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Search Results: 1 - 10 of 4131 matches for " Ko Matsudaira "
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Potential Risk Factors of Persistent Low Back Pain Developing from Mild Low Back Pain in Urban Japanese Workers
Ko Matsudaira, Hiroaki Konishi, Kota Miyoshi, Tatsuya Isomura, Kyoko Inuzuka
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0093924
Abstract: Study Design Two-year, prospective cohort data from the Japan epidemiological research of occupation-related back pain study in urban settings were used for this analysis. Objective To examine the association between aggravated low back pain and psychosocial factors among Japanese workers with mild low back pain. Summary of Background Data Although psychosocial factors are strongly indicated as yellow flags of low back pain (LBP) leading to disability, the association between aggravated LBP and psychosocial factors has not been well assessed in Japanese workers. Methods At baseline, 5,310 participants responded to a self-administered questionnaire including questions about individual characteristics, ergonomic work demands, and work-related psychosocial factors (response rate: 86.5%), with 3,811 respondents completing the 1-year follow-up questionnaire. The target outcome was aggravation of mild LBP into persistent LBP during the follow-up period. Incidence was calculated for the participants with mild LBP during the past year at baseline. Logistic regression was used to explore risk factors associated with persistent LBP. Results Of 1,675 participants who had mild LBP during the preceding year, 43 (2.6%) developed persistent LBP during the follow-up year. Multivariate analyses adjusted for individual factors and an ergonomic factor found statistically significant or almost significant associations of the following psychosocial factors with persistent LBP: interpersonal stress at work [adjusted odds ratio (OR): 1.96 and 95% confidence interval (95%CI): 1.00–3.82], job satisfaction (OR: 2.34, 95%CI: 1.21–4.54), depression (OR: 1.92, 95%CI: 1.00–3.69), somatic symptoms (OR: 2.78, 95%CI: 1.44–5.40), support from supervisors (OR: 2.01, 95%CI: 1.05–3.85), previous sick-leave due to LBP (OR: 1.94, 95%CI: 0.98–3.86) and family history of LBP with disability (OR: 1.98, 95%CI: 1.04–3.78). Conclusions Psychosocial factors are important risk factors for persistent LBP in urban Japanese workers. It may be necessary to take psychosocial factors into account, along with physical work demands, to reduce LBP related disability.
Diagnosis and Treatment of Attention-Deficit Hyperactivity Disorder in Patients with Chronic Pain  [PDF]
Satoshi Kasahara, Yumiko Okamura, Ko Matsudaira, Hiroyuki Oka, Yoshie Suzuki, Yasuko Murakami, Toshiharu Tazawa, Hayato Shimazaki, Shin-ichi Niwa, Yoshitsugu Yamada
Open Journal of Psychiatry (OJPsych) , 2017, DOI: 10.4236/ojpsych.2017.74023
Abstract: Aims: To investigate rates of attention-deficit hyperactivity disorder (ADHD) in patients with chronic pain attending a pain clinic, the effects of a screening measure for ADHD in patients with chronic pain, and the effects of ADHD drugs on both pain and ADHD symptoms. Methods: We retrospectively surveyed 110 patients with chronic pain visiting the Anesthesiology and Pain Relief Center at the University of Tokyo in Japan, who had also consulted a psychiatrist, between April 2012 and July 2015. Results: Of the total of 110 patients with chronic pain, 35 (31.8%) were also diagnosed with ADHD, and the average Wender Utah Rating Scale (WURS) score among the ADHD patients was 39.0 ± 22.1 (n = 25). Only 36.0% of these patients exceeded the cutoff value, suggesting that 64.0% of the patients with ADHD were not identified by screening with the WURS. Twenty-six patients initiated treatment with ADHD medication, with dosage adjustment completed in 21. Of these 21 patients 20 (95.0%) had improved ADHD symptoms. Improved pain symptoms were observed in 14 patients (66.6%), with a reduction in the pain numerical rating scale of 64.7% ± 30.1%. Conclusions: This is the first study investigating the comorbidity of ADHD and chronic pain at pain clinics showing a high level of comorbidity and amelioration of pain and ADHD symptoms with treatment. Careful interpretation is required when the WURS is used to screen patients with chronic pain.
Workaholism as a Risk Factor for Depressive Mood, Disabling Back Pain, and Sickness Absence
Ko Matsudaira, Akihito Shimazu, Tomoko Fujii, Kazumi Kubota, Takayuki Sawada, Norimasa Kikuchi, Masaya Takahashi
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0075140
Abstract: Objectives Although it is understood that work-related factors, including job demands, job control, and workplace support, are associated with workers' health and well-being, the role played by personal characteristics, especially workaholism, has not been fully investigated. This study examined workaholism's associations with psychological ill health, low back pain with disability, and sickness absence among Japanese workers. Methods A cross-sectional Internet survey was conducted using self-administered questionnaires. Data from 3,899 Japanese workers were analyzed. Workaholism was measured using the Dutch Workaholism Scale (DUWAS). Scores were divided into tertiles, where respondents were classified into three groups (high, middle, and low). Depressive mood as a measure of psychological ill health was assessed using the SF-36 mental health subscale, and low back pain using a standardized question. Sickness absence, except that due to physical injuries, was categorized either as absence due to mental health problems or to physical/somatic problems including the common cold. Multiple logistic regression analyses were conducted to examine the association between workaholism and depressive mood, low back pain with disability, and sickness absence, adjusting for demographic characteristics, job demand, job control, and workplace support. Results Compared to the low workaholism group, the middle and high workaholism groups had significantly higher odds for depressive mood (Odds ratio (OR) = 1.93 and 3.62 for the middle and high groups, respectively), disabling back pain (ORs = 1.36 and 1.77 for the middle and high groups, respectively). Workaholism was more strongly associated with sickness absence due to mental health problems than that for other reasons (ORs = 1.76 vs. 1.21 for the middle group and 3.52 vs. 1.37 for the high groups). Conclusions Workaholism is significantly associated with poor psychological health, disabling back pain, and sickness absence, particularly from mental health problems. Therefore, workaholism must be considered when addressing well-being of workers.
Tension, Free Space, and Cell Damage in a Microfluidic Wound Healing Assay
Michael Murrell, Roger Kamm, Paul Matsudaira
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0024283
Abstract: We use a novel, microfluidics-based technique to deconstruct the classical wound healing scratch assay, decoupling the contribution of free space and cell damage on the migratory dynamics of an epithelial sheet. This method utilizes multiple laminar flows to selectively cleave cells enzymatically, and allows us to present a ‘damage free’ denudation. We therefore isolate the influence of free space on the onset of sheet migration. First, we observe denudation directly to measure the retraction in the cell sheet that occurs after cell-cell contact is broken, providing direct and quantitative evidence of strong tension within the sheet. We further probe the mechanical integrity of the sheet without denudation, instead using laminar flows to selectively inactivate actomyosin contractility. In both cases, retraction is observed over many cell diameters. We then extend this method and complement the enzymatic denudation with analogies to wounding, including gradients in signals associated with cell damage, such as reactive oxygen species, suspected to play a role in the induction of movement after wounding. These chemical factors are evaluated in combination with the enzymatic cleavage of cells, and are assessed for their influence on the collective migration of a non-abrasively denuded epithelial sheet. We conclude that free space alone is sufficient to induce movement, but this movement is predominantly limited to the leading edge, leaving cells further from the edge less able to move towards the wound. Surprisingly, when coupled with a gradient in ROS to simulate the chemical effects of abrasion however, motility was not restored, but further inhibited.
STORM: A General Model to Determine the Number and Adaptive Changes of Epithelial Stem Cells in Teleost, Murine and Human Intestinal Tracts
Zhengyuan Wang,Paul Matsudaira,Zhiyuan Gong
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0014063
Abstract: Intestinal stem cells play a pivotal role in the epithelial tissue renewal, homeostasis and cancer development. The lack of a general marker for intestinal stem cells across species has hampered analysis of stem cell number in different species and their adaptive changes upon intestinal lesions or during development of cancer. Here a two-dimensional model, named STORM, has been developed to address this issue. By optimizing epithelium renewal dynamics, the model examines the epithelial stem cell number by taking experimental input information regarding epithelium proliferation and differentiation. As the results suggest, there are 2.0–4.1 epithelial stem cells on each pocket section of zebrafish intestine, 2.0–4.1 stem cells on each crypt section of murine small intestine and 1.8–3.5 stem cells on each crypt section of human duodenum. The model is able to provide quick results for stem cell number and its adaptive changes, which is not easy to measure through experiments. Its general applicability to different species makes it a valuable tool for analysis of intestinal stem cells under various pathological conditions.
Studying the Utilization of Plastic Waste by Chemical Recycling Method  [PDF]
Adil Ko
Open Journal of Applied Sciences (OJAppS) , 2013, DOI: 10.4236/ojapps.2013.37051

The rapid increase in the use of plastic materials in the recent years led to the accumulation of excessive amounts of plastic waste. The so-called thermoplastics such as PE, PP, PS, PVC and PET as well as materials that are derived from these are the type of plastic that is most used and consequently creates most of the waste. In this study, the original and waste forms of PE and PP plastic types have been chosen for thermal and catalytic degradation. As process parameter, 410oC - 450oC temperature interval and 600 mL/min constant flow rate nitrogen gas have been chosen as the carrier gas and the reaction time was considered to be 90 minutes for all experiments. Liquid products collected in experiments were separated by means of fractioned distillation process. For purposes of determining product distribution, the fractions, which were separated by distillation, were diluted in an appropriate solution for analysis of GC/MS. In the study conducted, it has been observed that the liquid product distribution obtained mainly consists of a mixture of saturated and unsaturated (heptane, heptane, octane, nonane, dodecane, etc.) hydrocarbons.

A Study on Importance and Role of Irrigation and Hydropower Plant Operation in Integrated River Basin Management  [PDF]
Cengiz Ko
Computational Water, Energy, and Environmental Engineering (CWEEE) , 2017, DOI: 10.4236/cweee.2017.61001
Abstract: In this study, 16 irrigation schemes (Baklan, Irgilli, Sutlac, Cal, Cürüksu, Nazilli, Saraykoy, Pamukkale, Sultanhisar, Akcay, Aydin, Topcam, Karpuzlu, Isikli, Gümüssu ve Soke) having 166,381 hectares, built by State Hydraulic Works (DSI), and operated by participatory irrigation managements, and 14 hydroelectric power plants (HPP) operated and built on dams, canals and rivers by the public and private sectors are examined in the Büyük Menderes basin which is an important basin in terms of the agriculture, energy and ecology projects. Integrated basin management practices and the importance and role of irrigation and hydropower plant operation in integrated basin management, how it should be, optimal use of available water resources for irrigation and hydroelectric power plant operation, irrigation relationship with canal hydropower plants, operated under integrated basin management of irrigation and hydropower plants, environment and the ecological effects have been studied, and integrated basin management with the existing basin management conditions in terms of hydropower plant and irrigation operation on the basis of data of 2015 have been compared, reached important conclusions, and made recommendations on the subject.
A Study on Planned and Applied Irrigation Modules in Irrigation Networks: A Case Study at Büyük Menderes Basin, Turkey  [PDF]
Cengiz Ko
Computational Water, Energy, and Environmental Engineering (CWEEE) , 2016, DOI: 10.4236/cweee.2016.54011
Abstract: In this study, irrigation modules calculated in planning and actualized operational stage of the irrigation networks are examined. Irrigation module used irrigation networks is a constant discharge parameter, meeting the needs of irrigation water requirement smonthly of crops in one hectare of irrigation area and it is a constant discharge flowing continuously for a month. Extent of the overlapping between the irrigation planning module and the operation module actualized during the operational stage of the irrigation network depends on changes in the cropping patterns, differences in the effects of field irrigation methods used by farmers on the capacity of the constructed system, the increases or decreases in the water demands depending on the irrigation period, as well as the extent of sustainability according to the selected operation method. A2 irrigation area of Aydin plain irrigation network, locating in the Büyük Menderes basin, Turkey is selected as study area, with an area of 2500 ha. Irrigation planning module calculated for this network is q = 1.16 l/s/ha and it has been designed as per the supply demand operation method. For the study; actualized irrigation module in the operation stage has been compared with the planning irrigation module by using Excel software and taking parameters such as actual crop pattern and percentage distributions, actualized irrigated areas, irrigation networks and water distribution, water intake of irrigation networks which have been calculated without operation losses, as well as with 5%, 10%, and 15% operation losses. The July operation module calculated for the examined irrigation network generally conforms to the planning module, as it has received the values close to or below the value of irrigation planning modules.
Web-based GIS System for Real-time Field Data Collection Using Personal Mobile Phone  [PDF]
Ko Ko Lwin, Yuji Murayama
Journal of Geographic Information System (JGIS) , 2011, DOI: 10.4236/jgis.2011.34037
Abstract: Recently, use of mobile communicational devices in field data collection is increasing such as smart phones and cellular phones due to emergence of embedded Global Position System GPS and Wi-Fi Internet access. Accurate timely and handy field data collection is required for disaster management and emergency quick responses. In this article, we introduce web-based GIS system to collect the field data by personal mobile phone through Post Office Protocol POP3 mail server. The main objective of this work is to demonstrate real-time field data collection method to the students using their mobile phone to collect field data by timely and handy manners, either individual or group survey in local or global scale research.
Protein Array Patterning by Diffusive Gel Stamping
Mekhail Anwar, Piyush B. Gupta, Raja Palaniapan, Paul Matsudaira
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0046382
Abstract: Proteins and small molecules are the effectors of physiological action in biological systems and comprehensive methods are needed to analyze their modifications, expression levels and interactions. Systems-scale characterization of the proteome requires thousands of components in high-complexity samples to be isolated and simultaneously probed. While protein microarrays offer a promising approach to probe systems-scale changes in a high-throughput format, they are limited by the need to individually synthesize tens of thousands of proteins. We present an alternative technique, which we call diffusive gel (DiG) stamping, for patterning a microarray using a cellular lysate enabling rapid visualization of dynamic changes in the proteome as well protein interactions. A major advantage of the method described is that it requires no specialized equipment or in-vitro protein synthesis, making it widely accessible to researchers. The method can be integrated with mass spectrometry, allowing for the discovery of novel protein interactions. Here, we describe and characterize the sensitivity and physical features of DiG-Stamping. We demonstrate the biologic utility of DiG-Stamping by (1) identifying the binding partners of a target protein within a cellular lysate and by (2) visualizing the dynamics of proteins with multiple post-translational modifications.
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