typical vertebrate immune response depends on the orchestrated motility and activity of various haematopoietic compartments and their interactions that ultimately control the magnitude of the response [1–3]. Inflammation is one of the first responses of the immune system to infection or irritation. Stimulated by factors released from injured cells, it serves to establish a physical barrier against the spread of infection. This further promotes healing of any damaged tissue following the clearance of pathogens or cell debris. Molecules produced during inflammation sensitise pain receptors, cause localised vasodilatation of blood vessels, and attract phagocytes, especially neutrophils and macrophages, which then trigger other parts of the immune system. Failure to initiate a response allows uncontrolled proliferation of invading microorganisms and severe tissue damage that may become fatal. Failure to resolve an immune response can also cause severe tissue damage, due to persistent degranulation, and may lead to chronic inflammation, which ceases to be beneficial to the host. Overall, inflammation is now recognised as a central feature of prevalent pathologies, such as atherosclerosis, cancer, asthma, thyroiditis, inflammatory bowel disease, autoimmune disease, as well as Alzheimer’s and Parkinson’s disease [4–6]. Hence, the regulation of an inflammatory response is an active field of research. New players or novel functions of old players
A forma o da elite na primeira república
Hemerson Luiz Pase
Barbarói , 2006,
Abstract: Este artigo faz um resgate histórico da dinamica das elites na primeira república e problematiza a importancia do capital social articulado pelos intelectuais “bacharéis” para se al arem a postos de elite dirigente do poder central ou dos estados. Para realizar este trabalho faz-se um debate teórico sobre o conceito de capital social, um resgate da dinamica da elite dirigente da república velha para, finalmente, destacar o papel da articula o das rela es sociais, de alguns destes intelectuais, seja na forma característica da oligarquia agrária brasileira, o clientelismo, seja na forma de uma rela o positiva, o capital social. Abstract This article deals with the Brazilian elites of the First Republic and problematizes the importance of the social capital articulated by the intellectual “bachelors” that aimed to occupy the elite positions that came from the central power or from the states. In order to carry out this study, we propose a theoretical discussion on the concept of social capital and the dynamic of interaction among the power elites of the Old Republic. Finally, we point out the role of the articulation of the social relations among some of these intellectuals either in the characteristic form of the Brazilian rural oligarchy, the clientelism, or in the form of a positive relation, the social capital.
Hemerson Luiz Pase
Revista Debates , 2012,
Abstract: This article discusses the relationship between political culture and socioeconomic development, making a historical development, establishing the different matrices of the occupational area of Rio Grande do Sul. The central hypothesis takes the classical formulations stating that the higher the stock of social capital the greater will besocioeconomic development, which is why public policy should be structured in order to stimulate it. The methodology uses empirical data that define trust, reciprocity andsolidarity as indicators of social capital that is used as the independent variable of IDESE, an indicator of socioeconomic development. The results indicate the relevanceof Putnam's theory, saying that there is a proportional relationship between social capital and socioeconomic development. Rural citizens have a stock of social capitalabove the city, which allows them to survive against the hostility of agricultural development.
Hemerson Luiz Pase
Revista Debates , 2012,
Abstract: The article analyzes the public policy infrastructure of the electricity sector in the post democratization in Brazil. The policy analysis is used as theoretical tools and methodological options to interpret the guidelines and the method of implementation of energy policy. The research investigates the problem of how to set the agenda of the Brazilian electric sector after democratization. The findings indicate that public policy infrastructure of the electricity sector has an agenda to ensure the continued provision of service in a market environment, you need economic attractiveness, whose criterion is the assurance of accumulation.
Contrato social e (Des)igualdade
Hemerson Luiz Pase
Desenvolvimento em Quest?o , 2008,
Abstract: The article discusses the social contract through a theoretical perspective that reveals the limits of the category of equality to guide the action the contemporary state. The company is uneven and, if you want to overcome this condition, you need to sue the state treats the different uneven, namely, public policies need to be targeted with a view to enabling those social segments historically positioned precariously, acquiring conditions, become equal, For being able to contest the general policies. Democratic participation, materialized through mechanisms such as participatory budgeting, has conditions to create a public space for debate and influence the state to act unequally in favor of the most disadvantaged.
Or amento participativo em municípios predominantemente rurais
Hemerson Luiz Pase
Desenvolvimento em Quest?o , 2003,
Abstract: The work studies the possibilities for implementation of innovative ways of administration ofthe public resources with the citizens participation, just as the participatory budget , inmunicipal districts predominantly rural, considering the potentiality of these innovations forthe rural development. The preliminary results indicate that, nevertheless the disposition(programmaticaly assumed or not) of the rulers in giving important spaces of power to thecitizens′ group, serious difficulties exist predominantly of implanting with success the participatory budget in municipal districts rural. These difficulties are due to historicalrelationships of clientelism and patrimonialism among citizens, state bureaucracy and cannotpublic, and mainly the impossibility of the municipal administration in providing a minimum of resources (important) to be indeed managed for the citizens.
Hemerson Luiz Pase,Humbero José da Rocha
Revista Debates , 2010,
Abstract: This article examines the public policy infrastructure of the electricity sector in the period 2003 to 2010 when the two presidential administrations in Brazil have been in charge of Luis Inacio Lula da Silva of the Workers Party - PT. The policy analysis is used as theoretical tools and methodological options to interpret the theoretical guidelines and the method of implementation of energy policy in contemporary Brazil. In this sense we discuss the historical trajectory of the Brazilian energy production, highlighting the legacy of military governments, and the change/reform the state's role undertaken from democratization, and especially by the hand of Collor/Itamar (1990-1994) and Cardoso (1995-2002). The problem of research investigates the template configuration Brazilian energy from a federal administration headed by a political party formed center-left strongly linked to social movements and trade union critics of capitalist production relations. The findings indicate that public policy infrastructure and power sector in the Lula government did not break with the reformist outlook of the state, deepening its materialization because of the need to maintain external credibility and internal governance.
Hemerson Luiz Pase,Patrícia Rodrigues Chaves da Cunha
Revista Debates , 2012,
André Fagundes Pase,Ana Cecília Bisso Nunes,Marcelo Crispim da Fontoura
Brazilian Journalism Research , 2012,
Abstract: A comunica o transmidiática é utilizada sobretudo na fic o, mas também no jornalismo. Este artigo analisa tal sinergia informacional no campo das notícias. Por meio de uma digress o conceitual, discutimos os termos transmídia cunhado por Jenkins (2009), cross-media e multimídia, estabelecendo as diferen as de conceitos que ainda s o tratados como sin nimos por alguns autores, mas n o o s o. Os conceitos s o resgatados e verificados em suas aplica es no caso Inside Disaster, um documentário canadense sobre o terremoto haitiano de 2010, que oferece notícias em jogos, hipertextos e vídeos. Acima de tudo, propomos uma reflex o sobre as implica es da experiência transmidiática aplicada ao jornalismo, um olhar para a comunica o transmídia perpassando n o apenas os suportes, mas buscando um viés cultural e interligado com as sociedades, em uma perspectiva culturalista do estudo da tecnologia e do jornalismo.
André Fagundes Pase,Ana Cecília Bisso Nunes,Marcelo Crispim da Fontoura
Brazilian Journalism Research , 2012,
Abstract: Transmedia communication is used mainly in fiction, but also in journalism. This paper analyzes the informational synergy of transmedia in the news field. Through a conceptual digression, we discuss the word transmedia, as defined by Jenkins (2006), cross-media and multimedia, explaining the differences between all those concepts – sometimes treated by some authors as synonyms, although they are not. The ideas are revisited and verified through the study of Inside Disaster, a Canadian documentary about the 2010 Haitian earthquake that offers news by means of game, hypertext and video. Above all, we propose a reflection on the implications of the transmedia experience applied to journalism, a look at transmedia communication thinking not only about technology, but searching for a cultural and social interpretation, in a cultural perspective of the study of technology and journalism.
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