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Search Results: 1 - 10 of 219986 matches for " Koike C "
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Thermoluminescence of Simulated Interstellar Matter after Gamma-ray Irradiation
K. Koike,M. Nakagawa,C. Koike,M. Okada,H. Chihara
Physics , 2002,
Abstract: Interstellar matter is known to be strongly irradiated by radiation and several types of cosmic ray particles. Simulated interstellar matter, such as forsterite $\rm Mg_{2}SiO_{4}$, enstatite $\rm MgSiO_{3}$ and magnesite $\rm MgCO_{3}$ has been irradiated with the $\rm ^{60}Co$ gamma-rays in liquid nitrogen, and also irradiated with fast neutrons at 10 K and 70 K by making use of the low-temperature irradiation facility of Kyoto University Reactor (KUR-LTL. Maximum fast neutron dose is $10^{17}n_f{\rm /cm^{2}}$). After irradiation, samples are stored in liquid nitrogen for several months to allow the decay of induced radioactivity. We measured the luminescence spectra of the gamma ray irradiated samples during warming to 370K using a spectrophotometer. For the forsterite and magnesite, the spectra exhibit a rather intense peak at about 645 -- 655 nm and 660 nm respectively, whereas luminescence scarcely appeared in olivine sample. The spectra of forsterite is very similar to the ERE of the Red Rectangle.
Affect-Loaded Questions in Japanese Storytelling: An Analysis of Grammar, Prosody, and Body Movements of Story Recipients’ Questions  [PDF]
Chisato Koike
Open Journal of Modern Linguistics (OJML) , 2015, DOI: 10.4236/ojml.2015.55043
Abstract: The present study explores affective stance in conversational storytelling by investigating the ways in which unknowing story recipients display affective stances toward a teller’s story through questions that deploy multimodal resources. The data are based on videotaped natural face-to-face conversations between native Japanese speakers. While unknowing story recipients ask questions of the storyteller only to elicit factual information (“neutral questions”), they also ask questions layered with affect (“affect-loaded questions”). Building on studies on affect and stance, assessment, questions, and alignment and affiliation in storytelling, I demonstrate how unknowing story recipients ask affect-loaded questions to elicit and display affective stances toward story contents by exploiting linguistic and non-linguistic resources. First, I explicate how unknowing story recipients employ not only linguistic devices (e.g., emotion words, wh-questions, and deictic expressions such as sonna “like that”), but also prosody, facial expressions, body movements, and pre-/concurrent-laughter in order to load questions with affective stance that display, for example, disgust, humor, sarcasm, criticism, or surprise. Secondly, I show how unknowing story recipients use rhetorical questions to express their affect (rather than to elicit information from the storyteller). Thirdly, I demonstrate how affiliation of affective stance between storyteller and unknowing story recipients influences the trajectory of storytelling and how the participants negotiate their affective stances. This study sheds light on the interactional process of how participants in talk-in-interaction display affective stance through a range of multimodal resources, by examining how unknowing story recipients ask affect-loaded questions of the storyteller. It illuminates the social practice of story recipients’ active participation in storytelling activity that is embedded in social interaction, through their use of questions that dynamically co-construct and negotiate affective stance.
Expression of CD133 and Extracellular Matrix Molecules in Malignant Brain Tumors  [PDF]
Seiichi Yoshida, Toshiro Koike
Neuroscience & Medicine (NM) , 2011, DOI: 10.4236/nm.2011.24052
Abstract: Background: CD133 could be characterized as a “stem-like” cell subpopulation and an invasive tumor phenotype. The objectives of this study were to investigate the relationship of CD133 and other remodeling factors such as matrix metalloproteinases (MMP) in the brain tumors. Methods: Tumors from 13 patients with brain tumors (8 lung cancer metastasis, 3 breast cancer metastasis, 2 gliomas) were studied to investigate the expression-patterns of CD133, EGFR, MT1-MMP, and MMP7 using the immunostaining and RT-PCR analysis. Results: EGFR immunostaining was detected in 75% (6/8) and 67% (1/3) of brain metastasis from lung adenocarcinoma and breast cancer, respectively. MT1-MMP immunostaining was also detected in 73% (8/11) of these brain metastasis. CD133 was not detected in these 13 patients. EGFR immunostaining was detected in 75% (6/8) and 67% (1/3) of brain metastasis from lung adenocarcinoma and breast cancer, respectively. MT1-MMP immunostaining was also detected in 73% (8/11) of these brain metastasis. CD133 was not detected in these 13 patients. Conclusions: The expression of CD133 indicates a marker for brain tumor initiating.
Influence of Fine Zirconia Particle Shot Peening on Sliding Wear of Zirconia-Silicon Carbide Composites  [PDF]
Hitonobu Koike, Koji Takahashi
Journal of Surface Engineered Materials and Advanced Technology (JSEMAT) , 2017, DOI: 10.4236/jsemat.2017.72004
Abstract: In this paper, the sliding contact fatigue wear performance of shot-peened zirconia-silicon carbide composite (ZrO2/SiC) plates in contact with silicon nitride balls under compressive residual stress in dry conditions was investigated in order to improve the wear resistance of ZrO2/SiC friction parts. The wear resistance of ZrO2/SiC plates after shot peening was higher than that of plates not treated with shot peening in sliding wear testing under Hertziancontact. Due to fine Zirconia particle shot peening, the tetragonal phase crystal structure in ZrO2 in the near-surface of ZrO2/SiC plates was changed, and 1100 MPa compressive residual stress could be introduced into the near-surface layer of ZrO2/SiC plates. The compressive residual stress was determined to be the main factor in the improvement of the sliding wear resistance of ZrO2/SiC plates.
Subendocardial fibrosis in remote myocardium results from reduction of coronary driving pressure during acute infarction in rats
Frimm, Clovis de Carvalho;Koike, Marcia Kiyomi;Cúri, Mariana;
Arquivos Brasileiros de Cardiologia , 2003, DOI: 10.1590/S0066-782X2003000500004
Abstract: objective: to investigate the role of hemodynamic changes occurring during acute mi in subsequent fibrosis deposition within non-mi. methods: by using the rat model of mi, 3 groups of 7 rats each [sham, smi (mi <30%), and lmi (mi >30%)] were compared. systemic and left ventricular (lv) hemodynamics were recorded 10 minutes before and after coronary artery ligature. collagen volume fraction (cvf) was calculated in picrosirius red-stained heart tissue sections 4 weeks later. results: before surgery, all hemodynamic variables were comparable among groups. after surgery, lv end-diastolic pressure increased and coronary driving pressure decreased significantly in the lmi compared with the sham group. lv dp/dtmax and dp/dtmin of both the smi and lmi groups were statistically different from those of the sham group. cvf within non-mi interventricular septum and right ventricle did not differ between each mi group and the sham group. otherwise, subendocardial (se) cvf was statistically greater in the lmi group. se cvf correlated negatively with post-mi systemic blood pressure and coronary driving pressure, and positively with post-mi lv dp/dtmin. stepwise regression analysis identified post-mi coronary driving pressure as an independent predictor of se cvf. conclusion: lv remodeling in rats with mi is characterized by predominant se collagen deposition in non-mi and results from a reduction in myocardial perfusion pressure occurring early on in the setting of mi.
Subendocardial fibrosis in remote myocardium results from reduction of coronary driving pressure during acute infarction in rats
Frimm Clovis de Carvalho,Koike Marcia Kiyomi,Cúri Mariana
Arquivos Brasileiros de Cardiologia , 2003,
Abstract: OBJECTIVE: To investigate the role of hemodynamic changes occurring during acute MI in subsequent fibrosis deposition within non-MI. METHODS: By using the rat model of MI, 3 groups of 7 rats each [sham, SMI (MI <30%), and LMI (MI >30%)] were compared. Systemic and left ventricular (LV) hemodynamics were recorded 10 minutes before and after coronary artery ligature. Collagen volume fraction (CVF) was calculated in picrosirius red-stained heart tissue sections 4 weeks later. RESULTS: Before surgery, all hemodynamic variables were comparable among groups. After surgery, LV end-diastolic pressure increased and coronary driving pressure decreased significantly in the LMI compared with the sham group. LV dP/dt max and dP/dt min of both the SMI and LMI groups were statistically different from those of the sham group. CVF within non-MI interventricular septum and right ventricle did not differ between each MI group and the sham group. Otherwise, subendocardial (SE) CVF was statistically greater in the LMI group. SE CVF correlated negatively with post-MI systemic blood pressure and coronary driving pressure, and positively with post-MI LV dP/dt min. Stepwise regression analysis identified post-MI coronary driving pressure as an independent predictor of SE CVF. CONCLUSION: LV remodeling in rats with MI is characterized by predominant SE collagen deposition in non-MI and results from a reduction in myocardial perfusion pressure occurring early on in the setting of MI.
Application of 2-octyl-cyanoacrylate for corneal perforation and glaucoma filtering bleb leak
Okabe M,Kitagawa K,Yoshida T,Koike C
Clinical Ophthalmology , 2013,
Abstract: Motonori Okabe,1 Kiyotaka Kitagawa,2 Toshiko Yoshida,1 Chika Koike,1 Takeshi Katsumoto,2 Etsuko Fujihara,2 Toshio Nikaido1 1Department of Regenerative Medicine, University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences, Toyama, 2Division of Ophthalmology, Matsue Red Cross Hospital, Japanese Red Cross Society, Shimane, Japan Background: This paper reports on the efficacy of a tissue adhesive, 2-octyl-cyanoacrylate, in the treatment of corneal perforation and glaucoma filtering bleb leak. Methods: Two eyes from two patients with corneal perforation or laceration and two eyes from two patients with bleb leak were included. The patients underwent application of 2-octyl-cyanoacrylate onto the perforated or leaking site, and a hydrogel contact lens was applied as a bandage. We also evaluated the in vitro cell toxicity of 2-octyl-cyanoacrylate in HeLa cells. Results: The two cases of corneal perforation were repaired within 22 days with one application of the tissue adhesive. The two cases of bleb leak were repaired with 2–4 applications of the tissue adhesive over 134 (range 17–134) days). There were no recurrences or adverse effects during a mean follow-up period of 12.7 months. In vitro testing revealed that 2-octyl-cyanoacrylate was markedly toxic to HeLa cells. Conclusion: Four patients with corneal perforation or bleb leak were successfully managed using 2-octyl-cyanoacrylate tissue adhesive. This simple and easy surgical technique may become an alternative therapeutic option for corneal perforation or bleb leak, although several applications of this tissue adhesive may be required. Although 2-octyl-cyanoacrylate was toxic to HeLa cells, no adverse clinical effects were noted using this adhesive. Keywords: corneal perforation, bleb leak, tissue adhesive, 2-octyl-cyanoacrylate
A'Campo curvature bumps and the Dirac phenomenon near a singular point
S. Koike,T-C. Kuo,L. Paunescu
Mathematics , 2012,
Abstract: The level curves of an analytic function germ almost always have bumps at unexpected points near the singularity. This profound discovery of N. A'Campo is fully explored in this paper for $f(z,w)\in \C\{z,w\}$, using the Newton-Puiseux infinitesimals and the notion of gradient canyon. Equally unexpected is the Dirac phenomenon: as $c\ra 0$, the total Gaussian curvature of $f(z,w)=c$ accumulates in the gradient canyons.
The new era of autoimmune disease research
Takao Koike
Arthritis Research & Therapy , 2011, DOI: 10.1186/ar3335
Abstract: Microarray analysis and gene expression profiling allow patterns of gene expression in diseases and developmental processes to be assessed. Advances in biological databases have enabled the large-scale expression profiling data to be processed and the foundation for biological interpretation to be laid. Despite this, a major limitation involves the interpretation of massive amounts of microarray data. In microarray analysis, which is often used to identify differentially expressed genes, genes that are expressed at higher or lower levels than controls are of interest. In the previous issue of Arthritis Research & Therapy, Lee and colleagues [1] conducted gene expression and bioinformatics analyses between healthy individuals and patients with systemic lupus erythematosus (SLE) and provided insights into biological and functional abnormalities in SLE as well as abnormal regulatory networks. Such analyses - that is, gene ontology analysis, which is used to classify genes into functionally related gene groups, and network pathway analysis, which identifies relationships among these genes - provide an additional layer of insight that cannot be achieved by focusing on individual molecules [1].Lee and colleagues [2] previously demonstrated, by DNA microarray and bioinformatics analyses, that genes related to the immune response were differentially expressed in patients with SLE compared with healthy controls. Other studies have also reported increased expression of IFN-inducible genes (that is, the 'IFN signature') in peripheral blood cells from patients with SLE [2-4]. Many groups are currently looking into pathological roles of plasmacytoid dendritic cells (pDCs) and IFN-inducible genes in SLE since pDCs are major producers of IFN-α [4-7]. Given that SLE is a systemic disease that influences multiple organs, Lee and colleagues [1] emphasized the importance of assessing biological and cellular abnormalities associated with SLE other than those related to the immune respo
Examples of a complex hyperpolar action without singular orbit
Koike,Naoyuki;
Cubo (Temuco) , 2010, DOI: 10.4067/S0719-06462010000200009
Abstract: the notion of a complex hyperpolar action on a symmetric space of non-compact type has recently been introduced as a counterpart to the hyperpolar action on a symmetric space of compact type. as examples of a complex hyperpolar action, we have hermann type actions, which admit a totally geodesic singular orbit (or a fixed point) except for one example. all principal orbits of hermann type actions are curvature-adapted and proper complex equifocal. in this paper, we give some examples of a complex hyperpolar action without singular orbit as solvable group free actions and find complex hyperpolar actions all of whose orbits are non-curvature-adapted or non-proper complex equifocal among the examples. also, we show that some of the examples possess the only minimal orbit.
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