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Search Results: 1 - 10 of 22545 matches for " Kikuchi-Fujimoto Disease "
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Kikuchi-Fujimoto Disease Associated to the Epstein-Barr Virus. A Type of Rare Necrotizing Lymphadenitis and Its Differential Diagnosis  [PDF]
Mónica Belinda Romero Guadarrama, Oscar Daniel Guzmán-Aguilar, Adriana Carolina López-Ugalde, José Samuel Almeida Navarro, Humberto Cruz-Ortíz
Open Journal of Pathology (OJPathology) , 2013, DOI: 10.4236/ojpathology.2013.34034
Abstract: Introduction: Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a specific and self-limited disease; its etiology is unknown. Some causal microorganisms have been proposed. The objective of the present article is to emphasize the clinicopathological characteristics of this disease that has been associated to the Epstein-Barr virus and to compare the histological changes with other types of necrotizing lymphadenopathies. Material and Methods: We studied 32 patients of the Surgical Pathology Service with necrotizing lymphadenitis, diagnosed in the years from 2004 to 2012 to found more cases of this rare disease in our Institution. Patients were 18 women and 14 men with an average age of 37 years. Results: The lymph nodes were cervical and axillary ones, some were associated to autoimmune diseases and no cause was identified in others. One of the cases, was diagnosed as KFD, presented morphological changes characteristic of this disease, such as subcapsular lymphoid follicles, zones with cell debris, epithelioid macrophages, clear-cytoplasm histiocytes, and immunoblast-reactive lymphocytes. Immunohistochemical markers were determined, such as CD20, CD2, CD4, CD8, CD68, lysozyme, CD56, granzyme B and EBER, which demonstrated the presence of B, T lymphocytes, histiocytes and cells positive to EBER. Histological changes in KFD occurred in three stages: proliferative stage, necrotizing, and xanthomatous. It is important to identify the histological stages of the disease because a differential diagnosis must be performed in regard to lymphadenopathies with necrosis and diverse types of lymphomas. Conclusion: We present a case of necrotizing lymphadenitis (KFD) associated to the Epstein-Barr virus and in some cases it is not possible to render a specific diagnosis based on morphologic findings, alone, and a diagnosis of necrotizing lymphadenitis may be used.


Kikuchi-Fujimoto Disease in Patients with Sjögren’s Syndrome  [PDF]
Lida Radfar, Mehdi Radfar, Kathy L. Moser, Robert Hal Scofield
Open Journal of Pathology (OJPathology) , 2013, DOI: 10.4236/ojpathology.2013.31006

Sjogren’s syndrome is a chronic autoimmune exocrinopathy associated with dry eyes and dry mouth as major clinical manifestations. It is characterized by lymphocytic infiltration of lacrimal and salivary glands and autoantibody production, especially anti-Ro (or SSA) and anti-La (or SSB). Lymphoproliferative disorders are a feature of Sjogren’s syndrome, and can be considered an extraglandular manifestation of the disease. Kikuchi-Fujimoto disease or histiocytic necrotizing lymphadenitis is a rare form of lymphadenitis. It is reported more often in young adult women with localized lymphadenopathy (usually cervical), fever, rashes, and leukopenia. It is a self-limiting disease with resolution within 1 - 4 months in almost all patients. Sjogren’s syndrome has been reported in patients with other systemic diseases including SLE and lymphomas. Here we present a patient with Kikuchi-Fujimoto disease who developed Sjogren’s Syndrome 8 years after her diagnosis of Kikuchi-Fujimoto disease.

Kikuchi-Fujimoto Disease Mimicking Tuberculosis  [PDF]
Madiha Mahfoudhi, Imen Gorsane, Sami Turki, Taieb Ben Abdallah
International Journal of Clinical Medicine (IJCM) , 2015, DOI: 10.4236/ijcm.2015.610096
Abstract: A 32-year-old woman presented with a fever and cervical lymphadenopathies. The research for Mycobacterium tuberculosis was negative. Tuberculin skin test was positive. Laboratory investigations showed an elevated erythrocyte sedimentation rate and a normal white blood cell count. Bacteriological and viral investigations were negative. Quantiferon-Tb Gold test was indeterminate. Thraco-abdominal and pelvic computed tomography, FDG-PET and gallium scintigraphy revealed no abnormalities. Histological study of cervical lymph node biopsy found signs in favor of histiocytic necrotizing lymphadenitis. There were no epithelioid cell granulomas. A test tuberculosis treatment was refused by the patient. The evolution was marked by spontaneous clinical and biological resolution in fifty days. The negative Lowenstein-Jensen culture eliminated formally the tuberculosis. KFD was thus the most likely diagnosis.
Enfermedad de Kikuchi-Fujimoto Kikuchi-Fujimoto disease
Juan Tordecilla C.,Mirta Medina F.,Ricardo ávila R.,Myriam Campbell B.
Revista chilena de pediatría , 2002,
Abstract: Se presenta el caso clínico de una paciente de 12 a os con el diagnóstico de enfermedad de Kikuchi-Fujimoto que evolucionó con fiebre dos meses previos acompa ado de adenopatías cervicales bilaterales, baja de peso de 5 kilos y compromiso del estado general. Sin respuesta a tratamiento antibiótico, se descartaron causas habituales de fiebre. La biopsia ganglionar mostró necrosis difusa, abundantes inmunoblastos, histiocitos, restos celulares necróticos y ausencia de neutrófilos. Evolucionó en forma favorable con caída de la fiebre a los 3 meses desde el inicio del cuadro y regresión de las adenopatías. Se destaca la importancia del diagnóstico diferencial de adenopatías cervicales persistentes acompa ado de síndrome febril prolongado A 12 year old girl with a diagnosis of Kikuchi-Fujimoto' disease is presented. The patient was referred with a history of 2 months of fever, bilateral cervical adenopathy, weight loss of 5 kg and malaise. There was no response to antibiotic therapy and laboratory studies excluded other aetiologies. A cervical lymph node biopsy showed diffuse necrosis, immunoblasts, histiocytes and absence of neutrophils. The patient’s evolution was favorable with disappearance of the fever by 3 months and regression of the adenopathy. We emphasize the importance of the differential diagnosis of persistent cervical adenopathies associated with prolonged fever
Enfermedad de Kikuchi-Fujimoto: estudio de cuatro casos
Montejo,M.; Lekerika,N.; Astigarraga,I.; Aguirrebengoa,K.; Goikoetxea,J.; Erdozain,J. G.; Bidaurrazaga,N.;
Anales de Medicina Interna , 2006, DOI: 10.4321/S0212-71992006000400006
Abstract: kikuchi fujimoto disease is an uncommon form of lymphadenitis, firstly described in japan. etiology is unknown. it affects mainly young women. it commonly manifests as a painful cervical lymphadenitis usually associated with fever and leukopenia. clinical course users to be benign, leading spontaneously to a complet recovery. histological findings include necrotizing changes with cariorrhesis, partial loss of ganglionar architecture and foci of histiocytic infiltrates in the cortical and/or paracortical zones of the lymph nodes. a common findings is the absence of neutrophil granulocytes in the inflammatory infiltrates, in contrast to other necrotizing lymphadenitis. we report four cases of kikuchi fujimoto disease, recently identified in our hospital.
Enfermedad de Kikuchi-Fujimoto
Tordecilla C.,Juan; Medina F.,Mirta; ávila R.,Ricardo; Campbell B.,Myriam;
Revista chilena de pediatría , 2002, DOI: 10.4067/S0370-41062002000500006
Abstract: a 12 year old girl with a diagnosis of kikuchi-fujimoto' disease is presented. the patient was referred with a history of 2 months of fever, bilateral cervical adenopathy, weight loss of 5 kg and malaise. there was no response to antibiotic therapy and laboratory studies excluded other aetiologies. a cervical lymph node biopsy showed diffuse necrosis, immunoblasts, histiocytes and absence of neutrophils. the patient?s evolution was favorable with disappearance of the fever by 3 months and regression of the adenopathy. we emphasize the importance of the differential diagnosis of persistent cervical adenopathies associated with prolonged fever
An atypical presentation of Kikuchi-Fujimoto disease mimicking systemic lupus erythematosus: case report and literature review  [PDF]
Diane Belder-Preston, Catherine-Maude Pound, Roman Jurencak
Open Journal of Pediatrics (OJPed) , 2011, DOI: 10.4236/ojped.2011.14016
Abstract: Purpose: To report a case of atypical Kikuchi-Fujimoto disease (KFD) that illustrates several overlapping features with systemic lupus erythematosus (SLE). Methods: A case is reported followed by a review of the current literature. Case report: A 16-year-old boy with an unusual manifestation of Kikuchi-Fujimoto disease (KFD) is described. The patient presented with fever, weight loss and severe abdominal pain, due to extensive necrotizing retroperitoneal and mesenteric lymphadenopathy. During the course of his illness, he developed several symptoms suggestive of systemic lupus erythematosus (SLE): a pericardial effusion, cotton wool spots on the retina and antibodies against nuclear antigens (ANA), Smith (Sm) and ribonucleoprotein (RNP) antigens. However, no additional features of SLE were found. The patient subsequently fully recovered within two months, without initiation of immunosuppressive therapy. His autoantibodies became negative five months after initial presentation and he remains well at his 23 month follow up visit. Discussion: We hypothesize that the autoantibodies developed by our patient were secondary to self-antigen induced autoimmunity related to his extensive tissue necrosis. Despite initially having clinical features suggestive of SLE, our patient’s full and spontaneous recovery strongly supports the diagnosis of KFD. This illustrates the need for careful diagnosis, in order to avoid unnecessary and potentially toxic treatment with immunosuppressive agents.
Enfermedad de Kikuchi-Fujimoto y su asociación a lupus eritematoso sistémico
Jiménez Sáenz,J. Ma.; Llorente Arenas,E. Ma.; Fuentes Solsona,F.; Miguel García,F. de; álvarez Alegret,R.;
Anales de Medicina Interna , 2001, DOI: 10.4321/S0212-71992001000800007
Abstract: kikuchi-fujimoto's disease (kfd), histiocytic necrotizing lymphadenitis, is a rare self-limiting condition characterized by lymphadenopathy, fever and neutropenia. the aetiology of kfd is controversial, and its diagnosis is confirmed histologically. although kfd has rarely been reporded associated to systemic lupus erythemotosus (sle) should be ruled out given its different prognosis and management. we present the clinical, histological and evolution the two cases of patients with kikuchi's disease; one case had evolution classic and the other case were associated with sle.
Enfermedad de Kikuchi-Fujimoto: Presentación de un caso clínico
Cuervo,José Luis; Dandin,Paula; Castiglioni,Teresa; Ortega,Liliana; Amaral,Diego; Faifman,Ruth;
Archivos argentinos de pediatr?-a , 2008,
Abstract: kikuchi-fujimoto disease is a self-limited condition of young adults, that usually involves the cervical lymph nodes and is associated with persistent hyperthermia. diagnosis is based on characteristic pathologic findings, that allows the diferential diagnosis with other similar clinical conditions. we report one case of kikuchi-fujimoto disease in a 12 years old girl and review the world literature.
Enfermedad de Kikuchi-Fujimoto: Presentación de un caso pediátrico
Hernández Cabezas,Ania; Díaz Linares,Nelkis C;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2010,
Abstract: this is the case of a white patient aged 14 diagnosed with kikuchi-fujimoto disease presenting adenopathies prevailing in left cervical region, short-term course fever and involvement of its general condition without weigh loss. authors made studies of general hematology, viral serology and fine needle aspiration biopsy of a cervical ganglion. there were suspicions of neoplasic cells in aspirate. ganglion biopsy showed abundant histiocytes, immunoblasts, and cellular necrosis with nuclear powder and caryorrhesis, as well as a lack of neutrophils and eosinophils. there was a favorable course with disappearance of fever at 20 days from the onset of its manifestations with a gradual regression of adenopathies.
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