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Search Results: 1 - 10 of 381879 matches for " López-Cárdenas "
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Aproximación a un estándar de reparación integral en procesos colectivos de violación a los derechos humanos. Jurisprudencia de la Corte Interamericana de Derechos Humanos
López-Cárdenas,Carlos-Mauricio;
Estudios Socio-Jurídicos , 2009,
Abstract: this article makes an approach to a standard to provide reparations for gross collective human rights violations. for this purpose, from the perspective of the jurisprudence of the inter-american court of human rights, the paper examines the concept of victim, individually and collectively, and reparation mechanisms (restitution, compensation, rehabilitation, satisfaction and guarantees of non repetition).
Características clinicopatológicas y distribución del número de autopsias de pacientes fallecidos por coccidioidomicosis en un hospital de referencia del noreste de México
Calderón-Garcidue?as, Ana Laura;Pi?a-Osuna, Karina;Leal-Moreno, Ana María;López-Cárdenas, Adriana;Cerda-Flores, Ricardo M;
Gaceta médica de México , 2004,
Abstract: aims: 1. to describe clinical and pathologic characteristics of patients with coccidioidomycosis (cm) who died from 1983-2000 at a hospital in northeastern mexico, and 2, to know distribution of number of deaths due to cm per year and month. methods: from 4598 autopsies, 31 cases of cm were selected. clinical chart and autopsy protocols were examined. distribution of cases was analyzed by contingence table and kolmogorov-smirnov tests. results: there were 10 women and 21 men (aged 4 months to 60 years). in women, pregnancy was present in 40%ofcases. in men, chronic renal failure (crf) (38%) and aids (19%) were the pathologic conditions most frequently observed. variation in distribution of cases throughout 18 years was not observed (p > 0.05). conclusions: mortality due to cm was 0.67% and variation in number of deaths was not found. in this endemic area, cm must be included in differential diagnosis of patients with risk factors such as pregnancy, crf, and aids, especially if associated with pneumonia with miliary pattern or septicemia with splenomegaly.
Evaluación del grado de ajuste de las revistas científicas espa?olas de ciencias de la salud a las normas internacionales de presentación de publicaciones periódicas
López-Cózar,Emilio Delgado;
Revista Espa?ola de Salud Pública , 1997, DOI: 10.1590/S1135-57271997000600003
Abstract: background: because standardization is important to ensure the successful transfer of scientific information, compliance with international standards for the presentation of periodicals in 205 spanish biomedical journals, with the aim of improving their quality as instruments of information transfer, is evaluated. methods: journals were identified by consulting five printed bibliographies and four electronic databases. a total of 136 parameters of evaluation for the presentation of periodicals derived from iso (international standardization organization) standards (86%) and recomendations published by unesco, the international committee of medical journal editors, the council of biology editors, and ej huth (14%) were evaluated. three features (inclusion, presentation and location) were recorded for most data item, and the total number of items studied was 342. results: the rate of compliance with standards in spanish biomedical journals was 33.5% ± 8,5 (de). compliance was highest for items related with the identification of the journal in the text pages and the issue contents list. the lowest rates of compliance were found for items related the volume and the abstract sheet. the worst standardized journals were those published by private firms and public administration organizations. as a group, journals published annually were the best standardized. conclusions: the low rate of compliance with standards did not reflect inadequate compliance with all items, but was rather the result of complete noncompliance with particular standards, especially those relating to the abstract sheet, volume front cover, volume contents list and volume index. to improve compliance a change in the policies governing the availability of standards, the preparation of guides and manuals for scientific periodical publishing, and the development of training programs aimed at authors, editors, publishers, librarians and information scientists, is suggested.
Evaluación del grado de ajuste de las revistas científicas espa olas de ciencias de la salud a las normas internacionales de presentación de publicaciones periódicas
López-Cózar Emilio Delgado
Revista Espa?ola de Salud Pública , 1997,
Abstract: FUNDAMENTO: Se evalúa el cumplimiento, por parte de 205 revistas científicas espa olas de ciencias de la salud, de las normas internacionales de presentación de publicaciones periódicas, con el fin de mejorar su calidad informativa, puesto que la normalización constituye un elemento importante en el éxito del proceso de transferencia de la información científica. MéTODOS: Las revistas se identificaron a través de cinco bibliografías impresas y cuatro bases de datos bibliográficas. Se controlaron 136 preceptos extraídos de las normas internacionales de presentación de publicaciones periódicas emitidas por la International Standardization Organization (86%) y de recomendaciones generadas por la UNESCO, el International Committee of Medical Journal Editors, el Council of Biology Editors y EJ Huth (14%). Para cada parámetro se valoraron tres niveles de evaluación (Inclusión, Presentación y Ubicación), por lo que el número total de ítemes evaluados fue de 342. RESULTADOS: El grado de normalización de las revistas biomédicas espa olas estudiadas fue del 33,5% ± 8,5. Destacan por su buen ajuste los parámetros referidos a la identificación de la revista en las páginas del texto y al sumario del fascículo. Los aspectos más descuidados se concentran en el volumen y sumario analítico. Las revistas peor normalizadas son las auspiciadas por empresas y organismos de gestión. Las revistas anuales son las mejor estandarizadas. CONCLUSIONES: El bajo nivel de normalización que resulta no se debe a un deficiente cumplimiento generalizado de todos los parámetros sino más bien al incumplimiento completo de algunos de los mismos, en concreto: las normas que regulan el sumario analítico y la cubierta, sumario e índices de volumen. Para conseguir una mayor normalización de las revistas se propone un cambio en la política de difusión de las normas, la elaboración de guías y manuales para la confección de publicaciones científicas y el desarrollo de programas docentes con vistas a la educación de autores, directores, editores, bibliotecarios y documentalistas.
Evaluación y aplicación de las normas de presentación de publicaciones periódicas: revisión bibliográfica
Delgado López-Cózar, Emilio
Revista Espa?ola de Documentación Científica , 1997,
Abstract: Bibliography written during the last four decades on thc dcgrce of application of international standards to the presentation of pcriodicals, on the Ioundations of the standardisation, and thc dcvcloprncnt of standards in the Iicld of Information Science and thc prescntation ol' puhlications is revicwcd. It is concludcd that thc literature puhlished on standardisation and its cffccts on information transfcr is vcry extensivo when cornparcd to literaturc dcdicated to the cvaluation of its use in general and its application to scienti fic periodicals. The intcrcst of studic s on standards compliance for the improvement hoth of the standardisation of scientific journals and the quality of thc standards which govern them is pointcd out. Se efectúa una revisión de la bibliografía aparecida en las cuatro últimas décadas sobre el grado de aplicación de las normas internacionales de presentación de publicaciones periódicas y sobre los fundamentos de la normalización, de las normas desarrolladas en el ámbito de la Documentación y la presentación de publicaciones. Se concluye que la literatura publicada sobre la normalización y sus efectos en la transferencia de la información es muy extensa comparada con la dedicada a la evaluación de su uso, en general, y su aplicación a las publicaciones periódicas de corte científico, en particular. Se destaca el interés de los estudios de cumplimiento normativo para la mejora tanto de la estandarización de las revistas científicas como de la calidad de las normas que las rigen.
A Model Metabolic Cycle Simulated with the Mathematica Program  [PDF]
Víctor García-Herrero, Francisco López-Cánovas, Antonio Sillero
Journal of Biomedical Science and Engineering (JBiSE) , 2014, DOI: 10.4236/jbise.2014.75031
Abstract: A system of differential equations has been used to simulate a model metabolic cycle, containing only one initial substrate and 8 irreversible enzymes. The metabolic course of the intermediates (products/substrates) was also explored in different situations: changes in the kinetic constants of one of the enzymes of the cycle; introduction of one reversible step; consecutive increments in the Km values of each enzyme of the cycle and the presence of two initial substrates. A decrease or an increase in the Km value of one of the enzymes of the cycle promotes a decrease or an increase in the steady state level of its own substrate, respectively; by the contrary, a decrease or an increase in the Vmax value promotes, respectively, an increase or a decrease in the stationary level of the corresponding substrate. A comparison between a linear and a cyclic metabolic pathway is also presented.
Mathematical model for the ubiquitin activating enzyme E1  [PDF]
Francisco Javier López-Cánovas, Francisca Cánovas, María Antonia Günther Sillero, Antonio Sillero
Journal of Biomedical Science and Engineering (JBiSE) , 2010, DOI: 10.4236/jbise.2010.33037
Abstract: The ubiquitin-activating enzyme E1 (EC 6.3.2.19) represents the first step in the degradation of proteins by the ubiquitin proteasome pathway. E1 transfers ubiquitin from the ubiquitinated E1 to the ubiquitin carrier proteins (E2), ubiquitin-protein ligases (E3) and proteins. This process is rather complex, and known from the work of Haas, Ciechanover, Hershko, Rose and others. The occurrence of 19 hypothetical intermediate enzyme forms (EFs) and 22 different reactions were considered in the presence of ubiquitin (Ub), ATP, adenosine 5’-tetraphosphate (p4A), pyrophosphate (P2), and tripolyphosphate (P3) as substrates, and iodoacetamide (IAA) and dithioth- reitol (DTT) as inhibitors. Inspired by the work of Cha (Cha (1968) J. Biol. Chem., 243, 820-825) we have treated these reactions in two complementary ways: in rapid equilibrium and in steady state. The kinetics of both types of reactions were simulated and solved with a system of ordinary differential equations using the Mathematica Program. The ubiquitination of E1 has been also theoretically coupled to the ubiquitination of E2, E3 and proteins. This makes the model useful to predict the theoretical influence of inhibitors (or of changes in some parameters of the reaction) on the ubiquitination of proteins. The Program responds to changes in the concentration of ATP or ubiquitin and has predictive properties as shown by the influence of AMP on the synthesis of p4A, calculated theoretically and confirmed experimentally.
LA NECESIDAD DE UN ENFOQUE ESTRATéGICO ANTE EL PLANTEAMIENTO DE LOS NUEVOS GRADOS EN EL áREA DE ADMINISTRACIóN Y DIRECCIóN DE EMPRESAS.
Cristina López-Cózar Navarro,Tiziana Priede Bergamini
REDU : Revista de Docencia Universitaria , 2011,
Abstract: RESUMEN El nuevo Espacio Europeo de Educación Superior supone para las universidades la necesidad de modificar su oferta académica actual, sustituyendo diplomaturas y licenciaturas por títulos de grado. Ante este reto, la principal aportación de este trabajo consiste en la aplicación del modelo de análisis estratégico a la formulación de nuevos títulos adaptados al EEES en el área empresarial. ABSTRACT The new space for higher education means for all European universities the need to modify their academic offer, creating new academic degrees that will replace the current ones. With this in mind, the main contribution of this article is based on the application of the strategic management model to the creation of new grades adapted to the ESHE, focused mainly on the business management area.
Photospheric emission from long duration gamma-ray bursts powered by variable engines
Diego López-Cámara,Brian Morsony,Davide Lazzati
Physics , 2014, DOI: 10.1093/mnras/stu1016
Abstract: We present the results of a set of numerical simulations of long-duration gamma-ray burst jets aimed at studying the effect of a variable engine on the peak frequency of the photospheric emission. Our simulations follow the propagation of the jet inside the progenitor star, its break-out, and the subsequent expansion in the environment out to the photospheric radius. A constant and two step-function models are considered for the engine luminosity. We show that our synthetic light-curves follow a luminosity-peak frequency correlation analogous to the Golenetskii correlation found in long-duration gamma-ray burst observations. Within the parameter space explored, it appears that the central engine luminosity profile does not have a significant effect on the location of a gamma-ray burst in the Luminosity-peak frequency plane, bursts from different central engines being indistinguishable from each other.
SECTOR DE LA FABRICACIóN DE PRODUCTOS FARMACéUTICOS EN ESPA A. REPRESENTACIóN DE LAS EMPRESAS DE PARTICIPACIóN EN LA INDUSTRIA
Priede Bergamini, T.,López-Cózar Navarro, C.,Benito Hernández, S.
Investigaciones Europeas de Direccion y Economia de la Empresa , 2009,
Abstract: La industria farmacéutica se caracteriza por ser uno de los sectores más intensivos en investigación científica y desarrollo tecnológico. Su capacidad innovadora contribuye a mejorar el tratamiento de las enfermedades y tiene una importante repercusión en otras ramas de la industria. Por estos motivos, se convierte en un sector estratégico para cualquier país. Con el presente trabajo se pretende estudiar la estructura demográfica para el sector farmacéutico espa ol, con el fin de analizar el peso de las empresas de participación en esta actividad económica.
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