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Neuroprotective effect of wormwood against lead exposure
Kharoubi O,Slimani M,Aoues A
Journal of Emergencies, Trauma and Shock , 2011,
Abstract: Background : Lead poisoning is a potential factor in brain damage, neurochemical dysfunction and severe behavioral problems. Considering this effect, our study was carried out to investigate the effects of wormwood to restore enzymes activities, lipid peroxidation and behavioral changes induced by lead. Methods : Thirty Wistar rats were divided into five groups (n = 6 in each group): three groups exposed to 750 ppm of lead acetate in the drinking water for 11 weeks and two groups as control. Aqueous wormwood extract (200 mg/kg body weight) was administrated to intoxicated (Pb(-)+A.AB) and control groups (A.AB) for four supplemental weeks. Activities of acetylcholinesterase (AchE), monoamine oxidase (MAO) and thiobarbituric acid-reactive substances (TBARS) level were determined in the hypothalamus, hippocampus, cortex and striatum of male rats and the grooming and locomotors activity were defined in all groups. Results: The intoxicated group (Pb) has a significantly increased TBARS value compared with the control in all brain regions (P < 0.05) and, after treatment with the wormwood extract, a significant reduction was noted. The enzyme activity decreased significantly (P < 0.05) in the Pb group compared with the control, essentially for the hippocampus (AchE: -57%, MAO: -41%) and the striatum (AchE: -43%, MAO: -51%). After wormwood extract administration, the AchE and MAO activity were significantly increased in all brain regions compared with the Pb group (P < 0.05). The behavioral test (locomotors and grooming test) indicates a significant hyperactivity in the Pb group compared with the control group. After treatment with wormwood extract, the Pb(-)+A.Ab indicates a lower activity compared with Pb. Conclusion : These data suggest that wormwood extract may play a very useful role in reduction of the neurotoxicological damage induced by lead.
Protective effect of Wormwood extract on lead induced neurotoxicity and cognitive disorder
Kharoubi O,Slimani M,Hamadouche N,Krouf D
International Journal of Green Pharmacy , 2010,
Abstract: Lead is a ubiquitous and a potent neurotoxicant causes several neurophysiological and behavioural alterations. Considering the vulnerability of the developing brain to Pb neurotoxicity, this study was carried out to investigate the effects of Pb exposure on brain regions acetylcholinesterase (AchE) and monoamino oxidase (MAO) enzymes activities and on behavioural changes. Wister rat were exposed to 750 ppm of lead acetate in the drinking water for 11-weeks after weaning, and treated by Artemisia Absinthium L. (wormwood) extract (200 mg.kg-1 body weight) for 4 weeks. The activities of AchE and MAO were determined in the hypothalamus, hippocampus, cortex and striatum of male rat; and general/ Locomotors activity was evaluated in the open-field test. Results indicated a significant decrease in AchE activity in intoxicated group (Pb) compared to untreated group (as contral) (hypothalamus: -12%, hippocampus: -57%, cerebral cortex: -18% and striatum: -43%) and in MAO activity (hypothalamus: -29%, hippocampus: -41%, cerebral cortex: -28% and striatum: -51%) respectively, with decrease crossing test score and increase sniffing test score. After, wormwood extract administration, the activity of AchE and MAO were significantly increased in all brain region compared to Pb group, but were significantly lower than control. The locomotors activity was reduced compared to Pb group. These data suggest that administration of wormwood extract for 4 weeks protect against the lead acetate-induced change in behavioural and neurobiochemical parameters changes.
Pneumatisation du cornet inferieur a propos d\'une observation
S Kharoubi
Journal Tunisien d'ORL et de Chirurgie Cervico-Faciale , 2006,
Abstract:
Reparation des pertes de substances partielles du pavillon de L\'oreille (Conque): a propos dune observation
S Kharoubi
Journal Tunisien d'ORL et de Chirurgie Cervico-Faciale , 2006,
Abstract:
Revue Generale Sur Les Rhinolithiases : A Propos De 20 Cas
S Kharoubi
Journal Tunisien d'ORL et de Chirurgie Cervico-Faciale , 2007,
Abstract: Cette étude rapporte 20 cas de rhinolithiases colligés entre 1990 et 2007. La population concernée surtout des adultes (55% de sexe féminin) ayant le plus souvent des conditions socio-économiques défavorables. Le tableau clinique est simple et non spécifique : rhinite obstructive purulente unilatérale et fétide. Des présentations déroutantes sont possibles mais rares (infection sinusienne, oculo-palpébrale). Le diagnostic repose sur l'examen endonasal notamment à l'optique rigide. Le scanner est très intéressant pour un bon bilan loco-régional permettant en particulier de reconna tre les lésions associées ou sous-jacentes. L'extraction par les voies naturelles le plus souvent sous anesthésie locale était le procédé thérapeutique habituel. Les rhinolithes avaient entre 5 et 50 mm de diamètre avec seulement 3 corps étranger associés (15 %). Les complications sont rares (épistaxis : 10%) et l'évolution était le plus souvent favorable. This study reports 20 cases of rhinolithiasis treated between 1990 and 2007. The population concerns especially adults. The symptoms are generally represented by unilateral purulent rhinorrhea and nasal obstruction. The diagnosis is based on clinical examination. The CT-scan precises extension and associated or underlying lesions. The extraction by natural ways, often under local anesthesia, was proceeded as habitual therapeutic. The rhinoliths had between 5 and 50 mm of diameter with only 3 foreign bodies associated (15%). The complications are rare (nasal bleeding: 10%).
Oxidative Stress Induction by Lead in Leaves of Radish (Raphanus sativus) Seedlings
Nadjet BITEUR,Abdelkader AOUES,Omar KHAROUBI,Miloud SLIMANI
Notulae Scientia Biologicae , 2011,
Abstract: Oxidative stress was induced by lead acetate (Pb) in Raphanus sativus seedlings grown in a hydroponic system using sand as substrate. Thirty day old acclimated seeds were treated for 7 days with five Pb levels (0 as control, 100, 200, 500 and 1000 mg l-1). Parameters such as growth, oxidative damage markers (lipid peroxidation, protein oxidation and hydrogen peroxide contents) and enzymatic activities of catalase (CAT) and peroxidase (POD) were investigated. Lead concentration in plant tissues increased with increasing of Pb levels. Shoot fresh weight, chlorophyll and carotenoid concentration were significantly decreased at 100 mg l-1 Pb. Lipid peroxidation, protein oxidation and H2O2 levels were increased at 500 and 1000 mg l-1 Pb compared to control treatment, in shoots. Peroxidase activity showed a straight correlation with H2O2 concentration, whereas CAT activity decreased only in shoots. These changes in enzymatic and non-enzymatic antioxidants showed that the Pb exposition had a significant disturbance on Raphanus sativus plantlets and affect the biochemical and physiological processes.
Thymoquinone, the Nigella sativa Bioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in Erythrocyte during Colon Postinitiation Carcinogenesis
Hanene Jrah Harzallah,Rahma Grayaa,Wafa Kharoubi,Aya Maaloul,Mohamed Hammami,Touhami Mahjoub
Oxidative Medicine and Cellular Longevity , 2012, DOI: 10.1155/2012/854065
Abstract: We have performed this study to investigate the modulatory effect of thymoquinone (TQ), the Nigella sativa active compound, on erythrocyte lipid peroxidation and antioxidant status during 1,2-dimethylhydrazine- (DMH-) induced colon carcinogenesis after initiation in male Wistar rats. Rats exposed to DMH showed an increase of malondialdehyde and conjugated diene levels, and an augmentation of enzyme activities like catalase, glutathione peroxidase, and superoxide dismutase activities was also noted. The TQ pretreatment restored the parameters cited above to near-normal values. However, the posttreatment shows an activity similar as that presented by DMH. Therefore, our investigation revealed that TQ was a useful compound preventing DMH-induced erythrocyte damages.
Stress Loops Effect in Ductile Failure of Mild Steel  [PDF]
O.O. Oluwole
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2009, DOI: 10.4236/jmmce.2009.84026
Abstract: A simulation study of effect of stress on mild steel microstructure has revealed stress loops at areas of stress application which are believed to be the root cause of the ductile failure morphology (cup and cone) in ductile alloys under plane strain conditions. The areas of concentration of these stress loops were observed to be that of subsequent instability (or necking) observed in mild steel and other materials of low friction (flow) stress. Shear stress loops with angular bearing of 450 to the tensile axis were observed to instigate both the failure site and shear morphology in these materials. In plane stress conditions, shear was seen to be that of a wave shape running obliquely to area of stress application resulting in oblique necking observed in thin mild steel sheets.
Boundary Value Problem for an Operator-Differential Riccati Equation in the Hilbert Space on the Interval  [PDF]
O. O. Pokutnyi
Advances in Pure Mathematics (APM) , 2015, DOI: 10.4236/apm.2015.514081
Abstract: The paper is devoted to obtaining the necessary and sufficient conditions of the solvability of weakly perturbed boundary-value problems for the nonlinear operator-differential Riccati equation in the Hilbert space on the interval and whole line with parameter ?. We find the solution of the given boundary value problem which for ε = 0 turns in one of the solutions of generating boundary value problem. Solution of the generating problem is constructed with the using generalized operator in analytical form. Iterative process for finding of solutions of weakly nonlinear equation with quadratic error is constructed.
Vertex-transitive maps on a torus
O. Such
ACTA MATHEMATICA UNIVERSITATIS COMENIANAE , 2011,
Abstract: We examine FVT (free, vertex transitive) actions of wallpaper groups on semiregular tilings. By taking quotients by lattices we then obtain various families of FVT maps on a torus, and describe the presentations of groups acting on the torus. Altogether there are 29 families, 5 arising from the orientation preserving wallpaper groups and 2 from each of the remaining wallpaper groups. We prove that all vertex-transitive maps on torus admit an FVT map structure.
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