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Search Results: 1 - 10 of 3798 matches for " Kirti Patel "
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Nair Kavitha,Patel Kirti,Gandhi Tejal
Indian Journal of Pharmacology , 2009,
Abstract:
Authors′ reply
Nair Kavitha,Patel Kirti,Gandhi Tejal
Indian Journal of Pharmacology , 2009,
Abstract:
Is cytochrome modulation the new frontier for decreasing the risk of cataract?
Nair Kavitha,Patel Kirti,Gandhi Tejal
Indian Journal of Pharmacology , 2009,
Abstract: Aim: The present study was designed to study the effect of cytochrome P450 (CYP) modulators on the occurrence of cataract using male Sprague-Dawley rats weighing 40:50 gm. Materials and Methods: Macroscopical examination of the lens isolated from rats pretreated with diltiazem (30 mg/kg; once daily; PO) showed delayed occurrence of cataract while pioglitazone (3.8 mg/kg; once daily; PO) pretreatment demonstrated an early cataract. Results and Conclusion: A delayed occurrence of cataract with diltiazem (CYP inhibitor) and an early onset of cataract with pioglitazone (CYP inducer) indicate that a cytochrome P450 mediated pathway may affect the initiation of cataract but not the maturation pattern.
Comparison Of Infraclavicular Brachial Plexus Block With Supraclavicular Brachial Plexus Block In Upper Limb Surgeries. (A Study Of 100 Patients)
Sheetal Shah,kamla Mehta,Kirti Patel,Khyati Patel
NHL Journal of Medical Sciences , 2013,
Abstract: Comparative prospective study of two routes of Brachial plexus block – infraclavicular coracoid approach with conventional supraclavicular approach was carried out in 100 patients of ASA RISK I to III, undergoing elective or emergency surgeries on upper limb, at the level of elbow and below elbow. Patients were divided into 2 equal groups, Group I (Infraclavicular) and Group S (Supraclavicular), which were compared for block performance time, onset, quality and duration of block. The applied anatomy, methodology, complications and limitations have been emphasized. The study concludes that infraclavicular brachial plexus block with coracoid approach is a useful block without complications if practiced with precautions.
Novel hepatocyte growth factor (HGF) binding domains on fibronectin and vitronectin coordinate a distinct and amplified Met-integrin induced signalling pathway in endothelial cells
Salman Rahman, Yatin Patel, Jacqueline Murray, Kirti V Patel, Rushika Sumathipala, Michael Sobel, Errol S Wijelath
BMC Cell Biology , 2005, DOI: 10.1186/1471-2121-6-8
Abstract: Here we report that fibronectin (FN) and vitronectin (VN) modulate the responses of endothelial cells to HGF (Scatter Factor), an important pro-angiogenic mediator. Novel binding sites for HGF were identified on both FN and VN that generate molecular complexes with enhanced biological activity and these were identified in the supernatants of degranulated platelet suspensions implicating their release and formation in vivo. In the absence of co-stimulation with an ECM glycoprotein, HGF could not promote endothelial cell migration but retained the capacity to induce a proliferative response utilising the Map kinase pathway. Through promoting Met-Integrin association, HGF-FN and HGF-VN complexes coordinated and enhanced endothelial cell migration through activation of the PI-3 kinase pathway involving a Ras-dependent mechanism whereas a Ras-independent and attenuated migratory response was promoted by co-stimulation of cells with HGF and a non-binding partner ECM glycoprotein such as collagen-1.These studies identify a novel mechanism and pathway of HGF signalling in endothelial cells involving cooperation between Met and integrins in a Ras dependent manner. These findings have implications for the regulation of neovascularization in both health and disease.The generation and repair of blood vessels in adult life requires the regulation of endothelial cell survival, migration, proliferation and their differentiation from lineage-committed progenitors by the coordinated action of several classes of vaso-active agents including growth factors, cytokines, and the extracellular matrix (ECM) [1-4]. Elucidating the molecular mediators of these signals and their mechanism of action is vital to understanding the fine regulation of neo-vessel development and maintenance.There is growing evidence pointing to a close collaboration between growth factors and the ECM in several biological processes including vasculogenesis and post-natal revascularization. Studies have shown that t
Effect of fresh juice of Brassica oleracea Var. Capitata on isolated precontracted rat uterine horns
Kirti Patel V,Kalpana Patel G, Tejas Mehta, Tejal Gandhi R,Ramesh Goyal K
Hygeia : Journal for Drugs and Medicines , 2012,
Abstract: Plan: The present study was undertaken to investigate the H2 receptor antagonistic action of fresh juice of Brassica oleracea var. capitata Methodology: Two sets of experiments consisted of recording the responses of the uterine horn preparations (precontracted with potassium chloride, KCl) to histamine (4.5; 9; 17.99; 35.99; 71.98 × 10–4 and 14.40× 10–3 mol/L, 2 minute each concentration) in absence and presence of S- Chlorpheniramine, ranitidine and BOCJ. Relaxant responses were measured as changes in isometric tension and converted into percentage of the reference maximum relaxation induced by standard dose of histamine for each group of experiment.Outcome: Our results indicate that histamine (EC50 = 19.05 ± 1.76 × 10-4 mol/L, p < 0.001) produces relaxation of potassium chloride precontracted isolated rat uterus. This effect of histamine is abolished by ranitidine, a selective H2 histamine receptor antagonist and BOCJ in a concentration dependent manner.
Mantle Cell Lymphoma of GI Tract Presented as Multiple Lymphomatous Polyposis: A Rare Intestinal Malignancy
Rathod Kirti M, Gupta Monica V, Shah Kalpesh H, Patel Keyuri B
National Journal of Community Medicine , 2012,
Abstract: Primary lymphomas arising in the large intestine are less frequent than either gastric or small bowel lymphomas. Primary colorectal lymphomas account for about 0.2% of all neoplasm. Mantle cell lymphoma in form of multiple lymphomatous polyposis is less frequent in colorectum than in the small bowel.2 We present a case of 68 year-old man suffered from abdominal pain and diarrhoea for one year with complain of blood in stool for last 15 days. Multiple polypoid masses were found in the entire colon and caecum on colonoscopic examination. Computerized tomography of the abdomen revealed a large soft tissue mass lesion in caecum and ascending colon with diffuse polypoidal wall thickening involving the transverse colon, sigmoid colon, descending colon with mesenteric lymph node enlargement. Colonoscopic excision of polyp from ascending colon and transverse colon was done. The histological diagnosis was Non-Hodgkin lymphoma with multiple lymphomatous polyposis. In immunohitochemistry, there was positive staining for CD20, CD 5 and cyclin D1 and suggestive of mantle cell lymphoma B cell type. MCL is an aggressive lymphoma, which typically presents in advanced stage; there is often involvement of mesenteric and peripheral lymph nodes, spleen, bone marrow and peripheral blood 6.
Significant Factors for Reliability Estimation of Component Based Software Systems  [PDF]
Kirti Tyagi, Arun Sharma
Journal of Software Engineering and Applications (JSEA) , 2014, DOI: 10.4236/jsea.2014.711083
Abstract: Software reliability is defined as the probability of the failure-free operation of a software system for a specified period of time in a specified environment. Traditional approaches for software reliability analysis are black box approaches. These approaches use the software as a whole. At present, main emphasis of software is on reuse, hence component based software applications came into existence. Black box models are not appropriate for these applications. This paper introduces some significant factors for reliability estimation of Component Based Software Applications. Reliability of Component Based Software Application depends upon these factors. This paper also gives the definition of factors and explains its relation with reliability of software application.
Influence of Oil Price Volatility of Developed Countries on Emerging Countries Stock Market Returns by Using Threshold Based Approach  [PDF]
Kirti Arekar, Rinku Jain
Theoretical Economics Letters (TEL) , 2017, DOI: 10.4236/tel.2017.76125
Abstract: This study reveals the nonlinear relationship between oil price volatility of the developed countries and emerging stock market returns. We analyzed the effects of oil price volatility of the developed markets i.e. India, United States and United Kingdom on the emerging stock market returns. We used VAR, Granger Causality, impulse responses and logistic transition based autoregressive model (LSTR) in two groups. In group one, we considered US oil price volatility with six emerging countries and regions stock market returns i.e. France, Spain, Malaysia, Japan, Singapore and Taiwan. In group two, we considered oil price with respect to India with the same six emerging countries stock market returns. The data covers the daily closing prices for seven years from 2011 to 2017 for emerging countries and for oil prices the data we use West Texas Intermediate (WTI) spot price of crude oil for US and India. This study helps the investors to understand the impact of oil prices of US and Indian market with respect to emerging markets and whether to identify the dependency of emerging stock markets returns on the oil prices of US and India. All the analysis was performed by using R and EVIEWS software.
Clinical Utility of Serum Interleukin-8 and Interferon-Alpha in Thyroid Diseases
Toral P. Kobawala,Girish H. Patel,Dhara R. Gajjar,Kamini N. Patel,Premal B. Thakor,Urvi B. Parekh,Kirti M. Patel,Shilin N. Shukla,Pankaj M. Shah
Journal of Thyroid Research , 2011, DOI: 10.4061/2011/270149
Abstract: Serum interleukin-8 (IL-8) and interferon-alpha (IFN-α) levels have been estimated from a total of 88 individuals of which 19 were disease-free healthy individuals, and 69 were patients with thyroid diseases: goitre ( ), autoimmune diseases ( ), and carcinomas ( ). Both IL-8 and IFN-α were significantly higher in all the patients as compared to healthy individuals. Serum IL-8 levels showed significant positive correlation with disease stage in thyroid cancer patients. Higher serum IL-8 levels were associated with advanced disease stage while no significant correlation was observed between serum IFN-α levels and any of the clinicopathological parameters. IL-8 and IFN-α significantly correlated with each other in anaplastic carcinoma patients. Finally concluding, monitoring the serum IL-8 and IFN-α levels can help differentiate patients with thyroid diseases from healthy individuals, and IL-8 seems to have a role in the pathogenesis of thyroid diseases and may represent a target for innovative diagnostic and therapeutic strategies. 1. Introduction Although thyroid problems are among the most common medical conditions, because their symptoms often appear gradually, they are commonly misdiagnosed. The three most common thyroid problems are the underactive thyroid, the overactive thyroid, and thyroid nodules [1]. Based on these problems, the disorders of the thyroid gland include: goitre, autoimmune thyroid diseases, as well as thyroid carcinoma. Thyroid cancer is the fastest growing and most common cancer of the total endocrine malignancies, accounting for 94.5% of the total new endocrine cancers and 65.9% of the deaths due to endocrine cancers. It is the endocrine tumor that bears the highest incidence with 33 550 new cases per year in the US [2]. The vast majority of patients with thyroid diseases are curable using present treatment modalities. However, accumulating evidences indicate that follicular cell-derived thyroid cancer constitutes a biological continuum progressing from the highly curable well-differentiated thyroid cancer to the universally fatal anaplastic thyroid cancer [3, 4]. An association between thyroid cancer and a history of several benign diseases has been observed in most studies [5, 6]. However, the molecular mechanisms underlying thyroid cancer progression remain ill-defined. So it is important to decipher these mechanisms, since poorly differentiated and anaplastic carcinomas account for the majority of thyroid cancer-related deaths. Moreover, accumulated epidemiologic studies support that chronic inflammatory diseases are
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