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Influence of Substrate Feeding and Process Parameters on Production of Coenzyme Q10 Using Paracoccus denitrificans ATCC 19367 Mutant Strain P-87  [PDF]
Pradipta Tokdar, Prafull Ranadive, Rajendra Kshirsagar, Samanta Shekhar Khora, Sunil Kumar Deshmukh
Advances in Bioscience and Biotechnology (ABB) , 2014, DOI: 10.4236/abb.2014.512110
Abstract: Coenzyme Q10 (CoQ10), an important antioxidant molecule playing a major role in electron transport chain, has been commercially produced by fermentation process for the use in oral nutraceutical formulations. Constructing the high-yielding CoQ10 producing strains is a pre-requisite for cost-effective production. A superior mutant strain P-87 generated from Paracoccus denitrificans ATCC 19367, which showed 1.25-fold improvement in specific CoQ10 content higher than the wild type strain at shake flask level, was selected to carry out the studies on CoQ10 yield improvement through fermenter process optimization. In the course of study, initially the cane-molasses-based medium and fed-batch fermentation strategy using pHBA in combination with sucrose were standardized in shake flask using wild type strain. This strategy was subsequently translated at 2 L laboratory fermenter while optimizing the fermentation process parameters using improved mutant strain P-87. Under optimized fermentation condition, mutant strain P-87 produced 49.85 mg/L of CoQ10 having specific content of 1.63 mg/g of DCW, which was 1.36 folds higher than the specific CoQ10 content of wild-type strain under similar optimized condition. The temperature and DO were found to be critical parameters for CoQ10 production by mutant strain P-87. The optimum temperature was found to be 32
Full potential LAPW calculation of electron momentum density and related properties of Li
Tunna Baruah,Rajendra R. Zope,Anjali Kshirsagar
Physics , 1999, DOI: 10.1103/PhysRevB.60.10770
Abstract: Electron momentum density and Compton profiles in Lithium along $<100 >$, $<110>$, and $<111>$ directions are calculated using Full-Potential Linear Augmented Plane Wave basis within generalized gradient approximation. The profiles have been corrected for correlations with Lam-Platzman formulation using self-consistent charge density. The first and second derivatives of Compton profiles are studied to investigate the Fermi surface breaks. Decent agreement is observed between recent experimental and our calculated values. Our values for the derivatives are found to be in better agreement with experiments than earlier theoretical results. Two-photon momentum density and one- and two-dimensional angular correlation of positron annihilation radiation are also calculated within the same formalism and including the electron-positron enhancement factor.
Phenanthrenes of Eulophia ochreata Lindl.
Kshirsagar Rajendra,Kanekar Yogesh,Jagtap Suresh,Upadhyay Shakti
International Journal of Green Pharmacy , 2010,
Abstract: Pawra tribe of Satpuda mountain ranges that belong to Maharashtra region, India, is known to use tubers of Eulophia ochreata for rejuvenating and aphrodisiac properties and also for curing rheumatism. For systematic scientific validation of folk claims of E. ochreata tubers, we report here the collection, extraction, isolation and spectral characterization of molecules and also its evaluation for free radical scavenging activity. Isolation of molecules was carried out on activity-guided fractionation in 2,2 ′ -diphenyl-1-picrylhydrazyl assay. This is the first report of isolation of 9,10-Dihydro-2,5-Dimethoxyphenanthrene-1,7-diol and 5,7-Dimethoxyphenanthrene-2,6-diol from this orchid.
ANTIOXIDANT ACTIVITY OF HYDROCHLORIDE SALT OF TYLOPHORINIDINE AND TYLOPHORININE ISOLATED FROM AERIAL PARTS OF TYLOPHORA INDICA
Dhiman Mini,Naik Vinayak,Kshirsagar Rajendra,Desai Dattatraya Chandrakant
International Journal of Research in Ayurveda and Pharmacy , 2012,
Abstract: The extracts from aerial parts (leaves and stem) of Tylophora indica were evaluated for their antioxidant activity. The antioxidant activity of crude extracts was determined by using DPPH free radical scavenging method in which methanol and ethyl acetate extracts showed highest antioxidant activity (IC50 values 87 μg/mL and 81 μg/mL respectively). Methanol extract was further purified to isolated hydrochloride salt of tylophorinidine and tylophorinine, identified by analytical and spectral data. Tylophorinidine hydrochloride showed promising antioxidant activity with IC50 24 μg/mL.
Momentum space properties from coordinate space electron density
M. K. Harbola,Rajendra R. Zope,Anjali Kshirsagar,Rajeev K. Pathak
Physics , 2005, DOI: 10.1063/1.1904588
Abstract: Electron density and electron momentum density, while independently tractable experimentally, bear no direct connection without going through the many-electron wave function. However, invoking a variant of the constrained-search formulation of density functional theory, we develop a general scheme (valid for arbitrary external potentials) yielding decent momentum space properties, starting exclusively from the coordinate space electron density. Numerical illustration of the scheme is provided for the closed-shell atomic systems He, Be and Ne and for $1s^1~2s^1$ singlet electronic excited state for Helium by calculating the Compton profiles and the $$ expectation values derived from given coordinate space electron densities.
Is India ready to face 21st Century?
Kshirsagar S
IETE Technical Review , 2008,
Abstract:
Therapeutic drug monitoring.
Kshirsagar N
Journal of Postgraduate Medicine , 1994,
Abstract:
Foreword
Kshirsagar Nilima
Journal of Postgraduate Medicine , 2004,
Abstract:
Medical research in 21st Century - What is needed
Kshirsagar Nilima
Journal of Postgraduate Medicine , 2004,
Abstract:
Malaria: Antimalarial resistance and policy ramificationsand challenges
Kshirsagar N
Journal of Postgraduate Medicine , 2006,
Abstract: ′The National health Policy 2002" of India and the "Roll Back Malaria" policy makers have set up an ambitious goal of reducing malaria mortality and morbidity by 25% by 2007, and by 50% by 2010. To achieve these goals, problems should be identified, available evidence analyzed and policy should be changed early. Infection with drug resistant malarial parasites has a tremendous impact on health (prolonged recurrent illness, increased hospital admissions and death), health system (higher cost of treatment) and socioeconomics of the region. In view of the evidence of the economic burden of malaria, it has been suggested that second line treatment could be considered at 10% failure instead of 25%. Effective schizonticidal drugs will not only reduce morbidity and mortality but will also reduce transmission. Studies have shown that prevalence of viable (as tested by exflagellation test) gametocytes is considerably more after the Chloroquine or Chloroquine + Sulphadoxine-Pyrimethamine treatment compared to Quinine. Unfortunately, the only gametocytocidal drug for Plasmodium falciparum, primaquine, is also loosing its efficacy. 45 mg Primaquine reduces gametocyte prevalence by 50% while a new drug, 75 mg bulaquine or 60 mg primaquine reduces it by 90%. Plasmodium vivax forms 60-70% of malaria cases in India. Relapses which occur in 10-20% of cases adds to the burden. Efficacy, as confirmed by Polymerase Chain Reaction-Single Strand Conformational Polymorphism (PCRSSCP) to differentiate relapse and re-infection, of standard dose of primaquine (15 mg/day for 5 days, even 15 mg/day for 14 days) for vivax malaria is reducing. Fourteen day treatment is also impractical as compliance is poor. Newer drugs, newer drug delivery systems are thus needed. Slow release formulations with blood levels maintained for one week may be useful. Rationale of giving primaquine in higher doses and different timing need to be considered. The genome of Plasmodium falciparum and genome of Anopheles gambiae have been unraveled in last past 3 years. This has given us an opportunity to develop new tools. Whatever be the tool, educating health care workers as well as lay public and ensuring appropriate use of available drug are essential to achieve our goals of controlling malaria.
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