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Search Results: 1 - 10 of 168530 matches for " Kyle E. Hultgren "
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Embracing Pharmacy E-Learning: Models of Success
Jaclyn A. Jeffries,Pamela R. Jeffries,John B. Hertig,Kyle E. Hultgren
Pharmacy , 2013, DOI: 10.3390/pharmacy1010043
Abstract: Traditionally, education has revolved around the idea of a learner being taught in a physical classroom setting. With recent technological developments and the “immediate results” world we now live in, elearning has become much more common. Students and professionals are now able to access and acquire lectures, tests, certifications and degrees online. The Purdue University College of Pharmacy’s Center for Medication Safety Advancement has developed three eresources to enhance medication safety: The Veterans Affairs Yellow Belt Lean Certification Course, the Medication Safety Essentials Continuing Education Modules, and the Virtual Clean Room Simulation Certificate. These three modalities offer valuable content for additional knowledge, training and certification at a convenient location—your computer.
Application of tomographic algorithms to Polar Mesospheric Cloud observations by Odin/OSIRIS
K. Hultgren,J. Gumbel,D. A. Degenstein,A. E. Bourassa
Atmospheric Measurement Techniques Discussions , 2012, DOI: 10.5194/amtd-5-3693-2012
Abstract: Limb-scanning satellites can provide global information about the vertical structure of Polar Mesospheric Clouds. However, information about horizontal structures usually remains limited. This is due to both a long line of sight and a long scan duration. On eighteen days during the Northern Hemisphere summers 2010–2011 and the Southern Hemisphere summer 2011/2012, the Swedish-led Odin satellite was operated in a special mesospheric mode with short limb scans limited to the altitude range of Polar Mesospheric Clouds. For Odin's Optical Spectrograph and InfraRed Imager System (OSIRIS) this provides multiple views through a given cloud volume and, thus, a basis for tomographic analysis of the vertical/horizontal cloud structure. Here we present algorithms for tomographic analysis of mesospheric clouds based on maximum probability techniques. We also present results of simulating OSIRIS tomography and retrieved cloud structures from the special tomographic periods.
Exploring the contexts of information designed for Swedish school-leavers
Hultgren, Frances
Svensk Biblioteksforskning , 2006,
Abstract: In this paper the institutional origins of information designed for school leavers have been examined using a discourse analytical approach. Texts from three of the major actors in the careers guidance system constitute the empirical basis of the study. It was found that information and the individual are constituted in different ways in each of the texts. Different ways of viewing the individual and information are related to different views on the nature of society, the labour market and the individual’s position within it, and on the value of education. Such views mediate to the reader which actions may be appropriate or inappropriate to take. The implications of the study are that young people need to develop skills in the critical analysis of informational texts as a tool in discerning their own best interests in relation to the range of interests promoted by career guidance literature. Furthermore, it is suggested that technical solutions need to be developed that increase the transparency of literature designed for school leavers.
Lameness and Udder Health in Swedish Dairy Herds, as Influenced by Housing Changes
Hultgren Jan
Acta Veterinaria Scandinavica , 2003, DOI: 10.1186/1751-0147-44-s1-p61
Aqueous Ti(IV)-Catalyzed Diels-Alder Reaction
Kyle E. Litz
Molecules , 2007, DOI: 10.3390/12081674
Abstract: The aqueous Diels-Alder reaction of 1,3-cyclohexadiene with 1,4-benzoquinone was compared and contrasted to the same reaction catalyzed with Flextyl P?, a novel Ti(IV) performance catalyst. The catalyst improved conversion by 22% versus the uncatalyzed reaction and represents a rare example of a Ti(IV) catalyzed Diels-Alder reaction in water.
Failure to prevent medication errors: We need smarter nearly error proof systems  [PDF]
Loren G. Yamamoto, Kyle M. Watanabe, Joan E. Kanemori
Open Journal of Pediatrics (OJPed) , 2013, DOI: 10.4236/ojped.2013.32013
Abstract: Purpose: To determine if nurses are able to identify medication errors that have the potential to bypass computer physician order entry (CPOE) and smart ordering systems. Background: Medical care systems employ computer “smart” systems to reduce medication errors by using artificial intelligence (preprogrammed methods of decision support and error reduction). However, these systems are not perfect and they can be bypassed. Nurses who carry out the order represent the last check point in error prevention prior to the administration of medication orders. Methods: A paper exercise was created with 513 physician orders. Nurses were asked to indicate whether they would carry out the order, refuse to carry out the order, consult a pharmacist for clarification, or carry out the order with special precautions. Nurses were given the option of using any nursing or medical reference. Results: The rate of correctly identifying 23 of the contraindicated orders was low. Both experienced and inexperienced nurses had high rates of not identifying the errors despite similar use of references and requests for assistance from pharmacists. Conclusions: This study demonstrates that if an error escapes a smart system, nurses were able to identify most of these errors, but not all of these. The current system features high stress, self-esteem issues, time pressure, high volume, and high risk. The system must change radically to meet the public’s expectations of being nearly error free which can only be achieved with smarter systems that are more resistant to human errors.
A Five-Year Review of Enhanced Learning through Integration: Anatomy and Clinical Practice  [PDF]
Melanie Hagen, Brian K. Cooke, Ashleigh Wright, Kyle E. Rarey
Creative Education (CE) , 2017, DOI: 10.4236/ce.2017.811121
Abstract: Many medical schools have undergone curricula revisions and attempted to integrate basic and clinical sciences. In 2012, our program at the University of Florida College of Medicine underwent significant curricular reform, transitioning from the standard medical curriculum to a systems-based approach. The teaching of anatomy, clinical skills, radiology, ethics, population health, human behavior, and evidence-based medicine was integrated into one class, “Introduction to Clinical Medicine”, which spans 68 weeks in the pre-clerk- ship curriculum. As a result, there was a reduction of anatomy teaching from 166 to 120 hours. Our curriculum integration demonstrates opportunities for enhanced teaching including increasing peer learning, incorporating multidisciplinary case presentations, and allowing for a deliberate overlap and layering of anatomy education across two years of medical school. This paper describes our reflection on the effect of the curriculum change on student learning. Five years after implementation of these changes shows that our efforts also illustrate the challenges inherent to curricular integration including scheduling constraints, unclear sources of financial support, apprehension about the effect on future National Board of Medical Examiners (NBME) scores, and difficulty assessing which areas a student needs to remediate within a failed integrated course. Overall, the integration of anatomy with other classes into a revised course at our College of Medicine has been well received and successful.
Detection of Intracellular Bacterial Communities in Human Urinary Tract Infection
David A Rosen,Thomas M Hooton,Walter E Stamm,Peter A Humphrey,Scott J Hultgren
PLOS Medicine , 2007, DOI: 10.1371/journal.pmed.0040329
Abstract: Background Urinary tract infections (UTIs) are one of the most common bacterial infections and are predominantly caused by uropathogenic Escherichia coli (UPEC). While UTIs are typically considered extracellular infections, it has been recently demonstrated that UPEC bind to, invade, and replicate within the murine bladder urothelium to form intracellular bacterial communities (IBCs). These IBCs dissociate and bacteria flux out of bladder facet cells, some with filamentous morphology, and ultimately establish quiescent intracellular reservoirs that can seed recurrent infection. This IBC pathogenic cycle has not yet been investigated in humans. In this study we sought to determine whether evidence of an IBC pathway could be found in urine specimens from women with acute UTI. Methods and Findings We collected midstream, clean-catch urine specimens from 80 young healthy women with acute uncomplicated cystitis and 20 asymptomatic women with a history of UTI. Investigators were blinded to culture results and clinical history. Samples were analyzed by light microscopy, immunofluorescence, and electron microscopy for evidence of exfoliated IBCs and filamentous bacteria. Evidence of IBCs was found in 14 of 80 (18%) urines from women with UTI. Filamentous bacteria were found in 33 of 80 (41%) urines from women with UTI. None of the 20 urines from the asymptomatic comparative group showed evidence of IBCs or filaments. Filamentous bacteria were present in all 14 of the urines with IBCs compared to 19 (29%) of 66 samples with no evidence of IBCs (p < 0.001). Of 65 urines from patients with E. coli infections, 14 (22%) had evidence of IBCs and 29 (45%) had filamentous bacteria, while none of the gram-positive infections had IBCs or filamentous bacteria. Conclusions The presence of exfoliated IBCs and filamentous bacteria in the urines of women with acute cystitis suggests that the IBC pathogenic pathway characterized in the murine model may occur in humans. The findings support the occurrence of an intracellular bacterial niche in some women with cystitis that may have important implications for UTI recurrence and treatment.
Macrophage-Mediated Lymphangiogenesis: The Emerging Role of Macrophages as Lymphatic Endothelial Progenitors
Sophia Ran,Kyle E. Montgomery
Cancers , 2012, DOI: 10.3390/cancers4030618
Abstract: It is widely accepted that macrophages and other inflammatory cells support tumor progression and metastasis. During early stages of neoplastic development, tumor-infiltrating macrophages (TAMs) mount an immune response against transformed cells. Frequently, however, cancer cells escape the immune surveillance, an event that is accompanied by macrophage transition from an anti-tumor to a pro-tumorigenic type. The latter is characterized by high expression of factors that activate endothelial cells, suppress immune response, degrade extracellular matrix, and promote tumor growth. Cumulatively, these products of TAMs promote tumor expansion and growth of both blood and lymphatic vessels that facilitate metastatic spread. Breast cancers and other epithelial malignancies induce the formation of new lymphatic vessels ( i.e., lymphangiogenesis) that leads to lymphatic and subsequently, to distant metastasis. Both experimental and clinical studies have shown that TAMs significantly promote tumor lymphangiogenesis through paracrine and cell autonomous modes. The paracrine effect consists of the expression of a variety of pro-lymphangiogenic factors that activate the preexisting lymphatic vessels. The evidence for cell-autonomous contribution is based on the observed tumor mobilization of macrophage-derived lymphatic endothelial cell progenitors (M-LECP) that integrate into lymphatic vessels prior to sprouting. This review will summarize the current knowledge of macrophage-dependent growth of new lymphatic vessels with specific emphasis on an emerging role of macrophages as lymphatic endothelial cell progenitors (M-LECP).
Efficiency Enhancement of a Cantilever-Based Vibration Energy Harvester
Ali E. Kubba,Kyle Jiang
Sensors , 2014, DOI: 10.3390/s140100188
Abstract: Extracting energy from ambient vibration to power wireless sensor nodes has been an attractive area of research, particularly in the automotive monitoring field. This article reports the design, analysis and testing of a vibration energy harvesting device based on a miniature asymmetric air-spaced cantilever. The developed design offers high power density, and delivers electric power that is sufficient to support most wireless sensor nodes for structural health monitoring (SHM) applications. The optimized design underwent three evolutionary steps, starting from a simple cantilever design, going through an air-spaced cantilever, and ending up with an optimized air-spaced geometry with boosted power density level. Finite Element Analysis (FEA) was used as an initial tool to compare the three geometries’ stiffness (K), output open-circuit voltage (V ave), and average normal strain in the piezoelectric transducer (ε ave) that directly affect its output voltage. Experimental tests were also carried out in order to examine the energy harvesting level in each of the three designs. The experimental results show how to boost the power output level in a thin air-spaced cantilever beam for energy within the same space envelope. The developed thin air-spaced cantilever (8.37 cm 3), has a maximum power output of 2.05 mW (H = 29.29 μJ/cycle).
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