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Search Results: 1 - 10 of 21413 matches for " Kwang Myung Kim "
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The Aesthetic Turn in Everyday Life in Korea  [PDF]
Kwang Myung Kim
Open Journal of Philosophy (OJPP) , 2013, DOI: 10.4236/ojpp.2013.33054
Abstract: We are living in the transitional age from the rational, analytical, and scientific to the cultural, sensitive, and aesthetic. The aesthetics of everyday life lies at the center of this age. There is no boundary between art and life in contemporary art. Almost all the contents and objects of everyday life became a work of art in the condition of searching for the aesthetic. Since aesthetic theory was shifted from the artist-centered or a work of art-centered to the audience, spectator or beholder-centered, art and everyday life were more closely related to each other. So aesthetic attention or attitude is not specific to art, but pervasive broadly in everyday life. We can embrace the aesthetic concerns in everything we make and use every day. In the long tradition of Korean art, it can be seen that aesthetic consciousness is steeped in day-to-day life as well as the arts. I want to consider the problems of everydayness, Korean aesthetic consciousness in daily life, and contemplation in the aesthetic consciousness. Korean art was characterized by its “lack of refinement” and “nonchalance”. The characteristics of Korean art as the qualities of “technique without technique”, “Planning without plan”, “asymmetrical symmetry” have dominated the everyday consciousness of Korean people as well as Korean art. The extension of aesthetic emotion through experimentation shows us the change of aesthetic consciousness as a new possibility of interpretation. We stand in an urgent situation of the need for a new theory of art. It will be related to the future of aesthetics. For this reason, I think we have to consider the meaning of the aesthetic turn in everyday life.
Problems and Prospects of Geoaesthetics  [PDF]
Kwang Myung Kim
Open Journal of Philosophy (OJPP) , 2015, DOI: 10.4236/ojpp.2015.51001
Abstract: Geoaesthetics is the project of making aesthetic sense of nature through geological phenomena. The aesthetic appreciation of nature has recently become urgent because of the serious influence of the natural environment on human beings. The author’s geoaesthetical research is categorized into three problems: art in geology or geology in the arts as the close relationship between art and geology, geological cognition of nature and natural cognition in environmental aesthetics, and the geoaesthetical approach through works of art. Geologic forces and processes have become significant materials for aesthetic sensations. Based on the geoaesthetic perspective, the author explores the ultimate purpose of art as a return to natural order. It seems partly to be related to the ontological problem of art. Here we can feel earthly dynamics, universal calmness, and the contemplative atmosphere simultaneously.
Acidic pH shock induces the expressions of a wide range of stress-response genes
Yoon Kim, Myung Moon, Jae Song, Colin P Smith, Soon-Kwang Hong, Yong Chang
BMC Genomics , 2008, DOI: 10.1186/1471-2164-9-604
Abstract: According to the results of transcriptional and proteomic analyses, the major number of sigma factor genes were upregulated by an acidic pH shock. Well-studied sigma factor genes of sigH (heat shock), sigR (oxidative stress), sigB (osmotic shock), and hrdD that play a major role in the secondary metabolism, were all strongly upregulated by the pH shock. A number of heat shock proteins including the DnaK family and chaperones such as GroEL2 were also observed to be upregulated by the pH shock, while their repressor of hspR was strongly downregulated. Oxidative stress-related proteins such as thioredoxin, catalase, superoxide dismutase, peroxidase, and osmotic shock-related protein such as vesicle synthases were also upregulated in overall.From these observations, an acidic pH shock was considered to be one of the strongest stresses to influence a wide range of sigma factors and shock-related proteins including general stress response proteins. The upregulation of the sigma factors and shock proteins already found to be related to actinorhodin biosynthesis was considered to have contributed to enhanced actinorhodin productivity by mediating the pH shock signal to regulators or biosynthesis genes for actinorhodin production.Various environmental signals are known to enhance secondary metabolites production in Streptomycetes by initiating complex signal transduction system [1]. There have been a number of studies on the application of an environmental stimulus for the enhancement of productivity. These environmental stimuli include heat shock, cold shock, oxidative stress, osmotic stress, acidic sock, alkali shock [2-6].It is known that different sigma factors respond to different types of stresses, respectively in Streptomyces strains, which have a number of unique signal transduction mechanisms depending on the types of environmental shock [1]. Those sigma factors coordinate gene expression in response to various environmental and endogenous signals.A research group h
Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability
Ju-Mi Shin, Kyong-Jai Yoo, Myung-Sun Kim, Dongku Kim, Kwang-Hyun Baek
BMC Genomics , 2006, DOI: 10.1186/1471-2164-7-292
Abstract: While identifying putative ubiquitin specific protease (USP) enzymes that contain a conserved Asp (I) domain in humans, 4 USP17 subfamily members, highly homologous to DUB-3, have been found (USP17K, USP17L, USP17M, and USP17N), from human chorionic villi. Expression analysis showed that USP17 transcripts are highly expressed in the heart, liver, and pancreas and are expressed moderately in various human cancerous cell lines. Amino acid sequence analysis revealed that they contain the highly conserved Cys, His, and Asp domains which are responsible for the deubiquitinating activity. Biochemical enzyme assays indicated that they have deubiquitinating activity. Interestingly, the sequence analysis showed that these proteins, with exception of USP17N, contain the putative hyaluronan/RNA binding motifs, and cetylpyridinium chloride (CPC)-precipitation analysis confirmed the association between these proteins and intracellular hyaluronan and RNA.Here, we report that the overexpression of these proteins, with exception of USP17N, leads to apoptosis, suggesting that the hyaluronan and RNA binding motifs in these enzymes play an important role in regulating signal transduction involved in cell death.The post-translational modification by ubiquitin (Ub) plays an essential role for numerous cellular functions such as protein degradation, cell cycle control, transcriptional regulation, immune response, apoptosis, oncogenesis, pre-implantation, and intracellular signaling pathways [1-6]. Conjugation of ubiquitin to a target protein is achieved by the sequential enzymatic actions via ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin ligases (E3). A novel ubiquitination factor (E4) required for efficient multiubiquitination has been identified in yeast [7]. Proteins modified with a polyubiquitin chain are then unfolded and degraded by the 26S proteasome [1,4,5]. Deubiquitination, a removal of ubiquitin from ubiquitin-conjugated protein substrate
Problems of Expressiveness in Geoaesthetics  [PDF]
Kwang Myun Kim
Open Journal of Philosophy (OJPP) , 2014, DOI: 10.4236/ojpp.2014.44061
Abstract: Facing in the prospect of geo-environmental activities like volcanic explosions, earthquakes, floods, landslides, subsidence issues, tsunamis, etc., we have to reconsider a sustainable harmony between human beings and nature. Approaching the reality of the changing patterns of the earth’s surface and geological processes geoaesthetically will be helpful in establishing a more desirable relationship between human beings and nature. In this paper the author attempts to consider the meaning of expressiveness in relation to geoaesthetics, and further the author intends to reveal expressiveness through various phenomena of the earth. Expressiveness can evoke emotion as one experiences the aesthetic object. Empathy plays a role in drawing expression from expressiveness. One can find geoaesthetic expression through looking deeply into the expressiveness the earth presents. Earth itself is inanimate, but owing to its plentiful expressiveness it can restore the organic, animate world.
PPAR-γ Activation Increases Insulin Secretion through the Up-regulation of the Free Fatty Acid Receptor GPR40 in Pancreatic β-Cells
Hyo-Sup Kim, You-Cheol Hwang, Seung-Hoi Koo, Kyong Soo Park, Myung-Shik Lee, Kwang-Won Kim, Moon-Kyu Lee
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0050128
Abstract: Background It has been reported that peroxisome proliferator-activated receptor (PPAR)-γ and their synthetic ligands have direct effects on pancreatic β-cells. We investigated whether PPAR-γ activation stimulates insulin secretion through the up-regulation of GPR40 in pancreatic β-cells. Methods Rat insulinoma INS-1 cells and primary rat islets were treated with rosiglitazone (RGZ) and/or adenoviral PPAR-γ overexpression. OLETF rats were treated with RGZ. Results PPAR-γ activation with RGZ and/or adenoviral PPAR-γ overexpression increased free fatty acid (FFA) receptor GPR40 expression, and increased insulin secretion and intracellular calcium mobilization, and was blocked by the PLC inhibitors, GPR40 RNA interference, and GLUT2 RNA interference. As a downstream signaling pathway of intracellular calcium mobilization, the phosphorylated levels of CaMKII and CREB, and the downstream IRS-2 and phospho-Akt were significantly increased. Despite of insulin receptor RNA interference, the levels of IRS-2 and phospho-Akt was still maintained with PPAR-γ activation. In addition, the β-cell specific gene expression, including Pdx-1 and FoxA2, increased in a GPR40- and GLUT2-dependent manner. The levels of GPR40, phosphorylated CaMKII and CREB, and β-cell specific genes induced by RGZ were blocked by GW9662, a PPAR-γ antagonist. Finally, PPAR-γ activation up-regulated β-cell gene expressions through FoxO1 nuclear exclusion, independent of the insulin signaling pathway. Based on immunohistochemical staining, the GLUT2, IRS-2, Pdx-1, and GPR40 were more strongly expressed in islets from RGZ-treated OLETF rats compared to control islets. Conclusion These observations suggest that PPAR-γ activation with RGZ and/or adenoviral overexpression increased intracellular calcium mobilization, insulin secretion, and β-cell gene expression through GPR40 and GLUT2 gene up-regulation.
Bacillus anthracis Protease InhA Increases Blood-Brain Barrier Permeability and Contributes to Cerebral Hemorrhages
Dhritiman V. Mukherjee,Jessica H. Tonry,Kwang Sik Kim,Nalini Ramarao,Taissia G. Popova,Charles Bailey,Serguei Popov,Myung-Chul Chung
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017921
Abstract: Hemorrhagic meningitis is a fatal complication of anthrax, but its pathogenesis remains poorly understood. The present study examined the role of B. anthracis-secreted metalloprotease InhA on monolayer integrity and permeability of human brain microvasculature endothelial cells (HBMECs) which constitute the blood-brain barrier (BBB). Treatment of HBMECs with purified InhA resulted in a time-dependent decrease in trans-endothelial electrical resistance (TEER) accompanied by zonula occluden-1 (ZO-1) degradation. An InhA-expressing B. subtilis exhibited increased permeability of HBMECs, which did not occur with the isogenic inhA deletion mutant (ΔinhA) of B. anthracis, compared with the corresponding wild-type strain. Mice intravenously administered with purified InhA or nanoparticles-conjugated to InhA demonstrated a time-dependent Evans Blue dye extravasation, leptomeningeal thickening, leukocyte infiltration, and brain parenchymal distribution of InhA indicating BBB leakage and cerebral hemorrhage. Mice challenged with vegetative bacteria of the ΔinhA strain of B. anthracis exhibited a significant decrease in leptomeningeal thickening compared to the wildtype strain. Cumulatively, these findings indicate that InhA contributes to BBB disruption associated with anthrax meningitis through proteolytic attack on the endothelial tight junctional protein zonula occluden (ZO)-1.
Customized Tracheostomy Cannula as a Therapeutic Adjunct in Tracheal Stenosis
Doh Young Lee,Jungirl Seok,Wonjae Cha,Won Yong Lee,J. Hun. Hah,Tack-Kyun Kwon,Kwang Hyun Kim,Myung-Whun Sung
Case Reports in Otolaryngology , 2013, DOI: 10.1155/2013/921365
Abstract: Tracheotomy is often successfully used to manage tracheal stenosis, as a temporizing measure prior to definitive treatment or a long-term remedy. In some patients, where a sizeable portion trachea is stenotic, the fixed arm of an ordinary tracheotomy tube may not be of sufficient length to satisfactorily maintain the distal tracheal lumen, and commercially available adjustable tubes may not be at hand in certain clinical settings. Herein, we describe a simple method of constructing a temporary tracheotomy tube with an adjustable distal arm, allowing custom fit at the patient bedside. 1. Introduction Tracheal stenosis is a serious and potentially life-threatening condition of varied etiology [1, 2]. While tracheotomy usually maintains the airway prior to definitive treatment and may even serve as a long-term solution in some patients, the fixed distal arms of regular tracheotomy tubes simply do not provide the support needed to maintain tracheal lumen when the stenotic segment is lengthy. Furthermore, the tips of such relatively short tubes may be a source of mucosal irritation to exacerbate a patient’s condition. For airway stenting of either temporary or long-term duration, the stent tip ideally should bypass the stenosis without sacrificing ventilation to either of the lungs. Severe stenosis of the distal trachea thus poses a distinct challenge to surgeons who render care. 2. Case Presentation A 17-year-old male was referred to our institution for airway stenosis. He had been injured while bicycling (traffic collision), undergoing intensive treatment elsewhere for subarachnoid hemorrhage, left mandibular fracture, a fractured clavicle, and bilateral pneumothoraces. Tracheotomy was subsequently performed to accommodate long-term mechanical ventilation. In a matter of two weeks, however, he developed inspiratory stridor and respiratory distress due to obstructive proliferation of granulation tissue at the cannula tip. An endotracheal tube with internal diameter of 6?mm was inserted for temporary relief, but the problem recurred at the tip of the endotracheal tube. At this point, the patient was referred to our facility. Computed tomography (CT) showed narrowing of the entire trachea (Figure 1), prompting evaluation by rigid bronchoscopy. Upon endotracheal tube removal, there was copious oozing of blood from eroded and inflamed tracheal mucosa (Figure 2(a)). Nevertheless, a short silicone T-tube 4.5?cm (the length of lower arm) kept the narrowed and severe inflamed lumen widely patent. Figure 1: Initial CT of airway in coronal view with narrowed tracheal
Abnormal Liver Stiffness Assessed Using Transient Elastography (Fibroscan?) in HIV-Infected Patients without HBV/HCV Coinfection Receiving Combined Antiretroviral Treatment
Sang Hoon Han, Seung Up Kim, Chang Oh Kim, Su Jin Jeong, Jun Yong Park, Jun Yong Choi, Do Young Kim, Sang Hoon Ahn, Young Goo Song, Kwang-Hyub Han, June Myung Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0052720
Abstract: Background and Aims Liver stiffness measurement (LSM) using transient elastography (Fibroscan?) can identify individuals with potential underlying liver disease. We evaluated the prevalence of abnormal LSM values as assessed using LSM and its predictors in HIV-infected asymptomatic patients receiving combined antiretroviral treatment (cART) without HBV/HCV coinfection. Methods We prospectively recruited 93 patients who had consistently been undergoing cART for more than 12 months at Severance Hospital in Seoul, Republic of Korea, from June to December 2010. LSM values >5.3 kPa were defined as abnormal. Results Thirty-nine (41.9%) had abnormal LSM values. On multivariate correlation analysis, the cumulative duration of boosted and unboosted protease inhibitors (PIs) were the independent factors which showed a negative and positive correlation to LSM values, respectively (β = –0.234, P = 0.023 and β = 0.430, P<0.001). In multivariate logistic regression analysis, the cumulative exposure duration of boosted-PIs and γ-glutamyltranspeptidase levels were selected as the independent predictors which showed a negative and positive correlation with abnormal LSM values, respectively (odds ratio [OR], 0.941; 95% confidence interval [CI], 0.889–0.997; P = 0.039 and OR, 1.032; 95% CI, 1.004–1.060; P = 0.023). Conclusion The high percentage of HIV-infected asymptomatic patients receiving cART without HBV/HCV coinfection had abnormal LSM values. The cumulative exposure duration of boosted-PIs and γ-GT level were independent predictors which showed a negative and positive correlation with abnormal LSM values, respectively.
A Novel High-Pressure Monoclinic Metallic Phase of V2O3
Yang Ding,Cheng-Chien Chen,Qiaoshi Zeng,Heung-Sik Kim,Myung Joon Han,Mahalingam Balasubramanian,Robert Gordon,Fangfei Li,Ligang Bai,Dimitry Popov,Steve M. Heald,Thomas Gog,Ho-kwang Mao,Michel van Veenendaal
Physics , 2013, DOI: 10.1103/PhysRevLett.112.056401
Abstract: Vanadium sesquioxide, V2O3, is a prototypical metal-to-insulator system where, in temperature-dependent studies, the transition always coincides with a corundum-to-monoclinic structural transition. As a function of pressure, V2O3 follows the expected behavior of increased metallicity due to a larger bandwidth for pressures up to 12.5 GPa. Surprisingly, for higher pressures when the structure becomes unstable, the resistance starts to increase. Around 32.5 GPa at 300 K, we observe a novel pressure-induced corundum-to-monoclinic transition between two metallic phases, showing that the structural phase transition can be decoupled from the metal-insulator transition. Using X-ray Raman scattering, we find that screening effects, which are strong in the corundum phase, become weakened at high pressures. Theoretical calculations indicate that this can be related to a decrease in coherent quasiparticle strength, suggesting that the high-pressure phase is likely a critical correlated metal, on the verge of Mott-insulating behavior.
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