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Search Results: 1 - 10 of 208479 matches for " L. Manenti "
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O processo de constru??o do perfil de competências gerenciais para enfermeiros coordenadores de área hospitalar
Manenti, Simone Alexandra;Ciampone, Maria Helena Trench;Mira, Vera Lucia;Minami, Lígia Fumiko;Soares, Jaqueline Maria Sousa;
Revista da Escola de Enfermagem da USP , 2012, DOI: 10.1590/S0080-62342012000300027
Abstract: the objective of this study was to construct a profile of managerial competencies, based on the consensus of nurse coordinators in the field. this study was developed in a philanthropic hospital in s?o paulo, following the research-action model, and included 13 nurse coordinators as participants. the data collection was performed using the focal group technique. data analysis was performed using the theoretical frameworks related to the working process and managerial competencies. the results identified the greater emphasis assigned to the competencies related to the mentor, coordinator and director roles. it was, therefore, possible to construct a professional development plan that is based on competencies in the technical, ethical-political, and communicative domains, as well as the development of citizenship. the analysis of the managerial working process and the study of the competencies within the managerial environment were shown to be important, because they highlighted the professionals' need to improve, thus fulfilling personal, professional, and organizational demands.
Anticorpos contra beta2-glicoproteína I como fatores de risco para infarto agudo do miocárdio
Ranzolin, Aline;Bohn, Jussara Marilú;Norman, Gary L.;Manenti, Euler;Bodanese, Luis Carlos;Mühlen, Carlos Alberto von;Staub, Henrique Luiz;
Arquivos Brasileiros de Cardiologia , 2004, DOI: 10.1590/S0066-782X2004001400005
Abstract: objective: to determine whether high levels of antibodies against the phospholipid beta2-glycoprotein i (beta2-gpi) cofactor are associated with an increase in the risk of acute myocardial infarction. methods: the study comprised 82 patients with acute myocardial infarction and 82 controls, who were assessed in regard to age, sex, race, hypertension, smoking, previous heart disease, history of diabetes mellitus, and hypercholesterolemia. the following antibodies were detected using immunoassay: anticardiolipin and anti-beta2-gpi iga, igg, and igm. adjusted odds ratios (or) for risk factors were obtained through logistic regression. results: the mean ages of the cases and controls were, respectively, 57.7 and 51.1 years (p=0.003). men (p=0.005) and the white race predominated in both groups (p=0.798). of the risk factors, a history of diabetes (or=5.3; 95% ci: 1.9 to 14.9; p=0.001) and previous heart disease (or=4.7; 95% ci: 2.0 to 10.7; p<0.001) were the most consistent associations with myocardial infarction. the frequency of anticardiolipin igg, igm, and iga antibodies did not differ between cases and controls (p=1.000). anti-beta2-gpi iga antibodies were more frequent in cases than in controls (p=0.054). the adjusted or for anti-beta2-gpi iga antibodies was 3.4 (95% ci: 1.3 to 9.1; p=0.015). conclusion: anti-beta2-gpi iga antibodies, but not anticardiolipin antibodies, seemed to behave as independent risk factors for myocardial infarction, which may represent a link between autoimmunity and atherosclerosis in patients with acute myocardial infarction.
Alessandro Martorana,Guglielmo Manenti,Giacomo Koch
Frontiers in Aging Neuroscience , 2014, DOI: 10.3389/fnagi.2014.00254
Abstract: Current treatment options for patients with Alzheimer's disease (AD) are limited at providing symptomatic relief, with no effects on the underlying pathophysiology. Recently, advances in the understanding of the AD pathogenesis highlighted the role of ABeta (Aβ) oligomers particularly interfering with mechanisms of cortical plasticity such as long-term potentiation (LTP) and long-term depression (LTD). These findings led to the development of potential antiamyloid therapies, and among them homotaurine, a glycosaminoglycan (GAG) mimetic designed to interfere with the actions of Aβ early in the cascade of amyloidogenic events, and by its γ-aminobutyric acid type (GABA) A receptor affinity. Recently, we showed that AD patients have impaired LTP-like cortical plasticity, as measured by standard theta burst stimulation (TBS) protocols applied over the primary motor cortex (M1). Furthermore, AD patients have a weakened Short Latency Afferent Inhibition (SLAI), a neurophysiological measure of central cholinergic transmission, which changes reflect the cholinergic dysfunction occurring in the pathology. Here we aimed at investigating whether homotaurine administration could modulate in vivo measured mechanisms of synaptic plasticity, namely LTP and LTD, and also SLAI in a group of mild cognitive impaired patients. We observed that homotaurine administration did not induce relevant changes of both LTP and LTD recordings, while induced changes of SLAI in our group of patients. We suggest that homotaurine effects are dependent on changes of cortical GABA transmission suggesting a potential role for this compound in ameliorating the cholinergic transmission by modulating the inhibitory cortical activity.
A Checklist for the Evaluation of Pedestrian Simulation Software Functionalities
Mizar Luca Federici,Lorenza Manenti,Sara Manzoni
Computer Science , 2014,
Abstract: The employment of micro-simulation (agent-based) tools in the phase of design of public and private spaces and facilities and for the definition of transport schemes that impact on pedestrian flows, thanks to their achieved accuracy and predictive capacity, has become a consolidated practice. These instruments provide support to the organization of spaces, services and facilities and to the definition of management procedures for normal and emergency situations. The employment of these tools is effective for various but not for all the contexts, nevertheless new features and functions are under constant development and new products are often launched on the market. Therefore, there is a higher necessity of a standard criteria both for the evaluation of the kinds of function that these software provide, at use of practitioners and end-users, and for the definition of software requirements as a reference for the developers that aim at being competitive on this market. On the basis of our experience as pedestrian modellers and as researchers in the crowd modelling area, we designed a comprehensive and detailed ready-to-use checklist for the quantitative evaluation of Pedestrian Simulation Software functionalities that aims at capturing all the aspects that we claim that are useful to undertake a professional study. These functions in our opinion are necessary to provide accurate results in the planning of new facilities or schemes that involve pedestrian activities. With this work we propose a set of criteria of evaluation for these products also to encourage a debate for the definition of objective standards for pedestrian simulation software certification.
Safety Evaluation of New Polymer Materials Proposed for Relining Drinking Water Pipes in the City of Milano  [PDF]
Marinella Palmiotto, Giancarlo Bianchi, Laura Brunelli, Maurizio Lualdi, Carlo Lezzi, Angela Manenti, Enrico Davoli
International Journal of Analytical Mass Spectrometry and Chromatography (IJAMSC) , 2015, DOI: 10.4236/ijamsc.2015.34008
Abstract: Relining is a trenchless technology of recoating the inside walls of damaged water pipes using composite materials. In the Safe Pipe project, co-financed by Regione Lombardia, alternative polymeric materials for relining the drinking water distribution system of the city of Milan have been developed. Relining polymers have been evaluated for their toxicity. The identification of product impurities was performed by HPLC/HRMS and GC/MS analysis and safety evaluation was conducted applying toxicity data, when available, or applying QSAR models. Results showed low level of toxic substances in polymerized resins and in water samples in a migration/leaching test performed in a field experiment.
Antagonizing Retinoic Acid and FGF/MAPK Pathways Control Posterior Body Patterning in the Invertebrate Chordate Ciona intestinalis
Andrea Pasini, Raoul Manenti, Ute Rothb?cher, Patrick Lemaire
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0046193
Abstract: Vertebrate embryos exploit the mutual inhibition between the RA and FGF signalling pathways to coordinate the proliferative elongation of the main body axis with the progressive patterning and differentiation of its neuroectodermal and paraxial mesodermal structures. The evolutionary history of this patterning system is still poorly understood. Here, we investigate the role played by the RA and FGF/MAPK signals during the development of the tail structures in the tunicate Ciona intestinalis, an invertebrate chordate belonging to the sister clade of vertebrates, in which the prototypical chordate body plan is established through very derived morphogenetic processes. Ciona embryos are constituted of few cells and develop according to a fixed lineage; elongation of the tail occurs largely by rearrangement of postmitotic cells; mesoderm segmentation and somitogenesis are absent. We show that in the Ciona embryo, the antagonism of the RA and FGF/MAPK signals is required to control the anteroposterior patterning of the tail epidermis. We also demonstrate that the RA, FGF/MAPK and canonical Wnt pathways control the anteroposterior patterning of the tail peripheral nervous system, and reveal the existence of distinct subpopulations of caudal epidermal neurons with different responsiveness to the RA, FGF/MAPK and canonical Wnt signals. Our data provide the first demonstration that the use of the antagonism between the RA and FGF signals to pattern the main body axis predates the emergence of vertebrates and highlight the evolutionary plasticity of this patterning strategy, showing that in different chordates it can be used to pattern different tissues within the same homologous body region.
Quality of Reporting on the Vegetative State in Italian Newspapers. The Case of Eluana Englaro
Nicola Latronico,Ottavia Manenti,Luca Baini,Frank A. Rasulo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018706
Abstract: Media coverage of the vegetative state (VS) includes refutations of the VS diagnosis and describes behaviors inconsistent with VS. We used a quality score to assess the reporting in articles describing the medical characteristics of VS in Italian newspapers.
Habitat features and distribution of Salamandra salamandra in underground springs
Raoul Manenti,Gentile F. Ficetola,Barbara Bianchi,Fiorenza De Bernardi
Acta Herpetologica , 2009,
Abstract: Subterranean habitats are among the less known terrestrial habitats, but can reveal an unexpected biodiversity, and can play an underestimated role for amphibians. The fire salamander Salamandra salamandra is sometimes found in underground environments, but the factors affecting its distribution in subterranean spaces remain substantially unexplored. We repeatedly surveyed some hypogeous springs, such as draining galleries and “bottini” in NW Italy, in order to evaluate the relationship between environmental features and distribution of S. salamandra in these underground springs. We performed visual encounter surveys to assess the occurrence of larvae, juveniles or adults in springs. We also recorded four habitat variables: easy of access, isolation, macrobenthos richness and forest cover of the surrounding landscape. We used generalized linear models to evaluate the relationships between habitat features and occurrence of larvae. We observed larvae of S. salamandra in 13 out of 22 springs; their presence was associated to springs with high easy of access and with relatively rich macrobenthos communities. In underground springs, larval development apparently required longer time than in nearby epigeous streams. Nevertheless, S. salamandra can attain metamorphosis in this environment. The occurrence of S. salamandra in underground environments was not accidental, but repeated in the time and interesting from an ecological point of view, confirming the high plasticity of the species.
Non-IBD colitides: clinically useful histopathological clues Colitis no relacionadas con la enfermedad inflamatoria intestinal: claves histopatológicas de utilidad clínica
Vincenzo Villanacci,Stefania Manenti,Elisabetta Antonelli,Mariella Chiudinelli
Revista Espa?ola de Enfermedades Digestivas , 2011,
Abstract: Apart from inflammatory bowel diseases (IBD), there are several other form of colitis that may resemble macroscopically IBD, entering the differential diagnosis. These forms are represented by infectious colitis, ischemic colitis, pseudomembranous colitis, colitis related to diverticular disease, colitis related to mucosal prolapse, drug colitis, allergic colitis, and microscopic colitis. However, to distinguish between these forms is not always easy, and it frequently requires a strict interrelationship between the pathologist and the gastroenterologist. Here we discuss the more frequent forms of non- inflammatory bowel diseases colitides, trying to give useful hints for helping the clinician to better understand the extent to which the pathologist is called to give a definitive response in the differential diagnosis of these entities.
Valor prognóstico da resolu o da eleva o do segmento ST na reperfus o miocárdica
Nery Pablo Balbuena,Bodanese Luiz Carlos,Manenti Euler
Arquivos Brasileiros de Cardiologia , 2003,
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