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Search Results: 1 - 10 of 2305 matches for " Kimberly Rogers "
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Antimicrobial Activities of Leaf Extracts of Guava (Psidium guajava L.) on Two Gram-Negative and Gram-Positive Bacteria
Bipul Biswas,Kimberly Rogers,Fredrick McLaughlin,Dwayne Daniels,Anand Yadav
International Journal of Microbiology , 2013, DOI: 10.1155/2013/746165
Abstract: Aim. To determine the antimicrobial potential of guava (Psidium guajava) leaf extracts against two gram-negative bacteria (Escherichia coli and Salmonella enteritidis) and two gram-positive bacteria (Staphylococcus aureus and Bacillus cereus) which are some of foodborne and spoilage bacteria. The guava leaves were extracted in four different solvents of increasing polarities (hexane, methanol, ethanol, and water). The efficacy of these extracts was tested against those bacteria through a well-diffusion method employing 50?μL leaf-extract solution per well. According to the findings of the antibacterial assay, the methanol and ethanol extracts of the guava leaves showed inhibitory activity against gram-positive bacteria, whereas the gram-negative bacteria were resistant to all the solvent extracts. The methanol extract had an antibacterial activity with mean zones of inhibition of 8.27 and 12.3?mm, and the ethanol extract had a mean zone of inhibition of 6.11 and 11.0?mm against B. cereus and S. aureus, respectively. On the basis of the present finding, guava leaf-extract might be a good candidate in the search for a natural antimicrobial agent. This study provides scientific understanding to further determine the antimicrobial values and investigate other pharmacological properties. 1. Introduction Recently there has been a lot of attention focused on producing medicines and products that are natural. Several fruits and fruit extracts, as well as arrowroot tea extract [1] and caffeine [2], have been found to exhibit antimicrobial activity against E. coli O157:H7. This suggests that plants which manifest relatively high levels of antimicrobial action may be sources of compounds that can be used to inhibit the growth of foodborne pathogens. Bacterial cells could be killed by the rupture of cell walls and membranes and by the irregular disruption of the intracellular matrix when treated with plant extracts [1]. The guava (Psidium guajava) is a phytotherapic plant used in folk medicine that is believed to have active components that help to treat and manage various diseases. The many parts of the plant have been used in traditional medicine to manage conditions like malaria, gastroenteritis, vomiting, diarrhea, dysentery, wounds, ulcers, toothache, coughs, sore throat, inflamed gums, and a number of other conditions [3–5]. This plant has also been used for the controlling of life-changing conditions such as diabetes, hypertension, and obesity [3, 6–10]. In this study, we aim to evaluate the total extracts of P. guajava leaves, growing at Fort Valley State
A Two-Step Growth Curve: Approach to the von Bertalanffy and Gompertz Equations  [PDF]
Laura Rogers-Bennett, Donald W. Rogers
Advances in Pure Mathematics (APM) , 2016, DOI: 10.4236/apm.2016.65023
Abstract: Many curves have been proposed and debated to model individual growth of marine invertebrates. Broadly, they fall into two classes, first order (e.g. von Bertalanffy) and sigmoidal (e.g. Gompertz). We provide an innovative approach which demonstrates that the growth curves are not mutually exclusive but that either may arise from a simple three-stage growth model \"\" with two steps (k1 and k2) depending on the ratio of the growth parameters \"\". The new approach predicts sigmoidal growth when \"\" is close to 1, but if either growth from stage A to stage B or B to C is fast relative to the other, the slower of the two steps becomes the growth limiting step and the model reduces to first order growth. The resulting curves indicate that there is a substantial difference in the estimated size at time t during the period of active growth. This novel two-step rate model generates a growth surface that allows for changes in the rate parameters over time as reflected in the new parameter n(t) = k1(t) -?k2(t). The added degree of freedom brings about individual growth trajectories across the growth surface that is not easily mapped using conventional growth modeling techniques. This two (or more) stage growth model yields a growth surface that allows for a wide range of growth trajectories, accommodating staged growth, growth lags, as well as indeterminate growth and can help resolve debates as to which growth curves should be used to model animal growth. This flexibility can improve estimates of growth parameters used in population models influencing model outcomes and ultimately management decisions.=
Rectal Duplication Cyst in a 12 year old Female Presenting with Chronic Constipation and Rectal Bleeding: A Case Report  [PDF]
Kimberly Harris, Kishore Vellody
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.21002
Abstract: Constipation is a common presenting complaint in children. Rectal duplication cysts are rare congenital malformations that need to be considered in patients with chronic constipation that has not responded to typical therapy and in pa-tients presenting with rectal bleeding. It is important to maintain a high index of suspicion when diagnosing this condi-tion as other congenital malformations may be present and rectal duplication cysts have the potential for malignant transformation if they go unrecognized. This case report describes a 12 year old female with chronic constipation and rectal bleeding who was found to have a rectal duplication cyst. It discusses the pathophysiology of the disease and highlights the options available for treatment.
New insights on the pathogenesis of pyloric stenosis of infancy. A review with emphasis on the hyperacidity theory  [PDF]
Ian M. Rogers
Open Journal of Pediatrics (OJPed) , 2012, DOI: 10.4236/ojped.2012.22017
Abstract: A review is presented on the theories concerning the cause of pyloric stenosis with emphasis on the primary position of inherited hyperacidity in pathogenesis. Existing theories are critically analysed and the hyperacidity theory is precisely defined in the light of recent physiological insights into the gastrointestinal hormone motilin. The progressive fixed fasting hypergastrinaemia within the first few weeks of life will, in the baby who inherits acid secretion at the top of the normal range, produce hyperacidity of sufficient severity to trigger the process of acid-induced work hypertrophy of the pylorus. The potential contribution of motilin is discussed. The baby who inherits a normal gastric acidity will not reach acid levels severe enough to trigger sphincter hypertrophy despite the early gastrin stimulus. The potential threat will cease when gastrin naturally declines with age and the pyloric canal becomes wider. Genetic factors clearly must also be involved and these are separately discussed.
Molecular Targeted Therapy of Hepatocellular Carcinoma  [PDF]
Kimberly Terry, Mehmet Sitki Copur
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.42A052

Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third most common cause of cancer-related mortality worldwide. Despite decades of efforts by many investigators, systemic chemotherapy or hormonal therapy has notoriously failed to show an improvement in survival. With a median survival of 8 months, and 1- and 3-year survival rates of 20% and 5%, respectively, the effective treatment of HCC remains far from satisfactory. Better understanding of the pathogenesis of this disease, identification of molecular targets for therapeutic intervention and availability of promising molecularly targeted therapies may change this dismal picture. In this review we will focus on what is currently known about the molecular pathogenesis of HCC, and explore the currently available and future molecular based therapies targeting these pathways. Future research in this area will maximize clinical benefit while minimizing the toxicity and cost through utilization of novel targeted agents.

Outcome of Cataract Surgery in Patients Treated for Retinopathy of Prematurity  [PDF]
Huy Nguyen, Kimberly G. Yen
Open Journal of Ophthalmology (OJOph) , 2017, DOI: 10.4236/ojoph.2017.74038
Background/Aims: Pediatric patients with treated retinopathy of prematurity (ROP) may develop visually significant cataracts. We report the outcome of cataract surgery in patients who had ROP treatment. Method: Retrospective chart review of 19 eyes from 16 patients who had ROP treatment and subsequent cataract surgery between August, 2002 and March, 2015. Results: Eighteen of 19 eyes received laser treatment for ROP; 1 eye received intravitreal bevacizumab. 5 eyes received lens-sparing pars plana vitrectomy (LSPPV) in addition to laser. Average follow up was 10.1 ± 5.5 years. Average visual acuity improved from 20/324 prior to and 20/110 after cataract surgery (p = 0.06). 13/19 (68%) of the eyes received laser only and developed cataracts an average of 6.2 ± 5.6 years after laser treatment. 5/19 (26%) eyes developed cataracts an average of 6.4 ± 4.2 years after LSPPV and laser. In one eye, a cataract developed after a bevacizumab injection 2.9 years after the injection. Visual axis opacification (VAO) developed in 2/5 (40%) eyes after Ce/PCIOL/PPC-Antvx, 8/10 eyes (80%) after CE/IOL, and in 0/4 eyes after CE/PPC-AntVx. Ocular comorbidities included strabismus, nystagmus, amblyopia, optic atrophy, corneal band keratopathy, and phthisis bulbi. Conclusion: Cataract surgery in patients who have a history of ROP can be complicated by anatomical changes from prematurity and prior vitreoretinal surgeries. Vision improvement is limited by other ocular comorbidities.
Outcome of Pediatric Cataract Surgery in Patients Who Have Undergone Bone Marrow Transplantation  [PDF]
Ariel Chen, Kimberly G Yen
Open Journal of Ophthalmology (OJOph) , 2018, DOI: 10.4236/ojoph.2018.81008
Purpose: Bone marrow transplantation (BMT) and pre-treatment conditioning increases the risk of developing pediatric cataracts. We present the outcome of cataract surgery in children who have had BMT. Methods: We conducted a retrospective chart study with 15 BMT patients (28 eyes) who underwent cataract extraction between 2002 and 2012. Outcome measures include change in best corrected visual acuity (BCVA) and complications. Results: 7 (47%) patients had acute lymphoid leukemia, 3 (20%) had acute myeloid leukemia, 2 (13%) had myelodysplastic syndrome, 1 (7%) had Fanconi anemia, 1 (7%) had juvenile myelomonocytic leukemia, and 1 (7%) had adrenoleukodystrophy. Patients received BMT at a mean age of 3.9 ± 1.6 years. 12 (80%) patients received total body irradiation (TBI) and 3 of these 12 received cranial irradiation in addition to TBI; one (7%) received only cranial irradiation. Total body irradiation included head and eye exposure. Mean age of cataract surgery was 9.1 ± 2.3 years; mean follow-up was 55.9 ± 45.1 months. All cataracts were of posterior subcapsular subtype. Mean BCVA improved from 0.7 ± 0.4 logMAR to 0.3 ± 0.5 logMAR (p < 0.001). 23/28 eyes (80%) had cataract extraction with intraocular lens placement; 5/28 (20%) of the eyes had cataract extraction with primary posterior capsulotomy and anterior vitrectomy (PC/AVx). 23/23 (100%) of the eyes without primary PC/AVx developed PCO an average of 2.3 ± 6.9 months after surgery. No eyes with primary PC/AVx eyes developed PCO. Conclusions: Children with history of BMT have a predisposition of developing posterior subcapsular cataracts and have a high rate of visually significant PCO if the posterior capsule is left intact at the time of cataract surgery.
Género en transición: sentido común, mujeres y guerra
Theidon, Kimberly;
Cadernos Pagu , 2011, DOI: 10.1590/S0104-83332011000200003
Abstract: in august 28, 2003, after two years working and having collected 17000 testimonials, the peruvian committee for the truth and reconciliation presented its final information on the violence period from 1980 to 2000. this committee shared many traits with its equivalents from guatemala and south africa. all three committees were considered gender-sensitive for they tried to bring to light the experiences of violence suffered by women. such an emphasis reflected the will to write "more inclusive truths" as well as changes in international jurisprudence. in this article, i examine the gender-sensitive research strategies and the ways in which truth committees incorporated these strategies to their work. truth and memory are, in fact, crossed by gender, but not necessarily in the way that common sense understands it. thus, i hope to offer a more subtle understanding of the dimensions associated to gender in war.
Género En Transición: Sentido Común, Mujeres y Guerra.
Análisis Político , 2007,
Abstract: this article traces some testimonies emerged from commissions of truth in peru and their implications regarding women and war. it examines what "gender sensitive" research strategies mean as well as ways in which commissions of truth have incorporated them within their labor. truth and memory are categories that are in fact permeated by gender, not necessarily in the way that common sense would suggest. therefore, the text aims at offering a more detailed understanding of war dimensions while associated to gender.
Género en transición: sentido común, mujeres y guerra
Cuadernos de antropolog?-a social , 2006,
Abstract: in this article, i draw upon research i have conducted since 1995 in peru to explore the commissioning of truth and some implications in terms of women and war. i am interested in examining what constitutes "gender sensitive" research strategies, as well as the ways in which truth commissions have incorporated these strategies into their work. truth and memory are indeed gendered, but not in any common-sensical way. thus i hope to offer a more nuanced understanding of the gendered dimensions of war.
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