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Search Results: 1 - 10 of 67 matches for " Kharb Simmi "
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Low blood glutathione levels in acute myocardial infarction.
Kharb Simmi
Indian Journal of Medical Sciences , 2003,
Abstract: BACKGROUND: Although experimental studies have demonstrated that reduced glutathione (GSH) is involved in cellular protection from deleterious effects of oxygen free radicals in ischaemia and reperfusion, there are controversial data on the correlation between levels of GSH and the ischaemic process. AIM: The present study was planned to evaluate erythrocyte GSH levels in patients with acute myocardial infarction (AMI). SETTING & DESIGN: Erythrocyte GSH levels were determined in 22 patients with AMI and 15 age matched healthy volunteers served as control. MATERIAL & METHODS: Erythrocyte GSH levels were measured by using Bentler in AMI and control patients. Also lipid profile was analyzed enzymatically in these subject. STATISTICS: The values were expressed as means +/- standard deviation (SD) and data from patients and controls was compared using student′s ′t′-test. Results and CONCLUSION: GSH levels were significantly decreased in AMI as compared to control (p<0.001). Also, total cholesterol and triglycerides were higher is AMI subjects (p<0.05). These finding suggest that depressed GSH levels may be associated with enhanced protective mechanism to oxidative stress in AMI.
Activity of Extracellular Superoxide Dismutase in Gestational Diabetes
Simmi Kharb
Research Journal of Obstetrics and Gynecology , 2010,
Abstract: Recent studies indicate that Extracellular Superoxide (EC-SOD) may not be as scarce in some tissues as was initially believed. The EC-SOD is the major isoenzyme of SOD in the umbilical cord and is a major source of SOD activity in the uterus. The possible role of EC-SOD in gestational diabetes has not been reported. Hence, the present study was planned to study EC-SOD in healthy non-pregnant, healthy normotensive pregnant women and women with gestational diabetes. The present study was carried out in twenty healthy Non-Pregnant (NPW) controls (in age group 18-35 years), twenty healthy age-matched normotensive pregnant women (28-36 weeks gestation) and twenty (age-and parity-matched) women with gestational diabetes. Serum Extracellular Superoxide Dismutase Activity (EC-SOD) and superoxide generation was analyzed in these women. The EC-SOD levels were significantly decreased in G-DM as compared to HPW, NPW controls (p<0.001) and superoxide generation was raised in G-DM as compared to HPW (p<0.001). A significant negative correlation was observed between EC-SOD levels and superoxide generation (r = -0.175, p<0.05) in G-DM. These findings indicate that radical scavenging antioxidants are consumed by enhanced levels of free radicals produced during glucose induced oxidative stress.
Association Between Rheology and Lipoproteins in Menopausal Womens
Simmi Kharb
JK Science : Journal of Medical Education & Research , 2008,
Abstract: Lipid profile, haematocrit, fibrinogen, and blood viscosity were studied in 26 healthy volunteers (15premenopausal, 11 post menopausal). Menopausal women had significantly higher total cholesterol,fibrinogen, hematocrit and blood viscosity levels as compared to premenopausal women. Also, triglyceride,LDL-cholesterol and HDL-cholesterol levels were higher in menopausal women, but the difference wasstatistically insignificant. Since these parameters are considered to be risk factor for the development ofcoronary artery disease (CAD), menopausal women are at an increased risk of developing CAD.
Serum biochemical markers in carcinoma breast.
Seth R,Kharb Simmi,Kharb D
Indian Journal of Medical Sciences , 2003,
Abstract: BACKGROUND: Despite the extensive research for many years throughout the world, the etiopathogenesis of cancer still remains obscure. For the early detection of carcinoma of various origins, a number of biochemical markers have been studied to evaluate the malignancy. AIM: To analyse serum gamma glutamyl transpeptidase (GGTP), lactate dehydrogenase (LDH) and superoxide dismutase (SOD) in carcinoma breast patients. SETTINGS & DESIGN: The serum biochemical markers were estimated in twenty five histopathologically confirmed patients with carcinoma breast and equal number of healthy age- matched individuals served as control. MATERIAL & METHODS: Serum gamma glutamyl transpeptidase (GGTP), lactate dehydrogenase (LDH) and superoxide dismutase (SOD) were estimated and their sensitivity determined. Statistics: Data was analysed with student′s ′t′-test and sensitivity score of these markers was determined. RESULTS & CONCLUSIONS: The mean serum GGTP, LDH and SOD activities in patients with carcinoma breast were tremendously increased as compared to controls, and a steady increase was observed in their activities from stage I through stage IV as well as following distant metastasis. Serum GGTP, LDH and SOD might prove to be most sensitive biomarkers in carcinoma breast in early detection of the disease.
Thyroid hormones in pregnancy and preeclampsia
Divya Sardana,Smiti Nanda,Simmi Kharb
Journal of the Turkish-German Gynecological Association , 2009,
Abstract: Objective: There is a state of hypothyroxinemia in normal pregnancy and in preeclampsia, when biochemically raised TSH occurs. Identification of changes in thyroid hormones in preeclampsia might be of help in preventing the occurrence of preeclampsia.Material and Methods: The present study was carried out in a hundred women with preeclampsia, 100 age- and parity matched normotensive pregnant women and 50 age-matched healthy non-pregnant women. Thyroid hormones [total T3,T4 and TSH], serum albumin and uric acid were analyzed in these subjects.Results: Women with preeclampsia had higher TT3, TT4 levels as compared to non pregnant women [p<0.05], but preeclamptic TT3,TT4 levels were lower compared to normotensive pregnant women [p<0.05, p<0.01]. TSH levels were higher in both preeclamptic & normotensive pregnant women compared to nonpregnant women [p<0.001] and levels were lower in normotensive pregnant women as compared to nonpregnant women [p<0.001]. A significant negative correlation was observed between birth weight and TSH levels [r=-0.296, p<0.001] serum albumin and TSH levels in preeclamptic women [r=-0.781, p<0.01]. Also, a significant positive correlation was observed between birth weight and albumin [r=0.298, p<0.001]; birth weight and serum uric acid levels [r=-0.46, p<0.01], and serum albumin and TT3 & TT4 levels [r=0.409 & r=0.35, p<0.01 respectively]. Conclusion: These findings indicate that there is state of hypothyroxinemia in normal pregnancy and in preeclampsia. Identification of changes in thyroid hormones in preeclampsia might be of help in preventing the occurrence of preeclampsia.
Birth Weight, Cord Blood Lipoprotein and Apolipoprotein Levels in Indian Newborns
Simmi Kharb,Ramanjit Kaur,Veena Singh,Krishna Sangwan
International Journal of Preventive Medicine , 2010,
Abstract: Objectives: Primordial prevention of chronic disease is of clinical andpublic health importance. Considering the fetal onset of atherosclerosis,we aimed to determine the cord blood level of lipoproteins andapolipoproteins as well as their correlation with birth weight and gestationalage.Methods: This cross-sectional study comprised 100 healthy Indiannewborns. Ten ml. of cord blood was collected from placental end ofumbilical vein. Serum was separated by centrifugation and analyzed onthe same day for lipid profile including total cholesterol (TC), triglycerides(TG), high density lipoprotein- cholesterol (HDL-C), very lowdensity lipoprotein-cholesterol (VLDL) and low density lipoproteincholesterol(LDL-C), apolipoproteins A-I and B (ApoA-I, ApoB).Atherogenic index (AI) was calculated as the ratio of ApoB to ApoA-I.Results: Cord blood of female newborns had higher TC, HDL-C,LDL-C, Apo A-I, Apo B and AI as compared to male newborns,whereas TG and VLDL-C were higher in male than in female newborns.Significant positive correlation was observed between cordblood Apo A-I and HDL-C (r= 0.45, p<0.01), and between cord bloodApo-B and LDL-C (r= 0.44, p<0.01). Non-significant inverse correlationwas observed between Apo A-I and ApoB with gestational age.There was a significant inverse correlation between TG and gestationalage (r= –0.197, p <0.05). Positive non-significant correlation was observedbetween AI and birth weight (r=0.046, p>0.05).Conclusions: These findings are another confirmatory evidence forthe association of prenatal factors with cord blood lipid profile, andcan serve as starting point for studying lipid transport system changesduring early life.
CONCEPTUAL THREE PHASE KDD MODEL AND FINANCIAL RESEARCH
Dr. Simmi Bagga
International Journal of Computers & Technology , 2013,
Abstract: KDD model becomes used in financial process. Data Mining tools can be used to improve the efficiency of the professionals. The integration of Data Mining tools with the traditional financial research methods is relatively a new concept. If Data Mining tools for Financial are developed then it make the process fast, cheaper and relatively much more efficient. In this paper we have discussed the three phase model of KDD on Financial Research.
COREAN: A proposed Model for Predicting Effort Estimation having Reuse
Jyoti Mahajan,Simmi Dutta
International Journal of Soft Computing & Engineering , 2013,
Abstract: The estimation accuracy has been focused in various formal estimation models in recent research initiatives. The formal estimation models were developed to measure lines of code and function points in the software projects but most of them failed to improve accuracy in estimation. The concept of reusability in software development in estimating effort using artificial neural network is focused in this paper. Incorporation of reusability metrics in COCOMO II may yield better results. In COCOMO II it is very difficult to find the values of size parameters. A new model called COREAN has been proposed in this paper for better effort estimation accuracy and reliability. The proposed model has focused on two components of COCOMO II. First, instead of using RUSE cost driver, three new reuse cost drivers are introduced. Second, In order to reduce the project cost, three cost drivers such as PEXE, AEXE, LTEX are combined into single cost driver Personnel Experience (PLEX). Finally, this proposed model accuracy is more improved with the help of Enhanced RPROP algorithm and simulated annealing optimization technique.
The Implementation of Group Work in Hong Kong: A Case Study
Simmi Ho-Yan TAM
Asia-Pacific Forum on Science Learning and Teaching , 2001,
Abstract: This article focused on the practical experience of a primary school teacher in applying group work in General Studies in Hong Kong. The followings are the main points for discussion: to offer some ideas for using cooperative learning effectively in primary school; to discuss the role of assessment in group work and provide readers with guidance for designing effective group assessments; to state the importance of teachers' professional development in this area; and, to suggest problems and limitations that may arise when cooperative learning is implemented. In this paper, advice on solving the limitations of applying group work in school is provided, which will hopefully be useful for other teachers and students.
THERAPEUTIC SIGNIFICANCE OF QUINOLINE DERIVATIVES AS ANTIMICROBIAL AGENTS
Rajeev Kharb,Hardeep Kaur
International Research Journal of Pharmacy , 2013, DOI: 10.7897/2230-8407.04311
Abstract: Microbial infections are one of the leading diseases which are responsible for millions of deaths every year because of lack of effective antimicrobial therapy and this situation becomes more complicated because of microbial resistance towards conventional antibiotics. Quinoline derivatives have proved their medicinal importance by having broad spectrum of pharmacological activities like antimicrobial, anticancer, antiviral and anti-inflammatory activities etc. This review article deals with the antimicrobial potential of novel quinoline derivatives as an effort to provide better treatment for microbial infections.
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