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Search Results: 1 - 10 of 633 matches for " Krsti? Miodrag "
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Frequency of Helicobacter pylori infection in patients with liver cirrhosis
Alempijevi? Tamara,KrstiMiodrag,Antoni? Vesna,Krsti? Slobodan
Srpski Arhiv za Celokupno Lekarstvo , 2007, DOI: 10.2298/sarh0710536a
Abstract: Introduction Ulcer disease occurrence is increased among patients with liver cirrhosis. It is widely accepted that Helicobacter pylori infection is important in etiology of ulcer disease. The role of Helicobacter pylori infection in pathogenesis of ulcer disease in patients with liver cirrhosis has not been satisfactorily explored yet. Objective The aim of this study was to determine frequencies of Helicobacter pylori infection in patients with liver cirrhosis in relation to the etiology of cirrhosis, clinical stage and concomitant ulcer disease. Method We studied 50 patients with liver cirrhosis analyzing the etiology of liver cirrhosis, clinical stage, presence of ulcer disease, and existence of Helicobacter pylori infection. Results were thoroughly analyzed and compared. Results Among 50 studied subjects, 37 were male (average age 56.62±10.47 years), while 13 were female (average age 60.69±6.51 years). In 32 (64%) patients, liver cirrhosis was related to alcohol abuse, whereas in remaining 16 (36%) subjects, cirrhosis was due to chronic viral infection. Ulcer disease, determined by endoscopy, was present in 8 (16%) patients, although 18 (36%) subjects were Helicobacter pylori positive. There were no significant differences in occurrences of Helicobacter pylori infection amongst the patients with and without ulcer disease (χ2=0.923; p>0.05). No significant difference was found for the clinical stage and type of ulcer disease (χ2=0.869; p>0.05). The difference in presence of Helicobacter pylori infection and etiology of liver cirrhosis appeared to be of no significance, either (F=0.540; p>0.05). The presence of Helicobacter pylori infection in different clinical stages seemed to be of statistical significance (χ2=7.0; p<0.05). Conclusion The obtained results indicate that the prevalence of Helicobacter pylori infection in patients with liver cirrhosis is lower compared to general population, and that is of no significance for ulcer disease in these subjects. Moreover, it is likely that the frequency of Helicobacter pylori infection in patients with liver cirrhosis is not related to the etiology of cirrhosis, while this infection seems to be more frequently present in severe clinical forms of hepatic cirrhosis.
Observational study in primary health care: Symptoms control of gastroesophageal reflux disease and influence on the quality of life
KrstiMiodrag,Damjanov Dragomir,Nagorni Aleksandar
Srpski Arhiv za Celokupno Lekarstvo , 2013, DOI: 10.2298/sarh1302054k
Abstract: Introduction. Gastroesophageal reflux disease (GERD) is a common disease in primary care. The most effective medicamentous treatment is proton pump inhibitors (PPI). Objective. Observational study conducted in 13 primary health care centers from the whole Serbia with the aim to collect local epidemiology data on GERD and to investigate the intensity and frequency of disease symptoms and the quality of life of patients treated with proton pump inhibitors by using a Patient’s Questionnaire. Methods. Adult GERD patients treated with PPI were under follow-up for two months. The investigators evaluated typical symptoms and gave global assessment of disease severity. The patients filled-in the Patient’s Questionnaire on disease symptoms and quality of life. At the study end, the investigators evaluated the importance of the Patient’s Questionnaire in the management of these patients. Results. The study included 828 patients (66.3% female) of mean age 54.8 years. The most common life habits were coffee consumption (86.1%), exposure to stress (81.7%), smoking (45.7%) and alcohol consumption (25%). With PPI therapy a statistically significant reduction of typical GERD symptoms of any intensity was detected as evaluated by the investigators (p<0,001), as well as the reduction in the frequency of all symptoms and accompanying discomforts of the quality of life, as estimated by the patients (p<0.001). In 92.2% of the patients the investigators evaluated the Patient’s Questionnaire to be of significant help. Conclusion. Primary health care physicians evaluated the Patient’s Questionnaire as an important tool in the investigation of the disease symptoms and the quality of life of patients with GERD. The intensity and frequency of symptoms were reduced, and the quality of life of patients with GERD was improved by therapy with PPI.
Cholestatic hepatitis associated with nimesulide: A case report
Luki? Sne?ana,KrstiMiodrag,Damjanov Nemanja,Bori?i? Ivan
Srpski Arhiv za Celokupno Lekarstvo , 2009, DOI: 10.2298/sarh0910550l
Abstract: Introduction A toxic effect of drugs, including non-steroidal anti-inflammatory drugs, may be one of aetiological factors for the occurrence of acute hepatitis. Nimesulide is a selective cyclooxygenase-2 inhibitor, whose adverse effects on the liver range from acute hepatitis to more serious conditions, involving the development of acute liver failure and fatal outcome. Case Outline A female patient, aged 73, was admitted to the Gastroenterology and Hepatology Clinic of the Clinical Centre of Serbia in Belgrade because of liver failure. Due to the pain in the right knee, she received a therapy of 100 mg nimesulide in tablets, two times a day, for two months before admission to the Clinic. The analysis of the results of clinical, laboratory and radiographic examinations, and of histopathological findings of the liver biopsy showed that acute hepatitis was associated with the administration of nimesulide. Once the patient discontinued the intake of this drug, she fully convalesced. Conclusion The patient who received nimesulide over a period of two months developed acute hepatitis. In view of the similar cases described in literature and the fact that the use of nimesulide has been discontinued in a number of European countries and restricted by the European Medicines Agency, restriction or ban on the use of nimesulide on the Serbian market should be considered.
A review of current methods in the diagnostics of morphological changes in chronic pancreatitis
Alempijevi? Tamara,KrstiMiodrag,Jovanovi? Ivan,Popovi? Dragan
Srpski Arhiv za Celokupno Lekarstvo , 2008, DOI: 10.2298/sarh0812675a
Abstract: Chronic pancreatitis is a disease with well-defined histopathology, however, the diagnosis is not based on the grading of histological changes, but on the features registered by the methods of morphological and functional diagnostic procedures. The correct diagnosis of chronic pancreatitis is easy in advanced stages, but difficult in early stages of the disease. In this review, we present the current methods used (echosonography, computer tomography, magnetic resonance, endoscopic retrograde cholangiopancreatography, endoscopic echosonography) in the diagnostics of chronic pancreatitis.
THE ROLE OF CYTOPATHOLOGY IN THE EARLY DIAGNOSTICS OF THE CERVICAL CARCINOMA
Miodrag Radovi?,Milena Veljkovi?,Zoran Pop-Trajkovi?,Miljan Krsti
Acta Medica Medianae , 2002,
Abstract: The cytological diagnostic method has been more and more used in medical practice. Thanks to the Greek scientist Papanicolaou and his reports (1928), a new preventive struggle with the most frequent carcinoma of the genital tract, that is, the PVU carcinoma has begun. In the last few decades the number of cytological methods has increased as well while impressive results have been achieved upon the preparations obtained by exfoliative, brushing and lavage methods as well as the aspiration techniques with a thin and thicker needled.For the above-stated reasons as well as due to scant literature in our country, the aim of this paper is to present a survey of the history, examination of advantages and drawbacks of various cytological methods as well as of a still widely used Pap-classification in medical practice. The importance of the Bethesda-classification is also pointed out.Because of possible artifacts and errors in interpreting the obtained cytological results when the precancerous and malign lesions of the regenerative epithelium -such as the well-known squamous epithelium PVU - special attention is paid to cytological and nuclear characteristics of the taken sample.
Argon-plasma coagulation as a primary therapeutic method for the treatment of flat duodenal adenomas
Kne?evi? Slavko,Uglje?i? Milenko,Micev Marjan,KrstiMiodrag
Vojnosanitetski Pregled , 2008, DOI: 10.2298/vsp0804328k
Abstract: Background. Argon-plasma coagulation is a method for tissue coagulation that uses high-frequency electric energy and ionized argon gas. It is used in endoscopic haemostasis and in coagulation of smaller, superficial lesion on gastrointestinal mucosa such as flat adenomas, but also in reduction of tumor tissue. Case report. We presented a patient with flat adenoma duodeni. Adenoma had been treated with argon plasma coagulation, in one act, and with a complete restitution of mucosa in further follows up. Conclusion. Argon plasma can be efficiently used in coagulation of superficial lesion of gastrointestinal mucosa, that belongs to the type of flat adenomas, as well as other superficial lesions of mucosa that require endoscopic mucosectomy from smaller, bordered spaces.
Congenital intestinal lymphangiectasia
Popovi? Du?an ?.,?puran Milan,Alempijevi? Tamara,KrstiMiodrag
Vojnosanitetski Pregled , 2011, DOI: 10.2298/vsp1103270p
Abstract: Background. Congenital intestinal lymphangiectasia is a disease which leads to protein losing enteropathy. Tortous, dilated lymphatic vessels in the intestinal wall and mesenterium are typical features of the disease. Clinical manifestations include malabsorption, diarrhea, steatorrhea, edema and effusions. Specific diet and medication are required for disease control. Case report. A 19-year old male patient was hospitalized due to diarrhea, abdominal swelling, weariness and fatigue. Physical examination revealed growth impairment, ascites, and lymphedema of the right hand and forearm. Laboratory assessment indicated iron deficiency anaemia, lymphopenia, malabsorption, inflammatory syndrome, and urinary infection. Enteroscopy and video capsule endoscopy demonstrated dilated lymphatic vessels in the small intestine. The diagnosis was confirmed by intestinal biopsy. The patient was put on high-protein diet containing medium-chain fatty acids, somatotropin and suportive therapy. Conclusion. Congenital intestinal lymphangiectasia is a rare disease, usually diagnosed in childhood. Early recognition of the disease and adequate treatment can prevent development of various complications.
Watermelon stomach in a patient with primary Sj gren's syndrome
KrstiMiodrag,Alempijevi? Tamara,Andrejevi? Sla?ana,Zlatanovi? Maja
Vojnosanitetski Pregled , 2010, DOI: 10.2298/vsp1003256k
Abstract: Introduction. Watermelon stomach (WS) or gastric antral vascular ectasia (GAVE) is a rare cause of upper gastrointestinal bleeding described in a variety of autoimmune disorders. Association of watermelon stomach with Sj gren's syndrome is extremely rare. Case report. We presented a 67-year old female with primary Sj gren's syndrome (SS) who had developed a persistent severe iron-deficiency anemia. An upper gastric endoscopy revealed the presence of gastric antral vascular ectasia (GAVE) as a cause of occult gastrointestinal bleeding. The treatment with argon-plasma coagulation was postponed as the conservative therapy with iron substitution and proton pump inhibitor led to improvement of anemia and hemoglobin levels normalization. Conclusion. This is the first report of WS in a patient with primary SS without the presence of coexisting autoimmune disorder. Recognition of this rare, but clinically important, cause of gastrointestinal bleeding may decrease comorbidity in patients with autoimmune disorders including primary Sj gren's syndrome.
Correlation between findings of echosonography and endoscopic retrograde cholangiopancreatography examination in chronic pancreatitis patients
Alempijevi? Tamara,Kova?evi? Nada,?uranovi? Sr?an,KrstiMiodrag
Vojnosanitetski Pregled , 2005, DOI: 10.2298/vsp0511821a
Abstract: Background/Aim. Chronic pancreatitis is defined as an amount of chronic inflammatory lesions that lead to the destruction of pancreatic tissue and fibrosis development, whereas the later stages of the illness are characterized by the destruction of the endocrine portion of the organ. Although the results of different studies are abundant, chronic pancreatitis still remains enigmatic, both in its diagnostic and therapeutic aspect. To test the correlation between the findings of echosonography and endoscopic retrograde cholangiopancreatography (ERCP) examination in chronic pancreatitis patients. The observed degree of correlation may serve for the validation of echosonography as a diagnostic tool in chronic pancreatitis patients. Methods. We collected and analyzed data on morphological features in chronic pancreatitis patients revealed by echosonography as well as endoscopic retrograde cholangiopancreatography. Results. 35 patients 34 73 years of age were included in this study. In 60% (21 subject) history was subjective for alcohol abuse. significant correlation has been found between alcohol abuse and chronic pancreatitis (χ2 = 6.896; p < 0.05). Correlation between groups of chronic pancreatitis patients diagnosed by echosonography and endoscopic retrograde cholangiopancreatography was highly significant (p = 0.799; p < 0.01). Conclusion. Echosonography was proved to be a suitable first choice imaging method for the examination of patients when chronic pancreatitis was suspected. Echosonography might provide conclusive information on the morphology of pancreatic canalicular system, as well as on the state of pancreatic parenchyma.
Clarification and filtration of the floculated partuicles suspension from a chemical treatment of waste oil-in-water emulsions from a non-ferrous metalworking plant
Lazarevi? Vesna B.,Krsti? Ivan M.,Taki? Ljiljana M.,Lazi? Miodrag L.
Hemijska Industrija , 2011, DOI: 10.2298/hemind100801054l
Abstract: The effects of the coagulation/floculation conditions on clarification and filtration of the floculated particle suspension obtained by the chemical treatment of the waste oil-in-water emulsion (OWE) from a non-ferrous metalworking plant were studied. The treatment involved the addition of aluminum(III) sulfate and lime to the OWE. The main goal was to define the optimum conditions for clarification and filtration of the floculated particle suspension. The factors involved were amounts lime (i.e. pH) and filter aid added the OWE on clarification and filtration rates. At pH>10, the clarification rate was increased and the final volume of the concentrated suspension (sludge) was reduced, while filter aid affected negatively the clarification rate. The filtration rate was also increased when the coagulation was carried out at pH>10. The floculated particle suspension should be concentrated before filtration in order to decrease the filtration duration. The most efficient filter aid was Celite standard super-cel, its optimum initial concentration being found to be 2 g/dm3.
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