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Search Results: 1 - 10 of 302484 matches for " Kevin J. Carlin "
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Cancer and pH—A Prospective  [PDF]
Kevin J. Carlin
Open Journal of Internal Medicine (OJIM) , 2014, DOI: 10.4236/ojim.2014.43011
Abstract: How can cancer develop in so many different organs in so many different ways, but the outcome is similar enough to all be under the same title—cancer? There are so many causes of cancer—viruses, genetic defects, sunburn, gastroesophageal reflux, smoking, alcohol, radiation, chemicals, etc. The above variable well known etiologies of cancer could all induce a need for repair which involves alkalinizing the cells involved. Thus the commonality for cancers could be a pH change. If true, this could give the field of cancer prevention and therapy new avenues of pursuit.
On Extensions Between Verma Modules
Kevin J. Carlin
Mathematics , 2015,
Abstract: A recent result of N. Abe implies that the Gabber-Joseph conjecture is true for the first-degree extensions between Verma modules with regular integral highest weights.
Derived Functors Related to Wall Crossing
Kevin J. Carlin
Mathematics , 2008,
Abstract: The setting is the representation theory of a simply connected, semisimple algebraic group over a field of positive characteristic. There is a natural transformation from the wall-crossing functor to the identity functor. The kernel of this transformation is a left exact functor. This functor and its first derived functor are evaluated on the global sections of a line bundle on the flag variety. It is conjectured that the derived functors of order greater than one annihilate the global sections. Also, the principal indecomposable modules for the Frobenius subgroups are shown to be acyclic.
The nervous system and pH  [PDF]
Kevin Carlin
Open Journal of Internal Medicine (OJIM) , 2013, DOI: 10.4236/ojim.2013.34028
Abstract:

The mix of cellular pumps, channels, transporters, and isoenzymes is genetically inherited. However, the environment has the ability to impact the cellular pumps, channels, transporters, and isoenzymes to some degree. Cellular pumps, channels, transporters and isoenzymes help control cellular pH and vice versa. Therefore possibly the pH in the nervous system is more variable than previously believed. If so, that could explain some of the changes we see in the nervous system. 

Cloud Computing Technologies
Sean Carlin,Kevin Curran
International Journal of Cloud Computing and Services Science (IJ-CLOSER) , 2012, DOI: 10.11591/closer.v1i2.486
Abstract: This paper outlines the key characteristics that cloud computing technologies possess and illustrates the cloud computing stack containing the three essential services (SaaS, PaaS and IaaS) that have come to define the technology and its delivery model. The underlying virtualization technologies that make cloud computing possible are also identified and explained. The various challenges that face cloud computing technologies today are investigated and discussed. The future of cloud computing technologies along with its various applications and trends are also explored, giving a brief outlook of where and how the technology will progress into the future.
Serum profiling by MALDI-TOF mass spectrometry as a diagnostic tool for domoic acid toxicosis in California sea lions
Benjamin A Neely, Jennifer L Soper, Denise J Greig, Kevin P Carlin, Elizabeth G Favre, Frances MD Gulland, Jonas S Almeida, Michael G Janech
Proteome Science , 2012, DOI: 10.1186/1477-5956-10-18
Abstract: No single peak was a good classifier of acute DAT, and ANN models were the best predictors of acute DAT. Performance measures for a single median ANN were: sensitivity, 100%; specificity, 60%; positive predictive value, 71%; negative predictive value, 100%. When 101 ANNs were combined and allowed to vote for the outcome, the performance measures were: sensitivity, 30%; specificity, 100%; positive predictive value, 100%; negative predictive value, 59%.These results suggest that MALDI-TOF peptide profiling and neural networks can perform either as a highly sensitive (100% negative predictive value) or a highly specific (100% positive predictive value) diagnostic tool for acute DAT. This also suggests that machine learning directed by populations of predictive models offer the ability to modulate the predictive effort into a specific type of error.The toxicosis associated with domoic acid (DA) ingestion has been linked to massive marine mammal stranding events along the coastal areas of the Western United States [1]. The California sea lion (Zalophus californianus) appears to be the most commonly affected species, likely due to its foraging on fish containing domoic acid [2]. Of sea lions admitted to The Marine Mammal Center (TMMC; Sausalito, CA) between 1998 and 2006 more than 24% were diagnosed with domoic acid toxicosis (DAT), of which 77% were acute DAT [3]. Mortality was significant, regardless of acute or chronic diagnosis, exceeding 40%.Arriving at a diagnosis of DAT is not always straight forward. Clinical signs can be highly variable [4] and diagnosis often requires post mortem information derived from histological examination of the brain. Some of the variability in clinical signs in stranded animals is likely due to variation in ingested dose, the time at which the sea lion strands, and the time at which examination occurs during the course of the intoxication. Clinical suspicion of DAT is based on the observation of abnormal behavior, e.g., ataxia, constant
Recovery of information from multiple imputation: a simulation study
Katherine J Lee, John B Carlin
Emerging Themes in Epidemiology , 2012, DOI: 10.1186/1742-7622-9-3
Abstract: Simulated datasets (n?=?1000) drawn from a synthetic population were used to explore information recovery from multiple imputation in estimating the coefficient of a binary exposure variable when various proportions of data (10-90%) were set missing at random in a highly-skewed continuous covariate or in the binary exposure. Imputation was performed using multivariate normal imputation (MVNI), with a simple or zero-skewness log transformation to manage non-normality. Bias, precision, mean-squared error and coverage for a set of regression parameter estimates were compared between multiple imputation and complete case analyses.For missingness in the continuous covariate, multiple imputation produced less bias and greater precision for the effect of the binary exposure variable, compared with complete case analysis, with larger gains in precision with more missing data. However, even with only moderate missingness, large bias and substantial under-coverage were apparent in estimating the continuous covariate’s effect when skewness was not adequately addressed. For missingness in the binary covariate, all estimates had negligible bias but gains in precision from multiple imputation were minimal, particularly for the coefficient of the binary exposure.Although multiple imputation can be useful if covariates required for confounding adjustment are missing, benefits are likely to be minimal when data are missing in the exposure variable of interest. Furthermore, when there are large amounts of missingness, multiple imputation can become unreliable and introduce bias not present in a complete case analysis if the imputation model is not appropriate. Epidemiologists dealing with missing data should keep in mind the potential limitations as well as the potential benefits of multiple imputation. Further work is needed to provide clearer guidelines on effective application of this method.Statistical analysis of epidemiological data is often hindered by missing data. Multiple i
Blindly inserted nasogastric feeding tubes and thoracic complications in intensive care  [PDF]
Elpis Giantsou, Kevin J. Gunning
Health (Health) , 2010, DOI: 10.4236/health.2010.210166
Abstract: Purpose of review: This article reviews the thoracic complications from malpositioned blindly inserted nasogastric feeding tubes in mechanically ventilated patients in intensive care and the methods to check the position and promote safe placement of the feeding tubes. Recent findings: Malpositioned feeding tubes are not included in risk management databases. The reported incidence is 1-3% and more than half occur in mechanically ventilated patients. Eighty three mechanically ventilated patients were reported with malpositioned nasogastric tubes and 66% of them developed serious thoracic complications. Pneumothoraces accounted for 80% of thoracic complications that were evenly distributed between tubes with and without stylet. Repeated misplacements appear to increase the risk. Non-radiological confirmation of the position of the tube has suboptimal performance. Protocols to place feeding tubes and new technology are promising candidates. Summary: Malpositioned nasogastric feeding tubes are underreported and associated with serious thoracic complications in mechanically ventilated patients. We need more data to answer whether we can afford to prevent them.
Increasing the Pensionable Age: What Changes Are OECD Countries Making? What Considerations Are Driving Policy?  [PDF]
Hila Axelrad, Kevin J. Mahoney
Open Journal of Social Sciences (JSS) , 2017, DOI: 10.4236/jss.2017.57005
Abstract: The average age of retirement used to be low in most countries due to numerous policies introduced 30 to 40 years ago which encouraged lower retirement ages. However, in response to the growth of the older segment of the population, increased life expectancy, the need for skilled workers, and the precarious financial state of public pension systems, pension reforms have been implemented in the U.S. and Europe, and are now geared towards improving employment rates for older workers, increasing retirement ages and pension eligibility. This paper surveys recent changes in retirement age and maps the changes that have occurred in the last decades using data from 34 OECD (The Organization for Economic Cooperation and Development) countries. This paper then reviews the arguments for and against these changes, the criteria for setting a certain retirement age, and the differences in statutory retirement age by gender, occupation, employment status, and other factors unique to particular countries. The purpose of this paper is to analyze current trends in terms of raising the pensionable age.
Ratiometric Measurements of Adiponectin by Mass Spectrometry in Bottlenose Dolphins (Tursiops truncatus) with Iron Overload Reveal an Association with Insulin Resistance and Glucagon
Benjamin A. Neely,Kevin P. Carlin,Wayne E. McFee,Michael G. Janech
Frontiers in Endocrinology , 2013, DOI: 10.3389/fendo.2013.00132
Abstract: High molecular weight (HMW) adiponectin levels are reduced in humans with type 2 diabetes and insulin resistance. Similar to humans with insulin resistance, managed bottlenose dolphins (Tursiops truncatus) diagnosed with hemochromatosis (iron overload) have higher levels of 2 h post-prandial plasma insulin than healthy controls. A parallel reaction monitoring assay for dolphin serum adiponectin was developed based on tryptic peptides identified by mass spectrometry. Using identified post-translational modifications, a differential measurement was constructed. Total and unmodified adiponectin levels were measured in sera from dolphins with (n = 4) and without (n = 5) iron overload. This measurement yielded total adiponectin levels as well as site specific percent unmodified adiponectin that may inversely correlate with HMW adiponectin. Differences in insulin levels between iron overload cases and controls were observed 2 h post-prandial, but not during the fasting state. Thus, post-prandial as well as fasting serum adiponectin levels were measured to determine whether adiponectin and insulin would follow similar patterns. There was no difference in total adiponectin or percent unmodified adiponectin from case or control fasting animals. There was no difference in post-prandial total adiponectin levels between case and control dolphins (mean ± SD) at 763 ± 298 and 727 ± 291 pmol/ml, respectively (p = 0.91); however, percent unmodified adiponectin was significantly higher in post-prandial cases compared to controls (30.0 ± 6.3 versus 17.0 ± 6.6%, respectively; p = 0.016). Interestingly, both total and percent unmodified adiponectin were correlated with glucagon levels in controls (r = 0.999, p < 0.001), but not in cases, which is possibly a reflection of insulin resistance. Although total adiponectin levels were not significantly different, the elevated percent unmodified adiponectin follows a trend similar to HMW adiponectin reported for humans with metabolic disorders.
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