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Search Results: 1 - 10 of 882 matches for " Kentaro Taki "
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Effects of Curing Conditions and Formulations on Residual Monomer Contents and Temperature Increase of a Model UV Gel Nail Formulation  [PDF]
Kentaro Taki, Tomomi Nakamura
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2011, DOI: 10.4236/jcdsa.2011.14017
Abstract: Recently, the application of ultraviolet (UV) curable monomers to human nails, (also known as UV gel nails) has become a popular decoration technique for women’s nails. However, the unreacted layer, the depletion of residual monomers from the cured UV gel nails, which can cause allergy and asthma, and the increase in temperature during curing process, are major concerns. In this study, the thickness of the unreacted layer, the increase in temperature, and the residual contents in cured film of UV gel nail treatment were measured for the first time. The results of this study indicated that the thickness of unreacted layer was not affected by the cast thickness; however, the intensity of UV light and the photoinitiator concentration had significant effect on the thickness of the unreacted layer. To reduce the thickness of the unreacted layer, the intensity of the UV light and the photoinitiator concentration should be increased. However, the maximum temperature observed during the curing of UV gel nails increases with an increase in the intensity of the UV light and the photoinitiator concentration. A suitable cast thickness range (21 ~ 150 μm), which resulted in the formation of a cured film and without producing temperatures that exceed that of the human body, was identified. The mass fraction of the residuals in the cured layer decreased with an increase in the exposure time, the UV intensity, and the photoinitiator concentration.
Continuous glucose monitoring with Humalog Mix 25 versus Humalog Mix 50, twice daily: A comparative pilot study -Results from the Jikei-EValuation of insulin Lispro mixture on pharmacodynamics and glycemic VariancE (J-EVOLVE) study
Rimei Nishimura, Daisuke Tsujino, Kentaro Taki, Aya Morimoto, Naoko Tajima
Cardiovascular Diabetology , 2010, DOI: 10.1186/1475-2840-9-16
Abstract: Subjects comprised type 2 diabetic patients aged 20-79 years, treated with twice daily premixed insulin or insulin analogue formulations. All subjects were hospitalized for 6 days and randomized to receive either Humalog Mix 25 (Mix 25) or Humalog Mix 50 (Mix 50). They were then crossed over to the other arm between day 3 and day 4 of the study. Continuous glucose monitoring (CGM) was performed on all subjects to examine the differences in glycemic variability.Eleven type 2 diabetic patients were enrolled. No significant difference was found in 24-hour mean glucose values and their SDs, pre-meal glucose values, increases from pre-meal to peak glucose values, or time to peak glucose levels between either group. However, the mean glucose values observed during 0-8 hrs were significantly lower with Mix 25 compared to Mix 50 (128 vs. 147 mg/dL; p = 0.024).The twice-daily Mix 25 regimen provided superior overnight glycemic control compared to the Mix 50 regimen in Japanese patients with type 2 diabetes. However, both twice-daily regimens with either Mix 25 or Mix 50 provided inadequate post-lunch glycemic control.Current Controlled Trials UMIN000001327Results from the Diabetes Control Complications Trial (DCCT) [1] and the Kumamoto Study [2] demonstrated that in both type 1 and type 2 diabetes, intensive insulin therapy combining regular- and intermediate-acting insulin formulations, provides a significantly greater improvement in HbA1c values and reduces the onset and progression of diabetes-associated microangiopathy to a greater degree, than conventional insulin therapy. These findings have led to intensive insulin therapy being proactively and increasingly used in diabetic patients.Following these results, several clinical studies involving insulin analogue mixtures have been conducted, which have consistently demonstrated that there is no significant difference in efficacy between twice-daily regimens with insulin analogue mixtures and intensive insulin therapy. Rep
A Proteomic Approach for Comprehensively Screening Substrates of Protein Kinases Such as Rho-Kinase
Mutsuki Amano,Yuta Tsumura,Kentaro Taki,Hidenori Harada,Kazutaka Mori,Tomoki Nishioka,Katsuhiro Kato,Takeshi Suzuki,Yosuke Nishioka,Akihiro Iwamatsu,Kozo Kaibuchi
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0008704
Abstract: Protein kinases are major components of signal transduction pathways in multiple cellular processes. Kinases directly interact with and phosphorylate downstream substrates, thus modulating their functions. Despite the importance of identifying substrates in order to more fully understand the signaling network of respective kinases, efficient methods to search for substrates remain poorly explored.
The Overlapping Community Structure of Structural Brain Network in Young Healthy Individuals
Kai Wu,Yasuyuki Taki,Kazunori Sato,Yuko Sassa,Kentaro Inoue,Ryoi Goto,Ken Okada,Ryuta Kawashima,Yong He,Alan C. Evans,Hiroshi Fukuda
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0019608
Abstract: Community structure is a universal and significant feature of many complex networks in biology, society, and economics. Community structure has also been revealed in human brain structural and functional networks in previous studies. However, communities overlap and share many edges and nodes. Uncovering the overlapping community structure of complex networks remains largely unknown in human brain networks. Here, using regional gray matter volume, we investigated the structural brain network among 90 brain regions (according to a predefined anatomical atlas) in 462 young, healthy individuals. Overlapped nodes between communities were defined by assuming that nodes (brain regions) can belong to more than one community. We demonstrated that 90 brain regions were organized into 5 overlapping communities associated with several well-known brain systems, such as the auditory/language, visuospatial, emotion, decision-making, social, control of action, memory/learning, and visual systems. The overlapped nodes were mostly involved in an inferior-posterior pattern and were primarily related to auditory and visual perception. The overlapped nodes were mainly attributed to brain regions with higher node degrees and nodal efficiency and played a pivotal role in the flow of informa- tion through the structural brain network. Our results revealed fuzzy boundaries between communities by identifying overlapped nodes and provided new insights into the understanding of the relationship between the structure and function of the human brain. This study provides the first report of the overlapping community structure of the structural network of the human brain.
Significant association between Helicobacter pylori infection and serum C-reactive protein
Yoshiko Ishida, Koji Suzuki, Kentaro Taki, Toshimitsu Niwa, Shozo Kurotsuchi, Hisao Ando, Akira Iwase, Kazuko Nishio, Kenji Wakai, Yoshinori Ito, Nobuyuki Hamajima
International Journal of Medical Sciences , 2008,
Abstract: Background: Helicobacter pylori (H. pylori) infection in gastric mucosa may cause systemic inflammatory reaction. This study aimed to examine the association between the infection and serum high sensitivity C-reactive protein (hsCRP). Methods: Subjects were comprised of three groups; 453 health checkup examinees from Yakumo town inhabitants in Hokkaido, Japan (YTI, 153 males and 300 females), 449 health checkup examinees (ENUH, 273 males and 176 females), and 255 female patients of an infertility clinic (PIC), Nagoya University Hospital. Twenty participants with hsCRP more than 1 mg/dl were excluded from the analysis. Those with hsCRP more than 0.1mg/dl were defined as high hsCRP individuals. H. pylori infection status was examined with a serum IgG antibody test. Results: When the three groups were combined, the geometric mean of hsCRP concentration was significantly higher among the seropositives (0.047mg/dl) than among the seronegatives (0.035mg/dl); p<0.0001 by a t-test. The percentage of high hsCRP individuals was also higher in the seropositives than in the seronegatives among any group; 23.3% and 20.1% in YTI, 22.0% and 16.0% in ENUH, and 32.7% and 18.7% in PIC, respectively, although the difference was significant only in ENUH. The summary odds ratio of the high hsCRP for the seropositives relative to the seronegatives was 1.38 (95% confidence interval, 1.01-1.89), when age, sex, body mass index, smoking, and subject group were adjusted by a logistic model. Conclusions: In three groups, hsCRP was higher among the infected individuals. The summary odd ratio indicated that H. pylori infection could influence the serum hsCRP level.
Prognostic Value of Radiological Response to Chemotherapy in Patients with Osteosarcoma
Shinji Miwa, Akihiko Takeuchi, Toshiharu Shirai, Junichi Taki, Norio Yamamoto, Hideji Nishida, Katsuhiro Hayashi, Yoshikazu Tanzawa, Hiroaki Kimura, Kentaro Igarashi, Akishi Ooi, Hiroyuki Tsuchiya
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070015
Abstract: Background Chemotherapy is essential to improve the prognosis of the patients with osteosarcoma, and the response to chemotherapy is an important prognostic factor. In this study, the impact of various radiological examinations on overall survival (OS) and event-free survival (EFS) was evaluated. Method Eighty-two patients with high-grade osteosarcoma were included in this study, and we evaluated the following factors for prognostic significance: age (≥40 years), gender (male), tumor location (truncal site), metastatic disease, histological response to chemotherapy, radiological response to chemotherapy assessed using X-ray, angiography, CT, MRI, 201Tl scintigraphy, and 99mTc-MIBI scintigraphy (99mTc-MIBI), and combined radiological score (CRS). Results Univariate analyses revealed that metastatic disease, histological response, 99mTc-MIBI, and CRS were significantly correlated with OS. Multivariate analyses showed that metastatic disease (OS: HR 35.9, P<0.001; EFS: HR 17.32, P<0.001) was an independent predictor of OS and EFS. Tumor location (HR 36.1, P = 0.003), histological response (HR 31.1, P = 0.036), and 99mTc-MIBI (HR 18.4, P = 0.038) were significant prognostic factors for OS. Moreover, CRS was a marginally significant predictor of OS and EFS. Conclusion The chemotherapeutic effects evaluated by 99mTc-MIBI and CRS could be considered as prognostic factors in osteosarcoma.
Classification of non-symplectic automorphisms on K3 surfaces which act trivially on the Néron-Severi lattice
Shingo Taki
Mathematics , 2010, DOI: 10.1016/j.jalgebra.2012.02.021
Abstract: We treat non-symplectic automorphisms on $K3$ surfaces which act trivially on the N\'{e}ron-Severi lattice. In this paper, we classify non-symplectic automorphisms of prime-power order, especially 2-power order on $K3$ surfaces, i.e., we describe their fixed locus.
Classification of non-symplectic automorphisms of order 3 on $K3$ surfaces
Shingo Taki
Mathematics , 2008, DOI: 10.1002/mana.200810070
Abstract: In this paper, we study non-symplectic automorphisms of order 3 on algebraic $K3$ surface over $\mathbb{C}$ which act trivially on the N\'{e}ron-Severi lattice. In particular we shall characterize their fixed locus in terms of the invariants of 3-elementary lattices.
Effective Life and Area Based Data Storing and Deployment in Vehicular Ad-Hoc Networks  [PDF]
Hirokazu Miura, Hideki Tode, Hirokazu Taki
Communications and Network (CN) , 2015, DOI: 10.4236/cn.2015.73014
Abstract: In vehicular ad-hoc networks (VANETs), store-carry-forward approach may be used for data sharing, where moving vehicles carry and exchange data when they go by each other. In this approach, storage resource in a vehicle is generally limited. Therefore, attributes of data that have to be stored in vehicles are an important factor in order to efficiently distribute desired data. In VANETs, there are different types of data which depend on the time and location. Such kind of data cannot be deployed adequately to the requesting vehicles only by popularity-based rule. In this paper, we propose a data distribution method that takes into account the effective life and area in addition to popularity of data. Our extensive simulation results demonstrate drastic improvements on acquisition performance of the time and area specific data.
Practical Tips for Construction of Custom Peptide Libraries and Affinity Selection by Using Commercially Available Phage Display Cloning Systems
Keisuke Fukunaga,Masumi Taki
Journal of Nucleic Acids , 2012, DOI: 10.1155/2012/295719
Abstract: Phage display technology is undoubtedly a powerful tool for affinity selection of target-specific peptide. Commercially available premade phage libraries allow us to take screening in the easiest way. On the other hand, construction of a custom phage library seems to be inaccessible, because several practical tips are absent in instructions. This paper focuses on what should be born in mind for beginners using commercially available cloning kits (Ph.D. with type 3 vector and T7Select systems for M13 and T7 phage, respectively). In the M13 system, Pro or a basic amino acid (especially, Arg) should be avoided at the N-terminus of peptide fused to gp3. In both systems, peptides containing odd number(s) of Cys should be designed with caution. Also, DNA sequencing of a constructed library before biopanning is highly recommended for finding unexpected bias. 1. Introduction Phage display technology was born in 1985 when George Smith reported that foreign peptide could be displayed on the surface of filamentous bacteriophage [3]. Today, the phage display is a versatile tool for finding specific interactions between randomized library peptides/proteins on phage and target proteins, peptides, or other molecules. For example, it is applicable for generation of therapeutic peptides against cancer [4], microbe [5], novel functional protein [6], or fully humanized monoclonal antibody [7]. The advantages of the phage display technology over other selection methods are as follows. (1) Cost of a routine is cheap. (2) Time required for selection/amplification is fast. (3) Extreme care for handling, such as RNA isolation/selection, is not necessary. The phage is a DNA-containing virus that infects bacteria and makes many copies of the library within a very short time [8]. A phage that specifically binds a target can be selected from mixtures of billions of phages, propagated by in vivo amplification, and then subjected to additional rounds of affinity selection (Figure 1). This whole process is so-called “biopanning” [9]. After multiple rounds of the biopanning, enrichment of target-binding phage can be assessed by phage titering and enzyme-linked immunosorbent assay (ELISA). Finally, the peptide displayed on the phage can be analyzed by DNA sequencing. Figure 1: A typical procedure of the biopanning. (a) Incubation of phage library with an immobilized target. (b) Washing of unbound phage. (c) Elution of target-bound phage. (d) Amplification of the eluted phage for subsequent rounds of the biopanning. 1.1. Categorization of Phage Display Systems Based on vector systems,
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