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Search Results: 1 - 10 of 230192 matches for " López González "
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Challenges Analyzing RNA-Seq Gene Expression Data  [PDF]
Liliana López-Kleine, Cristian González-Prieto
Open Journal of Statistics (OJS) , 2016, DOI: 10.4236/ojs.2016.64053
Abstract: The analysis of messenger Ribonucleic acid obtained through sequencing techniques (RNA-se- quencing) data is very challenging. Once technical difficulties have been sorted, an important choice has to be made during pre-processing: Two different paths can be chosen: Transform RNA- sequencing count data to a continuous variable or continue to work with count data. For each data type, analysis tools have been developed and seem appropriate at first sight, but a deeper analysis of data distribution and structure, are a discussion worth. In this review, open questions regarding RNA-sequencing data nature are discussed and highlighted, indicating important future research topics in statistics that should be addressed for a better analysis of already available and new appearing gene expression data. Moreover, a comparative analysis of RNAseq count and transformed data is presented. This comparison indicates that transforming RNA-seq count data seems appropriate, at least for differential expression detection.
Relaciones Cuba-áfrica: marco para un bojeo bibliográfico
González López, David;
Estudos Afro-Asiáticos , 2002, DOI: 10.1590/S0101-546X2002000300007
Abstract: the author proposes the creation of bibliographical references for the study of the relations between cuba and africa, taking into consideration what it is most pertinent in the national and foreign publications. it is pointed out sources, themes, points of view, analysis, and most of all, omissions on these publications.
Políticas de innovación y servicios a empresas intensivos en conocimiento: una aproximación general
González López,Manuel;
Revista iberoamericana de ciencia tecnolog?-a y sociedad , 2008,
Abstract: in this paper we present a general view about the need of incorporating knowledge intensive business services (kibs) in the innovation policy agenda. we firstly discuss the role of these services as knowledge diffusers in innovation systems. secondly, the theoretical rationale for a policy that integrates kibs is argued about. finally we present some general guidelines for a policy that considers these activities. in this sense the strengthening of the kibs sector could be particulary interesting in peripheral regions where the existence of a wide and diversified kibs supply is not usual. by the same token, reinforcing kibs will be also interesting in order to facilitate the access of smes to these specialised services.
Sustentos ontológicos, teleológicos y metodológicos de los modelos de evaluación curricular aplicados en la educación superior en Venezuela
González López, Rosalina;
Revista electrónica de investigación educativa , 2010,
Abstract: scientific and technological changes, low relevance of the educative programs and economic globalization, have lead to the resurgence of evaluation as an innovative tool. however, the initiatives show a lack of delimitation in their interpretative understanding, adopting diffuse conceptions of curriculum and its evaluation. thus, the present study investigation was done to determine, through a content analysis using the classic method of sanz (2004), how the curriculum models most usually applied in the country are sustained ontologically, teleologically and methodologically. the models are based on a quite uniform ontological and teleological concept of curriculum. on the other hand, methodologically they adopt three-dimensional models that include knowing, doing and being; incorporating elements of the multidirectional approach. in curricular evaluation, they demonstrate homogeneity in their ontology and teleology, but not in their methodology.
Determinantes psicosociales en la aparición y curso del vitiligo
López González,Vivian;
Revista Cubana de Medicina General Integral , 2000,
Abstract: the purpose of this work is to show the importance of a number of social and psychological factors for the treatment of vitiligo patients. it encloses the onset of the disease, the search for medical aid, the diagnosis, as well as the development of the disease during treatment. among the main factors that bear an influence during the whole process of the disease are to be considered as important ones: some social - demographic characteristics, life events, the purported cause of the disease, decision making in search for medical help, the assimilation of his role by the sick person, emotional reactions, healing goals and expectations, mechanisms aimed at facing the disease and social support.
Aniversario 110 de la Organización Panamericana de la Salud 110th anniversary of the Pan-American Health Organization
Roxana González López
Revista Cubana de Salud Pública , 2012,
Abstract:
Determinantes psicosociales en la aparición y curso del vitiligo
Vivian López González
Revista Cubana de Medicina General Integral , 2000,
Abstract: Es el propósito de este trabajo mostrar la importancia que tienen para el manejo del enfermo de vitiligo diversos factores psicológicos y sociales. Abarca tanto el desencadenamiento de la enfermedad, la búsqueda de ayuda médica, el diagnóstico; como el curso de la enfermedad durante el tratamiento. Entre los principales factores que influyen durante todo el proceso de la enfermedad se destacan: algunas características sociodemográficas, los eventos vitales, la atribución causal de la enfermedad, la toma de decisión en la búsqueda de la ayuda médica, la asimilación del rol de enfermo, las reacciones emocionales, las expectativas y metas de curación, los mecanismos de afrontamiento y el apoyo social. The purpose of this work is to show the importance of a number of social and psychological factors for the treatment of vitiligo patients. It encloses the onset of the disease, the search for medical aid, the diagnosis, as well as the development of the disease during treatment. Among the main factors that bear an influence during the whole process of the disease are to be considered as important ones: some social - demographic characteristics, life events, the purported cause of the disease, decision making in search for medical help, the assimilation of his role by the sick person, emotional reactions, healing goals and expectations, mechanisms aimed at facing the disease and social support.
Rosario Castellanos: lo dado y lo creado en una ética de seres humanos y libres
Aralia López González
Política y cultura , 1996,
Abstract:
La reestructuración económico-territorial de la megalópolis de México ante la globalización (1a Parte)
Sergio González López
Urbano , 2004,
Abstract: El presente artículo aborda el análisis del proceso de configuración económico-territorial de la Megalópolis de México (MM) 3 , de la década de los ochenta a la fecha. Formulando, para tal fin, preguntas tales como cuáles son las principales transformaciones económicas y territoriales que se han presentado en este ámbito territorial?, en qué han consistido los principales planteamientos de ordenamiento económico- territorial durante este periodo?, y, se presenta alguna correspondencia entre los procesos económico-territoriales y los planteamientos vertidos? Al respecto, las respuestas que adelantamos en este trabajo son: Los principales cambios económico-territoriales de la MM no se circunscriben sólo hacia la desindustrialización y la disminución relativa del grado de concentración económica con respecto al total nacional; sino, y sobre todo, hacia la especialización productiva y territorial. El principal cambio entre los planteamientos de los documentos generales de ordenamiento territorial que se analizan consiste en el traslado de la prioridad del control en la zona metropolitana y de la desconcentración nacional hacia la competitividad internacional. Y, por último, si bien existe una correspondencia entre los procesos económico-territoriales y los planteamientos vertidos, es pertinente plantear que estos últimos son insuficientes que dificulta plantear tanto que los cambios de los procesos respondan a dichas políticas como que en la actualidad se cuenta con un proyecto económico-territorial que posibilite elevar las condiciones económicas de la MM.
La reestructuración económico-territorial de la megalópolis de México ante la globalización (2a parte)
Sergio González López
Urbano , 2005,
Abstract:
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