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Search Results: 1 - 10 of 127 matches for " Kitzman DW "
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Diastolic dysfunction as predominant form of CHF confirmed
Lyford Joanna,Kitzman DW,Gardin JM,Gottdiener JS
Current Controlled Trials in Cardiovascular Medicine , 2001, DOI: 10.1186/cvm-2001-72103
Abstract:
Sustained treatment effect in attention-deficit/hyperactivity disorder: focus on long-term placebo-controlled randomized maintenance withdrawal and open-label studies
Goodman DW
Therapeutics and Clinical Risk Management , 2013, DOI: http://dx.doi.org/10.2147/TCRM.S30762
Abstract: stained treatment effect in attention-deficit/hyperactivity disorder: focus on long-term placebo-controlled randomized maintenance withdrawal and open-label studies Review (19) Total Article Views Authors: Goodman DW Published Date March 2013 Volume 2013:9 Pages 121 - 130 DOI: http://dx.doi.org/10.2147/TCRM.S30762 Received: 30 November 2012 Accepted: 05 February 2013 Published: 21 March 2013 David W Goodman Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA Abstract: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that often persists throughout life. Approximately two-thirds of patients with a childhood diagnosis of ADHD continue to experience clinically significant symptoms into adulthood. Nevertheless, most of these individuals consider themselves “well,” and a vast majority discontinue medication treatment during adolescence. As evidence concerning the adult presentation of ADHD becomes more widely accepted, increasing numbers of physicians and patients will face decisions about the benefits and risks of continuing ADHD treatment. The risks associated with psychostimulant pharmacotherapy, including abuse, dependence, and cardiovascular events, are well understood. Multiple clinical trials demonstrate the efficacy of psychostimulants in controlling ADHD symptoms in the short term. Recent investigations using randomized withdrawal designs now provide evidence of a clinically significant benefit with continued long-term ADHD pharmacotherapy and provide insight into the negative consequences associated with discontinuation. Because many patients lack insight regarding their ADHD symptoms and impairments, they may place a low value on maintaining treatment. Nevertheless, for patients who choose to discontinue treatment, physicians can remain a source of support and schedule follow-up appointments to reassess patient status. Medication discontinuation can be used as an opportunity to help patients recognize their most impairing symptoms, learn and implement behavioral strategies to cope with ADHD symptoms, and understand when additional supportive resources and the resumption of medication management may be necessary.
The boy and his microscope: Interpreting section 56(1) of the National Health Act
DW Jordaan
South African Journal of Bioethics and Law , 2009,
Abstract: This article discusses the classic conflict between freedom and propriety with reference to the use of human gametes (sperm and egg cells) in South African law. The core question addressed is whether it is legal to use one’s own gametes, or others’ with their consent, for non-medical, non-sexual-intercourse purposes. This question is answered divergently by the two possible interpretations of the relevant statutory law – section 56(1) of the National Health Act – which is ambivalent. Since these two possible interpretations are representative of the two poles of the freedom v. propriety dichotomy, this matter can be perceived as a test of the depth of the South African juristic commitment to the principle of freedom. Section 56(1) is analysed, using the applicable common law presumptions as well as human rights. To illustrate the practical implications of these analyses, a hypothetical case study of a boy who studies human spermatozoa under his microscope at home is outlined and used throughout the article. The analyses conclude that the interpretation must be followed that answers the core question in the affirmative (in favour of freedom), namely that it is indeed legal to use one’s own gametes, or others’ with their consent, for non-medical, non-sexual-intercourse purposes.
Interpreting the gospel of Matthew in light of current global realities: A response
DW Ulrich
HTS Theological Studies/Teologiese Studies , 2009,
Abstract: This article consists of a response to fi ve papers presented by John Y.H. Yieh (Virginia Theological Seminary), Andries van Aarde (University of Pretoria), Dorothy Jean Weaver (Eastern Mennonite Seminary), Laura Anderson (Graduate Theological Union, Berkeley), and Lidija Novakovic (Baylor University, Waco), presented at the Matthew Section of the Society of Biblical Literature, held in Boston (Massachusetts), 21–25 November 2008. This response focuses on three questions: How can awareness of diverse perspectives or global realities enhance readers’ understandings of the Gospel of Matthew? In what ways might the Gospel of Matthew address global problems such as poverty, injustice and violence? To what extent do readers need a hermeneutics of suspicion in order to interpret Matthew responsibly in light of current global realities?
Sustained treatment effect in attention-deficit/hyperactivity disorder: focus on long-term placebo-controlled randomized maintenance withdrawal and open-label studies
Goodman DW
Therapeutics and Clinical Risk Management , 2013,
Abstract: David W GoodmanDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USAAbstract: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that often persists throughout life. Approximately two-thirds of patients with a childhood diagnosis of ADHD continue to experience clinically significant symptoms into adulthood. Nevertheless, most of these individuals consider themselves “well,” and a vast majority discontinue medication treatment during adolescence. As evidence concerning the adult presentation of ADHD becomes more widely accepted, increasing numbers of physicians and patients will face decisions about the benefits and risks of continuing ADHD treatment. The risks associated with psychostimulant pharmacotherapy, including abuse, dependence, and cardiovascular events, are well understood. Multiple clinical trials demonstrate the efficacy of psychostimulants in controlling ADHD symptoms in the short term. Recent investigations using randomized withdrawal designs now provide evidence of a clinically significant benefit with continued long-term ADHD pharmacotherapy and provide insight into the negative consequences associated with discontinuation. Because many patients lack insight regarding their ADHD symptoms and impairments, they may place a low value on maintaining treatment. Nevertheless, for patients who choose to discontinue treatment, physicians can remain a source of support and schedule follow-up appointments to reassess patient status. Medication discontinuation can be used as an opportunity to help patients recognize their most impairing symptoms, learn and implement behavioral strategies to cope with ADHD symptoms, and understand when additional supportive resources and the resumption of medication management may be necessary.Keywords: psychostimulant, nonstimulant, adult, child
Longterm investigation of the endometrial safety of a new seven-day sequential oestradiollevonorgestrel combination patch
Sturdee DW
Journal für Menopause , 2000,
Abstract:
Langzeituntersuchung der endometrialen Unbedenklichkeit/Vertr glichkeit eines neuen stradiol-Levonorgestrel-Kombinations-Pflasters für die siebent gige Anwendung
Sturdee DW
Journal für Menopause , 2000,
Abstract:
Global health policies that support the use of banked donor human milk: a human rights issue
Lois DW Arnold
International Breastfeeding Journal , 2006, DOI: 10.1186/1746-4358-1-26
Abstract: Donor milk banking thrives in countries such as Brazil, where there has been a concerted effort at the Health Ministry level to incorporate milk banks into health policy [1]. Its prime mover, Dr. Joao Aprigio Guerra de Almeida, has been honored with the prestigious WHO Sasekawa prize for making an important contribution to his country's overall health by establishing a network of donor human milk banks [2,3]. In countries where donor milk banking is protected, promoted, and supported as an extension of national breastfeeding policies, milk banking is considered a reasonable and effective part of health care delivery for infants and children.Premature infants who are fed infant formula have a higher risk of developing necrotizing enterocolitis (NEC) than when they are fed human milk, either mother's own milk or banked donor milk [4-6]. In this regard, donor milk banking could be considered preventive "medicine" in the premature population; by reducing the incidence of NEC and optimizing central nervous system development, the premature infant has a better start in life than he would have if fed premature infant formula. The argument has been made [7] that these infants become more productive members of society as adults if their health and neurological potential are maximized through optimal nutrition and appropriate health care from the start. This argument is made despite a general lack of published research on the efficacy of banked human milk because in many parts of the world there is a general belief that human milk in any form is superior to manufactured infant formulas. This is contrary to the pervading philosophy among many health care providers, especially in the US, that infant formula and human milk are equivalent.If donor milk banking has been incorporated into national public health policy and regulation, (such as France [8,9], Germany [10,11], and the Scandinavian countries [12]) and/or in other countries with socialized medicine, such as Canada and Gr
Children at Risk: A Study of the Psychosocial Impact of HIV on Orphans and other Vulnerable Children in Benin
LR stergaard, DW Meyrowitsch
Africa Development , 2008,
Abstract: This paper describes the effect of parental HIV on the life of children in Benin. A total of 2,043 children aged from 10 to 16 were surveyed on health, diet, violence, school attendance and psychosocial state. The results indicate that, while Beninese children who have had a parent living with HIV are not necessarily subjected to different economic and material conditions than those who have not, they do experience a much greater lack of psychosocial support. In contrast to children whose parents are not known to have HIV, these affected children are less prone to general illness (OR=0.69, 95 per cent CI 0.55-0.86). However, when they are sick, HIV-affected children are significantly more likely to undertake self-treatment (OR=1.38; 95 per cent CI 1.04-1.86) and more likely to work (OR=1.65, 95 per cent CI 1.04-2.60). They are also offered fewer meals than unaffected children (OR=1.94; 95 per cent CI 1.52-2.47). With respect to psychosocial factors, the data suggest that children who have had a parent with HIV have significantly higher levels of psychological distress than those who have not. Governments and civil society organisations need to address not only the material deprivation, especially hunger, of children thus affected by HIV, but also their need for social services.
Optimal management of testicular cancer: from self-examination to treatment of advanced disease
Stephen DW Beck
Research and Reports in Urology , 2010, DOI: http://dx.doi.org/10.2147/RRU.S7174
Abstract: imal management of testicular cancer: from self-examination to treatment of advanced disease Review (3283) Total Article Views Authors: Stephen DW Beck Published Date August 2010 Volume 2010:2 Pages 143 - 154 DOI: http://dx.doi.org/10.2147/RRU.S7174 Stephen DW Beck Department of Urology, Indiana University, Indianapolis, Indiana, USA Abstract: Germ-cell cancer is the most common solid tumor in men aged 15 to 35 years and has become the model for curable neoplasm. Over the last 3 decades, the cure rate has increased from 15% to 85%. This improved cure rate has been largely attributed to the -introduction of cisplatin-based chemotherapy. In stage I seminoma and nonseminoma, cure rates approach 100% and treatment is governed by patient choice based on the perceived morbidities of each therapy and personal preferences. For seminoma, treatments include surveillance, radiotherapy, and single course carboplatin. For nonseminoma, treatments include surveillance, retroperitoneal lymph node dissection (RPLND), and adjuvant chemotherapy. Low volume (<3 cm) stage II seminoma is typically managed with radiotherapy while higher volume (>3 cm) stage II and stage III disease treated with chemotherapy. Positron emission tomography (PET) imaging can differentiate active cancer versus necrosis for postchemotherapy residual masses. PET-positive masses are managed with either surgery or second-line chemotherapy. Low volume (<5 cm) stage II nonseminoma with normal serum tumor markers may be managed with either RPLND or chemotherapy. Patients with persistently elevated serum tumor markers and larger volume stage II and stage III disease are managed with systemic chemotherapy. As with -seminoma, good risk patients are typically treated with 3 courses of bleomycin, etoposide, and -cisplatin (BEP) and intermediate and poor risk patients are treated with 4 courses. Residual postchemotherapy masses should be resected due to the uncertainty of the histology with 50% to 60% harboring residual teratoma or active cancer. The majority of patients completing initial therapy who relapse do so within 2 years. A minority of patients (2%–3%) recur after 2 years and this phenomenon is termed late relapse. Excluding chemona ve patients, late relapse disease is typically managed surgically with 50% being cured of disease. Current therapeutic challenges in testis cancer include the accurate prediction of postchemotherapy histology to avoid surgery in patients harboring fibrosis only, improved therapy in platinum-resistant and platinum-refractory disease, and the understanding of the biology of late relapse.
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