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Search Results: 1 - 10 of 117840 matches for " Kosoglou T "
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Comparison of the systemic bioavailability of mometasone furoate after oral inhalation from a mometasone furoate/formoterol fumarate metered-dose inhaler versus a mometasone furoate dry-powder inhaler in patients with chronic obstructive pulmonary disease
Kosoglou T,Hubbell J,Xuan F,Cutler DL
International Journal of COPD , 2013,
Abstract: Teddy Kosoglou,1 James Hubbell,2 Fengjuan Xuan,3 David L Cutler,1 Alan G Meehan,4 Bhavna Kantesaria,5 Bret A Wittmer6, 1Clinical Pharmacology, 2Exploratory Drug Metabolism, 3Early Development Statistics, 4Medical Communications, 5Drug Metabolism/Pharmacokinetics, Merck Sharp & Dohme Corp, Whitehouse Station, NJ, USA; 6Commonwealth Biomedical Research, LLC, Madisonville, KY, USA Dr Bret A Wittmer passed away on May 9, 2012.Background: Coadministration of mometasone furoate (MF) and formoterol fumarate (F) produces additive effects for improving symptoms and lung function and reduces exacerbations in patients with asthma and chronic obstructive pulmonary disease (COPD). The present study assessed the relative systemic exposure to MF and characterized the pharmacokinetics of MF and formoterol in patients with COPD.Methods: This was a single-center, randomized, open-label, multiple-dose, three-period, three-treatment crossover study. The following three treatments were self-administered by patients (n = 14) with moderate-to-severe COPD: MF 400 μg/F 10 μg via a metered-dose inhaler (MF/F MDI; DULERA /ZENHALE ) without a spacer device, MF/F MDI with a spacer, or MF 400 μg via a dry-powder inhaler (DPI; ASMANEX TWISTHALER ) twice daily for 5 days. Plasma samples for MF and formoterol assay were obtained predose and at prespecified time points after the last (morning) dose on day 5 of each period of the crossover. The geometric mean ratio (GMR) as a percent and the corresponding 90% confidence intervals (CI) were calculated for treatment comparisons.Results: Systemic MF exposure was lower (GMR 77%; 90% CI 58, 102) following administration by MF/F MDI compared to MF DPI. Additionally, least squares geometric mean systemic exposures of MF and formoterol were lower (GMR 72%; 90% CI 61, 84) and (GMR 62%; 90% CI 52, 74), respectively, following administration by MF/F MDI in conjunction with a spacer compared to MF/F MDI without a spacer. MF/F MDI had a similar adverse experience profile as that seen with MF DPI. All adverse experiences were either mild or moderate in severity; no serious adverse experience was reported.Conclusion: Systemic MF exposures were lower following administration by MF/F MDI compared with MF DPI. Additionally, systemic MF and formoterol exposures were lower following administration by MF/F MDI with a spacer versus without a spacer. The magnitude of these differences with respect to systemic exposure was not clinically relevant.Keywords: mometasone furoate, chronic obstructive pulmonary disease, pharmacokinetics, systemic exposure, metered-
Comparison of the systemic bioavailability of mometasone furoate after oral inhalation from a mometasone furoate/formoterol fumarate metered-dose inhaler versus a mometasone furoate dry-powder inhaler in patients with chronic obstructive pulmonary disease
Kosoglou T, Hubbell J, Xuan F, Cutler DL, Meehan AG, Kantesaria B, Wittmer BA
International Journal of Chronic Obstructive Pulmonary Disease , 2013, DOI: http://dx.doi.org/10.2147/COPD.S36592
Abstract: mparison of the systemic bioavailability of mometasone furoate after oral inhalation from a mometasone furoate/formoterol fumarate metered-dose inhaler versus a mometasone furoate dry-powder inhaler in patients with chronic obstructive pulmonary disease Original Research (421) Total Article Views Authors: Kosoglou T, Hubbell J, Xuan F, Cutler DL, Meehan AG, Kantesaria B, Wittmer BA Published Date March 2013 Volume 2013:8 Pages 107 - 116 DOI: http://dx.doi.org/10.2147/COPD.S36592 Received: 01 August 2012 Accepted: 12 September 2012 Published: 07 March 2013 Teddy Kosoglou,1 James Hubbell,2 Fengjuan Xuan,3 David L Cutler,1 Alan G Meehan,4 Bhavna Kantesaria,5 Bret A Wittmer6, 1Clinical Pharmacology, 2Exploratory Drug Metabolism, 3Early Development Statistics, 4Medical Communications, 5Drug Metabolism/Pharmacokinetics, Merck Sharp & Dohme Corp, Whitehouse Station, NJ, USA; 6Commonwealth Biomedical Research, LLC, Madisonville, KY, USA Dr Bret A Wittmer passed away on May 9, 2012. Background: Coadministration of mometasone furoate (MF) and formoterol fumarate (F) produces additive effects for improving symptoms and lung function and reduces exacerbations in patients with asthma and chronic obstructive pulmonary disease (COPD). The present study assessed the relative systemic exposure to MF and characterized the pharmacokinetics of MF and formoterol in patients with COPD. Methods: This was a single-center, randomized, open-label, multiple-dose, three-period, three-treatment crossover study. The following three treatments were self-administered by patients (n = 14) with moderate-to-severe COPD: MF 400 μg/F 10 μg via a metered-dose inhaler (MF/F MDI; DULERA /ZENHALE ) without a spacer device, MF/F MDI with a spacer, or MF 400 μg via a dry-powder inhaler (DPI; ASMANEX TWISTHALER ) twice daily for 5 days. Plasma samples for MF and formoterol assay were obtained predose and at prespecified time points after the last (morning) dose on day 5 of each period of the crossover. The geometric mean ratio (GMR) as a percent and the corresponding 90% confidence intervals (CI) were calculated for treatment comparisons. Results: Systemic MF exposure was lower (GMR 77%; 90% CI 58, 102) following administration by MF/F MDI compared to MF DPI. Additionally, least squares geometric mean systemic exposures of MF and formoterol were lower (GMR 72%; 90% CI 61, 84) and (GMR 62%; 90% CI 52, 74), respectively, following administration by MF/F MDI in conjunction with a spacer compared to MF/F MDI without a spacer. MF/F MDI had a similar adverse experience profile as that seen with MF DPI. All adverse experiences were either mild or moderate in severity; no serious adverse experience was reported. Conclusion: Systemic MF exposures were lower following administration by MF/F MDI compared with MF DPI. Additionally, systemic MF and formoterol exposures were lower following administration by MF/F MDI with a spacer versus without a spacer. The magnitude of these differences with respe
REGULARYFRAMWORK AND LEGAL BASE OF ELECTRONIC DOCUMENT CIRCULATION НОРМАТИВНО-ПРАВОВА БАЗА ЕЛЕКТРОННОГО ДОКУМЕНТООБ ГУ
T.Г. Омельченко,Н.А. Джанджгава
Information Technologies and Learning Tools , 2010,
Abstract: The general characteristic of legal base of electronic document circulation is presented in the article. It legislatively regulates the relations which connected with the information and information communication technologies. There is presented the list of the basic acts of regulation of sphere of information relations. У робот подано загальну характеристику нормативно-правово бази, яка законодавчо регулю в дносини, пов'язан з нформац ю, нформац йно-комун кац йними технолог ями, представлено перел к основних законодавчих акт в регулювання сфери нформац йних в дносин.
THE APPROACH OF COMPETENCE AT THE STUDY OF MATHEMATICAL INFORMATICS IN A PEDAGOGICAL UNIVERSITY КОМПЕТЕНТН СНИЙ П ДХ Д ПРИ ВИВЧЕНН МАТЕМАТИЧНО НФОРМАТИКИ” У ПЕДАГОГ ЧНОМУ УН ВЕРСИТЕТ
T.П. Кобильник
Information Technologies and Learning Tools , 2010,
Abstract: In the paper the approach of competence at the study of mathematical informatics in a pedagogical university is considered. The special attention is paid to forming of professional pedagogical and educational-cognitive competences. The example of tasks on which formed a competence at the study of mathematical informatics is resulted. У статт розглянуто компетентн сний п дх д при вивченн математично нформатики у педагог чному ун верситет . Особливу увагу звернено на формування профес йно педагог чно та навчально-п знавальну компетентност . Наведено приклад завдань, як сприяють формуванню компетентностей при вивченн математично нформатики.
SYSTEM OF THE AUTOMATIC DOCUMENT PROCESSING IN SHELL OF BASE SOFTWARE СИСТЕМА АВТОМАТИЗОВАНОГО ДОКУМЕНТООБ ГУ В ОБОЛОНЦ БАЗОВОГО ПРОГРАМНОГО ЗАБЕЗПЕЧЕННЯ
В.Ю. Биков,T.О. Дерба
Information Technologies and Learning Tools , 2010,
Abstract: In the article the automatic system of the document processing, created with use of Microsoft Access – a component part of Microsoft Office is offered. This system can be used at school and Institutions of education with one computer or with system of 15 ones connecting in the local net. У статт запропоновано для ознайомлення автоматизовану систему документооб гу, створену з використанням Microsoft Access – складово частини Microsoft Office. Ця система може використовуватися в школах установах осв тньо галуз на одному комп’ютер чи на систем до 15 комп’ютер в, пов’язаних локальною мережею.
MODERN APPROACHES AND PRINCIPLES OF PORTAL BUILDING ТЕХНОЛОГ ЧН ОСНОВИ СТВОРЕННЯ ТА П ДТРИМКИ ПОРТАЛ В
Н.Т. Задорожна,T.Г. Омельченко
Information Technologies and Learning Tools , 2010,
Abstract: The paper presents the analysis of modern state of development and use of Internet portals, the peculiarities of approaches to creation and introduction of portals in educational system are described. В робот анал зуються принципи розробки та використання нтернет-портал в, описуються особливост п дход в до створення та впровадження портал в у систему осв ти.
REVIEW OF MODERN TOOLS OF INFORMATION AND COMMUNICATION TECHNOLOGIES IN THE MANAGEMENT OF SECONDARY EDUCATION ОГЛЯД СУЧАСНИХ ЗАСОБ В НФОРМАЦ ЙНО-КОМУН КАЦ ЙНИХ ТЕХНОЛОГ Й В УПРАВЛ НН СЕРЕДНЬОЮ ОСВ ТОЮ
T.О. Дерба
Information Technologies and Learning Tools , 2010,
Abstract: There are presented the up-to-date situation with information and communication technology use in the management of secondary education; information and communication technologies (ICT), that practically used in educational establishments are considered. There are some examples of educational institutions using IСT for the automation of management. У статт показаний зр з сучасного стану використання нформац йно-комун кац йних технолог й в управл нн середньою осв тою, розглянут нформац йно-комун кац йн технолог ( КТ), як на практиц використовуються в загальноосв тн х закладах, наведен в дгуки навчальних заклад в, як використовують КТ для автоматизац управл ння
EVALUATION OF INTEGRALS OF FUNCTIONS OF COMPLEX VARIABLE BY USING THE RESIDUES IN COMPUTER MATHEMATICS SYSTEMS ОБЧИСЛЕННЯ НТЕГРАЛ В В Д ФУНКЦ Й КОМПЛЕКСНО ЗМ ННО ЗА ДОПОМОГОЮ ЗАЛИШК В В СИСТЕМАХ КОМП’ЮТЕРНО МАТЕМАТИКИ
Н.Д. Парфьонова,T.В. Клочко
Information Technologies and Learning Tools , 2010,
Abstract: The article describes the methodology of teaching one of the major topics of the course of complex analysis using the system Maple. It also demonstrates how the use of computer mathematics systems facilitates the evaluation of students by the teacher during organization of independent work. В статт наведено методику викладання мабуть одн з найважлив ших тем курсу комплексного анал зу з використанням системи Maple; демонстру ться, як використання систем комп’ютерно математики полегшу викладачев оц нювання роботи студент в та при орган зац х самост йно роботи.
USE OF VEB 2.0 SOCIAL SERVICES FOR PLANNING OF INFORMATIVE SYSTEMS ВИКОРИСТАННЯ СОЦ АЛЬНИХ СЕРВ С В ВЕБ 2.0 ДЛЯ ПРОЕКТУВАННЯ НФОРМАЦ ЙНИХ СИСТЕМ
T.Г. Омельченко
Information Technologies and Learning Tools , 2010,
Abstract: In the article the definitions and the characteristic of Web 2.0 social networks and services are presented as well as tendencies of their development, approaches of use of Web 2.0 social services and technologies in information systems are considered and analyzed. Requirements to technological maintenance of information system “Planning of scientific researches in NPA of Ukraine” are analyzed. В робот представлен визначення характеристика соц альних мереж послуг Веб 2.0 та тенденц хнього розвитку, розглянуто проанал зовано напрямки використання соц альних послуг та технолог й Веб 2.0 в нформац йних системах. Проанал зовано вимоги до технолог чного забезпечення нформац йно системи “Планування наукових досл джень в АПН Укра ни”.
In memoriam: Люба Огненова-Маринова (1922–2012)
Tотко Стоянов
Bulgarian e-Journal of Archaeology , 2012,
Abstract: In memoriam: Luba Ognenova-Marinova (1922–2012)Totko Stoyanov
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