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Search Results: 1 - 10 of 168992 matches for " Konstantinos E. Nikolaou "
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Neurotrophin-3 and FLT3 Tyrosine Kinase Receptor in Perinatal Life
Ariadne Malamitsi-Puchner,Emmanouel Economou,Theodora Boutsikou,Konstantinos E. Nikolaou,Nikolaos Vrachnis
Mediators of Inflammation , 2005, DOI: 10.1155/mi.2005.53
Abstract: Our aim is to determine—in 30 healthy full-term infants and their mothers—circulating levels of neurotrophin-3 (NT-3) (important for antenatal and postnatal brain development and implicated in the immune response) and FLT3 tyrosine kinase receptor (FLT3) (controlling hematopoiesis and found in the nervous tissue), in the fetal and neonatal life. NT-3 levels, in contrast to FLT3 ones, increased significantly on the fourth postnatal day in relation to the low levels found in the mother, fetus, and day 1 neonate (P=.03, respectively). Maternal and umbilical NT3 levels positively correlated with respective FLT3 levels (P=.003 and P=.03). Circulating NT-3 levels increased in early neonatal life, possibly due to exposure to various stimuli soon after birth. FLT3 levels do not seem to behave accordingly, although these two substances probably synergize.
Necrotizing Fasciitis Complicating Pregnancy: A Case Report and Literature Review
Marinos Nikolaou,Petros Zampakis,Vasiliki Vervita,Konstantinos Almaloglou,Georgios Adonakis,Markos Marangos,Georgios Decavalas
Case Reports in Obstetrics and Gynecology , 2014, DOI: 10.1155/2014/505410
Abstract: Necrotizing fasciitis is a rare, life-threatening surgical infection in pregnancy with high rates of morbidity and mortality. A 15-year-old primigravid woman, at 28?weeks of gestation with no significant previous medical history, was admitted to our hospital complaining of severe left lower extremity pain and high fever the last 72?hours. During clinical examination, she had a swollen, erythematous and tender to palpation inflamed skin over the medial aspect of the upper thigh without any evidence of injury. Incision drainage was performed immediately and she received broad spectrum antibiotics. During initial laboratory examinations, diabetes mellitus was diagnosed. There was no clinical improvement over the following days. Magnetic resonance imaging (MRI) revealed subcutaneous tissue inflammation and edema of infected tissues confirming the disease entity. Multidisciplinary therapy with immediate aggressive surgical debridement of necrotic tissues, multiple antibiotics, and intensive care monitoring was performed successfully. The patient’s postoperative course was uncomplicated and skin defect was closed with split thickness skin grafting. Our case emphasized the potential immunosuppressive role of pregnancy state in conjunction with diabetes mellitus in the development of severe necrotizing soft tissue infections. 1. Introduction Necrotizing fasciitis (NF) is a rare life-threatening invasive soft tissue infection which is characterized by widespread necrosis of subcutaneous tissue, superficial fascia, and other adjacent tissue [1]. It is a surgical emergency with reported overall high mortality rate among patients with NF up to 76% [2]. It primarily involves the subcutaneous tissue and rapidly extends along superficial fascia planes [3]. Management of NF is based on early, aggressive surgical debridement of necrotic tissues, broad spectrum antibiotics, and intensive supportive care [3, 4]. Numerous aerobic and anaerobic pathogens are synergistically implicated in the pathogenesis of disease [1, 5]. NF occurs mainly in patients with predisposing factors such as diabetes mellitus, obesity, peripheral vascular disease, and immune system impairment or following a variety of injuries and surgical procedures which result in skin integrity interruption and rarely from hematogenous spread [2, 5]. Pregnancy is responsible for an immunosuppressive state, which may contribute to the development of severe necrotic soft tissue infections [6, 7]. Previous studies have showed that NF in pregnancy is rare and usually is characterized by acute onset and rapid
Insulin-Like Growth Factor 1 Receptor (IGF1R) Expression and Survival in Operable Squamous-Cell Laryngeal Cancer
Giannis Mountzios, Ioannis Kostopoulos, Vassiliki Kotoula, Ioanna Sfakianaki, Elena Fountzilas, Konstantinos Markou, Ilias Karasmanis, Sofia Leva, Nikolaos Angouridakis, Konstantinos Vlachtsis, Angelos Nikolaou, Ioannis Konstantinidis, George Fountzilas
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0054048
Abstract: Introduction Prognosis of patients with operable laryngeal cancer is highly variable and therefore potent prognostic biomarkers are warranted. The insulin-like growth factor receptor (IGFR) signaling pathway plays a critical role in laryngeal carcinogenesis and progression. Patients and Methods We identified all patients with localized TNM stage I–III laryngeal cancer managed with potentially curative surgery between 1985 and 2008. Immunohistochemical (IHC) expression of IGF1R-alpha, IGF1R-beta and IGF2R was evaluated using the immunoreactive score (IRS) and mRNA levels of important effectors of the IGFR pathway were assessed, including IGF1R, IGF-binding protein 3 (IGFBP3), suppressor of cytokine signaling 2 (SOCS2) and members of the MAP-kinase (MAP2K1, MAPK9) and phosphatidyl-inositol-3 kinase (PIK3CA, PIK3R1) families. Cox-regression models were applied to assess the predictive value of biomarkers on disease-free survival (DFS) and overall survival (OS). Results Among 289 eligible patients, 95.2% were current or ex smokers, 75.4% were alcohol abusers, 15.6% had node-positive disease and 32.2% had received post-operative irradiation. After a median follow-up of 74.5 months, median DFS was 94.5 months and median OS was 106.3 months. Using the median IRS as the pre-defined cut-off, patients whose tumors had increased IGF1R-alpha cytoplasm or membrane expression experienced marginally shorter DFS and significantly shorter OS compared to those whose tumors had low IGF1R-alpha expression (91.1 vs 106.2 months, p = 0.0538 and 100.3 vs 118.6 months, p = 0.0157, respectively). Increased mRNA levels of MAPK9 were associated with prolonged DFS (p = 0.0655) and OS (p = 0.0344). In multivariate analysis, IGF1R-alpha overexpression was associated with a 46.6% increase in the probability for relapse (p = 0.0374). Independent predictors for poor OS included node-positive disease (HR = 2.569, p<0.0001), subglottic/transglottic localization (HR = 1.756, p = 0.0438) and IGF1R-alpha protein overexpression (HR = 1.475, p = 0.0504). Conclusion IGF1R-alpha protein overexpression may serve as an independent predictor of relapse and survival in operable laryngeal cancer. Prospective evaluation of the IGF1R-alpha prognostic utility is warranted.
Chronic Idiopathic Neutrophilia in A Smoker, Relieved after Smoking Cessation with the Use of Electronic Cigarette: a Case Report
Konstantinos E. Farsalinos and Giorgio Romagna
Clinical Medicine Insights: Case Reports , 2012, DOI: 10.4137/CCRep.S11175
Abstract: Introduction: Smoking is a major risk factor for a variety of diseases. Electronic cigarettes are battery-operated devices that deliver nicotine to the lungs by evaporation of a liquid. Chronic idiopathic neutrophilia is a condition characterized by elevated white blood cell and neutrophil counts without any underlying disease; smoking has been implicated as a potential cause. Case Presentation: A male Caucasian patient, born in 1977, presented in September 2005 with asymptomatic elevation of white blood cell and neutrophil count, and mildly-elevated C-reactive protein levels. He was a smoker since 1996 and was treated with 20 mg/day of simvastatin since 2003 due to hyperlipidemia. Clinical examination, and laboratory and imaging investigations ruled out any infectious, haematological, rheumatological, or endocrine conditions. He was followed-up regularly and was advised to stop smoking. He had 2 unsuccessful attempts to quit smoking; one was unassisted and the second was performed with the use of both varenicline and nicotine replacement therapy (patches). During the subsequent 6.5 years, his leukocyte and C-reactive protein levels were repeatedly elevated; the condition was consistent with chronic idiopathic neutrophilia. In February 2012, he started using electronic cigarettes and he managed to quit smoking within 10 days. After 6 months, laboratory examination showed normalized leukocyte count and C-reactive protein levels, confirmed immediately by a second laboratory and by repeated tests after 1 and 2 months. Conclusion: Smoking cessation with the use of electronic cigarette led to reversal of chronic idiopathic neutrophilia. The daily use of electronic cigarette may help preserve the beneficial effects of smoking cessation.
Chronic Idiopathic Neutrophilia in A Smoker, Relieved after Smoking Cessation with the Use of Electronic Cigarette: a Case Report
Konstantinos E. Farsalinos,Giorgio Romagna
Clinical Medicine Insights: Case Reports , 2013,
Connection between Telomerase Activity in PBMC and Markers of Inflammation and Endothelial Dysfunction in Patients with Metabolic Syndrome
Elias Rentoukas, Konstantinos Tsarouhas, Ioannis Kaplanis, Eleni Korou, Maria Nikolaou, George Marathonitis, Stavroula Kokkinou, Alexander Haliassos, Avgi Mamalaki, Demetrios Kouretas, Christina Tsitsimpikou
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035739
Abstract: Metabolic syndrome (MS) is a constellation of metabolic derangements associated with vascular endothelial dysfunction and oxidative stress and is widely regarded as an inflammatory condition, accompanied by an increased risk for cardiovascular disease. The present study tried to investigate the implications of telomerase activity with inflammation and impaired endothelial function in patients with metabolic syndrome. Telomerase activity in circulating peripheral blood mononuclear cells (PBMC), TNF-α, IL-6 and ADMA were monitored in 39 patients with MS and 20 age and sex-matched healthy volunteers. Telomerase activity in PBMC, TNF-α, IL-6 and ADMA were all significantly elevated in patients with MS compared to healthy volunteers. PBMC telomerase was negatively correlated with HDL and positively correlated with ADMA, while no association between TNF-α and IL-6 was observed. IL-6 was increasing with increasing systolic pressure both in the patients with MS and in the healthy volunteers, while smoking and diabetes were positively correlated with IL-6 only in the patients' group. In conclusion, in patients with MS characterised by a strong dyslipidemic profile and low diabetes prevalence, significant telomerase activity was detected in circulating PBMC, along with elevated markers of inflammation and endothelial dysfunction. These findings suggest a prolonged activity of inflammatory cells in the studied state of this metabolic disorder that could represent a contributory pathway in the pathogenesis of atherosclerosis.
Increased plasma homocysteine levels in patients with multiple sclerosis and depression
Nikolaos Triantafyllou, Maria-Eleftheria Evangelopoulos, Vasilios K Kimiskidis, Evangelia Kararizou, Fotini Boufidou, Konstantinos N Fountoulakis, Melina Siamouli, Chrysoula Nikolaou, Constantinos Sfagos, Nikolaos Vlaikidis, Dimitrios Vassilopoulos
Annals of General Psychiatry , 2008, DOI: 10.1186/1744-859x-7-17
Abstract: Plasma homocysteine (Hcy), vitamin B12 and plasma folate were measured in 65 moderately disabled patients with relapsing/remitting MS (RR-MS) and 60 healthy controls. All subjects were assessed with the Beck Depression Inventory (BDI).Hcy levels were significantly increased in MS patients compared to controls (13.5 ± 4.7 μmol/l vs 8.5 ± 3.1, p < 0.001). A significant correlation was found between Hcy levels and BDI scores (Pearson r = 0.3025, p < 0.05). Plasma Hcy was not related to Extended Disability Status Scale (EDSS) score, age, disease duration or vitamin B12 and folate.Moderately disabled MS patients with elevated Hcy levels are particularly prone to develop depressive symptomatology. Further study is warranted in order to elucidate the prognostic and therapeutic implications of this novel finding.Homocysteine is a non-essential sulfur-containing amino acid derived from methionine by demethylation. Vitamins B12 and B6 as well as folate play an important role in the metabolic pathway of homocysteine [1]. A number of recent studies support the notion that homocysteine might cause neuronal damage by triggering oxidative injury and DNA damage [2-5]. As a result, homocysteine has been implicated in the pathogenesis of numerous neurodegenerative and psychiatric disorders [1].Amongst neurological conditions, multiple sclerosis (MS) has been extensively investigated with regard to homocysteine metabolism, with conflicting results. Some studies demonstrated elevated plasma homocysteine (Hcy) levels in MS patients with [6,7] or without B12 deficiency [8,9]. By contrast, a single report found no difference in Hcy levels between MS patients and controls [10].With regard to psychiatric disorders, depression has been linked in particular to increased Hcy plasma levels in the context of altered methylation reactions [11-13]. No study, however, has attempted to address these two issues jointly; that is, to investigate plasma homocysteine levels in patients with MS and depres
Identification and Validation of a Multigene Predictor of Recurrence in Primary Laryngeal Cancer
Elena Fountzilas, Vassiliki Kotoula, Nikolaos Angouridakis, Ilias Karasmanis, Ralph M. Wirtz, Anastasia G. Eleftheraki, Elke Veltrup, Konstantinos Markou, Angelos Nikolaou, Dimitrios Pectasides, George Fountzilas
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070429
Abstract: Purpose Local recurrence is the major manifestation of treatment failure in patients with operable laryngeal carcinoma. Established clinicopathological factors cannot sufficiently predict patients that are likely to recur after treatment. Additional tools are therefore required to accurately identify patients at high risk for recurrence. This study attempts to identify and independently validate gene expression models, prognostic of disease-free survival (DFS) in operable laryngeal cancer. Materials and Methods Using Affymetrix U133A Genechips, we profiled fresh-frozen tumor tissues from 66 patients with laryngeal cancer treated locally with surgery. We applied Cox regression proportional hazards modeling to identify multigene predictors of recurrence. Gene models were then validated in two independent cohorts of 54 and 187 patients (fresh-frozen and formalin-fixed tissue validation sets, respectively). Results We focused on genes univariately associated with DFS (p<0.01) in the training set. Among several models comprising different numbers of genes, a 30-probe set model demonstrated optimal performance in both the training (log-rank, p<0.001) and 1st validation (p = 0.010) sets. Specifically, in the 1st validation set, median DFS as predicted by the 30-probe set model, was 34 and 80 months for high- and low-risk patients, respectively. Hazard ratio (HR) for recurrence in the high-risk group was 3.87 (95% CI 1.28–11.73, Wald's p = 0.017). Testing the expression of selected genes from the above model in the 2nd validation set, with qPCR, revealed significant associations of single markers, such as ACE2, FLOT1 and PRKD1, with patient DFS. High PRKD1 remained an unfavorable prognostic marker upon multivariate analysis (HR = 2.00, 95% CI 1.28–3.14, p = 0.002) along with positive nodal status. Conclusions We have established and validated gene models that can successfully stratify patients with laryngeal cancer, based on their risk for recurrence. It seems worthy to prospectively validate PRKD1 expression as a laryngeal cancer prognostic marker, for routine clinical applications.
Surgery for colorectal cancer in the small town of Komotini
Simoglou C, Gymnopoulou E, Simoglou L, Gymnopoulou M, Nikolaou K, Gymnopoulos D
Journal of Multidisciplinary Healthcare , 2012, DOI: http://dx.doi.org/10.2147/JMDH.S30554
Abstract: rgery for colorectal cancer in the small town of Komotini Original Research (743) Total Article Views Authors: Simoglou C, Gymnopoulou E, Simoglou L, Gymnopoulou M, Nikolaou K, Gymnopoulos D Published Date October 2012 Volume 2012:5 Pages 273 - 276 DOI: http://dx.doi.org/10.2147/JMDH.S30554 Received: 04 February 2012 Accepted: 12 July 2012 Published: 18 October 2012 Christos Simoglou, Eirini Gymnopoulou, Lambros Simoglou, Marina Gymnopoulou, Konstantinia Nikolaou, Dimitrios Gymnopoulos Surgical Clinic, Sιsmanogleio General Hospital, Komotini, Greece Background: Here we report our experience in treating colon cancer in the 5 years from 200 to 2011. Our surgical clinic treated 49 patients with colorectal cancer, of whom 28 (57.14%) were men of mean age 62 years and 21 (42.86%) were women of mean age 66 years. Methods: In 15 cases, the cancer was related to the rectum (30.61%) and the remaining 34 cases (69.39%) were related to the colon. We found synchronous cancer in two patients. One was found in the blank and the upper right while the second was found in the transverse and sigmoid colon. Six of our patients suffered from coexisting biliary lithiasis and underwent simultaneous cholecystectomy, and simultaneous bile duct exploration for common bile duct lithiasis was performed in one of these patients. Results: Twenty-eight of the patients with colon cancer were treated surgically on an emergency basis. There were two postoperative deaths due to septic shock and multiple organ failure. In total, we noted seven complications, all of which involved patients who had undergone emergency surgery. The length of hospital stay was 8–14 days. Four patients with stage IV disease died 2 years after surgery, and the remainder are still alive. Conclusion: We conclude that colon cancer still occurs after the sixth decade, with a male predominance, and is mainly located in the rectum and sigmoid colon. The high rate of ileus in our region indicates inadequate diagnostic access for the residents of our region. However, mortality remains low.
Glomus Tumor of the Cheek: A Case Report
Konstantinos Veros,Konstantinos Markou,Chrysa Filitatzi,Dionysios E. Kyrmizakis
Case Reports in Medicine , 2012, DOI: 10.1155/2012/307294
Abstract: Glomus tumors are benign, subcutaneous neoplasms of the perivasculature. Though facial location is rare, the diagnosis of a glomus tumor should be considered in cases of undiagnosed painful facial nodules or chronic facial pain. Imaging aids in defining the tumor and planning a complete excision in order to avoid recurrence. Histological examination is mandatory after every attempted excision. A case of glomus tumor of the cheek along with the possible pitfalls of diagnosis and treatment and a brief review of the limited associated literature are presented.
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