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Search Results: 1 - 10 of 401978 matches for " Kosti? Milo? M. "
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ROLE OF TH1 AND TH17 IMMUNE RESPONCES IN PATHOGENESIS OF MULTIPLE SCLEROSIS
MiloKosti
Acta Medica Medianae , 2010,
Abstract: Th17 cells are novel cell subpopulation of CD4 + T lymphocytes which dominantly produce proinflammatory cytokine IL-17. Since their discovery in 2003, Th17 cells have been in the focus of interest, because of the numerous data pointing out their crucial significance in pathogenesis of multiple sclerosis and other disorders earlier considered as classical Th1-mediated autoimmune disorders. It is demonstrated, on animal model of multiple sclerosis, also known as experimental autoimmune encephalomyelitis, that Th17 cells are the main mediators of inflammatory process in autoimmunity, since Th1 cells have protective role, which is in contrast to the current concept of multiple sclerosis. Th17 and Th1 cell relationship determine if inflammation initiation and forming of demyelinisation plaque will occur. Inflammation will take place, if relationship between Th17 and Th1 cells is higher than 1 because of disproportional enhanced secretion of IL-17, which is considered to be the main regulator of autoimmune processes in the central nervous system. Discovery of TGF-β and IL-6 involvement in proinflammatory Th17 cells development was also surprising, according to the fact that TGF-β, itself, has anti-inflammatory effects and induces the activation of FOXP3 transcription factor, essential for the generation of regulatory T lymphocytes, the cells important for immunosuppression, development and maintenance of immunotolerance. Functional antagonism and similar differentiation factors of Th17 cells and regulatory T cells are very interesting in the aspect of immunomodulation therapy of autoimmune disorders. The aforementioned discoveries have constructed a novel concept of pathogenic mechanisms involved in multiple sclerosis development, mediated mainly by Th17 cells. That questions our knowledge of drug effect mechanisms that we commonly use today, but also raises the possibility for novel therapeutic approaches.
Effects of operational parameters of process UV radiation/hydrogen peroxide on decolorization of anthraquinone textile dye
Radovi? Miljana D.,Mitrovi? Jelena Z.,Boji? Danijela V.,KostiMiloM.
Hemijska Industrija , 2012, DOI: 10.2298/hemind111108112r
Abstract: The photodegradation of textile dye Reactive Blue 19, an anionic anthraquinone dye of reactive class, was investigated using UV radiation in the presence of H2O2 in UV reactor with low-pressure mercury lamps, with maximum energy output at the wavelength 254 nm. The effects of experimental variables, namely initial pH, initial dye concentration and concentration of peroxide were studied. The change of concentration of RB19 was followed by UV/vis spectrophotometric measurement of absorbance at 592 nm. The increase of the initial pH resulted in the efficiency increase of dye decolorization. The total decolorization was achieved in about 15 min. Results show that with the increase of dye concentration from 10 to 100 mg dm-3 the efficiency of process decreases. With the increase of the initial concentration of H2O2 from 10 to 30 mmol dm-3, the decolorization rate constant increased from 0.083 to 0.120 min1, with the decrease of process rate at the concentrations above. The highest decolorization rates were achieved at peroxide concentration of approx. 30 mmol dm-3, above which decolorization was inhibited by scavenging effect of peroxide. This study shows that UV/H2O2 process is promising treatment for dye RB 19 degradation in water and wastewater.
Adrenocortical hypertension
Kosti? Nada,Milo?evi? Maja M.,Jeli? Svetlana D.,Ne?ovi? Milica
Medicinski Pregled , 2003, DOI: 10.2298/mpns0308346k
Abstract: Introduction Endocrine hypertension is almost exclusively adrenal hypertension which includes syndromes of mineralocorticoid, glucocorticoid and amine excess. Aldosteronism Although primary aldosteronism accounts for less than 1% of hypertensive population, it is the most common form of endocrine hypertension and the second most common form of curable hypertension. It is possible that load in type 2 diabetes mellitus and cardiovascular fibrosis is related to aldosteronism. Diagnosis of primary aldosteronism The conventional approach to low plasma potassium level in hypertensive patients suggests mineralocorticoid excess, whereas high aldosterone level and chronically suppressed plasma renin activity (PRA) are basic for the diagnosis of primary aldosteronism. However, recent studies use the ratio of plasma aldosterone to plasma renin activity (ARR) in plasma. Differential diagnosis Differential diagnosis between idiopathic aldosteronism (IHA) and aldosterone-producing adenoma (APA) can be performed using postural testing, 18-hydro-xycorticosterone levels, adrenal computed tomograms, iodocholesterol scans and adrenal venous sampling. Glucocorticoid hypertension However, association between glucocorticoid excess and hypertension is complex and still poorly understood. Hypothesized mechanisms include: increased hepatic angiotensinogen synthesis, inhibition of vasodilator and stimulation of vasoconstrictor systems in vascular tissue, enhanced glucocorticoid-mediated vascular reactivity to noradrenaline, shifting of sodium and fluid from intracellular to extracellular compartment, and increase of local endothelial growth factor activity.
LED facades in urbarchitecture
Ceki? Nikola,Da?i? Milo,Kosti? Aleksandra
Facta Universitatis Series : Architecture and Civil Engineering , 2012, DOI: 10.2298/fuace1201033c
Abstract: Rapid development of electronic technologies at the beginning of this century resulted in intensive changes in urbarchitectonic formation of fa ade planes and physical structures. Advent of LED lights and LED panels made possible that the physical structures in urban agglomerations worldwide, old or new, have opened a new chapter for strategic urbarchitectonic design and different cultural illumination diversity of houses in space. The user relationship towards activities in physical environment, exterior and interior has been changed, and new visual-esthetic living style has been established, a new and more dynamic form of social communication behavior towards the identity of a place and total evaluation of environment characteristics. A new orientation in ivisual and functional creation of urbarchitectonic forms was born, in redefining of a concept of culture of walls, culture of house facades and in general of facade planes, whose life is active not only during daytime by around the clock. [Projekat Ministarstva nauke Republike Srbije, br. 36037: Construction of Student hostels in Serbia at the beginning of 21st century]
Casual and ambulatory blood pressure monitoring in children with renal scarring
Milo?evski Gordana,Kosti? Mirjana,Babi? Dragan,Jovanovi? Olga
Srpski Arhiv za Celokupno Lekarstvo , 2005, DOI: 10.2298/sarh0510417m
Abstract: INTRODUCTION Renal scarring is the most common cause of arterial hypertension in children. High blood pressure (BP) and microalbuminuria contribute to the progression of chronic renal disease. OBJECTIVE The aims of the study were: to assess BP in children with renal scarring by continuous ambulatory blood pressure measurement (ABPM) in comparison to the casual method (CBP), and to determine the correlation between ambulatory blood pressure (ABP) and/or casual blood pressure (CBP) values and proteinuria in children with renal scarring. METHOD This forward-looking study comprised thirty-five children (26 girls and 9 boys), aged between 3-13 years, 10.4±3.9, X+SD. Blood pressure was measured using the casual method (CBP) with a mercury manometer; BP was measured three times and the average was taken as a referent value. ABPM was performed using the oscillometric method with the Space Labs device, model 90207. RESULTS 45.71% of patients were classified as hypertensive by ABPM, while only 22.6% of CBP measurements were above the 95th percentile (p<0.01). "White coat hypertension" was present in 40% of the patients. Non-dipping BP alteration was detected in 37.14% of the patients. CONCLUSION Nocturnal systolic hypertension (systolic non-dipping alteration) is very frequent in children with renal scarring. Nocturnal diastolic blood pressure, detectable only via ABPM, is positively correlated with proteinuria and may be an initial sign of the progression of renal scarring. ABPM is more sensitive than CBP in the evaluation of BP in children with renal scarring.
Control of prehension for the transradial prosthesis: Natural-like image recognition system
Klisi? ?or?e,KostiMilo,Do?en Strahinja,Popovi? Dejan B.
Journal of Automatic Control , 2009, DOI: 10.2298/jac0901027k
Abstract: We describe the hardware and software for the control of prehension for a dexterous transradial prosthesis. The prehension process comprises hand orientation (three degrees of freedom) and the opening of the hand in a manner that is appropriate for the shape and size of the object. The hardware consists of a standard web camera, accelerometer, ultrasound distance sensor, laser pointer and an LED illumination system. Software operating in real time estimates the shape and size of the object as well as the relative orientation of the hand with respect to the object. Based on this data, the controller generates signals that are sent to the three-dimensional (3D) wrist rotator, and drives which control fingers and thumb of the transradial prosthesis, thereby preparing the hand for palmar, lateral, or precision (2-digit or 3-digit) grasps. The choice of the grasp follows heuristics captured from healthy humans when grasping and expressed in the form of IF-THEN rules.
Convoluted $C$-cosine functions and semigroups. Relations with ultradistribution and hyperfunction sines
M. Kosti,S. Pilipovi?
Mathematics , 2007, DOI: 10.1016/j.jmaa.2007.05.083
Abstract: Convoluted $C$-cosine functions and semigroups in a Banach space setting extending the classes of fractionally integrated $C$-cosine functions and semigroups are systematically analyzed. Structural properties of such operator families are obtained. Relations between convoluted $C$-cosine functions and analytic convoluted $C$-semigroups, introduced and investigated in this paper are given through the convoluted version of the abstract Weierstrass formula which is also proved in the paper. Ultradistribution and hyperfunction sines are connected with analytic convoluted semigroups and ultradistribution semigroups. Several examples of operators generating convoluted cosine functions, (analytic) convoluted semigroups as well as hyperfunction and ultradistribution sines illustrate the abstract approach of the authors. As an application, it is proved that the polyharmonic operator $(-\Delta)^{2^{n}},$ $n\in {\mathbb N},$ acting on $L^{2}[0,\pi]$ with appropriate boundary conditions, generates an exponentially bounded $K_{n}$-convoluted cosine function, and consequently, an exponentially bounded analytic $K_{n+1}$-convoluted semigroup of angle $\frac{\pi}{2},$ for suitable exponentially bounded kernels $K_{n} $ and $K_{n+1}.$
Cognitive vision system for control of dexterous prosthetic hands: Experimental evaluation
Strahinja Do?en, Christian Cipriani, MiloKosti, Marco Controzzi, Maria C Carrozza, Dejan B Popovi?
Journal of NeuroEngineering and Rehabilitation , 2010, DOI: 10.1186/1743-0003-7-42
Abstract: The central component of the proposed method is an autonomous controller comprising a vision system with rule-based reasoning mounted on a dexterous hand (CyberHand). The controller, termed cognitive vision system (CVS), mimics biological control and generates commands for prehension. The CVS was integrated into a hierarchical control structure: 1) the user triggers the system and controls the orientation of the hand; 2) a high-level controller automatically selects the grasp type and size; and 3) an embedded hand controller implements the selected grasp using closed-loop position/force control. The operation of the control system was tested in 13 healthy subjects who used Cyberhand, attached to the forearm, to grasp and transport 18 objects placed at two different distances.The system correctly estimated grasp type and size (nine commands in total) in about 84% of the trials. In an additional 6% of the trials, the grasp type and/or size were different from the optimal ones, but they were still good enough for the grasp to be successful. If the control task was simplified by decreasing the number of possible commands, the classification accuracy increased (e.g., 93% for guessing the grasp type only).The original outcome of this research is a novel controller empowered by vision and reasoning and capable of high-level analysis (i.e., determining object properties) and autonomous decision making (i.e., selecting the grasp type and size). The automatic control eases the burden from the user and, as a result, the user can concentrate on what he/she does, not on how he/she should do it. The tests showed that the performance of the controller was satisfactory and that the users were able to operate the system with minimal prior training.Most commercially available hand prostheses are simple one degree-of-freedom grippers [1,2] in which one motor drives the index and middle fingers synchronously with the thumb. The remaining fingers serve aesthetic purposes and move passiv
The preoperative assessment of patients with valvular heart disease as a comorbidity
Markovi? Dejan,Jankovi? Radmilo,Kova?evi?-Kosti? Nata?a,Velinovi? Milo
Acta Chirurgica Iugoslavica , 2011, DOI: 10.2298/aci1102031m
Abstract: In patients with valvular heart disease planned for any type of surgery preoperative evaluation and preparation are especially important for a successfull outcome of the surgery. Preoperative preparation and intraoperative treatment of patients with valvular heart disease are different depending on the type of valvular disease: aortic stenosis, aortic regurgitation, mitral stenosis, mitral regurgitation or mitral valve prolapse. In this paper we have outlined the criteria for evaluating the severity of valvular disease, given that the risk in surgery is proportional to the degree of valvular disease. Also, given that the risk in surgery is also directly proportional to the type and extent of non cardiac surgery, it will be presented recommendations for intraoperative monitoring, with the purpose of evaluating patient’s hemodynamic state, as well as recommendations for perioperative treatment of hypotension, tachycardia, and other hemodynamic disturbances. In the paper we will separately discuss bacterial endocarditis profilaxys which can occur after the surgery of patients with valvular disease. Since the patients with valvular disease, and especially the ones with implanted prosthetic valve or heart arrhythmia, are usually on oral anticoagulation therapy, it will be given recommendations for treatment of patients on oral anticoagulation therapy as part of preoperative preparations.
Effects of the family-school cooperation on student social behavior and academic achievement
Milo?evi? Nikoleta M.
Zbornik Instituta za Pedago?ka Istra?ivanja , 2002, DOI: 10.2298/zipi0204193m
Abstract: Cooperation between a family and school makes provisions for solving problems students face in their interpersonal relations and academic achievement. We are singling out a view of the effects of a micro-system on child's development, which states that immediate interrelations in a micro-system - a family - can effect interrelations in another micro-system -peer groups - or can effect academic achievement. The majority of authors agree that modes and spheres of influences that family exerts are numerous and diverse and that they depend on characteristics of a broader social and cultural community where a child is growing up as well as on parents' abilities and preparations. How successful the family-school cooperation will be is largely determined by teacher's personality and the way he/she is communicating with parents. A joint planning and implementation of decisions reached, identical norms of behavior, commonly adopted goals are a prerequisite for a child's normal development. It is pointed out that school should plan and organize its activities (courses, seminars, forums lectures, discussions), so as to popularize knowledge of pedagogy and psychology among parents as well as teacher training in communication competence.
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