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Search Results: 1 - 10 of 132 matches for " Khanam Razia "
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AMELIORATION OF MYOCARDIAL ISCHEMIA REPERFUSION INJURY BY SIMVASTATIN IN RATS
Rohilla Ankur,Singh Gurfateh,Khan M.U.,Khanam Razia
International Research Journal of Pharmacy , 2011,
Abstract: The present study has been designed to investigate the effect of Simvastatin, a 3-hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitor, on ischemia-reperfusion (I/R)-induced myocardial injury. The isolated Langendorff-perfused rat hearts were subjected to global ischemia for 30 min followed by reperfusion for 120 min. Myocardial injury was assessed by measuring myocardial infarct size alongwith release of lactate dehydrogenase (LDH) and creatine kinase (CK) in the coronary effluent. Additionally, the oxidative stress parameters were analyzed in the heart which was assessed by measuring lipid peroxidation, superoxide anion generation and reduced glutathione. I/R was noted to produce myocardial injury, as assessed in terms of increase in myocardial infarct size, LDH and CK in coronary effluent. Moreover, oxidative stress was noted to be increased due to I/R injury as assessed in terms of decreased TBARS (thiobarbituric acid-reactive substance) and superoxide anion generation levels alongwith increase in reduced glutathione levels in the heart. Treatment with Simvatstain at different concenterations (3 μMol, 10 μMol and 30 μMol) afforded cardioprotection against I/R-induced myocardial injury in rat hearts as assessed in terms of reductions in myocardial infarct size, LDH and CK levels in coronary effluent. Moreover, the high degree of oxidative stress produced as a result of I/R injury was noted to be reduced by Simvastatin treatment. It may be concluded that reductions in myocardial infarct size and oxidative stress may be responsible for the observed cardioprotective potential of Simvastatin against I/R-induced myocardial injury.
CARDIOPROTECTION OF FIBRATES IN RAT MODEL OF MYOCARDIAL ISCHEMIA: REPERFUSION
Singh Gurfateh,Rohilla Ankur,Khan M.U.,Khanam Razia
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: The present study was designed to investigate the effect of Clofibrate, an agonist of peroxisome proliferator activated receptor-α (PPAR-α), on ischemia-reperfusion (I/R)-induced myocardial injury. The isolated Langendorff-perfused rat hearts were subjected to global ischemia for 30 min followed by reperfusion for 120 min. Myocardial infarct size was assessed by volume methods using triphenyltetrazolium chloride staining. Coronary effluent was analyzed for the release of lactate dehydrogenase (LDH) and creatine kinase (CK) to assess the degree of cardiac injury. Moreover, oxidative stress in the heart was assessed by measuring lipid peroxidation, superoxide anion generation and reduced glutathione. I/R was noted to produce myocardial injury, as assessed in terms of increase in myocardial infarct size, LDH and CK in coronary effluent. Moreover, oxidative stress was noted to be increased due to I/R injury as assessed in terms of decreased TBARS (thiobarbituric acid-reactive substance) and superoxide anion generation levels alongwith increase in reduced glutathione levels in the heart. Treatment with Clofibrate showed cardioprotection against I/R-induced myocardial injury in rat hearts as assessed in terms of reductions in myocardial infarct size, LDH and CK levels in coronary effluent. Moreover, I/R-induced oxidative stress was noted to be reduced by Clofibrate treatment. It may be concluded that the observed cardioprotective potential of Clofibrate against I/R-induced myocardial injury was due to the reductions in infarct size and oxidative stress .
Assessment of asthma and chronic obstructive pulmonary disorder in relation to reversibility, IgE, eosinophil, and neutrophil count in a University Teaching Hospital in South Delhi, India
Rathod Virender,Kapoor Prem,Pillai K,Khanam Razia
Journal of Pharmacy and Bioallied Sciences , 2010,
Abstract: Objectives : The physiological and clinical similarities between asthma and chronic obstructive pulmonary disorder (COPD) make their differentiation difficult. In the present study, we compared reversibility to bronchodilator, immunoglobulin E (IgE), blood eosinophil and neutrophil levels among asthma and COPD patients to differentiate these diseases. Materials and Methods : The study was carried on 20 asthmatics and 29 patients of COPD that reported to the outpatient and inpatient department in University Teaching Hospital, Jamia Hamdard, New Delhi, India. The parameters evaluated included pulmonary function (FEV 1 , FVC, and FEV 1 /FVC), IgE levels, and eosinophil and neutrophil count. Results : It was observed that reversibility was significantly higher in asthmatic patients, while irreversibility predominates in COPD patients. There was no significant difference in pre- and post-FEV 1 and pre- and post-FVC and in their percentage predicted. However the percentage change in FEV 1 significantly varies in asthma and COPD patients. No significant changes in neutrophil and eosinophil levels were observed in these patients. The serum IgE levels were found significantly higher in asthmatic patients. Conclusions : We conclude that reversibility in FEV 1 levels or percentage change in FEV 1 and serum IgE levels are promising lab parameter to distinguish these two conditions. However, further research is required to fully understand the role of neutrophil and eosinophil in the onset and development of asthma and COPD.
Fungi associated with wheat seed discolouration and abnormalities in in-vitro study  [PDF]
Neha Pathak, Razia. K. Zaidi
Agricultural Sciences (AS) , 2013, DOI: 10.4236/as.2013.49069
Abstract:

The main aim of present study is to ascertain the fungal species and their effect on germination associated with wheat seeds. Seeds of three varieties WH896, PBW-373 and HD264 of wheat (Triticum aestivum) were collected from Quarsi Agriculture Farm Aligarh. These three seed samples of wheat showing different forms of discouloration and abnormalities were screened for associated fungi. Microscopic examination of wheat seeds reveals that seeds of all the varieties of wheat possess injuries to varying extent. Detailed examination of the seeds has shown that the seeds can be classified on the basis of extent of injury in the three categories viz., seeds having minor cracks, cracks without exposed embryo and cracks with exposed embryo. Seed soaking and washing techniques were also employed. Fusarium moniliforme and Alternaria alternata were isolated from all the categories of seed tested. Floating mycelial bits and conidia of Alternaria, Fusarium, Drechslera, Curvularia lunata, Mucor were found in all the three varieties of wheat. The seeds were subjected to visual observation and examination under stereoscopic microscope. These findings are to study and detect the phytopathogenic mycoflora which causes damage and loss to our seeds and crops.

Genetic Regulation of Character Expression and its Interaction with Environments in Lablab purpureus
Sakina Khanam
Pakistan Journal of Biological Sciences , 1999,
Abstract: Components of genetic variation for pod yield and other associated yield characters in lablab bean have been estimated through six-parent diallel cross in F2 generation. Additive as well as dominance components were significant for all the characters in both environments. Diallel analysis after Hayman`s approach suggested environmental interaction for flowering date, pods/ inflorescence, inflorescence/plant, and pod yield/plant. Complete dominance was observed for flowering date in environment 2, flowers/inflorescence and pod yield/plant in environment 1, and pods/inflorescence, pod width in both environments. Over dominance was displayed for flowering date in environment 1 and for pod yield/plant in environment 2. Partial dominance was found for flowers/inflorescence in environment 2 only but for inflorescence/plant, pod length and 10-pod weight in both environments.
TERMINATION OF UNWANTED PREGNANCY
Razia Bahadur Khero
The Professional Medical Journal , 2000,
Abstract: A prospective study was done at LMC Jamshoro over period of one year to evaluate the incidence of complicationsrelated to termination of unwanted pregnancies. Total of 450 patients were admitted with abortion, of these12(2.66%) gave history of induced abortion. 9(75%) women were multiparae and 3(25%) were nulliparus.Three women (25%) died, one (8.33%) needed permanent colostomy and 2(16.66%) developed wound dehiscence.
POSTPARTUM HEMORRHAGE (PPH)
RAZIA BAHADUR KHERO
The Professional Medical Journal , 2003,
Abstract: OBJECTIVES: 80 cases of PPH were analyzed retrospectively to assess the risk factor association, modeof treatment and outcome. STUDY DESIGN: Retrospective study. PERIODS: 02 years, from June 1999to May 2002. SETTING: Peoples Medical College Hospital, Nawabshah. PATIENTS & METHODS: 180cases of PPH were analyzed, keeping in view their age, parity, booking status, mode, type and place ofdelivery. The efficacy of obstetric care was assessed by maternal morbidity and mortality related to PPH andits treatment. RESULTS: Out of 180 patients with PPH, 117 (65 %) were referred cases while 63 (35 %)were delivered at PMCH Nawabshah. Risk factors identified were increasing maternal age, grand multiparity, lack of antenatal care, operative and instrumental deliveries. Underlying pathology was uterine atony68.33 %, retained product of conceptions 20.55 %, GT. injuries 8.33 % and D.I.C 2.77 %. Out of 180patients, 71.11 % patients gave response to medical treatment, 20.55 % needed evacuation of uterus. Uterinepacking done in 15.55 % of cases and simple repair of GT. injuries done in 6.66 %. Obstetricalhysterectomies account for 10 % of cases. Complications in operated patients were paralytic ileus in 6.66%. chest infection 5.55 %. DVT in 1.11 % and pelvic infection in 5.55 % patients. During study period, 72maternal deaths occurred and PPH contributed 31.94 % of it. CONCLUSION: The study revealed that aneffective ante, intra and postpartum care, blood bank facilities and an alert action by Obstetric team are veryimportant in prevention of mortality and mobility of this challenging problem. Training of resident surgeonsand early involvement of skilled and senior personnel are needed to eliminate the substandard care and toreduce the large number of abdominal hysterectomies which were carried out in present series.
Synthesis and Characterization of Iron Oxide Nanoparticles Supported on Ziconia and Its Application in the Gas-Phase Oxidation of Cyclohexanol to Cyclohexanone  [PDF]
Mohammad Sadiq, Gul Zamin, Razia  , Mohammad Ilyas
Modern Research in Catalysis (MRC) , 2014, DOI: 10.4236/mrc.2014.31003
Abstract:

Iron oxide nanoparticles supported on zirconia were prepared by precipitation-deposition method and characterized by XRD, SEM, FT-IR, TGA/DTA, surface area and particle size analysis. Catalytic activities of the catalysts were tested in the gas-phase conversion of cyclohexanol in a fixed-bed flow type, Pyrex glass reactor, at 433 - 463 K. Major detected products were cyclohexanone, cyclohexene and benzene, depending on the used catalyst. The rate of reaction was significantly raised by the introduction of molecular oxygen in the feed gas, thereby suggesting the oxidation of cyclohexanol to cyclohexanone. Furthermore, the catalytic activity of iron oxide nanoparticles supported on zirconia treated with hydrogen at 553 K for 2 hours, was more selective and better than the unreduced iron oxide nanoparticles supported on zirconia, in the gas-phase oxidation of cyclohexanol to cyclohexanone. Experimental results showed that there was no leaching of metal, and that the catalyst was thus truly heterogeneous.

One-Pot Synthesis of Aldol Adduct Catalyzed by Immobilized Picolylamine on Zirconia  [PDF]
Mohammad Sadiq, Razia  , M. Naveed Umar, Gul Zamin
Modern Research in Catalysis (MRC) , 2014, DOI: 10.4236/mrc.2014.31001
Abstract:

Direct aldol reactions have been successfully performed using aromatic aldehyde and cyclic ketone in nonpolar solvent by using immobilized picolylamine on zirconia as a catalyst, in a double walled batch reactor. The prepared catalyst was characterized by SEM, XRD and FT-IR. FT-IR peaks reveal the presence of picolylamine on the surface of zirconia. The catalyst shows excellent catalytic activity in aldol reaction of cyclohexanone with benzaldehyde in cyclohexane giving 2-hydroxyphenylmethylcyclohexanone (55.7% yield) in 4 hr at 80?C. Furthermore, the catalyst is recoverable by simple filtration and could be used several times without significant loss in activity.

Efficiency of Iron Supported on Porous Material (Prepared from Peanut Shell) for Liquid Phase Aerobic Oxidation of Alcohols  [PDF]
Mohammad Sadiq, Razia  , Sajid Hussain, Gul Zamin
Modern Research in Catalysis (MRC) , 2014, DOI: 10.4236/mrc.2014.32006
Abstract:
Catalytic activity and selectivity of prepared catalysts (Fe2O3/ and Fe2O3/AC(KOH)) were investigated for liquid phase aerobic oxidation of primary and secondary alcohols, in a batch reactor, using solvent free condition and/or eco-friendly solvents. The catalysts were characterized by SEM, EDX, XRD, FTIR, TGA/DTA, and surface area and pore size analysis. Experimental data revealed that Fe2O3/AC(KOH) was an efficient catalyst for the oxidation (dehydrogenation) of alcohol while \"\" was found to show catalytic activity for both dehydration and dehydrogenation of alcohols. The catalysts were recycled by simple filtration, and used several times without any loss of catalytic activity.

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