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Search Results: 1 - 10 of 401048 matches for " Kerkez M. "
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Study of dentate gyrus granule cells of female rats neonatally treated with sex hormones
Dreki? Dmitar M.,Mrvi? Verica,Lozan?e Olivera,Kerkez M.
Acta Veterinaria , 2005, DOI: 10.2298/avb0506403d
Abstract: This study was designed to determine whether adult neurogenesis occurs in the dentate gyrus of rats, and to explore the possibility that this process is regulated by the activation of sex hormones. The proliferation of hippocampal dentate gyrus granule cells was investigated using 80 nC; 3H thymidine incorporation in the first group andin the second grouph 80 μCi3H - thymidine and 1mg estrogene dipropionae. We proved the existence of a stronger proliferation of granule cells in SGZ GD in female rats. The third group of newborn female Wistar rats was treated at 4 and 8 a days of ageold with a single dose of 2 mg of testosterone propionate. We proved the existence of minor damages of granule cells in SGZ GD. In the fourth group treated at 15 days of age, a single dose of 4 mg testosterone propionate and sacrificed when 60 days old, we proved the existence of minor damages of granular cells in SGZ GD. Our results suggest a differential effect of sex hormones on dentate gyrus granule cells proliferation through early life in rats.
Endometriosis in cesarean section surgical scar
Stefanovi? D.,Kerkez M.,?or?evi? Z.,Kne?evi? S.
Acta Chirurgica Iugoslavica , 2007, DOI: 10.2298/aci0702079s
Abstract: Introduction: Endometriosis is the presence of endometrial glands and stroma outside of uterine cavity. It may occur in the abdominal wall scar after the operation in which uterus was opened. In cesarean section scar it occurs in 0.4%. It is in 2/3 patients characterized with triad of: tumor, periodic pain associated with menses and history of cesarean section. The mechanism of endometriosis occurring in the cesarean scar is felt to be secondary to iatrogenic transplantation of endometrium or extrauterine decidual tissue into the incision during the cesarean section. Case outline. Forty years old patient with tumor 4,5x4 cm that appeared in abdominal wall scar one year after second cesarean section, followed by periodic pain and macroscopic changes associated with menses. First diagnosis was granuloma in the surgical scar, but as she had periodic symptoms, diferential diagnosis was endometriosis. Hormonal therapy with contraceptive drugs was ordered. As it was no improvement she was operated. The surgical excision of the tumor including fascia and muscle tissue was done. Sample revealed endometrium after histopathologic examination. Patient was completely recovered and without relapse of symptoms during follow up to date. Conclusion. When there is a tumor in the cesarean section scar or scar after the operation in which uterus or ovarial tube was opened, followed with periodical pain and macroscopic changes associated with menses, endometriosis should be considered. Surgical excision of the tumor is sufficient and patohistological examination confirms diagnosis. .
Comparison of clinical data, ultrasonography, mamography and histological findings obtained by ex tempore biopsy for breast cancer diagnosis
Stoja?i?-?eni? S.,Kerkez M.,Jovi? D.,Maksimovi? ?.
Acta Chirurgica Iugoslavica , 2008, DOI: 10.2298/aci0804037s
Abstract: Breast cancer is really one from tumor with highest mortality in this country as well as in the word. For early detection of the loco-regional breast cancer and disease confirmation, many diagnostic procedures were recommended with aims to help in decision for surgery treatment. This comparative study reported data by clinical analyses, ultrasonography, mammography and histological findings obtained after ex tempore biopsy, in 59 women with breast cancer aged from 16 to 69. The highest incidence of cancer was obtained in women over 61 years of age, although high rate of breast cancer was found in aging between 21 to 50 years. The fibroadenoma were founded in 40.68%, while malignant carcinoma ductale in 13.55% of all cases. Correlation between applied analyses for fibroadenoma was found in 86.05% cases, while in malignant lesions this percentage was highest (93.33%). Apart of these methods applied for early diagnosis in general hospital and obtained statistical significance in diagnosis, new techniques based on molecular level (hormone receptor status) must be used.
Influence of estrogen on the cerebellar cortex of male rats
Dreki? Dmitar,Rankovi? V.,Kerkez M.,Lozan?e Olivera
Acta Veterinaria , 2008, DOI: 10.2298/avb0801043d
Abstract: Effects of estrogen in the brain regions which are not directly related to neuroendocrine functions are not fully known. Therefore we investigated the long term effects on the cerebellar cortex of a neonatally (3rd day) administered single dose (1 mg) of estrogen. Golgi impregnated and paraffin sections (Bielschowsky, Kl ver-Barerra and basic fuchsin-alcian-blue) of cerebella of 10 treated adult (365 days old) male rats and of 10 matched controls were studied. Simultaneous to the morphological analysis of the cerebellar cortex, stereological methods were applied. In treated rats the Purkinje neurons had a more developed dendritic arborisation with numerous spines, but had significantly decreased (p<0.001) cellular body volumes (14 x 10-3 mm3) in comparison to controls (27 x 10-3 mm3). In treated animals the molecular layer thickness (148.94 μm) of the cerebellar cortex was significantly decreased (p<0.001) compared to controls (514.52 μm), and the thickness of the granular layer (372.35 μm) was significantly (p<0.001) increased compared to controls (270.80 μm). In treated rats the number of neurons in the granular layer was 338.87 mm2 (controls 118.81 mm2) and in the molecular layer was 22.86 mm2 (controls 55.23 mm2). Our results indicate significant and long term effects of a single dose of estrogen (administered in the neonatal period) on the cerebellar cortex of male rats.
The effects of estrogen on the morphology of the pyramidal neurons of the parietal cortex of female rats
Dreki? Dmitar,Lozan?e Olivera,Milovanovi? N.,Kerkez M.
Acta Veterinaria , 2006, DOI: 10.2298/avb0603215d
Abstract: In this study the effects of a neonatally (3rd day of life) administered single dose (1 mg) of estradiol dipropionate (E2) on the parietal cortex of juvenile (16 days of life) female rats were investigated. The morphology the volume of the soma and the thickness of the apical dendrite were studied in Golgi impregnated pyramidal neurons from both the external and internal pyramidal layers. In the treated female rats the volume of the soma and the thickness of the apical dendrite of pyramidal neurons was increased surpassing the values in the corresponding controls. These findings indicated significant and prolonged effects of a single dose of estrogen administered in the neonatal period, on the parietal neocortical pyramidal neurons of female rats.
Doppler hemodynamic study in evaluation of liver metastases
Stoj?i?-?eni? S.,?arenac-Kova? R.,Kerkez M.,Juri?i? V.
Acta Chirurgica Iugoslavica , 2007, DOI: 10.2298/aci0702009s
Abstract: The color Doppler spectral analyses can be usefully in description of the liver circulation as one from non-invasive methods. Using color Doppler B mod ultrasound (Toshiba Core Vision) with duplex ultrasound we founded difference in liver circulation between patients with colon cancer and liver metastasis in comparison with those without metastases. We suggested this non invasive method for early detection of occult liver metastasis presence. .
Gastric adenomyoma
Kerkez Mirko D.,Leki? Neboj?a S.,?ulafi? ?or?e M.,Ra?natovi? Zoran J.
Vojnosanitetski Pregled , 2011, DOI: 10.2298/vsp1106519k
Abstract: Bacground. Gastric adenomyoma is a rare, hamartomatous tumor localized most frequently in the gastric antrum. Review of the available literature shows only sporadic reports or smaller series. Case reports. We presented a 72-year-old woman admitted due to epigastric pain with dyspeptic difficulties. Biochemical parameters and tumor markers were within the referential limits. Diagnostic procedures (upper endoscopy, endoscopic ultrasonography and computerized tomography) revealed an intramural tumor prominence with intact mucosa on the posterior wall of gastric antrum, not accessible for biopsy. Surgical treatment was performed with total extirpation of the tumor. Histopathological examination verified adenomyoma with focal low grade epithelial dysplasia. Cytologic immunophenotype was consistent with smooth muscle stromal and epithelial tumor (CK7 and CK20 ++ immunophenotype). Stromal component revealed low proliferative index (Ki-67 protein immunoexpression level 3%), and p53 less than 0.1% in both epithelial and stromal components. Following the operation, the patient remained in good condition. Conclusion. Uncertain malignant potential of the gastric adenomyoma in the presented case indicates that timely diagnostics with adequate surgical treatment is crucial for an adequate treatment.
Liver actinomycosis mimicking liver tumor
?ulafi? ?or?e M.,Leki? Neboj?a S.,Kerkez Mirko D.,Mija? Dragana D.
Vojnosanitetski Pregled , 2009, DOI: 10.2298/vsp0911924c
Abstract: Background. The liver actinomycosis is a rare disease associated with complex differentiation from the liver metastases or hepatocellular carcinoma. Case report. A 50-year old immunocompetent female patient was admitted to the Surgical Department in an exhausted condition, with dyspnea, significant weight loss and intermittent fever in the recent two months. Diagnostic procedures that followed, including abdominal ultrasound and computed tomography led us to the diagnosis of metastatic liver disease of unknown etiology with pleural and pericardial effusion. Intraoperatively, the presence of liver pseudotumor without malignancy in the liver was confirmed. Histological examination confirmed the diagnosis of liver actinomycosis. Prolonged treatment with high dose penicillin was performed and all signs and symptoms resolved completely without further problems. The control abdominal ultrasound finding was normal. Conclusion. Liver actinomycosis has a nonspecific presentation, often mimicking liver tumor. A timely diagnosis as well as a combined surgical and antibiotic therapy is necessary in the treatment of patients with primary disease and prevention of complications.
The Effects of Aerobic Exercise Training on Basal Metabolism and Physical Fitness in Sedentary Women  [PDF]
Fatma Kizilay, Cengiz Arslan, Fatma ?. Kerkez, Aysegul Beykumul, Egemen Kizilay
Health (Health) , 2016, DOI: 10.4236/health.2016.82020
Abstract: Objective: Aerobic exercises are the basic activity on fight against obesity. And obesity is related with metabolic rate. So our study is aimed to investigate the effects of 8 weeks aerobic exercise on basal metabolic rate and physical parameters. Methods: Sedentary women between the ages of 35 - 45 (n = 40) were randomized into control group (CG) (n = 20) and exercise group (EG) (n = 20). EG underwent 8 weeks of aerobic-run-walk exercise training: 3 days a week, 1 hour sessions. The CG was not trained. Basal metabolic rate (BMR), body mass index (BMI), waist-hip ratio (WHR), body fat percentage (BFP), body fat mass (FM) and lean body mass (LBM) were measured for all of the subjects before and after the training program. Results: Mean BMR decreased from 1386 ± 213.6 kcal to 1327 ± 253.7 in CG, and raised from 1308 ± 201.8 to 1409 ± 218.3 kcal in EG. While BMI raised from 31.39 ± 6.15 kg/m2 to 31.51 ± 6.09 kg/m2 in CG, it decreased from 29.62 ± 3.78 kg/m2 to 28.47 ± 3.74 kg/m2 in EG. There was also statistically significant difference in parameters of WHR, BFP, FM and LBM in favour of EG (p < 0.05). Conclusion: After 8 weeks aerobic exercise training program, there was a statistically significant difference in favour of EG in BMR, BMI, BFP, FM, LBM, WHR and weight parameters.
A study of pulmonary embolism after abdominal surgery in patients undergoing prophylaxis
Mirko D Kerkez, ?or?e M ?ulafi?, Dragana D Mija?, Vitomir I Rankovi?, Neboj?a S Leki?, Dejan ? Stefanovi?
World Journal of Gastroenterology , 2009,
Abstract: AIM: To determine risk factors for pulmonary embolism and estimate effects and benefits of prophylaxis.METHODS: We included 78 patients who died subsequently to a pulmonary embolism after major abdominal surgery from 1985 to 2003. A first, retrospective analysis involved 41 patients who underwent elective surgery between 1985 and 1990 without receiving any prophylaxis. In the prospectively evaluated subgroup, 37 patients undergoing major surgery between 1991 and 2003 were enrolled: all of them had received a prophylaxis consisting in low-molecular weight heparin, given subcutaneously at a dose of 2850 IU AXa/0.3 mL (body weight < 50 kg) or 5700 IU AXa/0.6 mL (body weight ≥ 50 kg).RESULTS: A higher incidence of thromboembolism (43.9% and 46.34% in the two groups, respectively) was found in older patients (> 60 years). The incidence of pulmonary embolism after major abdominal surgery in patients who had received the prophylaxis was significantly lower compared to the subjects with the same condition who had not received any prophylaxis (P < 0.001, OR = 2.825; 95% CI, 1.811-4.408). Furthermore, the incidence of pulmonary embolism after colorectal cancer surgery was significantly higher compared to incidence of pulmonary embolism after other abdominal surgical procedures. Finally, the incidence of pulmonary embolism after colorectal cancer surgery among the patients who had received the prophylaxis (11/4316, 0.26%) was significantly lower compared to subjects undergoing a surgical procedure for the same indication but without prophylaxis (10/1562, 0.64%) (P < 0.05, OR = 2.522; 95% CI, 1.069-5.949).CONCLUSION: Prophylaxis with low molecular weight heparin is highly recommended during the preoperative period in patients with diagnosis of colorectal cancer due to high risk of pulmonary embolism after elective surgery.
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