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Search Results: 1 - 10 of 14235 matches for " Kye Won Park1 "
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Mesodermal repression of single-minded in Drosophila embryo is mediated by a cluster of Snail-binding sites proximal to the early promoter
Kye Won Park1 & Joung-Woo Hong2,*
BMB Reports , 2012,
Abstract: single-minded (sim) is a master regulatory gene that directs differentiationin the central nervous system during Drosophilaembryogenesis. Recent identification of the mesectoderm enhancer(MSE) of sim has led to the hypothesis that two Snail(Sna)-binding sites in the MSE may repress sim expression inthe presumptive mesoderm. We provide evidence here thatthree Sna-binding sites proximal to the sim promoter, but notthose of the MSE, are responsible for the mesodermal repressionof sim in vivo. Using transgenic embryos injectedwith lacZ transgenes, we showed that sim repression in themesoderm requires the three promoter-proximal Sna-bindingsites. These results suggest that Sna represses the mesectodermalexpression of sim by directly repressing the nearby promoter,and not by quenching adjacent transcriptional activatorsin the MSE. These data also showed how the MSE, lackingthe three proximal Sna-binding sites, reproduced the endogenouspattern of sim expression in transgenic embryos.
Meibomian Epithelioma of the Lower Eyelid in a Thoroughbred Horse
Seong-Kyoon Choi1§, Jin-Kyu Park1§, Won Bae Jeon, Kyung-Hyun Lee2 and Gil-Jae Cho*
Pakistan Veterinary Journal , 2013,
Abstract: A 9-year old, castrated male, thoroughbred horse presented for a left lower eyelid mass with ocular signs of mucopurulent discharge, conjunctival hyperemia and ocular discomfort. On physical examination, there was no other abnormality. Surgically, the mass arising from the inner surface of left lower eyelid was excised and examined histopathologically. Microscopically, the eyelid mass exhibited neoplastic basaloid cells forming irregular cell masses of variable size separated by thin fibrous tissues. The basaloid cells showed mildly pleomorphic and undifferentiated appearances with prominent oval nuclei and scant cytoplasm. Poorly differentiated meibocytes were observed occasionally in the periphery regions of the cell masses suggesting the mass of lower eyelid originated from meibomian glands. Based on histopathological observation, the present case was diagnosed as an equine meibomian epithelioma in the lower eyelid. To the author’s knowledge, the present case is the first report of equine meibomian epithelioma in veterinary literatures.
Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-Annexin protein
Sun Hwa Lee1,#, Dae Won Kim1,#, Seon Ae Eom1, Se-Young Jun1, Meeyoung Park1, Duk-Soo Kim2, Hyung Joo Kwon3, Hyeok Yil Kwon4, Kyu Hyung Han1, Jinseu Park1, Hyun Sook Hwang1, Won Sik Eum1,* & Soo Young Choi1,*
BMB Reports , 2012,
Abstract: We examined that the protective effects of ANX1 on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammationin animal models using a Tat-ANX1 protein. Topicalapplication of the Tat-ANX1 protein markedly inhibited TPAinducedear edema and expression levels of cyclooxygenase-2(COX-2) as well as pro-inflammatory cytokines such as interleukin-1 beta (IL-1β), IL-6, and tumor necrosis factor-alpha(TNF-α). Also, application of Tat-ANX1 protein significantlyinhibited nuclear translocation of nuclear factor-kappa B(NF-κB) and phosphorylation of p38 and extracellular signalregulatedkinase (ERK) mitogen-activated protein kinase(MAPK) in TPA-treated mice ears. The results indicate thatTat-ANX1 protein inhibits the inflammatory response byblocking NF-κB and MAPK activation in TPA-induced miceears. Therefore, the Tat-ANX1 protein may be useful as atherapeutic agent against inflammatory skin diseases.
PEP-1-p18 prevents neuronal cell death by inhibiting oxidative stress and Bax expression
Duk-Soo Kim2,#, Eun Jeong Sohn1,#, Dae Won Kim1, Young Nam Kim1, Seon Ae Eom1, Ga Hyeon Yoon1, Sung-Woo Cho3, Sang-Hyun Lee1, Hyun Sook Hwang1, Yoon Shin Cho1, Jinseu Park1, Won Sik Eum1,* & Soo Young Choi1,*
BMB Reports , 2012,
Abstract: P18, a member of the INK4 family of cyclin-dependent kinaseinhibitors, is a tumor suppressor protein and plays a key cellsurvival role in a variety of human cancers. Under pathophysiologicalconditions, the INK4 group proteins participate in novelbiological functions associated with neuronal diseases andoxidative stress. Parkinson’s disease (PD) is characterized by loss ofdopaminergic neurons, and oxidative stress is important in itspathogenesis. Therefore, we examined the effects of PEP-1-p18 onoxidative stress-induced SH-SY5Y cells and in a PD mouse model.The transduced PEP-1-p18 markedly inhibited 1-methyl-4-phenylpyridinium-induced SH-SY5Y cell death by inhibiting Baxexpression levels and DNA fragmentation. Additionally, PEP-1-p18prevented dopaminergic neuronal cell death in the substantia nigraof a 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine-induced PDmouse model. These results indicate that PEP-1-p18 may be auseful therapeutic agent against various diseases and is a potentialtool for treating PD.
An integrated database for the enhanced identification of silkworm gene resources
ChangKug Kim,KeeYoung Kim2,DongSuk Park1,YoungJoo Seol1
Bioinformation , 2010,
Abstract: The National Academy of Agricultural Science (NAAS) has developed a web-based database to provide characterization information in silkworm. The silkworm database has four major function menus: variety searching, characterization viewing, general information and photo gallery. It provides 321 silkworm varieties characterization information for six different regions namely, Korean, Japanese, Chinese, European, Tropical and non-classified group. Additionally, the database provides 1,132 photo images regarding life cycle of various silkworm varieties. A specific characterization information table provides accession number, variety, strain and larval marking, blood color, cocoon color, cocoon shape, egg colors, remarks and image table provides photos which consist of shape and color in the different stages of larval, egg and cocoon stages.
Application of Mini-abdominoplasty after Conservative Excision of Extensive Cesarean Scar Endometriosis
Eui Tai Lee1,Hyun Min Park1,Dong Geun Lee1,Kyung Jin Shin1
Archives of Plastic Surgery , 2012, DOI: http://dx.doi.org/10.5999/aps.2012.39.5.551
Abstract: Endometriosis is defined as the presence of functioning endometrial tissue outside the uterinecavity, and the standard treatment is extensive surgical excision. Cesarean scar endometriosisis a type of cutaneous endometriosis arising on or near a Cesarean section scar. A 44-year-oldwoman presented with a 9×6 cm sized dark-brown, stony-hard, irregular, lower abdominalmass of four years duration. The patient had a history of two Cesarean deliveries, 14 and16 years ago. Suspecting endometriosis, we excised the tumor conservatively rather thanextensively to prevent incisional hernia considering the benign nature of the tumor andthe low possibility of recurrence because the patient’s age was near menopause, alongwith simultaneous bilateral salpingo-oophorectomy that was performed in this case. Onreconstruction, mini-abdominoplasty was adopted to avoid possible wound complicationsand cosmetic deformities. The patient was satisfied with the cosmetic results, and neitherrecurrence nor functional problems occurred during the 1-year follow-up period. Plasticsurgeons should keep in mind the possibility of cutaneous endometriosis in an abdominalmass of a female of reproductive age with a previous history of pelvic or intra-abdominalsurgery. An optimal result from oncological, functional, and cosmetic standpoints can beachieved with conservative excision followed by mini-abdominoplasty of extensive Cesareanscar endometriosis.
Preferred Feeding Sites and Prey of the Adult Gold-spotted Pond Frog, Rana plancyi chosenica
Eom, Junho1,Jung-Hyun Lee2,Nam-Yong Ra2,Daesik Park1*
Journal of Ecology and Field Biology , 2007,
Abstract: To determine the feeding sites preferred by adult gold-spotted pond frogs, Rana plancyi chosenica,and the foods that induce favorable growth of the frogs in the laboratory, we conducted two separate experimentsbetween 27 May and 12 July 2007 in a vivarium. In the first experiment, we counted the number of cricketseaten by four gold-spotted pond frogs in a 60 min period at four different feeding sites within the experimentalarenas: on the water surface, at the edge of a pond, and at two terrestrial sites. Adult gold-spotted pond frogsate more crickets on the water surface and at the edge of the pond than the terrestrial sites. In the secondexperiment, we measured the growth of SVL (snout-vent length) and body mass of adult gold-spotted pond frogsfed crickets, mealworms, maggots, or earthworms in individual experimental boxes over a one month period. TheSVL and body mass of the adult gold-spotted pond frogs fed crickets, mealworms, or maggots were greater thanthose of the frogs that were fed earthworms. These results indicate that providing crickets, mealworms, ormaggots on the water or at the edge of a pond should induce favorable growth of captive-reared adult goldspottedpond frogs.
Cyclosporine A and bromocriptine attenuate cell death mediated by intracellular calcium mobilization
In Ki Kim1*, So Jung Park1, Jhang Ho Park1, Seung-Ho Lee2, Sung Eun Hong3 & John C. Reed3
BMB Reports , 2012,
Abstract: To identify the novel inhibitors of endoplasmic reticulumstress-induced cell death, we performed a high throughput assaywith a chemical library containing a total of 3280 bioactive smallmolecules. Cyclosporine A and bromocriptine were identified aspotent inhibitors of thapsigargiin-induced cell death (cut-off at4σ standard score) . However, U74389G, the potent inhibitor oflipid peroxidation had lower activity in inhibiting cell death. Theinhibition effect of cyclosporine A and bromocriptine wasspecific for only thapsigargin-induced cell death. The mechanismof inhibition by these compounds was identified as modificationof the expression of glucose regulated protein-78 (GRP-78/Bip)and inhibition of phosphorylation of p38 mitogen activatedprotein kinase (MAPK). However, these compounds did notinhibit the same events triggered by tunicamycin, which was inagreement with the cell survival data. We suggest that theinduction of protective unfolded protein response by thesecompounds confers resistance to cell death. In summary, weidentified compounds that may provide insights on cell deathmechanisms stimulated by ER stress.
Arabidopsis SIZ1 positively regulates alternative respiratory bypass pathways
Bong Soo Park1, Sung-Il Kim1, Jong Tae Song2 & Hak Soo Seo1,3,*
BMB Reports , 2012,
Abstract: Plant mitochondria possess alternative respiratory pathwaysmediated by the type II NAD(P)H dehydrogenases and alternativeoxidases. Here, E3 SUMO ligase was shown to regulatealternative respiratory pathways and to participate in the maintenanceof carbon and nitrogen balance in Arabidopsis. Thetranscript abundance of the type II NAD(P)H dehydrogenasesNDA2 and NDB2 and alternative oxidases AOX1a and AOX1dgenes was low in siz1-2 mutants compared to that in wild-type.The addition of nitrate or ammonium resulted in a decrease oran increase in the expression of the same gene families, respectively,in both wild-type and siz1-2 mutants. The amountof free sugar (glucose, fructose and sucrose) was lower in siz1-2mutants than that in wild-type. These results indicate that lownitrate reductase activity due to the AtSIZ1 mutation is correlatedwith an overall decrease in alternative respiration andwith a low carbohydrate content to maintain the carbon to nitrogenratio in siz1-2 mutants.
Identification and extensive analysis of inverted-duplicated HBV integration in a human hepatocellular carcinoma cell line
Jeong Bok1,#, Kwang Joong Kim1,#, Mi-Hyun Park1, Seung-Hak Cho2, Hye-Ja Lee1, Eun-Ju Lee1, Chan Park1 & Jong-Young Lee1,*
BMB Reports , 2012,
Abstract: Hepatitis B virus (HBV) DNA is often integrated intohepatocellular carcinoma (HCC). Although the relationshipbetween HBV integration and HCC development has beenwidely studied, the role of HBV integration in HCCdevelopment is still not completely understood. In the presentstudy, we constructed a pooled BAC library of 9 establishedcell lines derived from HCC patients with HBV infections. Byamplifying viral genes and superpooling of BAC clones, weidentified 2 clones harboring integrated HBV DNA. Screeningof host-virus junctions by repeated sequencing revealed anHBV DNA integration site on chromosome 11q13 in theSNU-886 cell line. The structure and rearrangement ofintegrated HBV DNA were extensively analyzed. An invertedduplicated structure, with fusion of at least 2 HBV DNAmolecules in opposite orientations, was identified in theregion. The gene expression of cancer-related genes increasednear the viral integration site in HCC cell line SNU-886.
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