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Relaxant effects of different fractions from Tymus vulgaris on guinea-pig tracheal chains
Keyhanmanesh,Rana; Boskabady,Mohammad H;
Biological Research , 2012, DOI: 10.4067/S0716-97602012000100009
Abstract: in previous studies, the relaxant effect of tymus vulgaris has been demonstrated on guinea pig tracheal chains. therefore, in the present study, the relaxant effects of n-hexane, dichloromethane, methanol and aqueous fractions of tymus vulgaris on tracheal chains of guinea pigs were examined. the relaxant effects of four cumulative concentrations of each fraction (0.4, 0.8, 1.2 and 1.6 g%) in comparison to saline as negative control and four cumulative concentrations of theophylline (0.2, 0.4, 0.6 and 0.8 mm) were examined for their relaxant effects on precontracted tracheal chains of guinea pig by 60 mm kcl (group 1) and 10 ìì methacholine (group 2, n = 7 for each group). in group 1, all concentrations of the n-hexane fraction and theophylline and three last concentrations (0.8, 1.2 and 1.6 g%) of dichloromethane and two higher concentrations (1.2 and 1.6 g%) of methanol fractions showed significant relaxant effects compared to that of saline (p<0.05 to p<0.001). in group 2, all concentrations of theophylline, n-hexane and dichloromethane fractions and three concentrations (0.8, 1.2 and 1.6 g%) of methanol and two higher concentrations (1.2 and 1.6 g%) of aqueous fractions showed significant relaxant effects compared to that of saline (p<0.05 to p<0.001). in addition, with group 1, the relaxant effect of all concentrations of all fractions except the n-hexane fraction, were significantly less than those of theophylline (p<0.05 to p<0.001). the n-hexane fraction showed higher relaxant effect than theophylline. the relaxant effect of all concentrations of the n-hexane fraction and the three last concentrations (0.8, 1.2 and 1.6 g%) of dichloromethane and aqueous fractions were significantly greater in group 2 than in group 1 (p<0.05 to p<0.001). there were significant positive correlations between the relaxant effects and concentrations for theophylline and all fractions (except aqueous fraction in group 1) in both groups, but a negative correlation for the aqueous f
Relaxant effects of different fractions from Tymus vulgaris on guinea-pig tracheal chains
Rana Keyhanmanesh,Mohammad H Boskabady
Biological Research , 2012,
Abstract: In previous studies, the relaxant effect of Tymus vulgaris has been demonstrated on guinea pig tracheal chains. Therefore, in the present study, the relaxant effects of n-hexane, dichloromethane, methanol and aqueous fractions of Tymus vulgaris on tracheal chains of guinea pigs were examined. The relaxant effects of four cumulative concentrations of each fraction (0.4, 0.8, 1.2 and 1.6 g%) in comparison to saline as negative control and four cumulative concentrations of theophylline (0.2, 0.4, 0.6 and 0.8 mM) were examined for their relaxant effects on precontracted tracheal chains of guinea pig by 60 mM KCl (group 1) and 10 ìì methacholine (group 2, n = 7 for each group). In group 1, all concentrations of the n-hexane fraction and theophylline and three last concentrations (0.8, 1.2 and 1.6 g%) of dichloromethane and two higher concentrations (1.2 and 1.6 g%) of methanol fractions showed significant relaxant effects compared to that of saline (p<0.05 to p<0.001). In group 2, all concentrations of theophylline, n-hexane and dichloromethane fractions and three concentrations (0.8, 1.2 and 1.6 g%) of methanol and two higher concentrations (1.2 and 1.6 g%) of aqueous fractions showed significant relaxant effects compared to that of saline (p<0.05 to p<0.001). In addition, with group 1, the relaxant effect of all concentrations of all fractions except the n-hexane fraction, were significantly less than those of theophylline (p<0.05 to p<0.001). The n-hexane fraction showed higher relaxant effect than theophylline. The relaxant effect of all concentrations of the n-hexane fraction and the three last concentrations (0.8, 1.2 and 1.6 g%) of dichloromethane and aqueous fractions were significantly greater in group 2 than in group 1 (p<0.05 to p<0.001). There were significant positive correlations between the relaxant effects and concentrations for theophylline and all fractions (except aqueous fraction in group 1) in both groups, but a negative correlation for the aqueous fraction in group 1 (p<0.05 to p<0.001). These results showed a potent relaxant effect for n-hexane and weaker relaxant effect for other fractions from Tymus vulgaris on tracheal chains of guinea pigs.
The effect of Nigella sativa extract on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs
Boskabady, Mohammad Hossein;Keyhanmanesh, Rana;Khamneh, Saeed;Ebrahimi, Mohammad Ali;
Clinics , 2011, DOI: 10.1590/S1807-59322011000500027
Abstract: objective: to examine the preventive effect of a hydro-ethanolic extract of nigella sativa on the tracheal responsiveness and white blood cell count in the lung lavage fluid of sensitized guinea pigs. methods: three groups of guinea pigs sensitized to intraperitoneally injected and inhaled ovalbumin were given drinking water alone (group s), drinking water containing a low concentration of n. sativa extract (group s+lns) or drinking water containing a high concentration of n. sativa extract (group s+hns). the tracheal responses of control animals (group c) and the three groups of sensitized guinea pigs (n = 7 for all groups) to methacholine were measured by the assessment of the tracheal smooth muscle response to increasing concentrations of methacholine, and the effective concentration causing 50% of the maximum response (ec50) was determined. tracheal responses to 0.1% ovalbumin and white blood cell counts in the lung lavage fluid were also examined. results: the tracheal response of the group s guinea pigs to both methacholine and ovalbumin was significantly higher than the response of the controls (p<0.01 for both cases). the tracheal responses of the s+lns and s+hns groups to both methacholine and ovalbumin were significantly decreased compared to those of the s group (p<0.05 to p<0.01). the total white blood cell and eosinophil counts in the lung lavage fluid of group s were significantly higher than those of group c (p<0.01). the white blood cell counts in both treated groups showed significant improvements (p<0.01 for both cases). conclusions: these results demonstrate the preventive effect of the n. sativa extract on the tracheal response and lung inflammation in sensitized guinea pigs.
Effect of vitamin C on tracheal responsiveness and pulmonary inflammation in chronic obstructive pulmonary disease model of guinea pig
Rana Keyhanmanesh,Mahdi Ahmadi,Sajjad Jeddy,Horyeh Bagban
Physiology and Pharmacology , 2013,
Abstract: Introduction: In the present study, the prophylactic effect of vitamin C, as a potent anti-oxidant, on tracheal responsiveness to methacholine and ovalbumin, bronchoalveolar lavage fluid white blood cell (WBC) count and differential count, and also lung pathology in chronic obstructive pulmonary disease (COPD) -guinea pigs (cigarette exposed guinea pigs) were examined. In addition, the relaxant effects of theophylline on tracheal chains of guinea pigs were studied. Methods: Twenty four male guinea pigs were randomly divided to three groups; control (C group), COPD model of guinea pigs (COPD group) and pretreated group (COPD+ Vit C group). The two first groups were given drinking water alone, and the third group used water containing vitamin C. The relaxant effects of four cumulative concentrations of theophylline were examined by their relaxant effects on precontracted tracheal chains of guinea pig by 60 mM KCl (group 1) and 10 μM methacholine (group 2). Results: The tracheal responsiveness to methacholine and ovalbumine, and WBC count of COPD guinea pigs were significantly higher than those of controls (p<0.05 to p<0.001). The lung in COPD group showed significant pathological changes. The tracheal responsiveness to methacholine and avalbumine and WBC count were significantly decreased in pretreated group compared with the COPD guinea pigs (COPD group) (p<0.05 to p<0.001). In both groups, the relaxant effect of theophylline in the COPD group was lower than the control group (group C) (p<0.05 to p<0.001). Conclusion: These results showed prophylactic effect of vitamin C on tracheal responsiveness and pulmonary inflammation of COPD-guinea pigs.
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