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Search Results: 1 - 10 of 10989 matches for " Kun Si "
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Fluorescence Resonance Energy Transfer Assay for High-Throughput Screening of ADAMTS1 Inhibitors
Jianhao Peng,Lili Gong,Kun Si,Xiaoyu Bai,Guanhua Du
Molecules , 2011, DOI: 10.3390/molecules161210709
Abstract: A disintegrin and metalloprotease with thrombospondin type I motifs-1 (ADAMTS1) plays a crucial role in inflammatory joint diseases and its inhibitors are potential candidates for anti-arthritis drugs. For the purposes of drug discovery, we reported the development and validation of fluorescence resonance energy transfer (FRET) assay for high-throughput screening (HTS) of the ADAMTS1 inhibitors. A FRET substrate was designed for a quantitative assay of ADAMTS1 activity and enzyme kinetics studies. The assay was developed into a 50-μL, 384-well assay format for high throughput screening of ADAMTS1 inhibitors with an overall Z’ factor of 0.89. ADAMTS1 inhibitors were screened against a diverse library of 40,960 total compounds with the established HTS system. Four structurally related hits, naturally occurring compounds, kuwanon P, kuwanon X, albafuran C and mulberrofuran J, extracted from the Chinese herb Morus alba L., were identified for further investigation. The results suggest that this FRET assay is an excellent tool, not only for measurement of ADAMTS1 activity but also for discovery of novel ADAMTS1 inhibitors with HTS.
Photon-added and photon-subtracted displaced Fock states and their non-classical properties

Si Kun,Zhang Miao,Jia Huan-Yu,

中国物理 B , 2009,
Abstract: A new kind of quantum optical state, photon-added and -subtracted displaced Fock states, is introduced by applying the inverse of bosonic creation and annihilation operators to displaced Fock states. The quantum statistical properties of these states are investigated by numerical methods. Numerical results indicate that these states reveal some interesting non-classical properties, such as anti-bunching effects, sub-Poisson distributions and negativities of their Wigner functions.
Adaptive Remote Sensing Texture Compression on GPU
Xiao-Xia Lu,Si-Kun Li
International Journal of Image, Graphics and Signal Processing , 2010,
Abstract: Considering the properties of remote sensing texture such as strong randomness and weak local correlation, a novel adaptive compression method based on vector quantizer is presented and implemented on GPU. Utilizing the property of Human Visual System (HVS), a new similarity measurement function is designed instead of using Euclid distance. Correlated threshold between blocks can be obtained adaptively according to the property of different images without artificial auxiliary. Furthermore, a self-adaptive threshold adjustment during the compression is designed to improve the reconstruct quality. Experiments show that the method can handle various resolution images adaptively. It can achieve satisfied compression rate and reconstruct quality at the same time. Index is coded to further increase the compression rate. The coding way is designed to guarantee accessing the index randomly too. Furthermore, the compression and decompression process is speed up with the usage of GPU, on account of their parallelism.
Electrophoresis of poly(dT)20 through α-hemolysin nanoporein high concentration potassium chloride solution
Si WeiYang HaojieJi AnpingLi Kun, Sha JingjieLiu Lei, Chen Yunfei
- , 2016, DOI: 10.3969/j.issn.1003-7985.2016.04.017
Abstract: Experiments of poly(dT)20 electrophoresis through α-hemolysin nanopores were performed to unveil the electrophoretic transport mechanism of DNA through nanopores in high concentration potassium chloride solution. It is found that there are two obvious current blockades induced by poly(dT)20 translocation and collision events. Both blockade currents increase linearly with the applied bias voltage. However, the normalized blockade currents are almost kept the same although variable bias voltages are applied. The collision time of poly(dT)20 in the luminal site of the pore remains constant for different voltages. The translocation speed of poly(dT)20 through the nanopore decreases with the increase of bias voltage. It is because as the potential increases, the drag force on the homopolymer helps it to crumple into a cluster much easier due to the poor stacking of thymine residues compared with homopolymers consisting of other nucleotides. Molecular dynamics simulations further confirm the experimental results. Increasing the applied bias voltage can slow down the translocation velocity of the flexible poly(dT)20, which favors increasing the precision of single molecule detection by using nanopores.

Liu Si-ming,Wei Ji-kun,Hao Li-kun,

中国物理 B , 1999,
Abstract: By analyzing the Einstein's equations for the static sphere, we find that there exists a non-singular static configuration whose radius can approach its corresponding horizon size arbitrarily.
The US Stock Market Leads the Federal Funds Rate and Treasury Bond Yields
Kun Guo,Wei-Xing Zhou,Si-Wei Cheng,Didier Sornette
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0022794
Abstract: Using a recently introduced method to quantify the time-varying lead-lag dependencies between pairs of economic time series (the thermal optimal path method), we test two fundamental tenets of the theory of fixed income: (i) the stock market variations and the yield changes should be anti-correlated; (ii) the change in central bank rates, as a proxy of the monetary policy of the central bank, should be a predictor of the future stock market direction. Using both monthly and weekly data, we found very similar lead-lag dependence between the S&P 500 stock market index and the yields of bonds inside two groups: bond yields of short-term maturities (Federal funds rate (FFR), 3M, 6M, 1Y, 2Y, and 3Y) and bond yields of long-term maturities (5Y, 7Y, 10Y, and 20Y). In all cases, we observe the opposite of (i) and (ii). First, the stock market and yields move in the same direction. Second, the stock market leads the yields, including especially the FFR. Moreover, we find that the short-term yields in the first group lead the long-term yields in the second group before the financial crisis that started in mid-2007 and the inverse relationship holds afterwards. These results suggest that the Federal Reserve is increasingly mindful of the stock market behavior, seen as key to the recovery and health of the economy. Long-term investors seem also to have been more reactive and mindful of the signals provided by the financial stock markets than the Federal Reserve itself after the start of the financial crisis. The lead of the S&P 500 stock market index over the bond yields of all maturities is confirmed by the traditional lagged cross-correlation analysis.
The Vasorelaxant Mechanisms of a Rho Kinase Inhibitor DL0805 in Rat Thoracic Aorta
Lili Gong,Jianhao Peng,Lianhua Fang,Ping Xie,Kun Si,Xiaozhen Jiao,Liping Wang,Guanhua Du
Molecules , 2012, DOI: 10.3390/molecules17055935
Abstract: Rho-kinase has been suggested as a potential therapeutic target in the treatment of cardiovascular diseases. The Rho-kinase signaling pathway is substantially involved in vascular contraction. The aim of the present study was to evaluate the vasorelaxant effects of Rho kinase inhibitor DL0805 in isolated rat aortic rings and to investigate its possible mechanism(s). It was found that DL0805 exerted vasorelaxation in a dose-dependent manner in NE or KCl-induced sustained contraction and partial loss of the vasorelaxation under endothelium-denuded rings. The DL0805-induced vasorelaxation was significantly reduced by the nitric oxide synthase inhibitor Nω-nitro-L-arginine methyl ester, the guanylate cyclase inhibitor methylene blue and the cyclooxygenase inhibitor indomethacin. The voltage-dependent K+ channel blocker 4-aminopyridine remarkably attenuated DL0805-induced relaxations. However, the ATP-sensitive K+ channel blocker glibenclamide and Ca2+-activated K+ channel blocker tetraethylammonium did not affect the DL0805-induced relaxation. In the endothelium-denuded rings, DL0805 also reduced NE-induced transient contraction and inhibited contraction induced by increasing external calcium. These findings suggested that DL0805 is a novel vasorelaxant compound associated with inhibition of Rho/ROCK signaling pathway. The NO-cGMP pathway may be involved in the relaxation of DL0805 in endothelium-intact aorta. The vasorelaxant effect of DL0805 is partially mediated by the opening of the voltage-dependent K+ channels.
Generation of Schr?dinger cat state of a single trapped cold ion

Zhang Miao,Jia Huan-Yu,Ji Xiao-Hui,Si Kun,

中国物理 B , 2009,
Abstract: The fidelity of the generated Schr\"{o}dinger Cat state (SCS) of a single trapped ion in the Lamb--Dicke approximation is discussed. The results show that the fidelity significantly decreases with the values of Lamb--Dicke parameter $\eta $ and coherent state amplitude $\alpha $ increasing. For $\eta = 0.20$ and $\alpha = 3$, the typical values of experimental parameters, the fidelity is rather low (30{\%}). A scheme for generating the SCS is proposed without making the Lamb--Dike approximation in laser--ion interaction, and the fidelity of the generated SCS is about 99{\%} for the typical values of experimental Lamb--Dicke parameters.
Nonclassicality of photon-added squeezed vacuum states

Si Kun,Ji Xiao-Hui,Jia Huan-Yu,

中国物理 B , 2010,
Abstract: By applying the bosonic creation operator to squeezed vacuum states, this paper introduces a new kind of quantum states: photon-added squeezed vacuum states. It also presents an experimental approach to prepare these states, and investigates their quantum statistical properties by the numerical method. The results indicate that these states reveal some interesting non-classical properties, such as anti-bunching effects, squeezing effects and negativities of the relevant Wigner functions.
Design and Implementation of Real-time GPS Signal Sampling System

GONG Guo-hui,LI Si-kun,

计算机应用研究 , 2005,
Abstract: A real-time GPS signal sampling system based on EPP protocol was developed. Key technical points of design and implementation was introduced, performance was analysed. The system is applicable for GPS positioning algorithm studying and GPS receiver prototype developing.
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