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Search Results: 1 - 10 of 27946 matches for " Khattak MA "
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Targeted therapy for esophagogastric cancers: a review
Khattak MA, Martin HL, Karapetis CS
OncoTargets and Therapy , 2012, DOI: http://dx.doi.org/10.2147/OTT.S25117
Abstract: rgeted therapy for esophagogastric cancers: a review Review (2462) Total Article Views Authors: Khattak MA, Martin HL, Karapetis CS Published Date May 2012 Volume 2012:5 Pages 91 - 102 DOI: http://dx.doi.org/10.2147/OTT.S25117 Received: 24 February 2012 Accepted: 27 March 2012 Published: 21 May 2012 Muhammad A Khattak,1 Hilary L Martin,2 Christos S Karapetis1,3 1Flinders Medical Centre, Adelaide, South Australia; 2Calvary Hospital, Adelaide, SA, Australia; 3Flinders University, Adelaide, SA, Australia Abstract: The incidence of esophagogastric cancers is increasing rapidly in the Western population. Despite better understanding of the biology and intense research in the treatment of these cancers, the long-term survival remains poor both in the locally advanced and metastatic settings. The addition of combined modality strategies has resulted in modest improvement in 5-year survival rates. A number of biologic agents targeting epidermal-derived growth factor receptor, vascular endothelial derived growth factor and its receptor, and mammalian target of rapamycin (mTOR) are being currently evaluated in Phase II and III clinical trials. Some of these, like trastuzumab, cetuximab, and bevacizumab, have shown promising results. This review provides a brief overview of the recent developments in biologic agents for the treatment of esophagogastric cancers.
Targeted therapy for esophagogastric cancers: a review
Khattak MA,Martin HL,Karapetis CS
OncoTargets and Therapy , 2012,
Abstract: Muhammad A Khattak,1 Hilary L Martin,2 Christos S Karapetis1,31Flinders Medical Centre, Adelaide, South Australia; 2Calvary Hospital, Adelaide, SA, Australia; 3Flinders University, Adelaide, SA, AustraliaAbstract: The incidence of esophagogastric cancers is increasing rapidly in the Western population. Despite better understanding of the biology and intense research in the treatment of these cancers, the long-term survival remains poor both in the locally advanced and metastatic settings. The addition of combined modality strategies has resulted in modest improvement in 5-year survival rates. A number of biologic agents targeting epidermal-derived growth factor receptor, vascular endothelial derived growth factor and its receptor, and mammalian target of rapamycin (mTOR) are being currently evaluated in Phase II and III clinical trials. Some of these, like trastuzumab, cetuximab, and bevacizumab, have shown promising results. This review provides a brief overview of the recent developments in biologic agents for the treatment of esophagogastric cancers.Keywords: adenocarcinoma, squamous cell carcinoma, VEGF, trastuzumab, Her2- positive EGC
Simplification of urea treatment method of wheat straw for its better adoption by the farmers
MA Jabbar, H Muzafar, FM Khattak, TN Pasha, A Khalique
South African Journal of Animal Science , 2010,
Abstract: Limited use of cereal straws in livestock feeding is due to their low voluntary intake, low protein contents and low digestibility. Nutritional value of these roughages can be improved through chemical or physical methods. Efficacy of treating straw with urea for improving its nutritive value is considered equivalent to anhydrous or aqueous ammonia. However, the adoption rate of urea treatment by farmers is low, maybe due to relatively tedious technology and higher requirement of labour. There is need to simplify urea treatment methods. In the present study an effort has been made to simplify the existing urea treatment method so that farmers could easily adopt this technique. The new method involves weighing the required amount of urea (4% of straw), mixing it with double the amount of farm manure (as urease source), giving 30% moisture by adding water, putting this mixture in a bag, piling the straw on the bag, again moistening the straw with water (50% of straw) and incubating this material for a month under the cover of plastic sheet or mud plaster. In this method three steps including preparation of urea solution, sprinkling of solution on straw and pressing the straw during treatment process, have been eliminated which resulted in saving labour by 55%. The efficiency of the new method, however, is about 30% less than the conventional urea treatment method.
Antiphospholipid Antibody Syndrome Presenting with Hemichorea
Yezenash Ayalew,Fazlihakim Khattak
Case Reports in Rheumatology , 2012, DOI: 10.1155/2012/471543
Abstract: A 25-year-old Bangladeshi lady presented to neurology with a three-month history of involuntary movements of her right arm, associated with loss of power. There was progression to the right leg, and she subsequently developed episodes of slurred speech and blurred vision. At the time of presentation, she was 12 weeks pregnant and the symptoms were reported to have started at conception. Past medical history was unremarkable apart from one first trimester miscarriage and there was no significant family history suggestive of a hereditary neurological condition. MRI of the head revealed no abnormalities but serology showed positive antinuclear antibodies (ANAs) at a titre of 1/400. Further investigations revealed strongly positive anticardiolipin antibodies (>120) and positive lupus anticoagulant antibodies. The patient had a second miscarriage at 19 weeks gestation strengthening the possibility that the chorea was related to antiphospholipid antibody syndrome and she was started on a reducing dose of Prednisolone 40 mg daily and aspirin 300 mg daily. Six months later, she had complete resolution of neurological symptoms. There are several reports of chorea as a feature of antiphospholipid syndrome, but no clear consensus on underlying pathophysiology.
Understanding Female College Students’ Mind-set towards Television Advertising in Pakistan
Jamshed Khattak,Aslam Khan
Suvremene Teme : Contemporary Issues , 2009,
Abstract: Purpose: This study examined the consequences and impact that television advertising has upon the general attitude of female college students towards television advertising in Pakistan. The data was collected from randomly selected 299 female college students. Methods: The respondents from five metropolitan cities like Peshawar, Islamabad,Rawalpindi, Quetta and Karachi were asked to answer a self-administered questionnaire. Descriptive, t-statistics, correlation and regression statistical tools were used to analyse data. Results: The results of the study reveal that these students have negative judgment about the ethical and social consequences of television advertising. However, they have positive judgment about the economic impact of television advertising. The students demand more regulation to control the television advertising. The results indicated that there is a significant positive general attitude of female college students towards the television advertising in Pakistan. The study predicted a positive relationship between the consequences/impact and general attitude of female college students towards the television advertising. Recommendation: The study recommends that marketers and the regulatory bodies have the responsibility to pay proper attention to the rising ethical, social and regulatory concerns of the female college students’ about the television advertising. Moreover the study provides a useful benchmarkfor future research studies.
Antiphospholipid Antibody Syndrome Presenting with Hemichorea
Yezenash Ayalew,Fazlihakim Khattak
Case Reports in Rheumatology , 2012, DOI: 10.1155/2012/471543
Abstract: A 25-year-old Bangladeshi lady presented to neurology with a three-month history of involuntary movements of her right arm, associated with loss of power. There was progression to the right leg, and she subsequently developed episodes of slurred speech and blurred vision. At the time of presentation, she was 12 weeks pregnant and the symptoms were reported to have started at conception. Past medical history was unremarkable apart from one first trimester miscarriage and there was no significant family history suggestive of a hereditary neurological condition. MRI of the head revealed no abnormalities but serology showed positive antinuclear antibodies (ANAs) at a titre of 1/400. Further investigations revealed strongly positive anticardiolipin antibodies (>120) and positive lupus anticoagulant antibodies. The patient had a second miscarriage at 19 weeks gestation strengthening the possibility that the chorea was related to antiphospholipid antibody syndrome and she was started on a reducing dose of Prednisolone 40?mg daily and aspirin 300?mg daily. Six months later, she had complete resolution of neurological symptoms. There are several reports of chorea as a feature of antiphospholipid syndrome, but no clear consensus on underlying pathophysiology. 1. Introduction We would like to report the case of a 25-year-old Bangladeshi lady who was referred to neurology with a three-month history of frequent, involuntary movements of her right arm, with associated loss of power. There was progression to the right leg and she subsequently developed episodes of slurred speech and blurred vision. At the time of presentation, she was 12 weeks pregnant and the symptoms were reported to have started at conception. Prior to this, she had no other relevant past medical history apart from a first trimester miscarriage. No significant family history suggestive of a hereditary neurological condition was elicited and a working diagnosis of chorea gravidarum was made. MRI of the head revealed no abnormalities; however serology showed positive antinuclear antibodies (ANAs) at a titre of 1/400 and a rheumatology opinion was sought. No other features of connective tissue disease were present and however further investigations revealed negative dsDNA antibodies, negative ENA antibodies, and normal compliment C3 but reduced C4 levels. Of particular significance, were the strongly positive anticardiolipin antibodies (>120) and positive lupus anticoagulant tests. During the course of investigations, the patient had a second miscarriage at 19-week gestation strengthening the
Energy and Nutrients Intakes of Male and Female University Students
M. Muzaffar Ali Khan Khattak,Alam Khan,M. Usman Khattak
Pakistan Journal of Nutrition , 2002,
Abstract: Male and female students residing in the on campus hostels were explained the aim and importance of this study. Among the students registered were 30 male and 30 female who volunteered to participate in this study. The age range of the registered students was 22 – 26 years. On the day of the registration the age, height and weight were recorded and at the same time, they were given food frequency questionnaires (FFQs). They were asked to record alternately for three days whatever they ate during the prescribed week. Out of sixty students 51 (22 male and 29 female) returned the FFQs and the rest were excluded from the study. From the anthropometry, the weight and height for the given ages were compared with the international standards. From the FFQs the energy and nutrients intake was calculated using the food composition table for all students and compared with the recommended nutrients intakes (RNIs) reported by the FAO/WHO for the same age, height and weight. The total energy consumption was more in the female students than in the male students. Eighty two percent of the male and 21% of the female students had lower energy intake than their RNIs for energy. Eighty two percent of the male students had lower relative energy from protein and 91% had lower energy from carbohydrate intake than their respective RNIs. Similarly, in 48% of the female students had lower relative energy from protein and 76% had lower energy from carbohydrate intake than their respective RNIs. The relative contribution of energy from fat was higher in 95 % of the male and 97 % of the female students than their RNIs. The mean mineral intake was lower both for male and female students with the exception that the intake of P was more than the RNIs by 18.4 and 11.5 % for the male and female students respectively. The mean Fe intake was more than the RNIs by 37.3% in male students. Similarly, the vitamins intake was lower as well, both in male and female students with exception that they were having higher intake for vitamin A and C. Apart from these nutrients, all the students surveyed had lower dietary intake of fibre and cholesterol. This study indicates that the students are at the risk of specific nutrient deficiencies and the energy requirement is mainly met through dietary fat intake instead of carbohydrate.
Effect of Germination Time and Type of Illumination on Proximate Composition of Chickpea Seed (Cicer arietinum L.)
Nizakat Bibi,Aurang Zeb,Amal Badshah Khattak,Mohammad Saeed Khattak
American Journal of Food Technology , 2008,
Abstract: Impact of germination time and type of illumination on proximate composition of chickpea seed was investigated. Germination time and type of illumination had highly significant influence (p<0.001) on the level of moisture, protein, fat, fiber, ash and Nitrogen Free Extract (NFE) contents. Increase in germination time was associated with increase in moisture, protein, ash and fat contents and decrease in fiber and NFE contents. Moisture accumulation increased significantly (p<0.001) with dark, fluorescent light and γ-irradiated seed sprouts, while green, blue and yellow lights have significant (p<0.001) promotional effects on protein and fiber contents. Germination of γ-irradiated chickpea seed had significant (p<0.001) promotional effect on ash and fat contents, while dark, fluorescent and yellow lights on NFE content. Interaction of the treatments (germination time X type of illumination) on all the parameters studied was also highly significant (p<0.001).
Physiological Effects of Dietary Complex Carbohydrates and its Metabolites Role in Certain Diseases
M. Muzaffar Ali Khan Khattak
Pakistan Journal of Nutrition , 2002,
Abstract: Carbohydrate is one of the basic and an important food nutrient consumed worldwide. Like-wise Pakistani foods contain more carbohydrates than any other food nutrient consumed. Sometimes, Pakistani foods are devoid of protein and may contain only carbohydrates and fats as the major nutrients of the diet e.g. eating chapati (wheat bread) with potato curry. Certain non-communicable diseases can be avoided with adoption of proper healthier food habits and eating foods according to the needs of the body. These diseases are obesity, coronary heart disease, colonic cancer and gastrointestinal disorders (diverticular disease, constipation, hiatal hernia and hemorrhoids). Therefore complex carbohydrate should be an important constituent of our daily meal and it can be adopted for the management of certain diseases provided that it is used in proper amounts. Consumption of certain complex carbohydrates is associated with lower body weight, reduced blood cholesterol, reduced blood glucose and an increased crypt cell proliferation. Therefore, it is necessary and utmost important to know the various types of carbohydrates to enable us to decide to include carbohydrates in our daily food according to our health requirements. Not necessarily all the community need to know but at least those who are associated with nutrition and health management must know the beneficial as well as the harmful effects of carbohydrates.
Growth Performance of a Neonate Exclusively Fed on Buffalo Milk: A Case Study
Muhammad Muzaffar Ali Khan Khattak
Pakistan Journal of Nutrition , 2003,
Abstract: A full term baby born through C-section with a birth-weight of 7.7lbs, which were within the standard range of 5.5-7.7 lbs. The baby was kept on the Nestle`s Lactogen-1 with the advice of a classified Pediatrician when the mother was failed to breast-feed the baby. Due to complications in the weight-gain with the Nestle`s Lactogen-1, it was abandoned at the age of fourth month and fresh boiled buffalo milk was introduced. The protein requirements were adjusted according to the recommended level of 2.46 g/kg body weight by adding boiled water. The protein contents of the buffalo milk were assumed to be 4-gram/100 ml of fresh milk. The amount of water lost during the boiling of the fresh milk was adjusted to the original volume of the milk. The milk was fed at ad labitum to the baby; however, the volume consumed over the reported period was not recorded. At the end of sixth month banana was introduced to the baby and at the start of ninth month family food was gradually introduced. The body weight was regularly recorded weekly and on monthly basis with the pediatric scale. In this case study it was noticed that when the infant was on the Nestle`s Lactogen-1, the weight-gain was severely less during first four months. However, the weight-gain with buffalo milk was steady up to 24 months. This study shows that the buffalo milk is as good as other milk sources provided that its protein content is adjusted properly.
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