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Search Results: 1 - 10 of 154 matches for " Kinikar Aarti "
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Encephalitis in a child with H1N1 infection: First case report from India
Kulkarni Rajesh,Kinikar Aarti
Journal of Pediatric Neurosciences , 2010,
Abstract: Neurological complications have been described with seasonal influenza infection. We report encephalitis manifesting as seizures in a child with confirmed H1N1 infection. Treatment with oseltamivir was started. Child was discharged without any neurological sequelae.
2009H1N1 Infection in a 1-day-old neonate
Valvi Chhaya,Kulkarni Rajesh,Kinikar Aarti,Khadse Sandhya
Indian Journal of Medical Sciences , 2010,
Abstract: A full-term female neonate was delivered with meconium stained amniotic fluid by cesarean section by a 2009H1N1 positive 22-year-old second gravida mother, who developed symptoms 8 days prior to delivery. The neonate was completely and immediately isolated from the mother after delivery. Oseltamivir was started at birth to the neonate who had a potential possibility of 2009H1N1 infection. At 5 hours of life, the neonate developed respiratory distress. The neonate′s throat swab sent for 2009H1N1 by real-time polymerase chain reaction (RT-PCR) assay was positive. The neonate required oxygen by hood for 3 days and made an uneventful recovery. The mother developed acute respiratory distress syndrome after delivery, requiring ventilatory care for 14 days and was discharged after 25 days stay in hospital. 2009H1N1 infection, although rare, needs a high index of suspicion and prompt therapy in neonates. Clinicians should be alert about the possibility of perinatal transmission of 2009H1N1.
Growth patterns among HIV-exposed infants receiving nevirapine prophylaxis in Pune, India
Ram Malathi,Gupte Nikhil,Nayak Uma,Kinikar Aarti A
BMC Infectious Diseases , 2012, DOI: 10.1186/1471-2334-12-282
Abstract: Background India has among the highest rates of infant malnutrition. Few studies investigating the growth patterns of HIV-exposed infants in India or the impact of timing of HIV infection on growth in settings such as India exist. Methods We used data from the Six Week Extended Nevirapine (SWEN) trial to compare the growth patterns of HIV-infected and HIV-exposed but uninfected infants accounting for timing of HIV infection, and to identify risk factors for stunting, underweight and wasting. Growth and timing of HIV infection were assessed at weeks 1, 2, 4, 6, 10, 14 weeks and 6, 9, 12 months of life. Random effects multivariable logistic regression method was used to assess factors associated with stunting, underweight and wasting. Results Among 737 HIV-exposed infants, 93 (13%) were HIV-infected by 12 months of age. Among HIV-infected and uninfected infants, baseline prevalence of stunting (48% vs. 46%), underweight (27% vs. 26%) and wasting (7% vs. 11%) was similar (p>0.29), but by 12 months stunting and underweight, but not wasting, were significantly higher in HIV-infected infants (80% vs. 56%, 52% vs. 29%, p< 0.0001; 5% vs. 6%, p=0.65, respectively). These differences rapidly manifested within 4–6 weeks of birth. Infants infected in utero had the worst growth outcomes during the follow-up period. SWEN was associated with non-significant reductions in stunting and underweight among HIV-infected infants and significantly less wasting in HIV-uninfected infants. In multivariate analysis, maternal CD4 < 250, infant HIV status, less breastfeeding, low birth weight, non-vaginal delivery, and infant gestational age were significant risk factors for underweight and stunting. Conclusion Baseline stunting and underweight was high in both HIV-infected and uninfected infants; growth indices diverged early and were impacted by timing of infection and SWEN prophylaxis. Early growth monitoring of all HIV-exposed infants is an important low-cost strategy for improving health and survival outcomes of these infants. Trial Registration NCT00061321
High Rates of All-cause and Gastroenteritis-related Hospitalization Morbidity and Mortality among HIV-exposed Indian Infants
Harjot K Singh, Nikhil Gupte, Aarti Kinikar, Renu Bharadwaj, Jayagowri Sastry, Nishi Suryavanshi, Uma Nayak, Srikanth Tripathy, Ramesh Paranjape, Arun Jamkar, Robert C Bollinger, Amita Gupta, the SWEN India Study Team
BMC Infectious Diseases , 2011, DOI: 10.1186/1471-2334-11-193
Abstract: Using data from a prevention of mother-to-child transmission (PMTCT) trial (India SWEN), where HIV-exposed breastfed infants were given extended nevirapine, we measured 12-month infant all-cause and cause-specific hospitalization rates and hospitalization risk factors.Among 737 HIV-exposed Indian infants, 93 (13%) were HIV-infected, 15 (16%) were on HAART, and 260 (35%) were hospitalized 381 times by 12 months of life. Fifty-six percent of the hospitalizations were attributed to infections; gastroenteritis was most common accounting for 31% of infectious hospitalizations. Gastrointestinal-related hospitalizations steadily increased over time, peaking around 9 months. The 12-month all-cause hospitalization, gastroenteritis-related hospitalization, and in-hospital mortality rates were 906/1000 PY, 229/1000 PY, and 35/1000 PY respectively among HIV-infected infants and 497/1000 PY, 107/1000 PY, and 3/1000 PY respectively among HIV-exposed, uninfected infants. Advanced maternal age, infant HIV infection, gestational age, and male sex were associated with higher all-cause hospitalization risk while shorter duration of breastfeeding and abrupt weaning were associated with gastroenteritis-related hospitalization.HIV-exposed Indian infants experience high rates of all-cause and infectious hospitalization (particularly gastroenteritis) and in-hospital mortality. HIV-infected infants are nearly 2-fold more likely to experience hospitalization and 10-fold more likely to die compared to HIV-exposed, uninfected infants. The combination of scaling up HIV PMTCT programs and implementing proven health measures against infections could significantly reduce hospitalization morbidity and mortality among HIV-exposed Indian infants.Pneumonia and gastroenteritis account for nearly 50% of early childhood morbidity and mortality, particularly in low-income country settings [1]. HIV-infection increases the risks of these infections several fold and of mortality approximately 9-fold in sub-S
Wisdom Web: The WWW Generation Next
Aarti Singh
International Journal of Advancements in Technology , 2012,
Abstract: Almost one decade before when Tim Berners Lee coined the idea of semantic web, it looked like a distant dream. Now we are already experiencing the initial waves of semantic web in the form of more intelligent context based searches. However human nature is insatiable which drives us towards exploring potential avenues of betterment. This fact is leading WWW towards transformation from Semantic Web to Wisdom Web. This article highlights the technologies contributing most towards the next generation of WWW and also suggests future direction for Web Personalization.
Aarti Tayal
Journal of Global Research in Computer Science , 2011,
Abstract: This paper is an attempt to discuss thesaurus already available in Indian languages and conversion rules during design of Punjabi thesaurus. Basically this paper is divided into four sections. In first section try to give introduction about varieties of thesaurus and brief introduction to thesaurus, ontology and dictionary. In next section, provide information about already built thesaurus for Indian languages. After that, give details of conversion rules which is basic necessity to provide correct result when user work under different-different fonts. Keywords- thesaurus, ontology, dictionary, Indian languages, conversion rules
Oral fluid, a substitute for serum to monitor measles IgG antibody?
Goyal A,Shaikh N,Kinikar A,Wairagkar N
Indian Journal of Medical Microbiology , 2009,
Abstract: We have analyzed the suitability and potential of Oral Fluid (OF) to substitute serum in estimating measles IgG antibodies, during community surveys, by comparing the Optical Density (OD) of measles IgG antibodies in OF and serum of 100 apparently asymptomatic children. IgG antibody status was determined using commercially available - Measles IgG Capture ELISA. Sensitivity 89.5%, specificity 90.6% Concordance of 89%, coefficient of correlation r is equal to 0.97 (Karl Pearson′s) and rho is equal to 0.86 (Spearman′s), was found between OD value of OF and serum. The study emphasizes the potential of OF to surrogate serum in estimating Measles IgG antibody among children. The OF collection is advantageous over blood as it is painless. It is suitable for non-technical staff, easy to transport and less bio-hazardous.
VirulentPred: a SVM based prediction method for virulent proteins in bacterial pathogens
Aarti Garg, Dinesh Gupta
BMC Bioinformatics , 2008, DOI: 10.1186/1471-2105-9-62
Abstract: In the present study we propose a bacterial virulent protein prediction method based on bi-layer cascade Support Vector Machine (SVM). The first layer SVM classifiers were trained and optimized with different individual protein sequence features like amino acid composition, dipeptide composition (occurrences of the possible pairs of ith and i+1th amino acid residues), higher order dipeptide composition (pairs of ith and i+2nd residues) and Position Specific Iterated BLAST (PSI-BLAST) generated Position Specific Scoring Matrices (PSSM). In addition, a similarity-search based module was also developed using a dataset of virulent and non-virulent proteins as BLAST database. A five-fold cross-validation technique was used for the evaluation of various prediction strategies in this study. The results from the first layer (SVM scores and PSI-BLAST result) were cascaded to the second layer SVM classifier to train and generate the final classifier. The cascade SVM classifier was able to accomplish an accuracy of 81.8%, covering 86% area in the Receiver Operator Characteristic (ROC) plot, better than that of either of the layer one SVM classifiers based on single or multiple sequence features.VirulentPred is a SVM based method to predict bacterial virulent proteins sequences, which can be used to screen virulent proteins in proteomes. Together with experimentally verified virulent proteins, several putative, non annotated and hypothetical protein sequences have been predicted to be high scoring virulent proteins by the prediction method. VirulentPred is available as a freely accessible World Wide Web server – VirulentPred, at http://bioinfo.icgeb.res.in/virulent/ webcite.Virulence of a bacterial pathogen is its relative ability to cause a disease usually described in terms of number of infecting bacteria, the route of its entry into the host body and intrinsic bacterial virulence factors. The bacterial virulence factors are commonly virulent proteins, carbohydrates and other
Golden Research Thoughts , 2013, DOI: 10.9780/22315063
Abstract: Tourism is the temporary short term movement of people to destinations outside the place where they normally live and work and, includes the activities they indulge in at the destination as well as all facilities and services specially created to meet their needs. It not only means travelling to a particular destination but also includes all activities undertaken during the stay, be it day visits and excursions. Tourism is the vital breath in any human activity while making a prolonged journey from place to place, it is a human desire to make round of places of interest – Religious, Spiritual, Natural Beautiful places, Monuments, Ancient Cities, Historical sites , Pilgrimage centre's, and places that arouse curiosity.
Ion activated bioadhesive in situ gel of clindamycin for vaginal application
Himanshu Gupta,Aarti Sharma
International Journal of Drug Delivery , 2011,
Abstract: Vaginal preparations, although generally perceived as safer most , still they are associated with a number of problems, including multiple days of dosing, dripping, leakage and messiness, causing discomfort to users and expulsion due to the self-cleansing action of the vaginal tract. These limitations lead to poor patient compliance and failure of the desired therapeutic effects. For effective vaginal delivery of antimicrobial agents, the drug delivery system should reside at the site of infection for a prolonged period of time. In our present work, we have developed and optimized a chitosan (bioadhesive and permeation enhancer) and gellan gum (ion activated gelling polymer) based in situ gel system of clindamycin for vaginal application. The developed formulation was characterized for various in-vitro parameters e.g. clarity, refractive index, pH, isotonicity, sterility, viscosity, drug release profile, statistical release kinetics, bioadhesive force, retention time, microbial efficacy, irritation test and stability studies. To simulate vaginal conditions, a synthetic membrane (cellophane hydrated with modified simulated vaginal fluid) and sheep vaginal mucosa were used as model membranes. The developed formulation was found to be non irritant, bioadhesive with good retention properties. Developed formulation shows matrix model release kinetic by PCP disso software. The developed formulation is thus a viable alternative to conventional vaginal dosage forms. Keywords: sol-to-gel system; chitosan; gellan gum; vaginal; clindamycin
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