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Search Results: 1 - 10 of 6449 matches for " Kevin Maringer "
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Improving Sharpe Ratios and Stability of Portfolios by Using a Clustering Technique
Jin Zhang,Dietmar Maringer
Lecture Notes in Engineering and Computer Science , 2009,
Abstract:
DENV Inhibits Type I IFN Production in Infected Cells by Cleaving Human STING
Sebastian Aguirre,Ana M. Maestre,Sarah Pagni,Jenish R. Patel,Timothy Savage,Delia Gutman,Kevin Maringer,Dabeiba Bernal-Rubio,Reed S. Shabman,Viviana Simon,Juan R. Rodriguez-Madoz,Lubbertus C. F. Mulder,Glen N. Barber,Ana Fernandez-Sesma
PLOS Pathogens , 2012, DOI: 10.1371/journal.ppat.1002934
Abstract: Dengue virus (DENV) is a pathogen with a high impact on human health. It replicates in a wide range of cells involved in the immune response. To efficiently infect humans, DENV must evade or inhibit fundamental elements of the innate immune system, namely the type I interferon response. DENV circumvents the host immune response by expressing proteins that antagonize the cellular innate immunity. We have recently documented the inhibition of type I IFN production by the proteolytic activity of DENV NS2B3 protease complex in human monocyte derived dendritic cells (MDDCs). In the present report we identify the human adaptor molecule STING as a target of the NS2B3 protease complex. We characterize the mechanism of inhibition of type I IFN production in primary human MDDCs by this viral factor. Using different human and mouse primary cells lacking STING, we show enhanced DENV replication. Conversely, mutated versions of STING that cannot be cleaved by the DENV NS2B3 protease induced higher levels of type I IFN after infection with DENV. Additionally, we show that DENV NS2B3 is not able to degrade the mouse version of STING, a phenomenon that severely restricts the replication of DENV in mouse cells, suggesting that STING plays a key role in the inhibition of DENV infection and spread in mice.
Geometry, mixing properties and hypocoercivity of a degenerate diffusion arising in technical textile industry
Martin Grothaus,Axel Klar,Johannes Maringer,Patrik Stilgenbauer
Mathematics , 2012,
Abstract: We study a stochastic equation modeling the lay-down of fibers in the production process of nonwovens. The equation can be formulated as some manifold-valued Stratonovich stochastic differential equation. Especially, we study the long time behaviour of the stochastic process. Demanding mathematical difficulties arising due to the degeneracity of the lay-down equation and its associated generator. We prove strong mixing properties by making use of the hypoellipticity of the generator and a new version of Doob's theorem derived recently by Gerlach and Nittka. Moreover, we show convergence to equilibrium exponentially fast with explicitly computable rate of convergence. This analytic approach uses powerful modern Hilbert space methods from the theory of hypocoercivity developed by Dolbeault, Mouhot and Schmeiser. Summarizing, we give interesting mathematical applications of geometric stochastic analysis to real world problems.
Shareholder Wealth Effects of CEO Succession  [PDF]
Kevin Banning
American Journal of Industrial and Business Management (AJIBM) , 2013, DOI: 10.4236/ajibm.2013.36067
Abstract: Companies often dismiss their chief executive officers (CEOs) when financial performance falters. This study examines why, despite the positive stock market effects, the replacement of the CEO often does little to change a company’s financial performance. Thanks to the agency arrangements in some companies, new CEOs are able to negotiate favorable contracts which benefit the CEO rather than the shareholders. In a sample of 140 publicly-traded firms, we found that compensation systems for new CEOs differed as a function of institutional ownership, with total executive compensation higher and compensation risk lower in firms with lower levels of institutional ownership. Financial performance was also weaker in firms with less institutional ownership.
The nervous system and pH  [PDF]
Kevin Carlin
Open Journal of Internal Medicine (OJIM) , 2013, DOI: 10.4236/ojim.2013.34028
Abstract:

The mix of cellular pumps, channels, transporters, and isoenzymes is genetically inherited. However, the environment has the ability to impact the cellular pumps, channels, transporters, and isoenzymes to some degree. Cellular pumps, channels, transporters and isoenzymes help control cellular pH and vice versa. Therefore possibly the pH in the nervous system is more variable than previously believed. If so, that could explain some of the changes we see in the nervous system. 

How to Raise Teachers’ Motivation through “Nudges” and Attribution Theory  [PDF]
Kevin Brinkmann
Open Journal of Social Sciences (JSS) , 2017, DOI: 10.4236/jss.2017.511002
Abstract:
Teachers’ motivation correlates positively with better teaching practices, higher student motivation, and better overall well-being. This case study reflects on an innovative approach being used to raise teachers’ motivation in India. The approach combines Nudge Theory (from the discipline of Political Science) and Attribution Theory (from the discipline of Psychology) into a comprehensive strategy that has the potential to change teachers’ long-term motivation, by changing their sense of identity.
Why 16 Million Bonded Labourers Remain Invisible: What Althusser Has to Say  [PDF]
Kevin Brinkmann
Advances in Applied Sociology (AASoci) , 2018, DOI: 10.4236/aasoci.2018.81003
Abstract: Seventy years after the UN Declaration of Human Rights, sixteen million bonded labours remain largely unnoticed in South Asia. Why? The most fundamental reason may not lie within economics or politics but in ideology.
Tetrahydrodipicolinate N-Succinyltransferase and Dihydrodipicolinate Synthase from Pseudomonas aeruginosa: Structure Analysis and Gene Deletion
Robert Schnell, Wulf Oehlmann, Tatyana Sandalova, Yvonne Braun, Carmen Huck, Marko Maringer, Mahavir Singh, Gunter Schneider
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0031133
Abstract: The diaminopimelic acid pathway of lysine biosynthesis has been suggested to provide attractive targets for the development of novel antibacterial drugs. Here we report the characterization of two enzymes from this pathway in the human pathogen Pseudomonas aeruginosa, utilizing structural biology, biochemistry and genetics. We show that tetrahydrodipicolinate N-succinyltransferase (DapD) from P. aeruginosa is specific for the L-stereoisomer of the amino substrate L-2-aminopimelate, and its D-enantiomer acts as a weak inhibitor. The crystal structures of this enzyme with L-2-aminopimelate and D-2-aminopimelate, respectively, reveal that both compounds bind at the same site of the enzyme. Comparison of the binding interactions of these ligands in the enzyme active site suggests misalignment of the amino group of D-2-aminopimelate for nucleophilic attack on the succinate moiety of the co-substrate succinyl-CoA as the structural basis of specificity and inhibition. P. aeruginosa mutants where the dapA gene had been deleted were viable and able to grow in a mouse lung infection model, suggesting that DapA is not an optimal target for drug development against this organism. Structure-based sequence alignments, based on the DapA crystal structure determined to 1.6 ? resolution revealed the presence of two homologues, PA0223 and PA4188, in P. aeruginosa that could substitute for DapA in the P. aeruginosa PAO1ΔdapA mutant. In vitro experiments using recombinant PA0223 protein could however not detect any DapA activity.
Topology and manipulation of multiferroic hybrid domains in MnWO$_4$
D. Meier,N. Leo,M. Maringer,Th. Lottermoser,P. Becker,L. Bohaty,M. Fiebig
Physics , 2009, DOI: 10.1103/PhysRevB.80.224420
Abstract: An investigation of the spatially resolved distribution of domains in the multiferroic phase of MnWO$_4$ reveals that characteristic features of magnetic and ferroelectric domains are inseparably entangled. Consequently, the concept of "multiferroic hybrid domains" is introduced for compounds in which ferroelectricity is induced by magnetic order. The three-dimensional structure of the domains is resolved. Annealing cycles reveal a topological memory effect that goes beyond previously reported memory effects and allows one to reconstruct the entire multiferroic multidomain structure subsequent to quenching it.
Non-English speaking background patients in a predominantly English-speaking region may be more likely to present with a dementia other than Alzheimer’s disease  [PDF]
Kevin Ong, Michael Woodward
Advances in Aging Research (AAR) , 2013, DOI: 10.4236/aar.2013.23013
Abstract: Information on 54 patients was retrospectively collected to compare the presentation trends of cognitive disorders in those of non-English speaking background (NESB)to English speaking background(ESB)attending an Australian memory clinic that extensively uses fluorodeoxyglucose positron emission tomography(FDG PET) in the diagnosis of cognitive concerns. NESB patients were less likely to be diagnosed with Alzheimer’s disease(AD)as the sole neurodegenerative diagnosis (Fisher exact test, p = 0.08), and NESB patients with dementia were more likely to have non-AD dementia (Fisher exact test, p = 0.06). They experienced symptoms 18 months longer before receiving a formal diagnosis (t(46) = 2.2, p = 0.03). Older elderly NESB females were under represented in those presenting to the clinic (Fisher exact test, p = 0.04). The clinical work-up of NESB patients as opposed to those of ESB relied more heavily on FDG PET (Fisher exact test, p = 0.04). ESB and NESB patients may have different attitudes towards dementia, affecting how they present, and biomarkers may be more heavily relied on when language affects history taking and neuropsychological testing.
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