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Search Results: 1 - 10 of 217420 matches for " Kim N. Dirks "
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Annoyance and Health-Related Quality of Life: A Cross-Sectional Study Involving Two Noise Sources  [PDF]
Daniel Shepherd, David McBride, Kim N. Dirks, David Welch
Journal of Environmental Protection (JEP) , 2014, DOI: 10.4236/jep.2014.55043
Abstract:

Noise remains a potent degrader of health in many global contexts, capable of inducing severe annoyance and sleep disturbance. An epidemiological study was undertaken to compare noise annoyance and health-related quality of life of individuals residing close to a major international airport or wind turbine complex with those located in demographically matched areas. Results indicate that domains of health-related quality of life may be degraded in those living in areas more likely to induce noise annoyance. Furthermore, the addition of aviation noise to environments already encroached by road noise may induce further annoyance and degradations in health-related quality of life, indicating that one noise sources may not mask the impact of another.

Exploring the Relationship between Noise Sensitivity, Annoyance and Health-Related Quality of Life in a Sample of Adults Exposed to Environmental Noise
Daniel Shepherd,David Welch,Kim N. Dirks,Renata Mathews
International Journal of Environmental Research and Public Health , 2010, DOI: 10.3390/ijerph7103580
Abstract: The relationship between environmental noise and health is poorly understood but of fundamental importance to public health. This study estimated the relationship between noise sensitivity, noise annoyance and health-related quality of life in a sample of adults residing close to the Auckland International Airport, New Zealand. A small sample ( n = 105) completed surveys measuring noise sensitivity, noise annoyance, and quality of life. Noise sensitivity was associated with health-related quality of life; annoyance and sleep disturbance mediated the effects of noise sensitivity on health.
Do Quiet Areas Afford Greater Health-Related Quality of Life than Noisy Areas?
Daniel Shepherd,David Welch,Kim N. Dirks,David McBride
International Journal of Environmental Research and Public Health , 2013, DOI: 10.3390/ijerph10041284
Abstract: People typically choose to live in quiet areas in order to safeguard their health and wellbeing. However, the benefits of living in quiet areas are relatively understudied compared to the burdens associated with living in noisy areas. Additionally, research is increasingly focusing on the relationship between the human response to noise and measures of health and wellbeing, complementing traditional dose-response approaches, and further elucidating the impact of noise and health by incorporating human factors as mediators and moderators. To further explore the benefits of living in quiet areas, we compared the results of health-related quality of life (HRQOL) questionnaire datasets collected from households in localities differentiated by their soundscapes and population density: noisy city, quiet city, quiet rural, and noisy rural. The dose-response relationships between noise annoyance and HRQOL measures indicated an inverse relationship between the two. Additionally, quiet areas were found to have higher mean HRQOL domain scores than noisy areas. This research further supports the protection of quiet locales and ongoing noise abatement in noisy areas.
Review Essay: M glichkeiten und Grenzen verstehenden Erkl rens am Beispiel sprach- und kulturwissenschaftlicher Ann herungen an Auto-/Biografien Review Essay: Chances and Obstacles of an "Understanding Explaining" Illustrated by Linguistic and Cultural Studies' Approaches to Auto-/Biographies Ensayo: Obstáculos y oportunidades de una "explicación comprensiva" ilustrados por estudios culturales y lingüísticos. Aproximaciones a las auto-biografías
Una Dirks
Forum : Qualitative Social Research , 2004,
Abstract: Der von Rita FRANCESCHINI herausgegebene Sammelband vereinigt eine Vielzahl unterschiedlicher Beitr ge, die sich v.a. aus linguistischer, literaturwissenschaftlicher und ethnologischer Perspektive mit einem breiten Spektrum auto-/biographischer und interkultureller Ph nomene befassen. Das Anliegen der in dem Band versammelten AutorInnen ist, Korrelationen zwischen diesen Ph nomenen aufzuzeigen, dabei den Stellenwert individueller und kollektiver Konstruktionen von Wirklichkeit herauszuarbeiten sowie biographische Struktureffekte auf den Umgang mit fremdsprachlichen Anforderungen in bi- oder trilingualen Kontaktsituationen nachzuweisen. – Die Rezension des Sammelbandes erfolgt im wesentlichen mithilfe einer verstehend erkl renden Kulturheuristik (Max WEBER) und in Orientierung an den für sozialwissenschaftliche, sozio-, pragma- und textlinguistische Arbeiten geltenden Standards. Dabei wird den literaturwissenschaftlichen Herangehensweisen eine gewisse – auf eigenwillige Sample-Bildungen und mangelnde methodische Kontrolliertheit zurückzuführende – Wildwüchsigkeit nachgewiesen, w hrend die sprachtheoretischen Abhandlungen v.a. hinsichtlich mikro- und makrotheoretisch relevanter Synthesebildungen diskutiert werden, die am ehesten auch als Beitrag zu einer kulturwissenschaftlichen (Sprach-) Biographieforschung verstanden werden k nnen. URN: urn:nbn:de:0114-fqs040132 Rita FRANCESCHINI has edited a book that deals with various elements of auto-/biographical and multicultural studies. Most of the authors' arguments draw on linguistic, literary and ethnological approaches. In several chapters attempts are made to exemplify the interdependencies between biography and culture, specifically between individual and collective constructions of reality. In addition, various chapters focus on biographical structural effects resulting from speakers' experience with foreign language challenges in bilingual or even trilingual contact situations. The review of the volume is framed by a cultural heuristic of an understanding explaining concept (Max WEBER); the reviewer's criticism is supported by qualitative standards of socio-pragmalinguistic and textlinguistic work. From this point of view evidence is provided that explains why literary studies' approaches tend to employ individual sampling procedures as well as other default procedures in gaining methodically controlled insights into properties and dimensions at issue. The linguistic contributions are discussed at length because of their efforts to connect micro- and macro-theoretical perspectives to each other, as such e
Review Essay: Fragen und Antworten der Kritischen Diskursanalyse zum Verstehenden Erkl ren aus mikro- und makrotheoretischer Perspektive Review Essay: How Critical Discourse Analysis Faces the Challenge of Interpretive Explanations from a Micro- and Macro-theoretical Perspective Ensayo: Como enfrenta el análisis crítico del discurso el desafío de las explicaciones interpretativas desde una perspectiva micro y macroteórica
Una Dirks
Forum : Qualitative Social Research , 2006,
Abstract: Zu Beginn wird ein knapper überblick zu aktuellen Ver ffentlichungen und den historischen Wurzeln der Kritischen Diskursanalyse (KDA) gegeben. Die anschlie ende Rezension des Sammelbandes orientiert sich an den von den HerausgeberInnen, Ruth WODAK and Gilbert WEISS, beschriebenen KDA-Merkmalen: 1) Kl rung der zentralen KDA-Begriffe, 2) die Erzeugung sowohl verstehend-erkl render als auch kritischer Erkenntnisse aufgrund der relationierenden Verknüpfung von institutionellen, strukturellen mit text-/diskursspezifischen, pragmatischen Dimensionen und 3) die methodisch kontrollierte Genese von Konstruktionen zweiter Ordnung. Mithilfe dieser Aspekte verdeutlicht der Rezensionsaufsatz, inwiefern die einzelnen Artikel beachtenswerte Thesen, Suchstrategien und Forschungsergebnisse beinhalten, v.a. im Hinblick auf die selbst-reflexive Kritik des "Kritischen" oder die Situation benachteiligter und diskriminierter Gruppenmitglieder in unterschiedlichen Handlungsfeldern. Dabei pr sentiert sich die KDA als ein interdisziplin res, unabgeschlossenes Projekt, das sich um die Erfüllung hoher empirischer Standards sowohl der Linguistik als auch der Sozialwissenschaften bemüht. Diesem Anliegen sind denn auch die Hinweise der Rezensentin u.a. auf die systematischen Unterschiede zwischen Grundlagen- und Verwendungsforschung sowie auf die umfassende Operationalisierung einer Handlungstheorie verpflichtet. URN: urn:nbn:de:0114-fqs0602261 The review starts with a brief outline of recent publications on Critical Discourse Analysis (CDA) and its historical roots. Next, the volume is discussed on behalf of the features its editors, Ruth WODAK and Gilbert WEISS, have attributed to CDA themselves: i.e., 1) clarification of the basic CDA-notions, 2) the interpretive explanatory as well as critical impact of providing insights into institutional, structure-related dimensions in connection with textual/discursive, action-related aspects, and 3) the formation of methodically controlled second-grade constructions. Against this background, the volume's articles bring to light remarkable theses, searching strategies, and research findings that focus on the self-reflexive critique of the "critical" or on the situation of underprivileged and discriminated group members in different fields of action. Herewith, CDA presents itself as an interdisciplinary project in process that strives to meet high empirical standards, of both linguistics and social studies. In line with this endeavour, the reviewer puts emphasis on the systematic differences between basic research and applied research as well
Lifetime health effects and medical costs of integrated stroke services - a non-randomized controlled cluster-trial based life table approach
Stefan A Baeten, N Job A van Exel, Maaike Dirks, Marc A Koopmanschap, Diederik WJ Dippel, Louis W Niessen
Cost Effectiveness and Resource Allocation , 2010, DOI: 10.1186/1478-7547-8-21
Abstract: The EDISSE study is a prospective non-randomized controlled cluster trial that compared stroke services (n = 151 patients) to usual care (n = 187 patients). Health status and cost trial-data were entered in multi-dimensional stroke life-tables. The tables distinguish four levels of disability which are defined by the modified Rankin scale. Quality-of-life scores (EuroQoL-5D), transition and survival probabilities are based on concurrent Dutch follow-up studies. Outcomes are quality-adjusted life years lived and lifetime medical cost by disability category. An economic analysis compares outcomes from a successful stroke service to usual care, by bootstrapping individual costs and effects data from patients in each arm.Lifetime costs and QALYs after stroke depend on age-of-onset of first-ever stroke. Lifetime QALYs after stroke are 2.42 (90% CI - 0.49 - 2.75) for male patients in usual care and 2.75 (-0.61; 6.26) for females. Lifetime costs for men in the usual care setting are €39,335 (15,951; 79,837) and €42,944 (14,081; 95,944) for women. A comparison with the stroke service results in an ICER of €11,685 saved per QALY gained (€14,211 and €7,745 for men and women respectively). This stroke service is with 90% certainty cost-effective.Our analysis shows the potential of large health benefits and cost savings of stroke services, taking a lifetime perspective, also in other European settings.In The Netherlands, as in most Western countries, stroke is a major contributor to the total burden of disease, in terms of morbidity, mortality and concomitant costs. In 2007, incidence of primary stroke was 2.12 per 1,000 men and 2.23 per 1,000 women, prevalence of stroke was 11.89 per 1,000 men and 11.48 per 1,000 women, and mortality from stroke was 46.50 per 100,000 men and 69.84 per 100,000 women [1]. The incidence rates in the Netherlands have only fluctuated around the same level since the early 1990 s. Yet, mortality has been steadily declining [1].The burden of stroke in
High Accuracy Mutation Detection in Leukemia on a Selected Panel of Cancer Genes
Zeynep Kalender Atak, Kim De Keersmaecker, Valentina Gianfelici, Ellen Geerdens, Roel Vandepoel, Daphnie Pauwels, Micha?l Porcu, Idoya Lahortiga, Vanessa Brys, Willy G. Dirks, Hilmar Quentmeier, Jacqueline Cloos, Harry Cuppens, Anne Uyttebroeck, Peter Vandenberghe, Jan Cools, Stein Aerts
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038463
Abstract: With the advent of whole-genome and whole-exome sequencing, high-quality catalogs of recurrently mutated cancer genes are becoming available for many cancer types. Increasing access to sequencing technology, including bench-top sequencers, provide the opportunity to re-sequence a limited set of cancer genes across a patient cohort with limited processing time. Here, we re-sequenced a set of cancer genes in T-cell acute lymphoblastic leukemia (T-ALL) using Nimblegen sequence capture coupled with Roche/454 technology. First, we investigated how a maximal sensitivity and specificity of mutation detection can be achieved through a benchmark study. We tested nine combinations of different mapping and variant-calling methods, varied the variant calling parameters, and compared the predicted mutations with a large independent validation set obtained by capillary re-sequencing. We found that the combination of two mapping algorithms, namely BWA-SW and SSAHA2, coupled with the variant calling algorithm Atlas-SNP2 yields the highest sensitivity (95%) and the highest specificity (93%). Next, we applied this analysis pipeline to identify mutations in a set of 58 cancer genes, in a panel of 18 T-ALL cell lines and 15 T-ALL patient samples. We confirmed mutations in known T-ALL drivers, including PHF6, NF1, FBXW7, NOTCH1, KRAS, NRAS, PIK3CA, and PTEN. Interestingly, we also found mutations in several cancer genes that had not been linked to T-ALL before, including JAK3. Finally, we re-sequenced a small set of 39 candidate genes and identified recurrent mutations in TET1, SPRY3 and SPRY4. In conclusion, we established an optimized analysis pipeline for Roche/454 data that can be applied to accurately detect gene mutations in cancer, which led to the identification of several new candidate T-ALL driver mutations.
On Linear Coding Schemes for Stabilizing LTI Control with Multiple Sensors
Anna N. Kim
International Journal of Distributed Sensor Networks , 2010, DOI: 10.1155/2010/514521
Abstract: We examine the problem of designing the encoding and control policies of a linear stochastic control system, where the communication channel between the plant state observer (sensor) and the controller is a lossy wireless channel that is constrained in terms of transmit power and bandwidth. For a first-order ARMA modeled plant with Gaussian statistics, when there are two sensors observing the plant, nonlinear encoding is shown to result in smaller cost at time instant compared to the linear schemes, if transmissions are carried out over parallel Gaussian independent channels. In this paper, optimal linear coding schemes for the case of multiple sensors are examined. They are shown to minimize the control cost at the infinite time horizon, when the wireless channel is accessed using time division multiplexing. Our analysis is carried out for when separation between the state estimation and control is possible, and the optimal steady state control law is certainty equivalent. The distortion lower bound for estimating the plant state is derived, along with the necessary conditions on the transmit power that minimize the steady state control cost. We also propose a linear scheme that reaches the distortion bound asymptotically under relaxed conditions. 1. Introduction Wireless sensors and communication have become an integral part of closed-loop control systems in the recent years. Consider for example, the following simple control application. We wish to regulate the temperature of a room. Multiple sensor nodes are placed at different locations in the room for taking temperature measurements. The measurements are then sent to the controller, which utilizes the sensor observations when issuing new control commands to the heating or cooling elements. Naturally, benefits such as flexible placement, reduced costs on installation, and easier maintenance can be expected if sensor nodes communicate to the controller via wireless channels. This, however, also means that the sensor nodes are now sharing the communication medium, which is lossy and in general also restricted in terms of bandwidth and power. Such information constraints make the networked control systems differ from the classic wired setting. As pointed out in [1], designing the optimal communication and control policies in this case is no simple task, since the changes in one directly influence the outcome of the other. The controller may have to tolerate large errors and/or delays in sensor observations, while the sensors may have to encode and transmit their measurements subject to strict
Assessment by Simu ation of Benefits of New HEV Powertrain Configurations évaluation par simulation des bénéfices de nouvelles cha nes de traction hybrides
Kim N.,Rousseau A.
Oil & Gas Science and Technology , 2013, DOI: 10.2516/ogst/2013107
Abstract: During the past couple of years, numerous powertrain configurations for Hybrid Electric Vehicles (HEV) have been introduced into the marketplace. The current dominant architecture is the power-split configuration with the input split (single-mode) from Toyota and Ford. General Motors (GM) recently introduced a two-mode power-split configuration for applications in sport utility vehicles. Also, the first commercially available Plug-In Hybrid Electric Vehicle (PHEV) — the GM Volt — was introduced into the market in 2010. The GM Volt uses a series-split powertrain architecture, which provides benefits over the series architecture, which typically has been considered for Electric-Range Extended Vehicles (E-REV). This paper assesses the benefits of these different powertrain architectures (single-mode versus multi-mode for HEV) (series versus GM Voltec for PHEV) by comparing component sizes, system efficiency and fuel consumption over several drive cycles. On the basis of dynamic models, a detailed component control algorithm was developed for each configuration. The powertrain components were sized to meet all-electric-range, performance and grade-capacity requirements. This paper presents and compares the impact of these different powertrain configurations on component size and fuel consumption. Durant les dernières années, de nombreuses configurations de motorisation pour véhicules hybrides ont été introduites sur le marché. La solution dominante est actuellement la dérivation de puissance en configuration ‘input split’ simple mode utilisée par Toyota et Ford. General Motors (GM) a récemment introduit une configuration basée sur la dérivation de puissance avec deux modes pour application sur des SUV (Sport Utility Vehicle). Par ailleurs, le premier véhicule hybride rechargeable la Volt de GM a été introduite sur le marché en 2010. La Volt utilise une architecture qui autorise plusieurs modes : électrique, série et dérivation de puissance, et qui est plus performante que l’architecture série mise en uvre généralement pour les véhicules électriques à prolongateur d’autonomie (E-REV, Electric-Range Extended Vehicles). Ce papier est dédié à l’étude des bénéfices de différentes motorisations simple mode contre multi-mode pour les véhicules hybrides, série contre GM Voltec pour les véhicules hybrides rechargeables. Le dimensionnement des composants, leur rendement ainsi que celui du systeme et la consommation énergétique sur différents cycles sont étudiés. Un modèle dynamique détaillé avec son algorithme de contr le a été développé pour chacune des configurati
Riociguat: an upcoming therapy in chronic thromboembolic pulmonary hypertension?
N. H. Kim
European Respiratory Review , 2010,
Abstract: Although pulmonary endarterectomy remains the treatment of choice for patients with chronic thromboembolic pulmonary hypertension (CTEPH), not all patients will benefit from or receive this highly specialised surgery. Patients whose CTEPH is deemed inoperable by an experienced centre and patients with persistent pulmonary hypertension after surgery are candidates for trial of pulmonary arterial hypertension (PAH) specific pharmacotherapies. However, the currently available PAH specific pharmacotherapies have not demonstrated a clear benefit in either of these patient groups. Accordingly, PAH therapies remain off-label for use in CTEPH. Riociguat (BAY 63-2521) is a stimulator of soluble guanylate cyclase, and may represent a novel agent in the treatment of select patients with CTEPH. Pre-clinical and human phase II studies with riociguat have reported promising results, and a multinational, randomised, controlled, double-blinded phase III study is currently underway to investigate the effect of riociguat in patients with inoperable CTEPH and those with persistent or recurrent pulmonary hypertension following pulmonary endarterectomy.
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