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Search Results: 1 - 10 of 876 matches for " Kristian; "
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The Shaping of Inquiry: Histories of the Exact Sciences after the Practical Turn  [PDF]
Kristian Camilleri
Advances in Historical Studies (AHS) , 2015, DOI: 10.4236/ahs.2015.42008
Abstract: In this paper I examine three emergent trends in praxis-oriented historiography that have underpinned historical studies of the exact sciences covering the period from 1750 to 1960. The first of these refers to what I call “tradition-centred” histories of scientific practice. This approach focuses on the formation of “cultures of practice” characterized by distinctive epistemic styles, which distinguish them from other such cultures. The second involves “tool-centred” histories of practice. This approach focuses on the way in which tools and techniques of inquiry open up new fields of inquiry, and the way in which the crafting of new tools and the refashioning of existing ones shape the dynamics of scientific practice. The third approach I examine relates to “actor-centred” histories, which typically take the form of biographical accounts focusing on the motivations, judgments and choices of individuals that shape scientific inquiry. This provide a useful analytic framework, in piecing together a broad picture of the different ways in which scientific inquiry is shaped and structured, and to see more clearly how different historiographical approaches complement one another in enriching our understanding of scientific practice.
Melanoma Immunotherapy: Overcoming Obstacles to Augment Anti-Tumor Immune Responses  [PDF]
Kristian M. Hargadon
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2013, DOI: 10.4236/jcdsa.2013.32a002
Abstract: Melanoma is the most aggressive form of skin cancer and accounts for the vast majority of skin cancer-related deaths. Its ability to metastasize quickly, often before diagnosis, makes this cancer difficult to treat with traditional therapies. The identification of anti-melanoma immune responses in patients and the discovery of tumor antigens targeted by these immune responses have paved the way for immunotherapy as a novel approach to treating this cancer. In this review, the major immunotherapies targeting these melanoma tumor antigens are discussed. The advantages and limitations of peptide-, protein-, and gene-based vaccination maneuvers and adoptive cell transfer therapies are emphasized. Recent insights into melanoma immune evasion strategies are also highlighted, with particular focus on how our increasing knowledge of tumor/immune cell interactions is driving the development of novel immunotherapeutic strategies for the treatment of melanoma.
Melanoma Immunotherapy: Overcoming Obstacles to Augment Anti-Tumor Immune Responses  [PDF]
Kristian M. Hargadon
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2013, DOI: 10.4236/jcdsa.2013.32A002
Abstract:

Melanoma is the most aggressive form of skin cancer and accounts for the vast majority of skin cancer-related deaths. Its ability to metastasize quickly, often before diagnosis, makes this cancer difficult to treat with traditional therapies. The identification of anti-melanoma immune responses in patients and the discovery of tumor antigens targeted by these immune responses have paved the way for immunotherapy as a novel approach to treating this cancer. In this review, the major immunotherapies targeting these melanoma tumor antigens are discussed. The advantages and limitations of peptide-, protein-, and gene-based vaccination maneuvers and adoptive cell transfer therapies are emphasized. Recent insights into melanoma immune evasion strategies are also highlighted, with particular focus on how our increasing knowledge of tumor/immune cell interactions is driving the development of novel immunotherapeutic strategies for the treatment of melanoma.

Case report: Effect of immunoglobulin on pain in Post-Polio Syndrome—Three case reports  [PDF]
Lars Werhagen, Kristian Borg
Pain Studies and Treatment (PST) , 2013, DOI: 10.4236/pst.2013.11001
Abstract: Study design: Case reports. Setting: University hospital setting. Objective: To analyze the effect of intravenous immunoglobulin on neuropathic and nociceptive pain in three patients with Post-Polio Syndrome (PPS). Materials and Methods: Three patients with PPS and pain who received treatment with 90 g IvIg are described. Results: Before treatment one of the patients had pure neuropathic pain and the other two had a combination of neuropathic and nociceptive pain. There was no effect on pain in the patient with pure neuropathic pain and only effect on the nociceptive pain in the patients with a combination of neuropathic and nociceptive pain. Discussion: Pain is one of the most common symptoms in PPS. Previous studies have shown an effect on pain in PPS patients receiving IvIg. The results of the present study point to that the effect on pain is limited to nociceptive pain and that there is no effect on neuropathic pain which leads to increased knowledge of characterization of responders of IvIg treatment. Conclusion: IvIg treatment treatmentreduces nociceptive but not neuropathic pain in PPS patients.
Survey of Long-Term Sequelae in Survivors of a Malignant Hyperthermia Reaction  [PDF]
Kristian Werneid, Barbara Brandom
Open Journal of Anesthesiology (OJAnes) , 2016, DOI: 10.4236/ojanes.2016.61001
Abstract: BACKGROUND: Malignant Hyperthermia (MH) is a potentially fatal, autosomal dominant disorder associated with administration of volatile anesthetics and/or the depolarizing paralytic succinylcholine. Symptoms include muscle rigidity, tachycardia, elevated body temperature, and metabolic acidosis, which are secondary to accelerated skeletal muscle metabolism. MH susceptibility can be a chronic condition, and some MH susceptible patients may develop symptoms subsequent to anesthetic exposure. OBJECTIVE: This is the first study examining the sequelae of an MH event after hospital discharge. METHODS: A survey was sent to patients who voluntarily registered with the North American Malignant Hyperthermia Registry, which included questions on severity of symptoms predominating prior to the MH event, one month after the MH event, and presently on a scale of 1 - 10 with a free text option to expound further. Participants were also asked about their opinions on causality between MH and these symptoms. RESULTS: Twenty-three responses were analyzed (34.8% response rate). Participants were categorized by their age at the time of the MH event and years since the event. Most (83%) stayed in the ICU between 1 - 4 days, and 39% experienced the event over 25 years ago. While 43% did not attribute any long-term symptoms to their MH event, all others believed that certain symptoms were linked, including muscle pain (90%), muscle cramps (75%), muscle weakness (100%), back/joint pain (36%) and depression/anxiety (42%). CONCLUSIONS: Our study concluded that long-lasting morbidities may be attributed to an MH event. Chronic musculoskeletal symptoms are experienced by the majority of patients who experience acute MH.
The Perspicuity of the Scriptures: Presupposition, Principle or Phantasm
Kristian Brackett
Kairos : Evangelical Journal of Theology , 2010,
Abstract: The doctrine of the perspicuity of the Scriptures was clearly articulated and strongly defended by the Reformers. Evangelical Christians today also need to reaffirm and defend this biblical doctrine. This article addresses the importance of this doctrine and looks at different definitions of this doctrine as well as its limitations. In the second part, theological and biblical evidence supporting the perspicuity of the Scriptures is presented. In the final section, the author suggests an answer to the question of whether the perspicuity of the Scriptures is a presupposition brought to the biblical text or a principle of interpretation.
James, George G. M., Stolen Legacy: The Egyptian Origins of Western Philosophy
Kristian Urstad
Kritike : an Online Journal of Philosophy , 2009,
Abstract:
Transformaciones sociales en el Neolítico final de la Europa templada (4000-2000 a.C.)
Kristiansen, Kristian
Trabajos de Prehistoria , 1989,
Abstract: Changes in the archaeological record of temperate Europe from the TRB/ Megalithic to the Corded/Ware/Battle / Axe/Single Grave cultural complexes are examined in terms of transformations in subsistence patterns (slash-and-burn farming vs. pastoralísm), surplus distribution (feasting vs. wealth exchange), and ritual practices (collective vs. individualizing). Se examinan los cambios en el registro arqueológico de la Europa templada desde los complejos culturales TRB/Megalítico al de la Cerámica cordada/Hacha de Combate/ Tumba individual atendiendo a las transformaciones en los patrones de subsistencia (agricultura de rozas vs. pastoreo), distribución del excedente (festejos (2) vs. intercambio de riqueza) y prácticas rituales (colectivas vs. individualizadoras).
Challenges to Investment Ethics in the Norwegian Petroleum Fund: a Newspaper Debate
Kristian Alm
Philosophica , 2007,
Abstract: In this article I will describe the main elements of the Norwegian press s moral confrontation with the Government Pension Fund s ethical investment management when it was in an introductory phase in early 2005, with special emphasis on one newspaper, Stavanger Aftenblad. The press criticized the fund s fresh investment profile and intended exclusionary practice before it had really started in earnest. Then I will focus on how the press s unilateral criticism of the fund s investment practice at the time overshadowed a discussion of any defects in the ethical principles for investment. And I will focus on the press s lack of distinguishing between information and sensation. In conclusion I point out that in 2006 the press has abandoned its critical stance from 2005 and has now a tendency to idealize the fund s exclusionary practice and the underlying principles.
G. Garbo: A World of Difference. The International Distribution of Information / A. Streberny-Mohammadi, K. Nordenstreng, R. Stevenson og F. Ugboajah (red.): Foreign News in the Media / H. Mowlana: International Flow of Information
Kristian Paludan
MedieKultur : Journal of Media and Communication Research , 1987,
Abstract:
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