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Search Results: 1 - 10 of 2661 matches for " Kelsey Jack "
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Tetra-tert-butyl 13,14-dioxapentacyclo[,7.02,9.03,8]tetradeca-5,11-diene-5,6,11,12-tetracarboxylate
Alan J. Lough,Kelsey Jack,William Tam
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812039220
Abstract: The stereochemistry of the title compound, C32H44O10, at the cyclobutane ring is cis-anti-cis. The molecule lies across an inversion center. In the crystal, weak C—H...O hydrogen bonds connect molecules into chains along [100], forming R22(6) rings.
Tetramethyl 1,4-dimethyl-13,14-dioxapentacyclo[,7.02,9.03,8]tetradeca-5,11-diene-5,6,11,12-tetracarboxylate
Alan J. Lough,Kelsey Jack,William Tam
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812039219
Abstract: In the title compound, C22H24O14, the relative stereochemistry at the cyclobutane ring is cis-anti-cis and the methyl groups in the bicyclic rings are syn to each other. The two carboxylate groups attached to the same —C=C— bond are disordered over two sets of sites in a 0.603 (2):0.397 (2) ratio. In the crystal, weak C—H...O hydrogen bonds connect molecules into C(12) chains along [001] incorporating R222(10) rings.
Hexamethyl 13,14-dioxapentacyclo[,7.02,9.03,8]tetradeca-5,11-diene-1,4,5,6,11,12-hexacarboxylate
Alan J. Lough,Kelsey Jack,William Tam
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812039232
Abstract: In the title compound, C24H24O14, the stereochemistry at the cyclobutane ring is cis-anti-cis and the –COOMe groups in the bicyclic rings are syn to each other. The molecule lies on a twofold rotation axis. In the crystal, weak C—H...O hydrogen bonds connect molecules into chains along [001], forming R22(10) rings.
Negative differential mobility of weakly driven particles in models of glass formers
Robert L. Jack,David Kelsey,Juan P. Garrahan,David Chandler
Physics , 2008, DOI: 10.1103/PhysRevE.78.011506
Abstract: We study the response of probe particles to weak constant driving in kinetically constrained models of glassy systems, and show that the probe's response can be non-monotonic and give rise to negative differential mobility: increasing the applied force can reduce the probe's drift velocity in the force direction. Oth er significant non-linear effects are also demonstrated, such as the enhancement with increasing force of the probe's fluctuations away from the average path, a phenomenon known in other contexts as giant diffusivity. We show that these res ults can be explained analytically by a continuous-time random walk approximatio n where there is decoupling between persistence and exchange times for local dis placements of the probe. This decoupling is due to dynamic heterogeneity in the glassy system, which also leads to bimodal distributions of probe particle disp lacements. We discuss the relevance of our results to experiments.
Design and Development of the Telescope-deployment High-vacuum teleOperated Rover (THOR) in an Airless Body Environment
Chris Womack,Miles Crist,Laura Kruger,Kelsey DeGeorge,Karynna Tuan,Jack Burns
Physics , 2014,
Abstract: The harsh environment on the lunar surface presents unique technological challenges for space exploration. This paper presents research on the design and development of the Tele- scope-deployment High-vacuum teleOperated Rover (THOR), currently being built and tested in the Lunar and Airless Bodies Simulator (LABS) facility at the University of Colorado Boulder. This rover is fabricated entirely out of cost-effective commercial off-the-shelf (COTS) components and materials. THOR can potentially survive for more than one simulated year in conditions similar to that of the lunar environment, demonstrating the successful initial results of a first phase research study on material and electronic survivability in an extreme environment such as the Moon.
Cost and Emissions Implications of Coupling Wind and Solar Power  [PDF]
Seth Blumsack, Kelsey Richardson
Smart Grid and Renewable Energy (SGRE) , 2012, DOI: 10.4236/sgre.2012.34041
Abstract: We assess the implications on long-run average energy production costs and emissions of CO2 and some criteria pollutants from coupling wind, solar and natural gas generation sources. We utilize five-minute meteorological data from a US location that has been estimated to have both high-quality wind and solar resources, to simulate production of a coupled generation system that produces a constant amount of electric energy. The natural gas turbine is utilized to provide fill-in energy for the coupled wind/solar system, and is compared to a base case where the gas turbine produces a constant power output. We assess the impacts on variability of coupled wind and solar over multiple time scales, and compare this variability with regional demand in a nearby load center, and find that coupling wind and solar does decrease variability of output. The cost analysis found that wind energy with gas back-up has a lower levelized cost of energy than using gas energy alone, resulting in production savings. Adding solar energy to the coupled system increases levelized cost of energy production; this cost is not made up by any reductions in emissions costs.
Insulin Resistance, Ceramide Accumulation, and Endoplasmic Reticulum Stress in Human Chronic Alcohol-Related Liver Disease
Lisa Longato,Kelsey Ripp,Mashiko Setshedi,Miroslav Dostalek,Fatemeh Akhlaghi,Mark Branda,Jack R. Wands,Suzanne M. de la Monte
Oxidative Medicine and Cellular Longevity , 2012, DOI: 10.1155/2012/479348
Abstract: Background. Chronic alcohol-related liver disease (ALD) is mediated by insulin resistance, mitochondrial dysfunction, inflammation, oxidative stress, and DNA damage. Recent studies suggest that dysregulated lipid metabolism with accumulation of ceramides, together with ER stress potentiate hepatic insulin resistance and may cause steatohepatitis to progress. Objective. We examined the degree to which hepatic insulin resistance in advanced human ALD is correlated with ER stress, dysregulated lipid metabolism, and ceramide accumulation. Methods. We assessed the integrity of insulin signaling through the Akt pathway and measured proceramide and ER stress gene expression, ER stress signaling proteins, and ceramide profiles in liver tissue. Results. Chronic ALD was associated with increased expression of insulin, IGF-1, and IGF-2 receptors, impaired signaling through IGF-1R and IRS1, increased expression of multiple proceramide and ER stress genes and proteins, and higher levels of the C14, C16, C18, and C20 ceramide species relative to control. Conclusions. In human chronic ALD, persistent hepatic insulin resistance is associated with dysregulated lipid metabolism, ceramide accumulation, and striking upregulation of multiple ER stress signaling molecules. Given the role of ceramides as mediators of ER stress and insulin resistance, treatment with ceramide enzyme inhibitors may help reverse or halt progression of chronic ALD.
Peroxiredoxin 3 Is a Redox-Dependent Target of Thiostrepton in Malignant Mesothelioma Cells
Kheng Newick, Brian Cunniff, Kelsey Preston, Paul Held, Jack Arbiser, Harvey Pass, Brooke Mossman, Arti Shukla, Nicholas Heintz
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0039404
Abstract: Thiostrepton (TS) is a thiazole antibiotic that inhibits expression of FOXM1, an oncogenic transcription factor required for cell cycle progression and resistance to oncogene-induced oxidative stress. The mechanism of action of TS is unclear and strategies that enhance TS activity will improve its therapeutic potential. Analysis of human tumor specimens showed FOXM1 is broadly expressed in malignant mesothelioma (MM), an intractable tumor associated with asbestos exposure. The mechanism of action of TS was investigated in a cell culture model of human MM. As for other tumor cell types, TS inhibited expression of FOXM1 in MM cells in a dose-dependent manner. Suppression of FOXM1 expression and coincidental activation of ERK1/2 by TS were abrogated by pre-incubation of cells with the antioxidant N-acetyl-L-cysteine (NAC), indicating its mechanism of action in MM cells is redox-dependent. Examination of the mitochondrial thioredoxin reductase 2 (TR2)-thioredoxin 2 (TRX2)-peroxiredoxin 3 (PRX3) antioxidant network revealed that TS modifies the electrophoretic mobility of PRX3. Incubation of recombinant human PRX3 with TS in vitro also resulted in PRX3 with altered electrophoretic mobility. The cellular and recombinant species of modified PRX3 were resistant to dithiothreitol and SDS and suppressed by NAC, indicating that TS covalently adducts cysteine residues in PRX3. Reduction of endogenous mitochondrial TRX2 levels by the cationic triphenylmethane gentian violet (GV) promoted modification of PRX3 by TS and significantly enhanced its cytotoxic activity. Our results indicate TS covalently adducts PRX3, thereby disabling a major mitochondrial antioxidant network that counters chronic mitochondrial oxidative stress. Redox-active compounds like GV that modify the TR2/TRX2 network may significantly enhance the efficacy of TS, thereby providing a combinatorial approach for exploiting redox-dependent perturbations in mitochondrial function as a therapeutic approach in mesothelioma.
El movimiento libertario espa ol en vísperas de la sublevación fascio-militar de julio de 1936
Graham Kelsey
Historia Actual Online , 2010,
Abstract: Este trabajo dibuja la presencia del anarcosindicalismo, de la CNT, durante la Segunda República hasta los momentos previos del golpe de estado del verano de 1936. Se estudia la peculiaridad espa ola, en el contexto europeo, de la existencia de un movimiento de masas articulado en un sindicato que hundía sus raíces directamente de los movimientos obreros del siglo XIX; las corrientes que lo conformaban, con sus deferentes proyectos finalistas, y su trayectoria desde su creación. Es especial el trabajo se detiene en la primavera de 1936. Cuando el anarcosindicalismo se había rehecho y, junto a la UGT, sus millones de afiliados parecían representar un muro infranqueable para cualquier intentona fascista. Se estudian las cuestiones puntuales presentes: la cuestión de la Alianza revolucionaria, las transformaciones en las posiciones de importantes militantes, la reunificación de las escisiones de los a os precedentes y el propio proyecto sindicalista. Finalmente, se analizan las transformaciones que el desarrollo del conflicto originó en el seno de la CNT y los problemas con los que tuvo que enfrentarse y resolver.
The Tidal Stream Power Curve: A Case Study  [PDF]
Jack Hardisty
Energy and Power Engineering (EPE) , 2012, DOI: 10.4236/epe.2012.43018
Abstract: It is important to understand the relationship between the ambient ebb and flood currents and the electricity generated by tidal stream power generators to minimise investment risk and to optimise power generation for distribution purposes. Such analyses no longer rely on average descriptions of the flow field or on single values for the device efficiency. In the present paper, we demonstrate a new method involving the integration of synthesised long termflow vectors with logistic descriptions of the device power curves. New experiments are then described with the Neptune Proteus vertical axis tidal stream power generator involving tow tests at speeds to 1.5 ms–1 in William Wright Dock on the Humber. The results are used to derive appropriate coefficients in the logisticcurve and to estimate the device’s annual electrical output.
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