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Search Results: 1 - 10 of 417741 matches for " Khan M.U "
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AMELIORATION OF MYOCARDIAL ISCHEMIA REPERFUSION INJURY BY SIMVASTATIN IN RATS
Rohilla Ankur,Singh Gurfateh,Khan M.U.,Khanam Razia
International Research Journal of Pharmacy , 2011,
Abstract: The present study has been designed to investigate the effect of Simvastatin, a 3-hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitor, on ischemia-reperfusion (I/R)-induced myocardial injury. The isolated Langendorff-perfused rat hearts were subjected to global ischemia for 30 min followed by reperfusion for 120 min. Myocardial injury was assessed by measuring myocardial infarct size alongwith release of lactate dehydrogenase (LDH) and creatine kinase (CK) in the coronary effluent. Additionally, the oxidative stress parameters were analyzed in the heart which was assessed by measuring lipid peroxidation, superoxide anion generation and reduced glutathione. I/R was noted to produce myocardial injury, as assessed in terms of increase in myocardial infarct size, LDH and CK in coronary effluent. Moreover, oxidative stress was noted to be increased due to I/R injury as assessed in terms of decreased TBARS (thiobarbituric acid-reactive substance) and superoxide anion generation levels alongwith increase in reduced glutathione levels in the heart. Treatment with Simvatstain at different concenterations (3 μMol, 10 μMol and 30 μMol) afforded cardioprotection against I/R-induced myocardial injury in rat hearts as assessed in terms of reductions in myocardial infarct size, LDH and CK levels in coronary effluent. Moreover, the high degree of oxidative stress produced as a result of I/R injury was noted to be reduced by Simvastatin treatment. It may be concluded that reductions in myocardial infarct size and oxidative stress may be responsible for the observed cardioprotective potential of Simvastatin against I/R-induced myocardial injury.
GASTRORETENTIVE DOSAGE FORMS: REVIEW ON FLOATING DRUG DELIVERY SYSTEMS
Dahiya Amarjeet,Rohilla Ankur,Rohilla Seema,Khan M.U
International Research Journal of Pharmacy , 2011,
Abstract: Gastroretentive drug delivery system has been a significant approach over the past few years that have been noted to prolong gastric residence time, thereby targeting site-specific drug release in the upper gastrointestinal (GI) tract for local or systemic effects. The present study has been investigated to compile the recent as well as past literature with special focus on various gastroretentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. Floating systems have been considered as one of the imperative categories of drug delivery systems with gastric retentive behavior. The review article explains the various floating drug delivery systems that are formulated in order to enhance the drug bioavailability. Moreover, various gastroretentive approaches designed and developed such as high density, floating, bioadhesive, super porous hydrogel and magnetic systems have been clearly discussed in the article.
CARDIOPROTECTION OF FIBRATES IN RAT MODEL OF MYOCARDIAL ISCHEMIA: REPERFUSION
Singh Gurfateh,Rohilla Ankur,Khan M.U.,Khanam Razia
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: The present study was designed to investigate the effect of Clofibrate, an agonist of peroxisome proliferator activated receptor-α (PPAR-α), on ischemia-reperfusion (I/R)-induced myocardial injury. The isolated Langendorff-perfused rat hearts were subjected to global ischemia for 30 min followed by reperfusion for 120 min. Myocardial infarct size was assessed by volume methods using triphenyltetrazolium chloride staining. Coronary effluent was analyzed for the release of lactate dehydrogenase (LDH) and creatine kinase (CK) to assess the degree of cardiac injury. Moreover, oxidative stress in the heart was assessed by measuring lipid peroxidation, superoxide anion generation and reduced glutathione. I/R was noted to produce myocardial injury, as assessed in terms of increase in myocardial infarct size, LDH and CK in coronary effluent. Moreover, oxidative stress was noted to be increased due to I/R injury as assessed in terms of decreased TBARS (thiobarbituric acid-reactive substance) and superoxide anion generation levels alongwith increase in reduced glutathione levels in the heart. Treatment with Clofibrate showed cardioprotection against I/R-induced myocardial injury in rat hearts as assessed in terms of reductions in myocardial infarct size, LDH and CK levels in coronary effluent. Moreover, I/R-induced oxidative stress was noted to be reduced by Clofibrate treatment. It may be concluded that the observed cardioprotective potential of Clofibrate against I/R-induced myocardial injury was due to the reductions in infarct size and oxidative stress .
PHYLLANTHUS AMARUS: AN AMPLE THERAPEUTIC POTENTIAL HERB
Kiran Divya,Rohilla Ankur,Rohilla Seema,Khan M.U.
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: Herbal drugs have been one of the primarily used drugs since olden times for the treatment of a range of diseases. In addition, the medicinal plants have played a vital role in world health as the herbal plants still make an important contribution to health care. Phyllanthus amarus, a world-renowned botanical, has been used since ages because of its rich medicinal values and ethnomedical importance. Phyllanthus amarus is a small, erect, annual herb which is a rich source of phytochemicals that are attributed to biologically active lignans, glycosides, flavonoids, alkaloids, ellagitannins and phenylpropanoids that are present in the leaf, stem and root of the plant. It is a little wonder that the plant is used for so many purposes in herbal medicine systems and in clinical research over the years. Numerous studies have reported that Phyllanthus amarus have anti-inflammatory, antidiabetic, antimicrobial, antihyperlipidemic, antioxidant and anticancer activities. Moreover, studies have demonstrated hepatoprotective, antifertility, antidiarrhoeal, antiallodynic, antioedematogenic, antispasmodial, chemoprotective, antihypercalciuric, antiviral, antispasmodic, antinociceptive and diuretic properties associated with Phyllanthus amarus. The present review article summarizes the potent pharmacological properties exhibited by the plant.
Prevalence of Helminth Infections in Dairy Animals of Nestle Milk Collection Areas of Punjab (Pakistan)
M.U. Iqbal,M.S. Sajid,A. Hussain,M.K. Khan
Italian Journal of Animal Science , 2010, DOI: 10.4081/ijas.2007.s2.935
Abstract: The objective of the current research project was to document the prevalent helminths of dairy animals of Nestle milk collection areas of Punjab (Pakistan). For this purpose, seven high milk-producing areas of Punjab province including Farooqa, Kot Adu, Dunya Pur, Layyah, Mor Mandi, Shorkot and Jalapur were selected. The animals were randomly selected and screened for parasitic eggs through standard coprological examination procedures. The helminth species found prevalent in the study areas included; Ascaris vitulorum, Fasciola hepatica, Haemonchus contortus, Bunostomum phlebotomum, Ostertagia circumcinta, Oesophagostomum radiatum, and Trichostrongylus spp. The possible determinants associated with the prevalence of these parasites were also studied in this project. The results of this study provided a basic epidemiological data for planning a wide scaled helminth control program in the above-mentioned high producing areas of Pakistan.
In vitro fertility assessment of Kundhi buffalo bull semen
Hamzo Khan Kunbhar,,T.A. Raho,M.U. Samo
Research Opinions in Animal & Veterinary Sciences , 2011,
Abstract: The study was conducted on in-vitro fertility assessment of frozen thawed semen collected from Kundhi buffalo bull maintained at Department of Animal Reproduction, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University Tandojam. Before freezing of semen, each ejaculate was assessed for volume, sperm concentration, mass activity and moss motility percentage. Twenty semen samples having motility 60% or above were frozen for post-thaw assessment. Frozen thawed semen was incubated at 250C for 5 hours and examined for progressive linear motility and live dead sperm count. The mean volume, mass activity, moss motility percentage sperm concentrations and pH of the semen were found to be 2.79±0.217 ml, 2.85±0.111, 71.75±2.621, 11.35±1.255 millions/ml and 5.8185±0.092 respectively of fresh semen. No significant difference was found between the parameters except pH, which was significantly different between the bulls. The mean sperm motility percentage and live dead sperm count % of Kundhi buffalo bull semen was found to be 20.46±1.62 and 6.9± 0.2% for frozen semen. A significant (P< 0.05) difference was found between the bulls for post-thaw motility percentage. It was found that at 01 hour incubation, 43.25±2.95% of sperms were motile having 11.78±0.28 % dead sperm count. It was gradually decline from 0 to 5 hours incubation, After 5 hours, all sperms were found dead. It is concluded that sperms maintaining long term motility and having less live dead sperms count were considered suitable for artificial insemination.
Comparative Efficacy of Some Organic Amendments and a Nematicide (Furadan-3G) Against Root-knot on Two Local Varieties of Groundnut
Sayeeda Fatema,M.U. Ahmad
Plant Pathology Journal , 2005,
Abstract: Six treatments with organic amendments like neem oil, mustard oil cake, til oil cake, garlic extract and a chemical Furadan-3G including control were tested against root-knot on two local varieties of groundnut caused by Meloidogyne javanica. Treatment with Furadan-3G as side-dressing after 7 and 14 days of inoculation gave the best response in plant growth characters including nodulation correspondingly with the lowest number of galls, adult females and different juvenile stages of the nematode within the treated plants. Neem oil gave better effect with the reduction of galls and nematode population like that of Furadan-3G. Garlic bulb extract showed comparatively higher response in promoting plant growth and suppressing the nematode. Good effects were observed with the oil cakes of mustard and til.
Promise of translational medicine: An evidence-based therapeutics
Naidu M.U.R
Indian Journal of Pharmacology , 2011,
Abstract:
Parameter Selection Schemes for Web Proxy Servers and their Performance Evaluation
M.U. Kharat,Narendra S. Chaudhari
Information Technology Journal , 2005,
Abstract: Tremendous increase in number of Internet users enforces the study of bandwidth optimization parameters. Analysis of Internet uses, in the specific educational locality, has shown importance of various parameters for satisfying the requirement of users. Results based on the simulation model are presented in this study. With this approach, in present experiment, we have cached 65111 number of web documents at proxy servers so that those can be accessed locally. This leads in the saving of the Internet bandwidth required to fetch 65111 number of web objects bearing average size of 10.87 kb. The total size of these documents is 707.756 Mbytes. Effectively, the bandwidth required to fetch 707.756 Mbytes has been saved whenever there is request for these web documents. Caching web proxy servers, popularity of web objects and their reference of locality, image-storing strategies are shown to be important issues for optimizing the bandwidth utilization.
Efficient Caching Proxy Server Parameters: An Integrated Approach
M.U. Kharat,Narendra S. Chaudhari
Information Technology Journal , 2006,
Abstract: Caching web proxy server improves the performance of over all web access. Since all the parameters of efficient cache performance are time and locality dependent, no single policy of caching proxy servers is ultimate and applicable for ever. To get more and more efficient performance of caching proxies, history based analysis for a specific locality is found advantageous. Using the history based algorithm popularity of web objects was determined which then further utilized for replacement of cache objects. This approach assures service of updated documents to the clients. Soft caching was used for storing low resolution versions of images which provides efficient and effective services to the clients. Study of various formats of image storing policies have enabled us for getting memory requirements of web objects which turn is closely related to the bandwidth utilization. An integrated approach of studying caching proxy server, recording history of web access, soft caching, improve over all efficiency of web proxy servers.
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