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Search Results: 1 - 10 of 208128 matches for " L. Iafrate "
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The archive and library of the former Italian Central Office for Meteorology and Climatology
M. C. Beltrano, S. Esposito,L. Iafrate
Advances in Science and Research (ASR) , 2012, DOI: 10.5194/asr-8-59-2012
Abstract: The Paper Archive and Library of CRA-CMA (Agricultural Research Council – Research Unit for Climatology and Meteorology applied to Agriculture) are an important source of meteorological data for climate research. CRA-CMA's Paper Archive gathers a collection of about 850 historical meteorological datasets. Among them, 40 are nowadays still in progress, 260 are more than thirty years long and 20 exceed one century. Moreover, the specialized Library of CRA-CMA gathers several publications containing meteorological data from many Italian and foreign observatories and an important collection of scientific journals and historical books on Atmospheric Sciences, Geophysics and Agrometeorology published both in Italy and abroad and dating from the second half of the sixteenth century. Even if input data for climate models are generally based on 30 yr long datasets, nevertheless longer observational series (up to 50 or 100 yr) are a key element to better understand the climate system behavior. Until today, the library described in this paper is a CRA-CMA heritage almost unknown to the international scientific community.
Entanglement in the interaction between two quantum oscillator systems
ILki Kim,Gerald J. Iafrate
Physics , 2006, DOI: 10.1007/s10702-004-0902-9
Abstract: The fundamental quantum dynamics of two interacting oscillator systems are studied in two different scenarios. In one case, both oscillators are assumed to be linear, whereas in the second case, one oscillator is linear and the other is a non-linear, angular-momentum oscillator; the second case is, of course, more complex in terms of energy transfer and dynamics. These two scenarios have been the subject of much interest over the years, especially in developing an understanding of modern concepts in quantum optics and quantum electronics. In this work, however, these two scenarios are utilized to consider and discuss the salient features of quantum behaviors resulting from the interactive nature of the two oscillators, i.e., coherence, entanglement, spontaneous emission, etc., and to apply a measure of entanglement in analyzing the nature of the interacting systems. ... For the coupled linear and angular-momentum oscillator system in the fully quantum-mechanical description, we consider special examples of two, three, four-level angular momentum systems, demonstrating the explicit appearances of entanglement. We also show that this entanglement persists even as the coupled angular momentum oscillator is taken to the limit of a large number of levels, a limit which would go over to the classical picture for an uncoupled angular momentum oscillator.
Comment on the quantum nature of angular momentum using a coupled-boson representation
ILki Kim,Gerald J. Iafrate
Physics , 2005,
Abstract: A simple approach for understanding the quantum nature of angular momentum and its reduction to the classical limit is presented based on Schwinger's coupled-boson representation. This approach leads to a straightforward explanation of why the square of the angular momentum in quantum mechanics is given by j(j+1) instead of just j^2, where j is the angular momentum quantum number.
The Sky is for Everyone - Outreach and Educaction with the Virtual Observatory
Florian Freistetter,Giulia Iafrate,Massimo Ramella
Physics , 2011,
Abstract: The Virtual Observatory (VO) is an international attempt to collect astronomical data (images, simulation, mission-logs, etc), organize it and develop tools that let astronomers access this huge amount of information. The VO not only simplifies the work of professional astronomers, it is also a valuable tool for education and public outreach. For teachers and astronomers who actively promote astronomy to the public the VO is an great opportunity to access real astronomical data, use them and have a taste of the workaday life of astronomers.
BRAF V600E Mutations Are Common in Pleomorphic Xanthoastrocytoma: Diagnostic and Therapeutic Implications
Dora Dias-Santagata,Quynh Lam,Kathy Vernovsky,Natalie Vena,Jochen K. Lennerz,Darrell R. Borger,Tracy T. Batchelor,Keith L. Ligon,A. John Iafrate,Azra H. Ligon,David N. Louis,Sandro Santagata
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017948
Abstract: Pleomorphic xanthoastrocytoma (PXA) is low-grade glial neoplasm principally affecting children and young adults. Approximately 40% of PXA are reported to recur within 10 years of primary resection. Upon recurrence, patients receive radiation therapy and conventional chemotherapeutics designed for high-grade gliomas. Genetic changes that can be targeted by selective therapeutics have not been extensively evaluated in PXA and ancillary diagnostic tests to help discriminate PXA from other pleomorphic and often more aggressive astrocytic malignancies are limited. In this study, we apply the SNaPshot multiplexed targeted sequencing platform in the analysis of brain tumors to interrogate 60 genetic loci that are frequently mutated in 15 cancer genes. In our analysis we detect BRAF V600E mutations in 12 of 20 (60%) WHO grade II PXA, in 1 of 6 (17%) PXA with anaplasia and in 1 glioblastoma arising in a PXA. Phospho-ERK was detected in all tumors independent of the BRAF mutation status. BRAF duplication was not detected in any of the PXA cases. BRAF V600E mutations were identified in only 2 of 71 (2.8%) glioblastoma (GBM) analyzed, including 1 of 9 (11.1%) giant cell GBM (gcGBM). The finding that BRAF V600E mutations are common in the majority of PXA has important therapeutic implications and may help in differentiating less aggressive PXAs from lethal gcGBMs and GBMs.
Motives for participating in a clinical research trial: a pilot study in Brazil
Solange A Nappo, Giovanna B Iafrate, Zila M Sanchez
BMC Public Health , 2013, DOI: 10.1186/1471-2458-13-19
Abstract: Mixed-methods research was used (a qualitative-quantitative approach). A sample of 80 volunteers underwent a semi-structured interview, which was based on a survey script that was elaborated from discussions with key informants. The sample was randomly selected from a database of clinical study volunteers that was provided by Brazilian clinical study centers. The interviews were recorded and transcribed. Descriptive statistics were used for content analysis, including contingency tables with hypothesis testing.The motivations for clinical study participation were linked to types of benefit. The most frequently encountered motivations were financial gain and therapeutic alternative. Altruism was not a common motivator, and when altruism was present, it was observed as a secondary motivator. All participants reported that they understood the Informed Consent Statement (ICS). However, only two parts of the form were remembered by all of the volunteers: the section on being able to leave the study at any point and the section that stated that there would be some responsible professional at their disposal for the entirety of the study.The present study shows that study participants are primarily motivated by personal benefit when volunteering to participate in clinical studies. Whether these study participants had an integral understanding of the ICS is not clear.A clinical study is an investigation that uses human subjects to contribute to knowledge that can be applied to benefit society. Clinical studies typically evaluate an intervention that is applied to study subjects. The intervention might be a drug, vaccine or therapeutic or surgical procedure [1]. Clinical studies are indispensable for the progress of medicine, especially for the discovery of new pharmaceuticals [2]. However, the use of human subjects in these studies as a unit of analysis introduces certain challenges [3].In the past, study participants have suffered from the experiments that they were subject
Colorectal cancer screening: The role of CT colonography
Andrea Laghi, Franco Iafrate, Marco Rengo, Cesare Hassan
World Journal of Gastroenterology , 2010,
Abstract: Computed tomography colonography (CTC) in colorectal cancer (CRC) screening has two roles: one present and the other potential. The present role is, without any further discussion, the integration into established screening programs as a replacement for barium enema in the case of incomplete colonoscopy. The potential role is the use of CTC as a first-line screening method together with Fecal Occult Blood Test, sigmoidoscopy and colonoscopy. However, despite the fact that CTC has been officially endorsed for CRC screening of average-risk individuals by different scientific societies including the American Cancer Society, the American College of Radiology, and the US Multisociety Task Force on Colorectal Cancer, other entities, such as the US Preventive Services Task Force, have considered the evidence insufficient to justify its use as a mass screening method. Medicare has also recently denied reimbursement for CTC as a screening test. Nevertheless, multiple advantages exist for using CTC as a CRC screening test: high accuracy, full evaluation of the colon in virtually all patients, non-invasiveness, safety, patient comfort, detection of extracolonic findings and cost-effectiveness. The main potential drawback of a CTC screening is the exposure to ionizing radiation. However, this is not a major issue, since low-dose protocols are now routinely implemented, delivering a dose comparable or slightly superior to the annual radiation exposure of any individual. Indirect evidence exists that such a radiation exposure does not induce additional cancers.
The Double Didactic Astronomical Quadrant for the XIII International Astronomical Olympiad
Michele Maris,Claudio Corte,Conrad Boehm,Giulia Iafrate,Massimo Ramella
Physics , 2010,
Abstract: Here we present the development of a simplified version of double astronomical quadrant, designed for educational aims and realized on the occasion of the observational round of the XIII International Astronomy Olympiad, held in Trieste (Italy) October 13-21, 2008. (Italia: In questo contributo illustriamo il progetto di una versione semplificata di doppio quadrante astronomico, progettato per fini didattici e realizzato in occasione dello svolgimento della gara osservativa delle XIII Olimpiadi Internazionali di Astronomia (XIII International Astronomy Olympiad, XIII IAO), Trieste (I), 13-21 ottobre 2008))
Search for hig energy solar flares with Fermi-LAT
G. Iafrate,F. Longo,for the FERMI Large Area Telescope Collaboration
Physics , 2009,
Abstract: The Fermi Large Area Telescope (LAT) has been surveying the sky in gamma rays from 30 MeV to more than 300 GeV since August 2008. Fermi is the only mission able to detect high energy > few hundreds MeV emission from the Sun during the new solar cycle 24: the Solar System Science Group of the Fermi team is continuously monitoring high energy emission from the Sun searching for flare events. Preliminary upper limits (E>100 MeV) have been derived for all solar flares detected so far by other missions and experiments (RHESSI, Fermi, GBM, GOES). Upper limit for flaring Sun emission (integrated over one year of data) has also been derived. Here we present the analysis techniques as well as the details of this search and the preliminary results obtained so far.
Electron spin relaxation in semiconducting carbon nanotubes: the role of hyperfine interaction
Y. G. Semenov,K. W. Kim,G. J. Iafrate
Physics , 2006, DOI: 10.1103/PhysRevB.75.045429
Abstract: A theory of electron spin relaxation in semiconducting carbon nanotubes is developed based on the hyperfine interaction with disordered nuclei spins I=1/2 of $^{13}$C isotopes. It is shown that strong radial confinement of electrons enhances the electron-nuclear overlap and subsequently electron spin relaxation (via the hyperfine interaction) in the carbon nanotubes. The analysis also reveals an unusual temperature dependence of longitudinal (spin-flip) and transversal (dephasing) relaxation times: the relaxation becomes weaker with the increasing temperature as a consequence of the particularities in the electron density of states inherent in one-dimensional structures. Numerical estimations indicate relatively high efficiency of this relaxation mechanism compared to the similar processes in bulk diamond. However, the anticipated spin relaxation time of the order of 1 s in CNTs is still much longer than those found in conventional semiconductor structures.
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