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Search Results: 1 - 10 of 208335 matches for " Keri L. Ryniak "
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Multidisciplinary Service Utilization Pattern by Advanced Head and Neck Cancer Patients: A Single Institution Study
Jacqueline C. Junn,Irene A. Kim,Marianna L. Zahurak,Marietta Tan,Katherine Y. Fan,Spencer T. Lake,David Zaboli,Barbara P. Messing,Karen Ulmer,Karen B. Harrer,Dorothy Gold,Keri L. Ryniak,Eva S. Zinreich,Mei Tang,Marshall A. Levine,Ray G. Blanco,John R. Saunders,Joseph A. Califano,Patrick K. Ha
International Journal of Otolaryngology , 2012, DOI: 10.1155/2012/628578
Abstract: Purpose. To analyze the patterns and associations of adjunctive service visits by head and neck cancer patients receiving primary, concurrent chemoradiation therapy. Methods. Retrospective chart review of patients receiving adjunctive support during a uniform chemoradiation regimen for stages III-IV head and neck squamous cell carcinoma. Univariate and multivariate models for each outcome were obtained from simple and multivariate linear regression analyses. Results. Fifty-two consecutive patients were assessed. Female gender, single marital status, and nonprivate insurance were factors associated with an increased number of social work visits. In a multivariate analysis, female gender and marital status were related to increased social work services. Female gender and stage IV disease were significant for increased nursing visits. In a multivariate analysis for nursing visits, living greater than 20 miles between home and hospital was a negative predictive factor. Conclusion. Treatment of advanced stage head and neck cancer with concurrent chemoradiation warrants a multidisciplinary approach. Female gender, single marital status, and stage IV disease were correlated with increased utilization of social work and nursing services. Distance over 20 miles from the center was a negative factor. This information may help guide the treatment team to allocate resources for the comprehensive care of patients.
Multidisciplinary Service Utilization Pattern by Advanced Head and Neck Cancer Patients: A Single Institution Study
Jacqueline C. Junn,Irene A. Kim,Marianna L. Zahurak,Marietta Tan,Katherine Y. Fan,Spencer T. Lake,David Zaboli,Barbara P. Messing,Karen Ulmer,Karen B. Harrer,Dorothy Gold,Keri L. Ryniak,Eva S. Zinreich,Mei Tang,Marshall A. Levine,Ray G. Blanco,John R. Saunders,Joseph A. Califano,Patrick K. Ha
International Journal of Otolaryngology , 2012, DOI: 10.1155/2012/628578
Abstract: Purpose. To analyze the patterns and associations of adjunctive service visits by head and neck cancer patients receiving primary, concurrent chemoradiation therapy. Methods. Retrospective chart review of patients receiving adjunctive support during a uniform chemoradiation regimen for stages III-IV head and neck squamous cell carcinoma. Univariate and multivariate models for each outcome were obtained from simple and multivariate linear regression analyses. Results. Fifty-two consecutive patients were assessed. Female gender, single marital status, and nonprivate insurance were factors associated with an increased number of social work visits. In a multivariate analysis, female gender and marital status were related to increased social work services. Female gender and stage IV disease were significant for increased nursing visits. In a multivariate analysis for nursing visits, living greater than 20 miles between home and hospital was a negative predictive factor. Conclusion. Treatment of advanced stage head and neck cancer with concurrent chemoradiation warrants a multidisciplinary approach. Female gender, single marital status, and stage IV disease were correlated with increased utilization of social work and nursing services. Distance over 20 miles from the center was a negative factor. This information may help guide the treatment team to allocate resources for the comprehensive care of patients. 1. Introduction With approximately 400,000 new cases per year worldwide, squamous cell carcinoma is the most common cancer of the head and neck. Concurrent chemo- and radiation therapy is one well-established treatment option for patients who present with advanced stage disease [1–3]. Frequent side effects from radiation therapy include dysphagia, hoarseness, skin desquamation, xerostomia, and mucositis [4]. In addition to improving survival, functional preservation of the involved structures has become increasingly important [5, 6]. The close relationship between the structures involved and fundamental daily activities adds to the challenge in treating patients with head and neck cancer. Hence, assessing their quality of life and identifying characteristics salient to patients utilizing adjunctive services are especially necessary. Thus far, relatively few studies have sought to investigate the pattern and features attributed to increased use of adjunctive services. The purpose of this study was to identifydemographic and clinical characteristics contributing to an increase in the management needs of patients with advanced head and neck cancer. We
Identification of a T-cell epitope in the Staphylococcus aureus Panton-Valentine LukS-PV component  [PDF]
Eric L. Brown, Keri Csencsits Smith, Maria Gabriela Bowden
Open Journal of Immunology (OJI) , 2012, DOI: 10.4236/oji.2012.23013
Abstract: We previously observed the elicitation of a significant delayed-type hypersensitivity response to the Panton-Valentine leukocidin (PVL) LukS-PV subunit following subcutaneous immunization (Brown et al., Clinical Microbiology and Infection, 2009, 156: 156-164). A LukS-PV-specific cell line (LST) was screened for proliferative responses against a panel of 25 amino acid-long peptides spanning the length of LukS-PV (amino acids 29-312). This analysis demonstrated that stimulation of LST with LukS-PV resulted in significant proliferative responses and adoptive transfer of LST into na?ve mice conferred a LukS-PV-specific DTH response following challenge. Challenge of mice adoptively transferred with LST with peptides 7 (149-173), 8 (169-193) and 14 (289-312) also elicited a measurable DTH response suggesting that these peptides contained T cell epitopes.
A Review of Seismic Isolation for Buildings: Historical Development and Research Needs
Gordon P. Warn,Keri L. Ryan
Buildings , 2012, DOI: 10.3390/buildings2030300
Abstract: Seismic isolation is a technique that has been used around the world to protect building structures, nonstructural components and content from the damaging effects of earthquake ground shaking. This paper summarizes current practices, describes widely used seismic isolation hardware, chronicles the history and development of modern seismic isolation through shake table testing of isolated buildings, and reviews past efforts to achieve three-dimensional seismic isolation. The review of current practices and past research are synthesized with recent developments from full-scale shake table testing to highlight areas where research is needed to achieve full seismic damage protection of buildings. The emphasis of this paper is on the application of passive seismic isolation for buildings primarily as practiced in the United States, though systems used in other countries will be discussed.
The evolution of the helium-ionizing background at z ~ 2-3
Keri L. Dixon,Steven R. Furlanetto
Physics , 2009, DOI: 10.1088/0004-637X/706/2/970
Abstract: Recent observations suggest that helium became fully ionized around redshift z ~ 3. The HeII optical depth derived from the Lyman-alpha forest decreases substantially from this period to z ~ 2; moreover, it fluctuates strongly near z ~ 3 and then evolves smoothly at lower redshifts. From these opacities, we compute, using a semi-analytic model, the evolution of the mean photoionization rate and the attenuation length for helium over the redshift range 2.0 < z < 3.2. This model includes an inhomogeneous metagalactic radiation background, which is expected during and after helium reionization. We find that assuming a uniform background underestimates the required photoionization rate by up to a factor ~2. When averaged over the (few) available lines of sight, the effective optical depth exhibits a discontinuity near z = 2.8, but the measurement uncertainties are sizable. This feature translates into a jump in the photoionization rate and, provided the quasar emissivity evolves smoothly, in the effective attenuation length, perhaps signaling the helium reionization era. We then compute the evolution of the effective optical depth for a variety of simple helium reionization models, in which the measured quasar luminosity function and the attenuation length, as well as the evolving HeIII fraction, are inputs. A model with reionization ending around redshift z ~ 2.7 is most consistent with the data, although the constraints are not strong thanks to the sparseness of the data.
Verification of Intraovum Transmission of a Microsporidium of Vertebrates: Pseudoloma neurophilia Infecting the Zebrafish, Danio rerio
Justin L. Sanders, Virginia Watral, Keri Clarkson, Michael L. Kent
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076064
Abstract: Direct transmission from parents to offspring, referred to as vertical transmission, occurs within essentially all major groups of pathogens. Several microsporidia (Phylum Microsporidia) that infect arthropods employ this mode of transmission, and various lines of evidence have suggested this might occur with certain fish microsporidia. The microsporidium, Pseudoloma neurophilia, is a common pathogen of the laboratory zebrafish, Danio rerio. We previously verified that this parasite is easily transmitted horizontally, but previous studies also indicated that maternal transmission occurs. We report here direct observation of Pseudoloma neurophilia in the progeny of infected zebrafish that were reared in isolation, including microscopic visualization of the parasite in all major stages of development. Histological examination of larval fish reared in isolation from a group spawn showed microsporidian spores in the resorbing yolk sac of a fish. Infections were also observed in three of 36 juvenile fish. Eggs from a second group spawn of 30 infected fish were examined using a stereomicroscope and the infection was observed from 4 to 48 hours post-fertilization in two embryos. Intraovum infections were detected in embryos from 4 of 27 pairs of infected fish that were spawned based on qPCR detection of P. neurophilia DNA. The prevalence of intraovum infections from the four spawns containing infected embryos was low (~1%) based on calculation of prevalence using a maximum likelihood analysis for pooled samples. Parasite DNA was detected in the water following spawning of 11 of the infected pairs, suggesting there was also potential for extraovum transmission in these spawning events. Our study represents the first direct observation of vertical transmission within a developing embryo of a microsporidian parasite in a vertebrate. The low prevalence of vertical transmission in embryos is consistent with observations of some other fish pathogens that are also readily transmitted by both vertical and horizontal routes.
Semi-numeric simulations of helium reionization and the fluctuating radiation background
Keri L. Dixon,Steven R. Furlanetto,Andrei Mesinger
Physics , 2013, DOI: 10.1093/mnras/stu374
Abstract: Recent He II Lyman-alpha forest observations from 2.0 < z < 3.2 show large fluctuations in the optical depth at z > 2.7. These results point to a fluctuating He-ionizing background, which may be due to the end of helium reionization of this era. We present a fast, semi-numeric procedure to approximate detailed cosmological simulations. We compute the distribution of dark matter halos, ionization state of helium, and density field at z = 3 in broad agreement with recent simulations. Given our speed and flexibility, we investigate a range of ionizing source and active quasar prescriptions. Spanning a large area of parameter space, we find order-of-magnitude fluctuations in the He II ionization rate in the post-reionization regime. During reionization, the fluctuations are even stronger and develop a bimodal distribution, in contrast to semi-analytic models and the hydrogen equivalent. These distributions indicate a low-level ionizing background even at significant He II fractions.
Triboelectric charging of volcanic ash from the 2011 Grímsv?tn eruption
Isobel M. P. Houghton,Karen L. Aplin,Keri A. Nicoll
Physics , 2013, DOI: 10.1103/PhysRevLett.111.118501
Abstract: The plume from the 2011 eruption of Gr\'{i}msv\"{o}tn was highly electrically charged, as shown by the considerable lightning activity measured by the UK Met Office's low-frequency lightning detection network. Previous measurements of volcanic plumes have shown that ash particles are electrically charged up to hundreds of km away from the vent, which indicates that the ash continues to charge in the plume [Harrison et al., Env. Res. Lett. 5 024004 (2010), Hatakeyama J. Met. Soc. Japan 27 372 (1949)]. In this paper we study triboelectric charging of different size fractions of a sample of volcanic ash experimentally. Consistently with previous work, we find that the particle size distribution is a determining factor in the charging. Specifically, our laboratory experiments demonstrate that the normalised span of the particle size distribution plays an important role in the magnitude of charging generated. The influence of the normalised span on plume charging suggests that all ash plumes are likely to be charged, with implications for remote sensing and plume lifetime through scavenging effects.
Electrical charging of ash in Icelandic volcanic plumes
Karen L Aplin,Isobel M P Houghton,Keri A Nicoll
Physics , 2014,
Abstract: The existence of volcanic lightning and alteration of the atmospheric potential gradient in the vicinity of near-vent volcanic plumes provides strong evidence for the charging of volcanic ash. More subtle electrical effects are also visible in balloon soundings of distal volcanic plumes. Near the vent, some proposed charging mechanisms are fractoemission, triboelectrification, and the so-called "dirty thunderstorm" mechanism, which is where ash and convective clouds interact electrically to enhance charging. Distant from the vent, a self-charging mechanism, probably triboelectrification, has been suggested to explain the sustained low levels of charge observed on a distal plume. Recent research by Houghton et al. (2013) linked the self-charging of volcanic ash to the properties of the particle size distribution, observing that a highly polydisperse ash distribution would charge more effectively than a monodisperse one. Natural radioactivity in some volcanic ash could also contribute to self-charging of volcanic plumes. Here we present laboratory measurements of particle size distributions, triboelectrification and radioactivity in ash samples from the Gr\'{i}msv\"{o}tn and Eyjafjallaj\"{o}kull volcanic eruptions in 2011 and 2010 respectively, and discuss the implications of our findings.
Harmonic analysis of iterated function systems with overlap
Palle E. T. Jorgensen,Keri A. Kornelson,Karen L. Shuman
Mathematics , 2007, DOI: 10.1063/1.2767004
Abstract: In this paper we extend previous work on IFSs without overlap. Our method involves systems of operators generalizing the more familiar Cuntz relations from operator algebra theory, and from subband filter operators in signal processing.
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