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Search Results: 1 - 10 of 221573 matches for " Krishna C. Vadodaria "
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Functional neurogenesis in the adult hippocampus: then and now
Krishna C. Vadodaria,Sebastian Jessberger
Frontiers in Neuroscience , 2014, DOI: 10.3389/fnins.2014.00055
Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases
Krishna C. Vadodaria,Sebastian Jessberger
Frontiers in Synaptic Neuroscience , 2013, DOI: 10.3389/fnsyn.2013.00004
Abstract: Adult neurogenesis, restricted to specific regions in the mammalian brain, represents one of the most interesting forms of plasticity in the mature nervous system. Adult-born hippocampal neurons play important roles in certain forms of learning and memory, and altered hippocampal neurogenesis has been associated with a number of neuropsychiatric diseases such as major depression and epilepsy. Newborn neurons go through distinct developmental steps, from a dividing neurogenic precursor to a synaptically integrated mature neuron. Previous studies have uncovered several molecular signaling pathways involved in distinct steps of this maturational process. In this context, the small Rho GTPases, Cdc42, Rac1, and RhoA have recently been shown to regulate the morphological and synaptic maturation of adult-born dentate granule cells in vivo. Distinct upstream regulators, including growth factors that modulate maturation and integration of newborn neurons have been shown to also recruit the small Rho GTPases. Here we review recent findings and highlight the possibility that small Rho GTPases may act as central assimilators, downstream of critical input onto adult-born hippocampal neurons contributing to their maturation and integration into the existing dentate gyrus (DG) circuitry.
Design for Test for MIPS Multi – cycle processor and Open SPARC T1 Processor
International Journal of Innovative Research in Computer and Communication Engineering , 2013,
Abstract: :The purpose of this paper is to understand the process of DFT to be performed on a particular design using the SYNOPSYS tool set. Verification of which can be done at the end by the count of number of DRC s (Design Rule Check) violations in the process.All the faults should be checked to get the fault free design based on the theoretical background available. The process is then followed on the SYNOPSYS tools for the removal of faults and also for the verification of the same.
Chimeric oncogenic interferon regulatory factor-2 (IRF-2): Degradation products are biologically active  [PDF]
Krishna Prakash, Pardeep Kumar, Pramod C. Rath
American Journal of Molecular Biology (AJMB) , 2012, DOI: 10.4236/ajmb.2012.24038
Abstract: Interferon Regulatory Factor-2 (IRF-2) belongs to IRF family, was identified as a mammalian transcription factor involved in Interferon beta (IFNβ) gene regulation. Besides that IRF-2 is involved in immunomodulation, hematopoietic differentiation, cell cycle regulation and oncogenesis. We have done molecular sub-cloning and expression of recombinant murine IRF-2 as GST (Glutathione-S-Transferase)- IRF-2 fusion protein in E. coli/XL-1blue cells. Recombinant IRF-2 with GST moiety at N-terminus expressed as GST-IRF-2 (~66 kd) in E. coli along with different low molecular mass degradation products revealed approximately 30, 42, 60 and 62 kd by SDS-PAGE and Western blot, respectively. We further confirm that degradation takes place at C-terminus of the fusion protein not at N-terminus as anti-GST antibody was detecting all bands in the immunoblot. The recombinant IRF-2 was biologically active along with their degradation products in terms of their DNA binding activity as assessed by Electrophoretically Mobility Shift Assay (EMSA). We observed three different molecular mass DNA/protein complexes (1 - 3) with Virus Response Element (VRE) derived from human Interferon IFNβ gene and five different molecular mass complexes (1 - 5) with IRF-E motif (GAAAGT)4 in EMSA gel. GST only expressed from empty vector did not bind to these DNA elements. To confirm that the binding is specific, all complexes were competed out completely when challenged with 100-X fold molar excess of IRF-E oligo under cold competition. It means degradation products along with full-length protein are able to interact with VREβ as well as IRF-E motif. This means degradation products may regulate the target gene (s) activation/repression via interacting with VRE/IRF-E.
Time Series Modeling of River Flow Using Wavelet Neural Networks  [PDF]
B. Krishna, Y. R. Satyaji Rao, P. C. Nayak
Journal of Water Resource and Protection (JWARP) , 2011, DOI: 10.4236/jwarp.2011.31006
Abstract: A new hybrid model which combines wavelets and Artificial Neural Network (ANN) called wavelet neural network (WNN) model was proposed in the current study and applied for time series modeling of river flow. The time series of daily river flow of the Malaprabha River basin (Karnataka state, India) were analyzed by the WNN model. The observed time series are decomposed into sub-series using discrete wavelet transform and then appropriate sub-series is used as inputs to the neural network for forecasting hydrological variables. The hybrid model (WNN) was compared with the standard ANN and AR models. The WNN model was able to provide a good fit with the observed data, especially the peak values during the testing period. The benchmark results from WNN model applications showed that the hybrid model produced better results in estimating the hydrograph properties than the latter models (ANN and AR).
Magnetic Properties of Ni-Zn Ferrites by Citrate Gel Method  [PDF]
K. Rama Krishna, K. Vijaya Kumar, C. Ravindernathgupta, Dachepalli Ravinder
Advances in Materials Physics and Chemistry (AMPC) , 2012, DOI: 10.4236/ampc.2012.23022
Abstract: Ni-Zn ferrite with a nominal composition of Ni1-xZnxFe2O4 (x = 0, 0.2, 0.6, 0.8, 0.9) are prepared by citrate gel method and characterized by X-ray diffraction. Magnetic properties of all samples are obtained by using VSM (Vibrating Sample Magnetometer) in the range of 10 Koe. The saturation magnetization values of the samples are carried out from the B-H loop. The effect of composition on saturation magnetization and magnetic moment are studied in this paper. The results showed that Saturation magnetization and magnetic moment values increases gradually as Zn2+ composition increases, it reaches maximum value 70.28 emu/gm for (x = 0.6) and decreases further with increasing Zn2+ composition.
Study of Stability Analysis for a Class of Fourth Order Boundary Value Problems  [PDF]
C. Bala Rama Krishna, P. S. Rama Chandra Rao
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.513182
Abstract: Fourth order differential equations are considered to develop the class of methods for the numerical solution of boundary value problems. In this paper, we have discussed the regions of absolute stability of fourth order boundary value problems. Methods proposed and derived in this paper are applied to solve a fourth-order boundary value problem. Numerical results are given to illustrate the efficiency of our methods and compared with exact solution.
Pheromones in Human Urine: A Study  [PDF]
K. P. Skandhan, S. Amith, H. Vadodaria, B. N. Mazumdar, K. Dhuri, M. Gondalia
Advances in Sexual Medicine (ASM) , 2013, DOI: 10.4236/asm.2013.32007

The present study was conducted to understand if pheromone or any similar substance was present in human semen and whether it could be recognized by smell. One hundred and fifty two subjects of either sex participated in this study. The study lasted for one month. They were to identify urine by smell. Daily first urine sample was submitted by five male and five female subjects for this study. Menstrual status of female subjects was recorded. Many distinguished the smell of urine of male from that of female. Interestingly male subjects recognized the smell of female urine of ovulation day. Reason may be pheromone. A woman may be releasing maximally pheromone on this day. This supports the theory of pheromone which attracts a man to a woman on her ovulation day.

Improving Landsat and IRS Image Classification: Evaluation of Unsupervised and Supervised Classification through Band Ratios and DEM in a Mountainous Landscape in Nepal
Krishna Bahadur K.C.
Remote Sensing , 2009, DOI: 10.3390/rs1041257
Abstract: Modification of the original bands and integration of ancillary data in digital image classification has been shown to improve land use land cover classification accuracy. There are not many studies demonstrating such techniques in the context of the mountains of Nepal. The objective of this study was to explore and evaluate the use of modified band and ancillary data in Landsat and IRS image classification, and to produce a land use land cover map of the Galaudu watershed of Nepal. Classification of land uses were explored using supervised and unsupervised classification for 12 feature sets containing the LandsatMSS, TM and IRS original bands, ratios, normalized difference vegetation index, principal components and a digital elevation model. Overall, the supervised classification method produced higher accuracy than the unsupervised approach. The result from the combination of bands ration 4/3, 5/4 and 5/7 ranked the highest in terms of accuracy (82.86%), while the combination of bands 2, 3 and 4 ranked the lowest (45.29%). Inclusion of DEM as a component band shows promising results.
Detection of excretory Entamoeba histolytica DNA in the urine, and detection of E. histolytica DNA and lectin antigen in the liver abscess pus for the diagnosis of amoebic liver abscess
Subhash C Parija, Krishna Khairnar
BMC Microbiology , 2007, DOI: 10.1186/1471-2180-7-41
Abstract: E. histolytica DNA was detected in liver abscess pus specimen of 80.4% of ALA patients by a nested multiplex polymerase chain reaction (PCR) targeting 16S-like r RNA gene. The nested PCR detected E. histolytica DNA in all 37 (100%) liver abscess pus specimens collected prior to metronidazole treatment, but were detected in only 53 of 75 (70.6%) pus specimens collected after therapy with metronidazole. Similarly, the PCR detected E. histolytica DNA in 21 of 53 (39.6%) urine specimens of ALA patients. The test detected E. histolytica DNA in only 4 of 23 (17.4%) urine specimens collected prior to metronidazole treatment, but were detected in 17 of 30 (56.7%) urine specimens collected after treatment with metronidazole. The enzyme-linked immunosorbent assay (ELISA) for the detection of lectin E. histolytica antigen in the liver abscess pus showed a sensitivity of 50% and the indirect haemagglutination (IHA) test for detection of amoebic antibodies in the serum showed a sensitivity of 76.8% for the diagnosis of the ALA.The present study for the first time shows that the kidney barrier in ALA patients is permeable to E. histolytica DNA molecule resulting in excretion of E. histolytica DNA in urine which can be detected by PCR. The study also shows that the PCR for detection of E. histolytica DNA in urine of patients with ALA can also be used as a prognostic marker to assess the course of the diseases following therapy by metronidazole. The detection of E. histolytica DNA in urine specimen of ALA patients provides a new approach for the diagnosis of ALA.Infection with Entamoeba histolytica, results in 34 million to 50 million symptomatic cases of amoebiasis worldwide each year, causing 40 to 100 thousand deaths annually [1]. Mortality from amoebiasis is mainly due to extra-intestinal pathology, of which amoebic liver abscess (ALA) is the most common. If left untreated, ALA can rupture into neighboring tissue and spread to the brain and other organs via hematological route
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