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Search Results: 1 - 10 of 198148 matches for " Keerthi N "
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Our Experience with Autologous Bone Marrow Stem Cell Application in Dilated Cardiomyopathy
Mukund K,Keerthi N,Arjun K.Nambiar,Jayakrishnan AG
Journal of Stem Cells and Regenerative Medicine , 2009,
Abstract: Background - Use of autologous bone marrow stem cell is a newly evolving treatment modality for end stage cardiac failure as reported in the literature. We report our experience with two patients with dilated cardiomyopathy who underwent this treatment after failure of maximal conventional therapy. Methods - A 29 year old Male patient with history of orthopnea and PND, with a diagnosis of dilated cardiomyopathy and echocardiographic evidence of severe LV dysfunction was referred for further treatment. His echo on admission showed EF of 17% and no other abnormal findings except elevated bilirubin levels. He was in NYHA functional class IV. He received intracoronary injection of autologous bone marrow stem cells in January 2009. 254X106 cells were injected with a CD34+ of 0.20%. His clinical condition stabilized and he was discharged home. He received a second injection of 22X106 in vitro expanded stem cells with a CD34+ of 0.72% in Aug 2009. He is now in NYHA class II-III with EF 24%. A 31year old Male patient with history of increasing shortness of breath, severe over the past 3-4 days was admitted for evaluation and treatment. His echo on admission showed EF of 20% and was in NYHA functional class IV. Coronary angiogram was normal and he was stabilized on maximal anti failure measures. He received intracoronary autologous bone marrow stem cell injection of 56X106 with a CD34+ of 0.53% in August 2009. His clinical condition stabilized over the next 10 days and he was discharged home. Conclusions - In our experience of two cases of dilated cardiomyopathy, safety of intracoronary injection of autologous bone marrow stem cells both isolated and in vitro expanded has been proven in both the cases with efficacy proven in one of the cases. Long term follow-up of these two cases and inclusion of more number of similar cases where all available conventional therapies have not resulted in significant improvement for such studies are planned.
Non-Communicating inactive rudimentary horn of the uterus presenting with dysmenorrhoea—a case report of successful laparoscopic excision  [PDF]
Rachana Dwivedi, Keerthi Perera, Padma Eedarapalli
Open Journal of Obstetrics and Gynecology (OJOG) , 2011, DOI: 10.4236/ojog.2011.14041
Abstract: Uterine developmental abnormalities can cause both obstetric and gynaecological complications. Non-functioning rudimentary uterine horn is a rare cause of dysmenorrhoea which usually starts after menarche. Cases with lateral/inferior arrangement of blood supply to the functioning rudimentary horn and lapascopic removal have been described in literature. Ours is a unique case of non-functioning rudimentary horn with an unusual medial arrangement of vasculature successfully treated by laparoscopic excision. We also present a brief review of the literature. The patient presented with irretractable dysmenorrhoea despite hormonal manipulation and analgesics. Following the diagnosis using laparoscopy and hysteroscopy and MRI, the left sided non-communicating rudimentary horn with inactive endometrium was removed laparoscopically. Her symptoms were resolved and this was followed by successful pregnancies. Diagnosis of rudimentary horn with inactive endometrium is difficult. Ultrasound is unreliable. MRI, 3D CT scan and 3D ultrasound are gaining popularity. Accurate, prior identification of the type using laparoscopy and hysteroscopy if necessary is essential. This helps in surgical planning. The laparoscopic approach is increasingly being used to resect these horns due to its safety and merits.
Tuberculous Olecranon Bursitis  [PDF]
Arcot Rekha, Keerthi Kumaran, Parimuthukumar  
Case Reports in Clinical Medicine (CRCM) , 2014, DOI: 10.4236/crcm.2014.35064

Olecranon bursal involvement due to tuberculosis is not often seen in literature. Involvement is often seen in the subdeltoid and trochanteric bursa, with concomitant skeletal involvement. We report a patient with isolated tuberculous granuloma of the olecranon bursa with no comorbid illness.

Synthesis, Characterization, and Biological Activity of 5-Phenyl-1,3,4-thiadiazole-2-amine Incorporated Azo Dye Derivatives
Chinnagiri T. Keerthi Kumar,Jathi Keshavayya,Tantry N. Rajesh,Sanehalli K. Peethambar,Angadi R. Shoukat Ali
Organic Chemistry International , 2013, DOI: 10.1155/2013/370626
Abstract: 5-Phenyl-1,3,4-thiadiazole-2-amine has been synthesized by single step reaction. A series of heterocyclic azodyes were synthesized by diazotisation of 5-phenyl-1,3,4-thiadiazole-2-amine by nitrosyl sulphuric acid followed by coupling with different coupling compounds such as 8-hydroxyquinoline, 2,6-diaminopyridine, 2-naphthol, N,N-dimethyl aniline, resorcinol, and 4,6-dihydroxypyrimidine. The dyes were characterized by UV-Vis, IR, 1H-NMR, 13C NMR, and elemental analysis. The synthesized compounds were also screened for biological activity. 1. Introduction Azo dyes are the most widely used class of colouring materials because of their massive applications in various fields of science and technology [1–3]. The azo dyes are synthesized by diazotization of aromatic amines and coupling reagent, which include one or more azo groups (–N=N–) attached to one or more aromatic moieties (Karci et al. [4]). These dyes play a major role in textile, printing, leather, papermaking, drug (Torres et al. [5]) and food industries (Yousefi et al. [6]). Heterocyclic azo dyes have wide applications as high level-dying agents in the dyestuff industries (Hallas and Choi [7]). It has been known that the activity of azo linkage increases with the incorporation of suitable heterocyclic moiety. The increasing usage of these dyes in electronic industry, such as colorimetric sensors, nonlinear optical (NLO) devices and liquid crystalline displays (LCDs) used as potential sensitizers for photodynamic therapy (PDT) has attracted much attention (Demirbas et al. [8]). Nowadays, much attention has been focused on 1,3,4-thiadiazole derivatives as a very important class of nitrogen-containing aromatic heterocyclic compounds due to their diverse biological activities such as antitumor [9, 10], antibacterial [11, 12], anti-inflammatory, antimycotic (Fernandez et al. [13]), and powerful antifungal agents (Waring and Hallas [14]). In contrast, 1,3,4-thiadiazole derivatives exhibits a broad spectrum of biocidal activities possibly due to the presence of toxophoric-N-C-S moiety (Mavrova et al. [15]). With these objects in view and also work carried out in our lab on this class of azo dyes [16, 17], we now focus on synthesis and screening for antimicrobial and antioxidant activities of 5-phenyl-1,3,4-thiadiazole-2-amine containing azo group in their structure. 5-phenyl-1,3,4-thiadiazole-2-amine was synthesized by single step reaction and it was transformed to its corresponding diazonium salt by diazotization reaction and was further coupled with various coupling agents (8-hydroxy quinoline,
Current approaches to the management of Her2-negative metastatic breast cancer
Keerthi Gogineni, Angela DeMichele
Breast Cancer Research , 2012, DOI: 10.1186/bcr3064
Abstract: Current management of metastatic breast cancer (MBC) requires nuanced decision-making, synthesizing an array of factors, including a patient's goals, performance status, comorbidities, the burden and pace of disease, tumor subtype, and exposure to prior therapies. Despite an ever-expanding armamentarium of cytotoxics, endocrine therapies, biologics, and small-molecule inhibitors, only 25% of white women and 15% of black women with MBC diagnosed between 2001 and 2008 survived 53 years [1]. The following review focuses on systemic management of Her2-negative MBC organized by disease subtype. In cases of locally recurrent disease or isolated distant metastasis, site- or organ-specific therapy and palliation may take precedence over systemic strategies. Figure 1 shows the current treatment paradigm for MBC on the basis of receptor status and key considerations guiding therapeutic decision-making within each group.Metastatic involvement may be identified through standard baseline radiologic staging at the time of diagnosis of the incident breast cancer, baseline or subsequent abnormalities in laboratory indices, or evaluation of focal symptoms such as persistent shortness of breath, cough, abdominal pain, nausea, bone pain, or neurologic changes. In the absence of focal symptoms, the American Society of Clinical Oncology (ASCO) and clinical practice guidelines produced by the National Comprehensive Cancer Network maintain that imaging of bone, chest, abdomen, and pelvis is, at best, based on lower-level evidence without expert consensus [2,3]. Similarly, the use of serum tumor markers and commercially available circulating tumor cell assays to detect recurrence after primary therapy is not recommended outside of a clinical trial [4]. ASCO does recognize the potential utility of serum tumor markers to assist in monitoring patients on therapy for metastatic disease.Given the potential for discordance between the receptor status of the primary and metachronous metastases, b
Seeking the elusive function of the root-colonising dark septate endophytic fungi
Keerthi Mandyam,Ari Jumpponen
Studies in Mycology , 2005,
Abstract: A comparison of published estimates of mycorrhizal and dark septate endophyte (DSE) colonisation from various ecosystems suggests that DSE may be as abundant as mycorrhizal fungi as judged by the proportion of host plants colonised in mixed plant communities, or by the extent of colonisation in sampled root systems. While many strides have been made in understanding the ecological significance of the mycorrhizal fungi, our knowledge about the role of DSE fungi is in its infancy. In order to provide a framework of testable hypotheses, we review and discuss the most likely functions of this poorly understood group of root-associated fungi. We propose that, like mycorrhizal symbioses, DSE-plant symbioses should be considered multifunctional and not limited to nutrient acquisition and resultant positive host growth responses. Admittedly, many mycorrhizal and endophyte functions, (e.g. stress tolerance, pathogen or herbivore deterrence) are likely to be mediated by improved nutritional status and increased fitness of the host. Accordingly, it is pivotal to establish whether or not the DSE fungi are involved in host nutrient acquisition, either from inorganic and readily soluble sources, or from organic and recalcitrant sources. Facilitation by DSE of the use of organic nitrogen, phosphorus and sulphur sources by plants is a topic that warrants further attention and research. Even in the absence of a clear nutrient uptake function, the extensive DSE colonisation that occurs is likely to pre-emptively or competitively deter pathogens by minimising the carbon available in host rhizosphere environment. The DSEs’ high melanin levels and their potential production of secondary metabolites toxic or inhibitory to herbivores are also likely to be factors influencing host performance. Finally, the broad host ranges speculated for most DSE fungi thus far suggest that they are candidates for controlling plant community dynamics via differential host responses to colonisation. We emphasise the need for simple experiments that allow unravelling of the basic biological functions of DSE fungi when they colonise their hosts.
Natural Languages Translation Using an Intermediate Language
Keerthi Kamal Adusumilli
IAENG International Journal of Computer Science , 2007,
Odd-Even Based Cryptography
Keerthi Kamal Adusumilli
IAENG International Journal of Applied Mathematics , 2007,
Toroidal compactifications of integral models of Shimura varieties of Hodge type
Keerthi Madapusi Pera
Mathematics , 2012,
Abstract: We construct projective toroidal compactifications for integral models of Shimura varieties of Hodge type that parameterize isogenies of abelian varieties with additional structure. We also construct integral models of the minimal (Satake-Baily-Borel) compactification. Our results essentially reduce the problem to understanding the integral models themselves. As such, they cover all previously known cases of PEL type, as well as all cases of Hodge type involving parahoric level structures. At primes where the level is hyperspecial, we show that our compactifications are canonical in a precise sense. We also provide a new proof of Y. Morita's conjecture on the everywhere good reduction of abelian varieties whose Mumford-Tate group is anisotropic modulo center. Along the way, we demonstrate an interesting rationality property of Hodge cycles on abelian varieties with respect to p-adic analytic uniformizations.
The Tate conjecture for K3 surfaces in odd characteristic
Keerthi Madapusi Pera
Mathematics , 2013,
Abstract: We show that the classical Kuga-Satake construction gives rise, away from characteristic 2, to an open immersion from the moduli of primitively polarized K3 surfaces (of any fixed degree) to a certain regular integral model for a Shimura variety of orthogonal type. This allows us to attach to every polarized K3 surface in odd characteristic an abelian variety such that divisors on the surface can be identified with certain endomorphisms of the attached abelian variety. In turn, this reduces the Tate conjecture for K3 surfaces over finitely generated fields of odd characteristic to a version of the Tate conjecture for certain endomorphisms on the attached Kuga-Satake abelian variety, which we prove. As a by-product of our methods, we also show that the moduli stack of primitively polarized K3 surfaces of degree 2d is quasi-projective and, when d is not divisible by p^2, is geometrically irreducible in characteristic p. We indicate how the same method applies to prove the Tate conjecture for co-dimension 2 cycles on cubic fourfolds.
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