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Search Results: 1 - 10 of 2560 matches for " Krishna Sneha "
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SNF8, a member of the ESCRT-II complex, interacts with TRPC6 and enhances its channel activity
Carrasquillo Robert,Tian Dequan,Krishna Sneha,Pollak Martin R
BMC Cell Biology , 2012, DOI: 10.1186/1471-2121-13-33
Abstract: Background Transient receptor potential canonical (TRPC) channels are non-selective cation channels involved in receptor-mediated calcium signaling in diverse cells and tissues. The canonical transient receptor potential 6 (TRPC6) has been implicated in several pathological processes, including focal segmental glomerulosclerosis (FSGS), cardiac hypertrophy, and pulmonary hypertension. The two large cytoplasmic segments of the cation channel play a critical role in the proper regulation of channel activity, and are involved in several protein-protein interactions. Results Here we report that SNF8, a component of the endosomal sorting complex for transport-II (ESCRT-II) complex, interacts with TRPC6. The interaction was initially observed in a yeast two-hybrid screen using the amino-terminal cytoplasmic domain of TRPC6 as bait, and confirmed by co-immunoprecipitation from eukaryotic cell extracts. The amino-terminal 107 amino acids are necessary and sufficient for the interaction. Overexpression of SNF8 enhances both wild-type and gain-of-function mutant TRPC6-mediated whole-cell currents in HEK293T cells. Furthermore, activation of NFAT-mediated transcription by gain-of-function mutants is enhanced by overexpression of SNF8, and partially inhibited by RNAi mediated knockdown of SNF8. Although the ESCRT-II complex functions in the endocytosis and lysosomal degradation of transmembrane proteins, SNF8 overexpression does not alter the amount of TRPC6 present on the cell surface. Conclusion SNF8 is novel binding partner of TRPC6, binding to the amino-terminal cytoplasmic domain of the channel. Modulating SNF8 expression levels alters the TRPC6 channel current and can modulate activation of NFAT-mediated transcription downstream of gain-of-function mutant TRPC6. Taken together, these results identify SNF8 as a novel regulator of TRPC6.
Use of Solid-Supported Reagents towards Synthesis of 2-Arylbenzoxazole, 3, 5-Diarylisoxazole and 1, 3, 5-Triarylpyrazole  [PDF]
Sneha Naik, Vidya Desai
Green and Sustainable Chemistry (GSC) , 2013, DOI: 10.4236/gsc.2013.31001
Abstract:

Herein we report a convenient and efficient synthesis of 2-Arylbenzoxazole from the Schiff’s bases of 2-Aminophenol, 3, 5-Diarylisoxazole from α, β-unsaturated ketoxime and 1,3,5-Triarylpyrazole from 2-pyrazoline and N-Arylhydrazone by using milder, less toxic and less expensive-NBS-SiO2, KMnO4-Al2O3, PCC-SiO2 and ACC-Al2O3 as solid-supported oxidizing agents at room temperature. Within the framework of Green Chemistry, the use of solid supported reagents has many advantages such as 1) they are easy to remove from reactions by filtration 2) excess reagents can be used to drive the reaction without introducing any difficulties in purification 3) such solid-supported reagents react differently, mostly more selectively, than their unbound counterparts and 4) toxic, noxious and explosive chemicals are handled more safely when contained on solid support.

Energy Efficient Air Conditioning System Using Geothermal Cooling-Solar Heating in Gujarat, India  [PDF]
Sneha Shahare, T. Harinarayana
Journal of Power and Energy Engineering (JPEE) , 2016, DOI: 10.4236/jpee.2016.41004
Abstract: It is well known that one unit of electrical energy saved is equal to more than two units produced. One way of economizing the power is utilization of energy efficient systems at all locations. In the present study, the air conditioning system is analysed and an innovative way is suggested. We use natural low temperature of shallow sub surface (1 - 3 m) of the earth—geothermal cooling system. It is known that majority of the households and the apartment complexes in India have two tanks for water storage. One is the underground water sump and the other is the overhead water tank. In our study, we use these two water storage systems for space cooling during summer and also for heating during winter. The main aim of our paper is air-conditioning of the space in an economic way to save electricity. It is based on a simple idea of transferring the low temperature from underground water sump to the room in the house using water as a mode of transport. Since India is a tropical country located at low latitude, most of the year, the air temperature is high and demands space cooling. However, for a couple of months during severe winter months (Dec.-Jan.) at Ahmedabad, heating of the space is required. For heating the space, we suggest to use the well-known solar water heater. Effective use of heat exchanger is shown through computation, modelling schemes and lab experiment. We recommend geothermal cooling for 10 months in a year and solar hot water system during 2 months of winter. It is observed that the ambient air temperature of 35°C - 40°C in the room can be brought down to 26°C without much consumption of electricity. In a similar manner, the room temperature at night (13°C) during winter in Ahmedabad can be increased to 27°C through circulation of water from solar water heater in the heat exchanger.
Vulnerability in Disasters II
Sneha Krishnan
Opticon1826 , 2012, DOI: 10.5334/opt.ap
Abstract: Schools and classrooms are used as relief camps during floods, which poses a huge challenge to maintaining educational levels.
Vulnerability in Disasters
Sneha Krishnan
Opticon1826 , 2012, DOI: 10.5334/opt.ao
Abstract: The elderly, the young and the sick are often the most vulnerable in times of flooding. The potential for water-borne diseases in the early stages of a disaster is high, but with the intervention of effective water and sanitation practices this can be greatly reduced or prevented. Special attention paid to the specific needs of the vulnerable population is essential. The floods in June 2012 in the Brahmaputra River in the state of Assam, North-east region of India devastated most states and led to huge displacement of population. This picture was shot at Sonitpur district, Assam.
Solitary Flight of Geese
Sneha Krishnan
Opticon1826 , 2012, DOI: 10.5334/opt.an
Abstract: This picture was shot at Buckingham Palace, London. This symbolic picture stands as a metaphor for the confidence and strength characteristic of the feeling of being loved, cherished and nourished. Birds are imaginative creatures and have historically been a species of interest for research.
First measurement of F_+^{4π} in D ->4πdecays and a new method for measuring CPV in charm decays
Sneha Malde
Physics , 2015,
Abstract: A first measurement of \fplus, the \CP-even content of the decay D->4pi using decays of $\psi(3770)$ to quantum correlated $D\bar{D}$ decays collected by the CLEO-c experiment is presented. The measured value is \fplus=$0.737 \pm 0.028$. This relatively high value makes the decay mode particularly suitable for both measurements of the CKM angle $\gamma$ and charm \CP-violation in a model independent way. This novel approach to studying indirect \CP-violation in charm decays is based on the time-dependent inclusive analysis of multi body self-conjugate states. These final states can be used to determine the indirect CP-violating observable $A_{\Gamma}$ and the mixing observable $y_{CP}$ provided that $F_+$ is known. This approach can yield significantly improved sensitivity compared with the conventional method that relies on decays to \CP~eigenstates.
Lifetime and mixing parameters of neutral D mesons and neutral B hadrons in experimental particle physics
Sneha Malde
Physics , 2011,
Abstract: A review of recent experimental measurements of the lifetime and mixing parameters of neutral D and B hadrons is presented. In particular, focus is given to measurements of D mixing and the Lambda_B lifetime.
The Khipu-Based Numeration System
Sneha Pilgaonkar
Mathematics , 2014,
Abstract: This paper presents a survey of the khipu-based enumeration system of the Incas. In this system, different knots are tied together and they are attached to a primary cord. The numerical basis of the khipu system is well understood but more recent theories suggest that the khipu also encoded narrative information and this may have been facilitated by binary mapping.
Preparation and Antibacterial Activity of Silver Nanoparticles  [PDF]
Ratan Das, Sneha Gang, Siddhartha Sankar Nath
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2011, DOI: 10.4236/jbnb.2011.24057
Abstract: Uniform silver nanoparticles have been prepared through the chemical reduction of silver ions by ethanol in presence of sodium linoleate. TEM micrograph shows a uniform distribution of the particles with an average size of 12 nm. Further, the antimicrobial activity of silver nanoparticles shows that these nanoparticles can be used as effective growth inhibitors against Staphylococcus Basillus, Staphylloccoccus Aureus, and Pseudimonas Aureginosa.
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