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Search Results: 1 - 10 of 479527 matches for " Kim A. Keating "
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Culture-Modified Bone Marrow Cells Attenuate Cardiac and Renal Injury in a Chronic Kidney Disease Rat Model via a Novel Antifibrotic Mechanism
Darren A. Yuen,Kim A. Connelly,Andrew Advani,Christine Liao,Michael A. Kuliszewski,Judy Trogadis,Kerri Thai,Suzanne L. Advani,Yuan Zhang,Darren J. Kelly,Howard Leong-Poi,Armand Keating,Philip A. Marsden,Duncan J. Stewart,Richard E. Gilbert
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0009543
Abstract: Most forms of chronic kidney disease are characterized by progressive renal and cardiac fibrosis leading to dysfunction. Preliminary evidence suggests that various bone marrow-derived cell populations have antifibrotic effects. In exploring the therapeutic potential of bone marrow derived cells in chronic cardio-renal disease, we examined the anti-fibrotic effects of bone marrow-derived culture modified cells (CMCs) and stromal cells (SCs).
Ovals and Hyperovals in Desarguesian Nets
David A. Drake,Kevin Keating
Mathematics , 2002,
Abstract: We determine the Desarguesian planes which hold $r$-nets with ovals and those which hold $r$-nets with hyperovals for every $r \le 7$.
Shared Bacterial and Viral Respiratory Agents in Bighorn Sheep (Ovis canadensis), Domestic Sheep (Ovis aries), and Goats (Capra hircus) in Montana
David S. Miller,Glen C. Weiser,Keith Aune,Brent Roeder,Mark Atkinson,Neil Anderson,Thomas J. Roffe,Kim A. Keating,Phillip L. Chapman,Cleon Kimberling,Jack Rhyan,P. Ryan Clarke
Veterinary Medicine International , 2011, DOI: 10.4061/2011/162520
Abstract: Transmission of infectious agents from livestock reservoirs has been hypothesized to cause respiratory disease outbreaks in bighorn sheep (Ovis canadensis), and land management policies intended to limit this transmission have proven controversial. This cross-sectional study compares the infectious agents present in multiple populations of bighorn sheep near to and distant from their interface with domestic sheep (O. aries) and domestic goat (Capra hircus) and provides critical baseline information needed for interpretations of cross-species transmission risks. Bighorn sheep and livestock shared exposure to Pasteurellaceae, viral, and endoparasite agents. In contrast, although the impact is uncertain, Mycoplasma sp. was isolated from livestock but not bighorn sheep. These results may be the result of historic cross-species transmission of agents that has resulted in a mosaic of endemic and exotic agents. Future work using longitudinal and multiple population comparisons is needed to rigorously establish the risk of outbreaks from cross-species transmission of infectious agents. 1. Introduction Bighorn sheep (Ovis canadensis) experienced substantial decreases in population numbers and range in the 19th and the early 20th centuries, and subsequent recovery efforts have often been limited by large-scale die-offs [1–3]. These initial population declines were associated with settlement of western North America and were attributed to unregulated hunting, competition for forage with domestic sheep (O. aries) and other livestock, and disruption of historic bighorn sheep migration patterns due to development. Clinical disease was apparently unimportant or was underreported in these early declines, though die-offs of bighorn sheep associated with sheep scab (Psoroptes sp.) were reported following settlement [4, 5]. Bighorn sheep die-offs associated with pneumonia were reported in the 1920s and 1930s [6–10]. These early reports and subsequent work largely focused on lungworm (Protostrongylus sp.) as the primary infectious agent, although the involvement of Pasteurella sp., Corynebacterium pyogenes (currently Arcanobacterium pyogenes), and other host and environmental determinants were also noted as potential causes of respiratory disease. Subsequently, inconsistent association of lungworm with respiratory disease in bighorn sheep, as well as further evidence for Pasteurella sp. as the cause of pneumonia, led to a focus on pasteurellosis as a cause of respiratory disease outbreaks [11–14]. This research included evidence that Pasteurella sp. strains from clinically
5s correlation confinement resonances in Xe-endo-fullerenes
V. K. Dolmatov,D. A. Keating
Physics , 2011, DOI: 10.1088/1742-6596/388/2/022010
Abstract: Spectacular trends in the modification of the Xe 5s photoionization via interchannel coupling with confinement resonances emerging in the Xe 4d giant resonance upon photoionization of the Xe@C60, Xe@C240 and Xe@C60@C240 endo-fullerenes are theoretically unraveled and interpreted.
Xe 4d photoionization in Xe@C60, Xe@C240, and Xe@C60@C240
V. K. Dolmatov,D. A. Keating
Physics , 2011, DOI: 10.1088/1742-6596/388/2/022097
Abstract: Re-evaluated parameters for the square-well potential model for photoionization of endo-fullerenes are proposed and employed to reveal the spectacular modifications in the Xe 4d photoionization giant resonance along the path from Xe@C60 to Xe@C240 to multi-walled Xe@C60@C240.
Early Clinical Outcomes with a 3-D Porous Titanium Acetabular Cup  [PDF]
Tatsuya Sueyoshi, E. Michael Keating, Merrill A. Ritter, John B. Meding, Matthew J. Brunsman
Open Journal of Orthopedics (OJO) , 2016, DOI: 10.4236/ojo.2016.66018
Abstract: Cementless acetabular components are associated with a significant incidence of polyethylene wear and secondary osteolysis. 3-dimentional (3-D) porous coating and enhanced shell to a liner fixation are expected to reduce the polyethylene wear and to increase the longevity of an acetabular cup. The authors report the early clinical outcome with a cementless acetabular cup, Regenerex Ringloc+ (Zimmer Biomet, Warsaw, IN) for total hip arthroplasty. Between 2007 and 2013, the registry with 476 hip joints was reviewed retrospectively. There were 210 (48.4%) female and 224 (51.6%) male patients. The average age of the patients at the surgery was 63.9 (± 12.0) years and the average follow-up period was 2.6 years [0.5, 6.5]. At the final follow-up, there was no loosening or cup failure. There were 2 infections, 1 dislocation and 1 liner fracture, resulting in revision hip surgery. Average Harris hip score improved from 53.9 preoperatively to 91.4 postoperatively. The survivorship of Regenerex Ring Loc+ cup and the low complication rate is comparable with previous studies using other 3-D porous metal prostheses. Although this short-term outcome from the institute is very encouraging, a longer follow-up study is required.
Copy Number Variations in Alternative Splicing Gene Networks Impact Lifespan
Joseph T. Glessner, Albert Vernon Smith, Saarene Panossian, Cecilia E. Kim, Nagahide Takahashi, Kelly A. Thomas, Fengxiang Wang, Kallyn Seidler, Tamara B. Harris, Lenore J. Launer, Brendan Keating, John Connolly, Patrick M. A. Sleiman, Joseph D. Buxbaum, Struan F. A. Grant, Vilmundur Gudnason, Hakon Hakonarson
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0053846
Abstract: Longevity has a strong genetic component evidenced by family-based studies. Lipoprotein metabolism, FOXO proteins, and insulin/IGF-1 signaling pathways in model systems have shown polygenic variations predisposing to shorter lifespan. To test the hypothesis that rare variants could influence lifespan, we compared the rates of CNVs in healthy children (0–18 years of age) with individuals 67 years or older. CNVs at a significantly higher frequency in the pediatric cohort were considered risk variants impacting lifespan, while those enriched in the geriatric cohort were considered longevity protective variants. We performed a whole-genome CNV analysis on 7,313 children and 2,701 adults of European ancestry genotyped with 302,108 SNP probes. Positive findings were evaluated in an independent cohort of 2,079 pediatric and 4,692 geriatric subjects. We detected 8 deletions and 10 duplications that were enriched in the pediatric group (P = 3.33×10?8–1.6×10?2 unadjusted), while only one duplication was enriched in the geriatric cohort (P = 6.3×10?4). Population stratification correction resulted in 5 deletions and 3 duplications remaining significant (P = 5.16×10?5–4.26×10?2) in the replication cohort. Three deletions and four duplications were significant combined (combined P = 3.7×10?4?3.9×10?2). All associated loci were experimentally validated using qPCR. Evaluation of these genes for pathway enrichment demonstrated ~50% are involved in alternative splicing (P = 0.0077 Benjamini and Hochberg corrected). We conclude that genetic variations disrupting RNA splicing could have long-term biological effects impacting lifespan.
The Cosmic Infrared Background Experiment (CIBER): the Narrow Band Spectrometer
P. M. Korngut,T. Renbarger,T. Arai,J. Battle,J. Bock,S. W. Brown,A. Cooray,V Hristov,B. Keating,M. G. Kim,A. Lanz,D. H. Lee,L. R. Levenson,K. R. Lykke,P. Mason,T. Matsumoto,S. Matsuura,U. W. Nam,B. Shultz,A. W. Smith,I. Sullivan,K. Tsumura,T. Wada,M. Zemcov
Physics , 2013, DOI: 10.1088/0067-0049/207/2/34
Abstract: We have developed a near-infrared spectrometer designed to measure the absolute intensity of the Solar 854.2 nm CaII Fraunhofer line, scattered by interplanetary dust, in the Zodiacal light spectrum. Based on the known equivalent line width in the Solar spectrum, this measurement can derive the Zodiacal brightness, testing models of the Zodiacal light based on morphology that are used to determine the extragalactic background light in absolute photometry measurements. The spectrometer is based on a simple high-resolution tipped filter placed in front of a compact camera with wide-field refractive optics to provide the large optical throughput and high sensitivity required for rocket-borne observations. We discuss the instrument requirements for an accurate measurement of the absolute Zodiacal light brightness, the measured laboratory characterization, and the instrument performance in flight.
The Cosmic Infrared Background Experiment (CIBER): The Wide-Field Imagers
J. Bock,I. Sullivan,T. Arai,J. Battle,A. Cooray,V. Hristov,B. Keating,M. G. Kim,A. C. Lam,D. H. Lee,L. R. Levenson,P. Mason,T. Matsumoto,S. Matsuura,K. Mitchell-Wynne,U. W. Nam,T. Renbarger,J. Smidt,K. Suzuki,K. Tsumura,T. Wada,M. Zemcov
Physics , 2012, DOI: 10.1088/0067-0049/207/2/32
Abstract: We have developed and characterized an imaging instrument to measure the spatial properties of the diffuse near-infrared extragalactic background light in a search for fluctuations from z > 6 galaxies during the epoch of reionization. The instrument is part of the Cosmic Infrared Background Experiment (CIBER), designed to observe the extragalactic background light above the Earth's atmosphere during a suborbital sounding rocket flight. The imaging instrument incorporates a 2x2 degree field of view, to measure fluctuations over the predicted peak of the spatial power spectrum at 10 arcminutes, and 7"x7" pixels, to remove lower redshift galaxies to a depth sufficient to reduce the low-redshift galaxy clustering foreground below instrumental sensitivity. The imaging instrument employs two cameras with \Delta \lambda / \lambda ~0.5 bandpasses centered at 1.1 and 1.6 microns to spectrally discriminate reionization extragalactic background fluctuations from local foreground fluctuations. CIBER operates at wavelengths where the electromagnetic spectrum of the reionization extragalactic background is thought to peak, and complements fluctuations measurements by AKARI and Spitzer at longer wavelengths. We have characterized the instrument in the laboratory, including measurements of the sensitivity, flat-field response, stray light performance, and noise properties. Several modifications were made to the instrument following a first flight in 2009 February. The instrument performed to specifications in subsequent flights in 2010 July and 2012 March, and the scientific data are now being analyzed.
The Cosmic Infrared Background Experiment (CIBER): The Low Resolution Spectrometer
K. Tsumura,T. Arai,J. Battle,J. Bock,S. Brown,A. Cooray,V. Hristov,B. Keating,M. G. Kim,D. H. Lee,L. R. Levenson,K. Lykke,P. Mason,T. Matsumoto,S. Matsuura,K. Murata,U. W. Nam,T. Renbarger,A. Smith,I. Sullivan,K. Suzuki,T. Wada,M. Zemcov
Physics , 2011, DOI: 10.1088/0067-0049/207/2/33
Abstract: Absolute spectrophotometric measurements of diffuse radiation at 1 \mu m to 2 \mu m are crucial to our understanding of the radiative content of the Universe from nucleosynthesis since the epoch of reionization, the composition and structure of the Zodiacal dust cloud in our solar system, and the diffuse galactic light arising from starlight scattered by interstellar dust. The Low Resolution Spectrometer (LRS) on the rocket-borne Cosmic Infrared Background Experiment (CIBER) is a \lambda / \Delta \lambda \sim 15-30 absolute spectrophotometer designed to make precision measurements of the absolute near-infrared sky brightness between 0.75 \mu m < \lambda < 2.1 \mu m. This paper presents the optical, mechanical and electronic design of the LRS, as well as the ground testing, characterization and calibration measurements undertaken before flight to verify its performance. The LRS is shown to work to specifications, achieving the necessary optical and sensitivity performance. We describe our understanding and control of sources of systematic error for absolute photometry of the near-infrared extragalactic background light.
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