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Search Results: 1 - 10 of 208608 matches for " L. Mosca "
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Drosophila Importin-α2 Is Involved in Synapse, Axon and Muscle Development
Timothy J. Mosca,Thomas L. Schwarz
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0015223
Abstract: Nuclear import is required for communication between the cytoplasm and the nucleus and to enact lasting changes in gene transcription following stimuli. Binding to an Importin-α molecule in the cytoplasm is often required to mediate nuclear entry of a signaling protein. As multiple isoforms of Importin-α exist, some may be responsible for the entry of distinct cargoes rather than general nuclear import. Indeed, in neuronal systems, Importin-α isoforms can mediate very specific processes such as axonal tiling and communication of an injury signal. To study nuclear import during development, we examined the expression and function of Importin-α2 in Drosophila melanogaster. We found that Importin-α2 was expressed in the nervous system where it was required for normal active zone density at the NMJ and axonal commissure formation in the central nervous system. Other aspects of synaptic morphology at the NMJ and the localization of other synaptic markers appeared normal in importin-α2 mutants. Importin-α2 also functioned in development of the body wall musculature. Mutants in importin-α2 exhibited errors in muscle patterning and organization that could be alleviated by restoring muscle expression of Importin-α2. Thus, Importin-α2 is needed for some processes in the development of both the nervous system and the larval musculature.
The Case for Quantum Key Distribution
Douglas Stebila,Michele Mosca,Norbert Lütkenhaus
Physics , 2009, DOI: 10.1007/978-3-642-11731-2_35
Abstract: Quantum key distribution (QKD) promises secure key agreement by using quantum mechanical systems. We argue that QKD will be an important part of future cryptographic infrastructures. It can provide long-term confidentiality for encrypted information without reliance on computational assumptions. Although QKD still requires authentication to prevent man-in-the-middle attacks, it can make use of either information-theoretically secure symmetric key authentication or computationally secure public key authentication: even when using public key authentication, we argue that QKD still offers stronger security than classical key agreement.
Approximating Fractional Time Quantum Evolution
L. Sheridan,D. Maslov,M. Mosca
Mathematics , 2008, DOI: 10.1088/1751-8113/42/18/185302
Abstract: An algorithm is presented for approximating arbitrary powers of a black box unitary operation, $\mathcal{U}^t$, where $t$ is a real number, and $\mathcal{U}$ is a black box implementing an unknown unitary. The complexity of this algorithm is calculated in terms of the number of calls to the black box, the errors in the approximation, and a certain `gap' parameter. For general $\mathcal{U}$ and large $t$, one should apply $\mathcal{U}$ a total of $\lfloor t \rfloor$ times followed by our procedure for approximating the fractional power $\mathcal{U}^{t-\lfloor t \rfloor}$. An example is also given where for large integers $t$ this method is more efficient than direct application of $t$ copies of $\mathcal{U}$. Further applications and related algorithms are also discussed.
Intensive care infections: risk factors and mortality
S Silvestri, L Toma, F Forfori, C Mosca, F Giunta
Critical Care , 2008, DOI: 10.1186/cc6224
Abstract: Patients with a longer than 48 hour stay in a teaching hospital ICU were retrospectively enrolled between January 2005 and December 2006. Risk factors for ICU and hospital mortality were analyzed with a logistic regression model adjusted for age, SAPS II, medical or surgical status of the patients. Univariate analysis permitted one to verify the relation between previous exposition to an antibiotic therapy and development of ICU pneumonia.Of 343 patients enrolled, 39 had a diagnosis for ICU infection: 18 had an infection on admission developing a second infection during ICU stay, and 21 had a primary infection after ICU admission. Among the patients with ICU-acquired infection, ICU mortality and hospital mortality were more than doubled (OR = 2.51 (95% CI = 1.05–5.98) and OR = 2.32 (95% CI = 1.10–4.86), respectively). Having more than one infection demonstrated an ICU mortality risk addiction more than tripled (OR = 3.36 (95% CI = 1.06–10.61)). Admission severity and an infection before ICU admission emerged as important risk factors for ICU-acquired infections (OR = 5.71 (95% CI = 1.19–27.29) and OR = 3.14 (95% CI = 1.42–6.97), respectively). Previous fluoroquinolone use demonstrated a clear role in favouring Pseudomonas aeruginosa pneumonia and linezolid in Acinetobacter baumannii pneumonia (Table 1).ICU-acquired infections are an independent risk factor for ICU and hospital mortality. Finally some antibiotic categories might show up as pneumonia inductors but further studies are needed to confirm our hypothesis.
Marcadores clínicos y humorales relacionados con la mortalidad en pacientes con insuficiencia cardíaca clase funcional III/IV
Capece,Raúl; Santoro,Beatriz; Mosca,Silvia; Borgo,José;
Insuficiencia card?-aca , 2011,
Abstract: aim. to study the existence of clinical and humoral variables that behave as predictors of mortality risk in patients with dilated cardiomyopathy (dcm) and heart failure (hf) functional class iii/iv new york heart association. material and methods. we consecutively included 84 patients with dcm and hf over a year old of diagnosis (mean 3.3 years/sd 2.1), hospitalized at coronary care unit due to cardiac decompensation. patients were divided into two groups: not dead group (gv) n=60, and group of those who died (gm) n=24. at the end of the study we compared: rehospitalizations, comorbidities, hygienic-dietary treatment accomplishment, adherence to pharmacological treatment, pharmacological treatment at income (drugs), and biochemical variables: natremia, white blood cell count, glucose, creatinine in blood, bilirubinemia. results. every patient had cardiothoracic index >0.5 and moderate to severe impairment of ventricular function by echocardiogram among both groups. within sex distribution there was a masculine predominance (gv: 83.3% and gm: 70.8%; p=ns), age gv: 61.3±11.0 years old and gm: 63.9±11.3 (p=ns). conclusion. of all analyzed variables, were associated with worst prognosis: the largest number of readmissions, treatment with furosemide, leukocytosis (white blood cells > 11000 per mm3) and creatinine values > 2 mg/dl.
?Se utiliza el tratamiento aconsejado en base a la evidencia en pacientes con insuficiencia cardíaca por disfunción sistólica?
Capece,Raúl; Santoro,Beatriz; Mosca,Silvia; José,Borgo;
Insuficiencia card?-aca , 2010,
Abstract: aim. to assess pharmacological evidence-based-treatment before admission in patients with heart failure (hf) due to systolic dysfunction, new york heart association functional class (fc) iii/iv who are hospitalized at coronary unit. material and methods. prospective study of patients hospitalized consecutively at coronary unit within june 2007 - june 2009. patients with hf and dilated cardiomyopathy fc iii/iv and echocardiographic ventricular function impairment where included. two groups where formed: patients with hf diagnosis within admission (admission group -ag-), in which we compared medication at discharge vs treatment at discharge of treatment group (tg); and patients with hf diagnosis for more than 1 year (3.3 years/sd 2.1), tg, in which we compared medication at admission vs medication at discharge. proportions test, statistix program, adjusted by fishera??s test was used for statistical analysis. results. average age was 55.2a±11.2 years in ag and 60.3a±11.3 years in tg (p=ns). there was masculine dominance (65% ag and 79.7% tg). 90% of patients in ag and 83.3% of patients in tg (p=ns) presented cardiomegaly at chest x-ray and moderate to severe impairment of ventricular function; with a mortality of 4 patients in ag (18.1%) and 24 in tg (28.5%) (p=ns). in tg there was relatively low indication of evidence-based-treatment at admission (60.7% furosemide; 32.1% spirinolactone; 58.35% angiotensin converting enzyme inhibitors (acei); 25% beta blockers and 27.3% digitalis), showing better results in comparison with discharge treatment. regarding therapeutic resorts optimization, ag treatment at discharge was similar than tga??s. conclusion. comparisons within ag and tg treatment at discharge only showed statistically significant differences about beta blocker indication. based on evidence, hf outpatients pharmacological treatment is less optimal, and tolerability to a mayor use of drugs with high impact in morbidity and mortality does not constitute a limitati
Adherence to cervical cancer screening in an Italian SLE cohort
C. Tani,L. Carli,M. Mosca,C. Baldini
Reumatismo , 2011, DOI: 10.4081/reumatismo.2011.11
Abstract: Objective: Papanicolau (Pap) smear abnormalities are more frequently observed in systemic lupus erythematosus (SLE) respect to the general population. The primary objective of the present study was to evaluate the adherence to cervical cancer (CC) screening in an Italian cohort of SLE patients and, secondly, to evaluate the disease-related factors possibly influencing the patients’ behavior. Methods: Consecutive 25 to 64 year old SLE patients and aged- matched healthy women were enrolled for the study. All patients were interviewed during ambulatory visits, at admission to the clinic or by a telephone contact; disease related variables were also collected from the clinical charts. Results: 140 SLE patients (mean age 48.3±12 years) and 70 controls matched for demographic and sociocultural characteristics were enrolled. Ninety-three SLE patients (66.4%) declared to perform the Pap test at least every three years (23.6% yearly and 42.8% when asked by the screening programs) while 47 (33.6%) did not perform regular CC screening (16.4% never did the test and 17.1% only occasionally). No significant differences were observed between patients and controls in cancer screening adherence. No significant associations were observed between the screening program behaviours and disease-related variables. Conclusions: Despite the growing evidence of an increased risk of CC in SLE, and regardless of the broad availability of screening programs and official recommendations, our results show insufficient CC surveillance among SLE patients and emphasize to rheumatologists and/or general practitioners the importance to discuss with patients this aspect during routine evaluations in order to encourage compliance to the recommended preventive measures.
Note on a 'hint' for an annual modulation signature of a 60 GeV WIMP
G. Gerbier,J. Mallet,L. Mosca,C. Tao
Physics , 1997,
Abstract: In a recent presentation at the TAUP97 conference about the analysis of data from a NaI(Tl) 100 kg underground detector run at the Gran Sasso Laboratory by the DAMA/NaI group, the speaker concluded there was a hint for a WIMP of mass 60 GeV with a cross section on proton of 10-5 pb (Spin Independent coupling) (see also ROM2F/97/33). Even if no claim of any definite signal is made, such a statement is strong enough to deserve a critical look. The present note puts forward a few arguments which point towards a largely overestimated statistical significance of the effect, an inconsistency in the energy distribution and several experimental effects which could easily mimic the observed excess. The conclusion is that, in no way, the presented result can be considered as a hint of a WIMP annual modulation.
Note about a second "evidence" for a WIMP annual modulation
G. Gerbier,J. Mallet,L. Mosca,C. Tao
Physics , 1999,
Abstract: This note, with its five questions, is intended to contribute to a clarification about a claimed "evidence" by the DAMA group of an annual modulation of the counting rate of a Dark Matter NaI(Tl) detector as due to a neutralino (SUSY-LSP) Dark Matter candidate.
On Quantum Algorithms
R. Cleve,A. Ekert,L. Henderson,C. Macchiavello,M. Mosca
Physics , 1999,
Abstract: Quantum computers use the quantum interference of different computational paths to enhance correct outcomes and suppress erroneous outcomes of computations. In effect, they follow the same logical paradigm as (multi-particle) interferometers. We show how most known quantum algorithms, including quantum algorithms for factorising and counting, may be cast in this manner. Quantum searching is described as inducing a desired relative phase between two eigenvectors to yield constructive interference on the sought elements and destructive interference on the remaining terms.
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