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Search Results: 1 - 10 of 30746 matches for " Kwang-Ho Lee "
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Plasma Post Oxidation of Plasma Nitrocarburized SKD 61 Steel

Insup Lee,Kwang-Ho Jeong,

材料科学技术学报 , 2008,
Simultaneous fabrication of line defects-embedded periodic lattice by topographically assisted holographic lithography
Choi Byung-Yeon,Pak Yusin,Kim Ki Seok,Lee Kwang-Ho
Nanoscale Research Letters , 2011,
Abstract: We have demonstrated simultaneous fabrication of designed defects within a periodic structure. For rapid fabrication of periodic structures incorporating nanoscale line-defects at large area, topographically assisted holographic lithography (TAHL) technique, combining the strength of hologram lithography and phase-shift interference, was proposed. Hot-embossing method generated the photoresist patterns with vertical side walls which enabled phase-shift mask effect at the edge of patterns. Embossing temperature and relief height were crucial parameters for the successful TAHL process. Periodic holes with a diameter of 600 nm at a 1 μm-pitch incorporating 250 nm wide line-defects were obtained simultaneously.
Evaluation of the Convergence Region of an Automated Registration Method for 3D Laser Scanner Point Clouds
Kwang-Ho Bae
Sensors , 2009, DOI: 10.3390/s90100355
Abstract: Using three dimensional point clouds from both simulated and real datasets from close and terrestrial laser scanners, the rotational and translational convergence regions of Geometric Primitive Iterative Closest Points (GP-ICP) are empirically evaluated. The results demonstrate the GP-ICP has a larger rotational convergence region than the existing methods, e.g., the Iterative Closest Point (ICP).
Mathematical Distinction in Action Potential between Primo-Vessels and Smooth Muscle
Seong-Jin Cho,Sang-Hun Lee,Wenji Zhang,Sae-Bhom Lee,Kwang-Ho Choi,Sun-Mi Choi,Yeon-Hee Ryu
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/269397
Abstract: We studied the action potential of Primo-vessels in rats to determine the electrophysiological characteristics of these structures. We introduced a mathematical analysis method, a normalized Fourier transform that displays the sine and cosine components separately, to compare the action potentials of Primo-vessels with those for the smooth muscle. We found that Primo-vessels generated two types of action potential pulses that differed from those of smooth muscle: (1) Type I pulse had rapid depolarizing and repolarizing phases, and (2) Type II pulse had a rapid depolarizing phase and a gradually slowing repolarizing phase.
Inhibitory Effects of Coptidis rhizoma and Berberine on Cocaine-Induced Sensitization
Bombi Lee,Chae Ha Yang,Dae-Hyun Hahm,Eun Sang Choe,Hye-Jung Lee,Kwang-Ho Pyun,Insop Shim
Evidence-Based Complementary and Alternative Medicine , 2009, DOI: 10.1093/ecam/nem070
Abstract: Substantial evidence suggests that the behavioral and reinforcing effects of cocaine can be mediated by the central dopaminergic systems. Repeated injections of cocaine produce an increase in locomotor activity and the expression of tyrosine hydroxylase (TH) in the main dopaminergic areas. Protoberberine alkaloids affect neuronal functions. Coptidis rhizoma (CR) and its main compound, berberine (BER) reduced the dopamine content in the central nervous system. In order to investigate the effects of CR or BER on the repeated cocaine-induced neuronal and behavioral alterations, we examined the influence of CR or BER on the repeated cocaine-induced locomotor activity and the expression of TH in the brain by using immunohistochemistry. Male SD rats were given repeated injections of saline or cocaine hydrochloride (15 mg/kg, i.p. for 10 consecutive days) followed by one challenge injection on the 4th day after the last daily injection. Cocaine challenge (15 mg/kg, i.p) produced a larger increase in locomotor activity and expression of TH in the central dopaminergic areas. Pretreatment with CR (50, 100, 200 and 400 mg/kg, p.o.) and BER (200 mg/kg, p.o.) 30 min before the daily injections of cocaine significantly inhibited the cocaine-induced locomotor activity as well as TH expression in the central dopaminergic areas. Our data demonstrate that the inhibitory effects of CR and BER on the repeated cocaine-induced locomotor activity were closely associated with the reduction of dopamine biosynthesis and post-synaptic neuronal activity. These results suggest that CR and BER may be effective for inhibiting the behavioral effects of cocaine by possibly modulating the central dopaminergic system.
How Current Clinical Practice Guidelines for Low Back Pain Reflect Traditional Medicine in East Asian Countries: A Systematic Review of Clinical Practice Guidelines and Systematic Reviews
Hyun-Woo Cho, Eui-Hyoung Hwang, Byungmook Lim, Kwang-Ho Heo, Jian-Ping Liu, Kiichiro Tsutani, Myeong Soo Lee, Byung-Cheul Shin
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088027
Abstract: Objectives The aims of this study were to investigate whether there is a gap between evidence of traditional medicine (TM) interventions in East-Asian countries from the current Clinical Practice Guidelines (CPGs) and evidence from current systematic reviews and meta-analyses (SR-MAs) and to analyze the impact of this gap on present CPGs. Methods We examined 5 representative TM interventions in the health care systems of East-Asian countries. We searched seven relevant databases for CPGs to identify whether core CPGs included evidence of TM interventions, and we searched 11 databases for SR-MAs to re-evaluate current evidence on TM interventions. We then compared the gap between the evidence from CPGs and SR-MAs. Results Thirteen CPGs and 22 SR-MAs met our inclusion criteria. Of the 13 CPGs, 7 CPGs (54%) mentioned TM interventions, and all were for acupuncture (only one was for both acupuncture and acupressure). However, the CPGs did not recommend acupuncture (or acupressure). Of 22 SR-MAs, 16 were for acupuncture, 5 for manual therapy, 1 for cupping, and none for moxibustion and herbal medicine. Comparing the evidence from CPGs and SR-MAs, an underestimation or omission of evidence for acupuncture, cupping, and manual therapy in current CPGs was detected. Thus, applying the results from the SR-MAs, we moderately recommend acupuncture for chronic LBP, but we inconclusively recommend acupuncture for (sub)acute LBP due to the limited current evidence. Furthermore, we weakly recommend cupping and manual therapy for both (sub)acute and chronic LBP. We cannot provide recommendations for moxibustion and herbal medicine due to a lack of evidence. Conclusions The current CPGs did not fully reflect the evidence for TM interventions. As relevant studies such as SR-MAs are conducted and evidence increases, the current evidence on acupuncture, cupping, and manual therapy should be rigorously considered in the process of developing or updating the CPG system.
Absorption spectrum of Gafchromic EBT2 film with angular rotation
Soah Park,Kwang-Ho Cheong,Taejin Hwang,Jai-Woong Yoon,Taejin Han,Haeyoung Kim,Me-Yeon Lee,KyoungJu Kim,Hoonsik Bae,Sei-Kwon Kang
Physics , 2015,
Abstract: It is important to study absorption spectrum in film dosimetry because the spectral absorbance of the film relates to the film's total absorption dose. We investigated the absorption spectra of Gafchromic EBT2 film with various rotational angles in a visible wavelength band. The film was irradiated with 6 MV photon beams and a total dose of 300 cGy. Absorption spectra were taken under different rotational angles after 24 h after irradiation and we fitted the spectra using Lorentzian functions. There were two dominant absorption peaks at approximately 586 nm (green) and 634 nm (red). The measured spectrum was decomposed 542 nm, 558 nm, 578 nm, 586 nm, 626 nm, 634 nm, and 641 nm. The maximum total area of the red band absorption spectrum was at 45{\deg}(225{\deg}) and the minimum at 90{\deg}(270{\deg}). As the angle of rotation changed, the intensity and integrated area of the blue and green peaks also changed with 180{\deg} period, with minima at 90{\deg} and 270{\deg}, and maxima at 0{\deg} and 180{\deg}, although the overall absorbance is very low. The spectral peak wavelengths remained constant within 2.4 nm for all angles. There was no hysteresis of absorption spectrum of the film; spectra taken at 0{\deg} and 360{\deg}were substantially the same and showed similar behavior for all rotational angles. The change of absorbance with rotational angle of the film affected the dosimetric properties, resulting in rotationalvariations of film dosimetry in each red-green-blue channel.
Building Environment Analysis Based on Temperature and Humidity for Smart Energy Systems
Jaeseok Yun,Kwang-Ho Won
Sensors , 2012, DOI: 10.3390/s121013458
Abstract: In this paper, we propose a new HVAC (heating, ventilation, and air conditioning) control strategy as part of the smart energy system that can balance occupant comfort against building energy consumption using ubiquitous sensing and machine learning technology. We have developed ZigBee-based wireless sensor nodes and collected realistic temperature and humidity data during one month from a laboratory environment. With the collected data, we have established a building environment model using machine learning algorithms, which can be used to assess occupant comfort level. We expect the proposed HVAC control strategy will be able to provide occupants with a consistently comfortable working or home environment.
Polymeric LabChip Real-Time PCR as a Point-of-Care-Potential Diagnostic Tool for Rapid Detection of Influenza A/H1N1 Virus in Human Clinical Specimens
Hyun-Ok Song, Je-Hyoung Kim, Ho-Sun Ryu, Dong-Hoon Lee, Sun-Jin Kim, Deog-Joong Kim, In Bum Suh, Du Young Choi, Kwang-Ho In, Sung-Woo Kim, Hyun Park
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0053325
Abstract: It is clinically important to be able to detect influenza A/H1N1 virus using a fast, portable, and accurate system that has high specificity and sensitivity. To achieve this goal, it is necessary to develop a highly specific primer set that recognizes only influenza A viral genes and a rapid real-time PCR system that can detect even a single copy of the viral gene. In this study, we developed and validated a novel fluidic chip-type real-time PCR (LabChip real-time PCR) system that is sensitive and specific for the detection of influenza A/H1N1, including the pandemic influenza strain A/H1N1 of 2009. This LabChip real-time PCR system has several remarkable features: (1) It allows rapid quantitative analysis, requiring only 15 min to perform 30 cycles of real-time PCR. (2) It is portable, with a weight of only 5.5 kg. (3) The reaction cost is low, since it uses disposable plastic chips. (4) Its high efficiency is equivalent to that of commercially available tube-type real-time PCR systems. The developed disposable LabChip is an economic, heat-transferable, light-transparent, and easy-to-fabricate polymeric chip compared to conventional silicon- or glass-based labchip. In addition, our LabChip has large surface-to-volume ratios in micro channels that are required for overcoming time consumed for temperature control during real-time PCR. The efficiency of the LabChip real-time PCR system was confirmed using novel primer sets specifically targeted to the hemagglutinin (HA) gene of influenza A/H1N1 and clinical specimens. Eighty-five human clinical swab samples were tested using the LabChip real-time PCR. The results demonstrated 100% sensitivity and specificity, showing 72 positive and 13 negative cases. These results were identical to those from a tube-type real-time PCR system. This indicates that the novel LabChip real-time PCR may be an ultra-fast, quantitative, point-of-care-potential diagnostic tool for influenza A/H1N1 with a high sensitivity and specificity.
Streptochlorin Suppresses Allergic Dermatitis and Mast Cell Activation via Regulation of Lyn/Fyn and Syk Signaling Pathways in Cellular and Mouse Models
Seung-Hwan Lee, Hee Jae Shin, Dong-Young Kim, Do-Wan Shim, Tack-Joong Kim, Sang-Kyu Ye, Hyung-Sik Won, Sushruta Koppula, Tae-Bong Kang, Kwang-Ho Lee
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074194
Abstract: Allergic diseases are chronic inflammatory conditions with specific immune and inflammatory mechanisms. Scientific interest in understanding the mechanisms and discovering novel agents for the prevention and treatment of allergic disease is increasing. Streptochlorin, a small compound derived from marine actinomycete possesses anti-angiogenic and anti-tumor activities. However, the anti-allergic effects and underlying mechanisms remain to be elucidated. In the present study, we investigated the effect of streptochlorin on allergic responses in vitro and in vivo. Streptochlorin inhibited degranulation and production of tumor necrosis factor-α and IL-4 by antigen-stimulated mast cells. Streptochlorin also inhibited the phosphorylation of Akt and the mitogen-activated protein kinases (MAPKs), including p38, ERK, and JNK. Further, streptochlorin reduced the phosphorylation of Syk in RBL-2H3 cells and inhibited the activity of Lyn and Fyn. Furthermore, administration of streptochlorin suppressed the allergic reactions in both passive cutaneous anaphylaxis reaction and 2, 4-dinitrofluorobenzene (DNFB)-induced allergic dermatitis in mice model. Considering the data obtained, we report for the first time that streptochlorin possess anti-allergic properties. The underlying mechanism of streptochlorin in exhibiting potent anti-allergic activity might be through the inhibition of the Lyn/Fyn and Syk signaling pathways.
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