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Search Results: 1 - 10 of 105143 matches for " Kuan Zhang "
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A Localized-Statistic-Based Approach for Biomarker Identification of Omics Data  [PDF]
Kuan Zhang, He Chen, Yongtao Li
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.510B089

Omics data provides an essential means for molecular biology and systems biology to capture the systematic properties of inner activities of cells. And one of the strongest challenge problems biological researchers have faced is to find the methods for discovering biomarkers for tracking the process of disease such as cancer. So some feature selection methods have been widely used to cope with discovering biomarkers problem. However omics data usually contains a large number of features, but a small number of samples and some omics data have a large range distribution, which make feature selection methods remains difficult to deal with omics data. In order to overcome the problems, wepresent a computing method called localized statistic of abundance distribution based on Gaussian window(LSADBGW) to test the significance of the feature. The experiments on three datasets including gene and protein datasets showed the accuracy and efficiency of LSADBGW for feature selection.

FPTAS for Hardcore and Ising Models on Hypergraphs
Pinyan Lu,Kuan Yang,Chihao Zhang
Computer Science , 2015,
Abstract: Hardcore and Ising models are two most important families of two state spin systems in statistic physics. Partition function of spin systems is the center concept in statistic physics which connects microscopic particles and their interactions with their macroscopic and statistical properties of materials such as energy, entropy, ferromagnetism, etc. If each local interaction of the system involves only two particles, the system can be described by a graph. In this case, fully polynomial-time approximation scheme (FPTAS) for computing the partition function of both hardcore and anti-ferromagnetic Ising model was designed up to the uniqueness condition of the system. These result are the best possible since approximately computing the partition function beyond this threshold is NP-hard. In this paper, we generalize these results to general physics systems, where each local interaction may involves multiple particles. Such systems are described by hypergraphs. For hardcore model, we also provide FPTAS up to the uniqueness condition, and for anti-ferromagnetic Ising model, we obtain FPTAS where a slightly stronger condition holds.
SACRM: Social Aware Crowdsourcing with Reputation Management in Mobile Sensing
Ju Ren,Yaoxue Zhang,Kuan Zhang,Xuemin,Shen
Computer Science , 2014, DOI: 10.1016/j.comcom.2015.01.022
Abstract: Mobile sensing has become a promising paradigm for mobile users to obtain information by task crowdsourcing. However, due to the social preferences of mobile users, the quality of sensing reports may be impacted by the underlying social attributes and selfishness of individuals. Therefore, it is crucial to consider the social impacts and trustworthiness of mobile users when selecting task participants in mobile sensing. In this paper, we propose a Social Aware Crowdsourcing with Reputation Management (SACRM) scheme to select the well-suited participants and allocate the task rewards in mobile sensing. Specifically, we consider the social attributes, task delay and reputation in crowdsourcing and propose a participant selection scheme to choose the well-suited participants for the sensing task under a fixed task budget. A report assessment and rewarding scheme is also introduced to measure the quality of the sensing reports and allocate the task rewards based the assessed report quality. In addition, we develop a reputation management scheme to evaluate the trustworthiness and cost performance ratio of mobile users for participant selection. Theoretical analysis and extensive simulations demonstrate that SACRM can efficiently improve the crowdsourcing utility and effectively stimulate the participants to improve the quality of their sensing reports.
1-[4-(β-d-Allopyranosyloxy)benzylidene]semicarbazide hemihydrate
Hua-Feng Chen,Xue Bai,Kuan Zhang,Ying Li
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536809055664
Abstract: The molecule of the title compound, C14H19N3O7·0.5H2O, exhibits an E conformation about the C=N double bond. The water molecule possesses crystallographically imposed twofold symmetry. In the crystal structure, the molecules are connected by intermolecular O—H...O and N—H...O hydrogen bonds into a three-dimensional network.
Kuan Zhang,Xue Bai,Hua-Feng Chen,Ying Li
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536809055652
Abstract: The asymmetric unit of the title compound, C29H29ClO11, contains two independent molecules of similar geometry, both adopting an E conformation about the C=C double bond. The dihedral angles formed by benzene rings are 10.73 (16) and 13.79 (18)°. The pyranoside rings adopt a chair conformation. Intramolecular C—H...O close contacts occur. The crystal packing is stabilized by intermolecular C—H...O hydrogen bonds.
Xue Bai,Hua-feng Chen,Kuan Zhang,Ying Li
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809043785
Abstract: In the title compound, C18H18N2O3, the dihedral angle formed by the benzene rings is 71.75 (4)°. In the crystal structure, centrosymmetrically related molecules are linked into dimers by intermolecular O—H...O hydrogen bonds and π–π stacking interactions with centroid–centroid distances of 3.5511 (6) .
Bovine herpes virus type 1 induces apoptosis through Fas-dependent and mitochondria-controlled manner in Madin-Darby bovine kidney cells
Xu Xingang,Zhang Kuan,Huang Yong,Ding Li
Virology Journal , 2012, DOI: 10.1186/1743-422x-9-202
Abstract: Background Bovine herpesvirus type 1 (BHV-1) is an important pathogen in cattle that is responsible for substantial economic losses. Previous studies suggest that BHV-1 may induce apoptosis in Madin-Darby bovine kidney (MDBK) cells via a mechanism only involving caspases and p53. However, the mechanism for BHV-1-induced MDBK cell apoptosis still requires more research. Methods MDBK was used as a model to study the precise signaling pathways of apoptosis induced by BHV-1 infection. Results BHV-1 infection activated a Fas/FasL-mediated apoptotic pathway, resulting in activation of caspase-8 and cleavage of Bid. In addition, BHV-1 infection down-regulated Bcl-2 and up-regulated Bax expression, thereby initiating the release of cytochrome c followed by caspase-9 activation. The combined activation of the extrinsic and intrinsic pathways resulted in activation of downstream effecter caspase-3 and poly ADP-ribose polymerase (PARP), leading to apoptosis. Furthermore, blocking apoptosis using caspase inhibitors improved BHV-1-infected MDBK cell viability to different extent. BHV-1 infection did not induce significant DNA fragmentation in MDBK cells pretreated with ammonium chloride (NH4Cl) or cells infected with UV-inactivated BHV-1. Blocking caspases activation increased BHV-1 replication. Conclusions BHV-1 induces apoptosis in MDBK cells through extrinsic and intrinsic pathways and there might be cross-talk between the two pathways. In addition, BHV-1 replication may be necessary for the induction of apoptosis in BHV-1-infected cells, and prolonged cell viability benefits BHV-1 replication.
Uncorrelated estimates of the primordial power spectrum
Zong-Kuan Guo,Yuan-Zhong Zhang
Physics , 2011, DOI: 10.1088/1475-7516/2011/11/032
Abstract: We use the localized principle component analysis to detect deviations from scale invariance of the primordial power spectrum of curvature perturbations. With the technique we make uncorrelated estimates of the primordial power spectrum with five wavenumber bins. In the framework of a minimal LCDM model, using the latest cosmic microwave background data from the WMAP and ACT experiments we find that more than 95% of the preferred models are incompatible with the assumption of scale-invariance, but still compatible with a power-law primordial spectrum. We also forecast the sensitivity and constraints achievable by the Planck experiment by performing Monte Carlo studies on simulated data. Planck could significantly improve the constraints on the primordial power spectrum, especially at small scales by roughly a factor of 4.
Parametrization of Quintessence and Its Potential
Zong-Kuan Guo,Nobuyoshi Ohta,Yuan-Zhong Zhang
Physics , 2005, DOI: 10.1103/PhysRevD.72.023504
Abstract: We develop a theoretical method of constructing the quintessence potential directly from the effective equation of state function $w(z)$, which describes the properties of the dark energy. We apply our method to four parametrizations of equation of state parameter and discuss the general features of the resulting potentials. In particular, it is shown that the constructed quintessence potentials are all in the form of a runaway type.
Cosmology with a Variable Chaplygin Gas
Zong-Kuan Guo,Yuan-Zhong Zhang
Physics , 2005, DOI: 10.1016/j.physletb.2006.12.063
Abstract: We consider a new generalized Chaplygin gas model that includes the original Chaplygin gas model as a special case. In such a model the generalized Chaplygin gas evolves as from dust to quiessence or phantom. We show that the background evolution for the model is equivalent to that for a coupled dark energy model with dark matter. The constraints from the current type Ia supernova data favour a phantom-like Chaplygin gas model.
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