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Search Results: 1 - 10 of 1233 matches for " Kennedy Mdaki "
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Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a Maternal Low-Protein Diet
Sarah Engeham,Kennedy Mdaki,Kirsty Jewell,Ruth Austin,Alexander N. Lehner,Simon C. Langley-Evans
Journal of Nutrition and Metabolism , 2012, DOI: 10.1155/2012/989037
Abstract: Maternal protein restriction in rat pregnancy is associated with impaired renal development and age-related loss of renal function in the resulting offspring. Pregnant rats were fed either control or low-protein (LP) diets, and kidneys from their male offspring were collected at 4, 13, or 16 weeks of age. Mitochondrial state 3 and state 4 respiratory rates were decreased by a third in the LP exposed adults. The reduction in mitochondrial function was not explained by complex IV deficiency or altered expression of the complex I subunits that are typically associated with mitochondrial dysfunction. Similarly, there was no evidence that LP-exposure resulted in greater oxidative damage to the kidney, differential expression of ATP synthetase β-subunit, and ATP-ADP translocase 1. mRNA expression of uncoupling protein 2 was increased in adult rats exposed to LP in utero, but there was no evidence of differential expression at the protein level. Exposure to maternal undernutrition is associated with a decrease in mitochondrial respiration in kidneys of adult rats. In the absence of gross disturbances in respiratory chain protein expression, programming of coupling efficiency may explain the long-term impact of the maternal diet.
Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a Maternal Low-Protein Diet
Sarah Engeham,Kennedy Mdaki,Kirsty Jewell,Ruth Austin,Alexander N. Lehner,Simon C. Langley-Evans
Journal of Nutrition and Metabolism , 2012, DOI: 10.1155/2012/989037
Abstract: Maternal protein restriction in rat pregnancy is associated with impaired renal development and age-related loss of renal function in the resulting offspring. Pregnant rats were fed either control or low-protein (LP) diets, and kidneys from their male offspring were collected at 4, 13, or 16 weeks of age. Mitochondrial state 3 and state 4 respiratory rates were decreased by a third in the LP exposed adults. The reduction in mitochondrial function was not explained by complex IV deficiency or altered expression of the complex I subunits that are typically associated with mitochondrial dysfunction. Similarly, there was no evidence that LP-exposure resulted in greater oxidative damage to the kidney, differential expression of ATP synthetase β-subunit, and ATP-ADP translocase 1. mRNA expression of uncoupling protein 2 was increased in adult rats exposed to LP in utero, but there was no evidence of differential expression at the protein level. Exposure to maternal undernutrition is associated with a decrease in mitochondrial respiration in kidneys of adult rats. In the absence of gross disturbances in respiratory chain protein expression, programming of coupling efficiency may explain the long-term impact of the maternal diet. 1. Introduction Retrospective associations between low weight or thinness at birth and risk of cardiovascular disease and type 2 diabetes gave rise to the hypothesis that maternal nutritional status may be one of a number of factors that programme long-term risk of disease [1–4].This hypothesis has received strong support from studies of small and large animal species, which overwhelmingly indicate that exposure to undernutrition in pregnancy, whether specific to macronutrients [5] or micronutrients (e.g., iron) [6], or in the form of lower overall food intake [7], programmes risk of adult hypertension, glucose intolerance, insulin resistance, and dyslipidaemia [5–9].Maternal protein restriction during rat pregnancy has been widely reported to impact upon blood pressure in the exposed offspring and the hypertension observed in such animals has partly been linked to programming of renal development [10]. Maternal protein restriction brings about early-life programming through remodelling of specific tissues [11]. In the kidney, the number of nephrons is reduced through exposure to maternal undernutrition, and with ageing, low-protein-exposed animals develop glomerular injury and progressive loss of renal function [10, 12, 13]. There is evidence to suggest that this is, at least in part, mediated by decreased activity of antioxidant
An antibody present in everybody that attacks malaria infected erythrocytes  [PDF]
James Kennedy
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.67A1001
Abstract: These malaria targeting antibodies are band 3 antibodies and they recognize a special configuration of a molecule called band 3 that is present on erythrocytes. The special band 3 configuration is present on the surface of senescent erythrocytes, malaria infected erythrocytes, the erythrocytes of certain hemoglobinnopathies such as sickle cell disease and on the erythrocytes of some metabolic disorders such as G6PD. Note that these hemoglobinopathies and metabolic disorders all aid in the survival of falciparum malaria to such an extent that their incidence is increased in falciparum endemic areas [1-3]. Though there are many adhesive molecules involved in the pathology of falciparum malaria and sickle cell anemia, the focus here is on the band 3 molecules.
A Dimensional Approach to Measuring Antidepressant Response: Implications for Agomelatine  [PDF]
Sidney H. Kennedy, Anna Cyriac
Psychology (PSYCH) , 2012, DOI: 10.4236/psych.2012.310130
Abstract: Current antidepressant treatments for Major Depressive Disorder (MDD) have limited efficacy and effectiveness. While measurement of response and remission is typically based on overall symptom reduction, the utilization of a dimensional approach, involving mood, cognitive and neurovegetative symptoms, may be more effective in predicting response to different antidepressant classes. In addition to these dimensions, evaluation of function is increasingly recognized as an important patient indicator of antidepressant efficacy. This paper reviews the efficacy of second generation antidepressant classes across the proposed symptom dimensions, and explores the potential benefits of agomelatine. While further research is required, agomelatine generally performed well in the mood dimension including measures of depressed mood, anxiety and anhedonia without inducing emotional blunting. Improvements in daytime alertness and clear thinking, combined with measures of subjective and objective sleep differentiate agomelatine from other currently available antidepressants, and likely contribute to favourable functional outcomes.
Scaling Symmetry and Integrable Spherical Hydrostatics  [PDF]
Sidney Bludman, Dallas C. Kennedy
Journal of Modern Physics (JMP) , 2013, DOI: 10.4236/jmp.2013.44069
Abstract:

Any symmetry reduces a second-order differential equation to a first integral: variational symmetries of the action (exemplified by central field dynamics) lead to conservation laws, but symmetries of only the equations of motion (exemplified by scale-invariant hydrostatics) yield first-order non-conservation laws between invariants. We obtain these non- conservation laws by extending Noethers Theorem to non-variational symmetries and present an innovative variational formulation of spherical adiabatic hydrostatics. For the scale-invariant case, this novel synthesis of group theory, hydrostatics, and astrophysics allows us to recover all the known properties of polytropes and define a core radius, inside which polytropes of index n share a common core mass density structure, and outside of which their envelopes differ. The Emden solutions (regular solutions of the Lane-Emden equation) are obtained, along with useful approximations. An appendix discusses the n = 3 polytrope in order to emphasize how the same mechanical structure allows different thermal structures in relativistic degenerate white dwarfs and zero age main sequence stars.

UV Photocatalytic Degradation of Commercial Naphthenic Acid Using TiO2-Zeolite Composites  [PDF]
Kennedy K. Kalebaila, Craig Fairbridge
Journal of Water Resource and Protection (JWARP) , 2014, DOI: 10.4236/jwarp.2014.612109
Abstract: The presence of naphthenic acids in oil sand products and process streams is the cause of toxicity to aquatic life and corrosion. The removal of organic acids from tailings pond water reduces the negative impact on marine life. The ultra-violet (UV) photocatalytic reduction of commercial naphthenic acid in water using TiO2-zeolitecomposites showed a significant decrease in the concentration of naphthenic acid, accompanied by an increase in carbon dioxide formation; the presence of carbon dioxide signifies degradation of the naphthenic acids. Mixtures of the acid and photocatalyst kept in the dark did not show any concentration changes. The extent of naphthenic acid reduction by UV light was verified by the reduction in total acidity. The total acidity values of mixtures of the acid and TiO2-zeoliteexposed to UV decreased by 31% compared to mixtures kept in the dark. A reduction in total acidity may lead to a decrease in the toxicity of naphthenic acid contaminated water.
Perception of college of education lecturers about technical education research and evaluation in Nigeria
O Kennedy
African Research Review , 2009,
Abstract: The study was conducted to ascertain the perception of Federal College of Education Technical lecturers towards technical education research in South-South geo-political zone of Nigeria. In pursuance of this purpose, four research questions were formulated and one hypothesis tested. The population comprised of 70 lecturers of Federal Colleges of Education (Technical) in Asaba, Umunze and Omoku. The entire population was used for the study. No sampling was done because of the fewness of the population. The design used was a survey. The instrument used was the questionnaire. On the whole 57 items were drawn using the likert scale format. The instrument was considered valid by experts with the reliability coefficient of 0.89 using Cronbach alpha. Simple percentage and t-test were used to analyse the data. The study revealed that: Government’s inactive role in supporting and promoting research activities in colleges of education (technical) caused low morale of lecturers towards research; A lot of constraints such as poor attitude to research, falsification of research data, among others are the challenges of technical education research. The study recommends among others that: About 10 percent of the education tax fund should be voted to research; Government should improve its communication network.
Safeguarding traditional craftsmanship : a project demonstrating the revitalisation of intangible heritage in Murad Khane, Kabul
Thalia Kennedy
International Journal of Intangible Heritage , 2010,
Abstract: The paper summarises the primary activities of Turquoise Mountain’s project to revitalise the craft traditions of Afghanistan within the historic quarter of Murad Khane in Kabul’s Old City. It lays out the primary methods and approaches employed to safeguard intangible heritage within the commercial crafts sector in both the national and international spheres through a holistic approach to economic and educational development. Particular focus is given to the development of vocational training programmes that act to safeguard the social structures and traditional knowledge of the country’s intangible heritage whilst also responding to contemporary educational systems and the demands of modern commercial markets. The paper summarises the main challenges that have been addressed during the first year’s activity and lays out project-based solutions of relevance to practitioners working in similar fields. The discussion aims to set the project within established widertheoretical frameworks and indicates where advances have been achieved based on existing theory, methods and recommendations. The paper forecasts how the project may develop, how it may expand its activities in the coming years and highlights the markers of futuresuccess.
Simtrade–A Computer Model Simulating World Trade for Three or More Countries
Tom Kennedy
Journal of Economics, Business and Management , 2014, DOI: 10.7763/joebm.2014.v2.105
Abstract: Simtrade is a computational model that simulates international trade between multiple countries. It predicts the economic status of countries based on purchasing preferences and yearly events. It generates trade activity and tracks the migration of currencies, using that data to predict exchange rates. It also follows the movements of assets and calculates bond ratings. The results are a yearly tabulation of economic aggregates including realistic levels of trade, debt and investment.
The academic writing of teacher candidates: Connecting speaking and writing.
Kennedy, E.
L1 Educational Studies in Language and Literature , 2007,
Abstract: This paper presents a small-scale study that examines the relationship between spoken and written discourse among master’s level teacher candidates at an urban American university. It analyzes the writing of teacher candidates before and after the introduction of a student-centered, group interaction methodology, the Nominal Group Technique. Some of the specific areas assessed are the relationship between what students said in their groups and what they wrote in essays, interaction dynamics among teacher candidates in groups, observer perceptions of group behaviors, and teacher candidates’ perceptions of writing performance before and after the intervention. The study also assesses teacher candidates’ essays (N=9) and compares them to the essays of a control group (N=8). A significant increase in scores is noted from pretest to posttest after the treatment. Reaction to the class experience was largely positive. Pedagogic implications arising from findings are considered together with some tentative pointers toward future research.
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