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Search Results: 1 - 10 of 110463 matches for " Kun-Huang Chen "
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Prediagnosis of Obstructive Sleep Apnea via Multiclass MTS
Chao-Ton Su,Kun-Huang Chen,Li-Fei Chen,Pa-Chun Wang,Yu-Hsiang Hsiao
Computational and Mathematical Methods in Medicine , 2012, DOI: 10.1155/2012/212498
Abstract: Obstructive sleep apnea (OSA) has become an important public health concern. Polysomnography (PSG) is traditionally considered an established and effective diagnostic tool providing information on the severity of OSA and the degree of sleep fragmentation. However, the numerous steps in the PSG test to diagnose OSA are costly and time consuming. This study aimed to apply the multiclass Mahalanobis-Taguchi system (MMTS) based on anthropometric information and questionnaire data to predict OSA. Implementation results showed that MMTS had an accuracy of 84.38% on the OSA prediction and achieved better performance compared to other approaches such as logistic regression, neural networks, support vector machine, C4.5 decision tree, and rough set. Therefore, MMTS can assist doctors in prediagnosis of OSA before running the PSG test, thereby enabling the more effective use of medical resources.
Targeting PML-RARα and Oncogenic Signaling Pathways by Chinese Herbal Mixture Tien-Hsien Liquid in Acute Promyelocytic Leukemia NB4 Cells
Chih-Jung Yao,Chia-Ming Yang,Shuang-En Chuang,Jiann-Long Yan,Chun-Yen Liu,Suz-Wen Chen,Kun-Huang Yan,Tung-Yuan Lai,Gi-Ming Lai
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/nep165
Abstract: Tien-Hsien Liquid (THL) is a Chinese herbal mixture that has been used worldwide as complementary treatment for cancer patients in the past decade. Recently, THL has been shown to induce apoptosis in various types of solid tumor cells in vitro. However, the underlying molecular mechanisms have not yet been well elucidated. In this study, we explored the effects of THL on acute promyelocytic leukemia (APL) NB4 cells, which could be effectively treated by some traditional Chinese remedies containing arsenic trioxide. The results showed THL could induce G2/M arrest and apoptosis in NB4 cells. Accordingly, the decrease of cyclin A and B1 were observed in THL-treated cells. The THL-induced apoptosis was accompanied with caspase-3 activation and decrease of PML-RARα fusion protein. Moreover, DNA methyltransferase 1 and oncogenic signaling pathways such as Akt/mTOR, Stat3 and ERK were also down-regulated by THL. By using ethyl acetate extraction and silica gel chromatography, an active fraction of THL named as EAS5 was isolated. At about 0.5–1% of the dose of THL, EAS5 appeared to have most of THL-induced multiple molecular targeting effects in NB4 cells. Based on the findings of these multi-targeting effects, THL might be regarding as a complementary and alternative therapeutic agent for refractory APL.
實徵研究/你用青春碰撞什麼 大學生閱讀行為的調查分析/黃焜煌;吳榮彬;張簡誌誠 | A Survey of the College Students' Reading Behavior in Taiwan/Kun-Huang Huarng;Jungpin Wu;Chih-Cheng Changchien
黃焜煌、吳榮彬、張簡誌誠 Kun-Huang Huarng; Jungpin Wu; Chih-Cheng Changchien
Journal of Library and Information Science , 2009,
Abstract: 鑑於「閱讀」是學習者藉以獲取資訊來源、判讀知識內容、吸收經驗智慧的主要途徑,閱讀動機、能力以及風氣的強弱對於學習成效的影響甚巨,因此,希望透過較大規模的調查,以觀察現階段大學生閱讀行為的整體樣貌與發展趨勢。本文以自編問卷作為調查工具,大學在校學生為調查對象,在2008年2月18日至3月3日期間,選擇北、中、南10所大學院校,以無名冊的系統抽樣方式施測,總計發出1500份問卷,有效問卷1,077份,並利用SPSS統計軟體進行分析。本文以外在環境影響、內在個人因素以及行為產出結果等三個構面為主,同時針對圖書館、校園書店等閱讀補助機構進行分析與觀察,並據以描繪大學生閱讀行為的輪廓與問題,進而提供改善閱讀風氣的策略方案。 The main purpose of this research is to explore the reading behavior of college students in Taiwan. The authors employed survey research method, and adopted a self-editing questionnaire, and used the systematic sampling to conduct the whole sampling survey. During February 18, 2008 to March 3, 2008, there were 1500 samples in total were surveyed. The number of the valid samples was 1077. Three factors consisted of the environmental factors, the individual factors, the outcome performance were used for data analysis. SPSS statistical software package was employed. This survey reported the college students’ reading behavior in Taiwan. Based on the research findings, the suggestions for reading improvement were proposed. 頁次:37-54
A distribution pattern assisted method of transcription factor binding site discovery for both yeast and filamentous fungi  [PDF]
Jinnan Hu, Chenxi Chen, Kun Huang, Thomas K. Mitchell
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.44067
Abstract: Transcription factors (TFs) are the core sentinels of gene regulation functioning by binding to highly specific DNA sequences to activate or repress the recruitment of RNA polymerase. The ability to identify transcription factor binding sites (TFBSs) is necessary to understand gene regulation and infer regulatory networks. Despite the fact that bioinformatics tools have been developed for years to improve computational identification of TFBSs, the accurate prediction still remains changeling as DNA motifs recognized by TFs are typically short and often lack obvious patterns. In this study we introduced a new attribute-motif distribution pattern (MDP) to assist in TFBS prediction. MDP was developed using a TF distribution pattern curve generated by analyzing 25 yeast TFs and 37 of their experimentally validated binding motifs, followed by calculating a scoring value to quantify the reliability of each motif prediction. Finally, MDP was tested using another set of 7 TFs with known binding sites to in silico validate the approach. The method was further tested in a non-yeast system using the filamentous fungus Magnaporthe oryzae transcription factor MoCRZ1. We demonstrate superior prediction reranking results using MDP over the commonly used program MEME and the other four predictors. The data showed significant improvements in the ranking of validated TFBS and provides a more sensitive statistics based approach for motif discovery.
The Analysis of the Differences between Electromechanical Transients Simulation and Electromagnetic Transients Simulation  [PDF]
Chengjun Xia, Haoyu Huang, Kun Men, Cuiqiong Chen
Journal of Power and Energy Engineering (JPEE) , 2014, DOI: 10.4236/jpee.2014.29020
Abstract:

The paper firstly interprets the differences between electromechanical transients program BPA and electromagnetic transients program EMTDC in the field of principle, model and algorithm. Then the authors carry out the simulation based on single-machine infinite-bus system and draw some conclusions. The time consumption of the simulation using EMTDC is much longer than the simulation using BPA under the same length of time. The results of BPA are close to those of EMTDC under steady conditions. The fundamental frequency component of the EMTDC results seems closer to the BPA results than its original value, but they still away from completely consistent. In this simulation of single-machine infinite-bus system, the transient stability results of BPA and EMTDC are close, but the results of BPA are apt to be more conservative. All the conclusions above have a certain reference value to both hybrid simulation and comprehensive analysis method in the study of the AC/DC digital simulation of large power grid.

Synthesis and characterization of a ladder-like structure compound formed by cadmium (II) and anionic nitronyl nitroxide  [PDF]
Jing Chen, You-Juan Zhang, Kun-Tao Huang, Qiang Huang
Open Journal of Inorganic Chemistry (OJIC) , 2013, DOI: 10.4236/ojic.2013.33008
Abstract:


A ladder-like structure compound formed by cadmium (II) and anionic nitronyl nitroxide,

[Cd2(NITpBA)4(H2O)4] (where NITpBA = 2-(4-carboxyphenyl)4,4,5,5-tetramethyl-4,5-dihydro-imidazol-1-oxyl-3-oxide), has been synthesized and characterized. X-ray analysis reveals that the compound 1 crystallizes in the monoclinic P21/c (No. 14) space group, and [Cd2(NITpBA)4(H2O)4] units are linked into infinite chains by radical bridging ligands.



Synthesis, structures, and properties of two new binuclear complexes based on carboxyl-substituted nitronyl nitroxide: [M2(NITpBA)4(H2O)2] (M = Zn and Cu)  [PDF]
Jing Chen, You-Juan Zhang, Kun-Tao Huang, Qiang Huang, Jun-Jie Wang
Open Journal of Inorganic Chemistry (OJIC) , 2013, DOI: 10.4236/ojic.2013.32005
Abstract:

Two new binuclear complexes, [M2(μ-NITpBA)4(H2O)2] (M = Zn 1 and Cu 2) [where NIpBA = 2-(4-carboxyl-phenyl)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazol-1-oxyl-3-oxide], were stylized and characterized. Magnetic susceptibility measurements revealed antiferromagnetic exchange interactions in two complexes.

Research on Practical Teaching of Anatomy for Undergraduate Nursing Program under Information Technology Background in China  [PDF]
Yunfeng Wang, Wei Chen, Luqing Zhang, Lei Li, Lin Li, Zijian Ren, Kun Huang
Creative Education (CE) , 2019, DOI: 10.4236/ce.2019.104051
Abstract: Human anatomy is an important part of the foundation curriculum for undergraduate nursing program in China. Practical teaching of human anatomy plays a key role in consolidating the theoretical knowledge and cultivating students’ innovative spirit and practical abilities. With the development of information technology, the characteristics of the nursing specialties combined with information-based education need to be targeted in practical teaching of nursing anatomy. This paper describes a mode we have created for practical teaching, which combines the application of anatomical knowledge and clinical nursing skills in practical teaching; the improvements we have made to the nursing anatomy course are less rote learning, more independent learning, the provision of the online facilities for self-directed learning, the improvement in the quality of the practical laboratory facilities and the humanistic quality of the students’ education.These innovations will improve the quality and effectiveness of the nursing anatomy teaching, and promote the provision of high-quality practical personnel training for undergraduate nurses under information technology in China.
α-Galactosyl Phytosphingosine 2,6’-Diamide as an Inducer of Invariant Natural Killer T Cell  [PDF]
Ying-Cheng Huang, Wei-Ting Chen, Shu-Fan Tien, Ho-Lien Huang, Chun-Nan Yeh, Kun-I Lin, Chung-Shan Yu
Open Journal of Medicinal Chemistry (OJMC) , 2013, DOI: 10.4236/ojmc.2013.33008
Abstract:

Four a-galactosyl phytosphingosine 2,6’-diamide analogs were prepared from 2,6’-diamino a-galactosylphytosphingosine and the aromatic-bearing carboxylic acids. After purification with High Performance Liquid Chromatography, a flowcytometry for the four compounds for stimulation of human Va24+/Vb11+ NKT cell populations was carried out. Additional keto groups on the acyl chains of the 2,6’-diamide compound was associated with the enhanced stimulating effect.


Discussion on Behavior of Platinum Group Metals in Pressure Cyanide Leaching
Pt族金属在加压氰化浸出过程中的行为探讨

HUANG Kun,CHEN Jing,
黄昆
,陈景

金属学报 , 2004,
Abstract: 对加压氰化浸出过程Pt族金属(Pt,Pd,Rh)行为的研究表明,Pt族金属氰化浸出率的顺序为Pd>Pt>Rh,而相应氰配合物高温下稳定性顺序为Rh≈Pt>Pd浸出过程中的行为规律实际上反映的是表面态Pt族金属的化学反应活性顺序,也即金属的原子态稳定性和金属键强度两种变化规律的综合表现,而Pt族金属氰配合物高温稳定性可以由“重Pt族配合物比相应结构的轻Pt族配合物的热力学稳定性更大,动力学惰性更高”以及金属氰配离子反应活性得到解释。
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